PNLIP (pancreatic lipase) - Rat Genome Database

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Gene: PNLIP (pancreatic lipase) Chlorocebus sabaeus
Analyze
Symbol: PNLIP
Name: pancreatic lipase
RGD ID: 18712590
Description: ENCODES a protein that exhibits lipase activity (ortholog); triglyceride lipase activity (ortholog); INVOLVED IN intestinal cholesterol absorption (ortholog); post-embryonic development (ortholog); response to lipid (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); Pancreatic Lipase Deficiency (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103216566; pancreatic triacylglycerol lipase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,330,050 - 109,375,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9109,352,806 - 109,375,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604870,600,324 - 70,623,276 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PNLIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,330,050 - 109,375,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9109,352,806 - 109,375,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604870,600,324 - 70,623,276 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PNLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810116,545,931 - 116,567,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10116,545,931 - 116,567,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3710118,305,443 - 118,327,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,295,418 - 118,317,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410118,295,448 - 118,317,356NCBI
Celera10112,034,704 - 112,056,644 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10111,932,653 - 111,954,591 (+)NCBIHuRef
CHM1_110118,588,590 - 118,610,538 (+)NCBICHM1_1
T2T-CHM13v2.010117,439,962 - 117,461,884 (+)NCBIT2T-CHM13v2.0
Pnlip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391958,658,797 - 58,670,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1958,640,930 - 58,670,220 (+)EnsemblGRCm39 Ensembl
GRCm381958,670,365 - 58,681,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,652,498 - 58,681,788 (+)EnsemblGRCm38mm10GRCm38
MGSCv371958,744,855 - 58,756,278 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361958,723,615 - 58,735,038 (+)NCBIMGSCv36mm8
Celera1960,867,340 - 60,878,784 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.46NCBI
Pnlip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81267,760,073 - 267,797,797 (+)NCBIGRCr8
mRatBN7.21257,774,012 - 257,811,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,798,581 - 257,811,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,009,226 - 266,022,367 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01272,715,238 - 272,728,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,351,509 - 265,364,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01279,798,187 - 279,811,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1279,798,187 - 279,811,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,136,617 - 287,172,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,107,812 - 265,120,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,318,856 - 265,332,014 (+)NCBI
Celera1253,456,158 - 253,469,343 (+)NCBICelera
Cytogenetic Map1q55NCBI
PNLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28128,391,967 - 128,445,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110128,428,918 - 128,451,163 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010113,067,443 - 113,158,473 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110116,568,110 - 116,589,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,568,273 - 116,589,729 (+)Ensemblpanpan1.1panPan2
PNLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,139,028 - 27,156,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,139,230 - 27,212,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,289,546 - 27,307,018 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02827,675,675 - 27,693,147 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,675,917 - 27,749,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,230,205 - 27,247,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,249,644 - 27,267,077 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,438,556 - 27,456,027 (+)NCBIUU_Cfam_GSD_1.0
PNLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,772,911 - 126,790,001 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,771,920 - 126,789,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,017,775 - 138,032,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 23 13 18
Below cutoff 8 4 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002868   ⟹   ENSCSAP00000001162
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl9109,352,806 - 109,375,670 (+)Ensembl
RefSeq Acc Id: XM_038009589   ⟹   XP_037865517
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604870,600,324 - 70,623,276 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037865517 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001162.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000001162   ⟸   ENSCSAT00000002868
RefSeq Acc Id: XP_037865517   ⟸   XM_038009589
- UniProtKB: A0A0D9QXS3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002868.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/TrEMBL
  Lipase_N UniProtKB/TrEMBL
  Lipase_panc UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  TAG_lipase UniProtKB/TrEMBL
NCBI Gene PNLIP ENTREZGENE
PANTHER PANCREATIC TRIACYLGLYCEROL LIPASE UniProtKB/TrEMBL
  PTHR11610 UniProtKB/TrEMBL
Pfam Lipase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PIRSF Lipoprotein_lipase_LIPH UniProtKB/TrEMBL
PRINTS PANCLIPASE UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/TrEMBL
PROSITE PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A0D9QXS3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 PNLIP  pancreatic lipase  LOC103216566  pancreatic lipase  Symbol and/or name change 5135510 APPROVED
2020-12-08 LOC103216566  pancreatic lipase  PNLIP  pancreatic lipase  Symbol and/or name change 5135510 APPROVED