RGD Reference Report - Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. - Rat Genome Database

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Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.

Authors: Harrison, EH 
Citation: Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
RGD ID: 6484679
Pubmed: PMID:21718801   (View Abstract at PubMed)
PMCID: PMC3525326   (View Article at PubMed Central)
DOI: DOI:10.1016/j.bbalip.2011.06.002   (Journal Full-text)

Vitamin A is an essential nutrient for humans and is converted to the visual chromophore, 11-cis-retinal, and to the hormone, retinoic acid. Vitamin A in animal-derived foods is found as long chain acyl esters of retinol and these are digested to free fatty acids and retinol before uptake by the intestinal mucosal cell. The retinol is then reesterified to retinyl esters for incorporation into chlylomicrons and absorbed via the lymphatics or effluxed into the portal circulation facilitated by the lipid transporter, ABCA1. Provitamin A carotenoids such as beta-carotene are found in plant-derived foods. These and other carotenoids are transported into the mucosal cell by scavenger receptor class B type I (SR-BI). Provitamin A carotenoids are partly converted to retinol by oxygenase and reductase enzymes and the retinol so produced is available for absorption via the two pathways described above. The efficiency of vitamin A and carotenoid intestinal absorption is determined by the regulation of a number of proteins involved in the process. Polymorphisms in genes for these proteins lead to individual variability in the metabolism and transport of vitamin A and carotenoids. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABCA1Humanretinol metabolic pathway   TAS  RGD 
Abca1Ratretinol metabolic pathway   ISOABCA1 (Homo sapiens) RGD 
Abca1Mouseretinol metabolic pathway   ISOABCA1 (Homo sapiens) RGD 
BCO1Humanretinol metabolic pathway   TAS  RGD 
Bco1Ratretinol metabolic pathway   TAS  RGD 
Bco1Mouseretinol metabolic pathway   ISOBco1 (Rattus norvegicus) RGD 
CD36Humanretinol metabolic pathway   TAS  RGD 
Cd36Ratretinol metabolic pathway   ISOCD36 (Homo sapiens) RGD 
Cd36Mouseretinol metabolic pathway   ISOCD36 (Homo sapiens) RGD 
LRATHumanretinol metabolic pathway   TAS  RGD 
LratRatretinol metabolic pathway   TAS  RGD 
LratMouseretinol metabolic pathway   ISOLrat (Rattus norvegicus) RGD 
PLB1Humanretinol metabolic pathway   TAS  RGD 
PNLIPHumanretinol metabolic pathway   TAS  RGD 
PNLIPRP2Humanretinol metabolic pathway   TAS  RGD 
Plb1Ratretinol metabolic pathway   TAS  RGD 
Plb1Mouseretinol metabolic pathway   ISOPlb1 (Rattus norvegicus) RGD 
PnlipRatretinol metabolic pathway   TAS  RGD 
PnlipMouseretinol metabolic pathway   TAS  RGD 
Pnliprp2Ratretinol metabolic pathway   ISOPNLIPRP2 (Homo sapiens) RGD 
Pnliprp2Mouseretinol metabolic pathway   ISOPNLIPRP2 (Homo sapiens) RGD 
RBP2Humanretinol metabolic pathway   TAS  RGD 
Rbp2Ratretinol metabolic pathway   ISORBP2 (Homo sapiens) RGD 
Rbp2Mouseretinol metabolic pathway   ISORBP2 (Homo sapiens) RGD 
SCARB1Humanretinol metabolic pathway   TAS  RGD 
Scarb1Ratretinol metabolic pathway   ISOSCARB1 (Homo sapiens) RGD 
Scarb1Mouseretinol metabolic pathway   ISOSCARB1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Abca1  (ATP binding cassette subfamily A member 1)
Bco1  (beta-carotene oxygenase 1)
Cd36  (CD36 molecule)
Lrat  (lecithin retinol acyltransferase)
Plb1  (phospholipase B1)
Pnlip  (pancreatic lipase)
Pnliprp2  (pancreatic lipase related protein 2)
Rbp2  (retinol binding protein 2)
Scarb1  (scavenger receptor class B, member 1)

Genes (Mus musculus)
Abca1  (ATP-binding cassette, sub-family A member 1)
Bco1  (beta-carotene oxygenase 1)
Cd36  (CD36 molecule)
Lrat  (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase))
Plb1  (phospholipase B1)
Pnlip  (pancreatic lipase)
Pnliprp2  (pancreatic lipase-related protein 2)
Rbp2  (retinol binding protein 2, cellular)
Scarb1  (scavenger receptor class B, member 1)

Genes (Homo sapiens)
ABCA1  (ATP binding cassette subfamily A member 1)
BCO1  (beta-carotene oxygenase 1)
CD36  (CD36 molecule (CD36 blood group))
LRAT  (lecithin retinol acyltransferase)
PLB1  (phospholipase B1)
PNLIP  (pancreatic lipase)
PNLIPRP2  (pancreatic lipase related protein 2 (gene/pseudogene))
RBP2  (retinol binding protein 2)
SCARB1  (scavenger receptor class B member 1)


Additional Information