PNLIP (pancreatic lipase) - Rat Genome Database

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Gene: PNLIP (pancreatic lipase) Canis lupus familiaris
Analyze
Symbol: PNLIP (Ensembl: PNLIPRP1)
Name: pancreatic lipase (Ensembl:pancreatic lipase related protein 1)
RGD ID: 12185777
Description: ENCODES a protein that exhibits lipase activity (ortholog); retinyl-palmitate esterase activity (ortholog); triacylglycerol lipase activity (ortholog); INVOLVED IN intestinal cholesterol absorption (ortholog); positive regulation of triglyceride lipase activity (ortholog); post-embryonic development (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH obesity (ortholog); Pancreatic Lipase Deficiency (ortholog); syndromic microphthalmia 11 (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pancreatic triacylglycerol lipase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,139,028 - 27,156,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,139,230 - 27,212,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,289,546 - 27,307,018 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02827,675,675 - 27,693,147 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,675,917 - 27,749,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,230,205 - 27,247,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,249,644 - 27,267,077 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,438,556 - 27,456,027 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PNLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,139,028 - 27,156,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,139,230 - 27,212,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,289,546 - 27,307,018 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02827,675,675 - 27,693,147 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,675,917 - 27,749,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,230,205 - 27,247,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,249,644 - 27,267,077 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,438,556 - 27,456,027 (+)NCBIUU_Cfam_GSD_1.0
PNLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810116,545,931 - 116,567,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10116,545,931 - 116,567,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3710118,305,443 - 118,327,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,295,418 - 118,317,357 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410118,295,448 - 118,317,356NCBI
Celera10112,034,704 - 112,056,644 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10111,932,653 - 111,954,591 (+)NCBIHuRef
CHM1_110118,588,590 - 118,610,538 (+)NCBICHM1_1
T2T-CHM13v2.010117,439,962 - 117,461,884 (+)NCBIT2T-CHM13v2.0
Pnlip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391958,658,797 - 58,670,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1958,640,930 - 58,670,220 (+)EnsemblGRCm39 Ensembl
GRCm381958,670,365 - 58,681,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,652,498 - 58,681,788 (+)EnsemblGRCm38mm10GRCm38
MGSCv371958,744,855 - 58,756,278 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361958,723,615 - 58,735,038 (+)NCBIMGSCv36mm8
Celera1960,867,340 - 60,878,784 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.46NCBI
Pnlip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81267,760,073 - 267,797,797 (+)NCBIGRCr8
mRatBN7.21257,774,012 - 257,811,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,798,581 - 257,811,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,009,226 - 266,022,367 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01272,715,238 - 272,728,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,351,509 - 265,364,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01279,798,187 - 279,811,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1279,798,187 - 279,811,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,136,617 - 287,172,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,107,812 - 265,120,969 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,318,856 - 265,332,014 (+)NCBI
Celera1253,456,158 - 253,469,343 (+)NCBICelera
Cytogenetic Map1q55NCBI
PNLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28128,391,967 - 128,445,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110128,428,918 - 128,451,163 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010113,067,443 - 113,158,473 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110116,568,110 - 116,589,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,568,273 - 116,589,729 (+)Ensemblpanpan1.1panPan2
PNLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,772,911 - 126,790,001 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,771,920 - 126,789,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,017,775 - 138,032,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNLIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,330,050 - 109,375,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9109,352,806 - 109,375,670 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604870,600,324 - 70,623,276 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in PNLIP
216 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
reproductive system
respiratory system
1 2 3 2 6 9 4 4 4 16 10 1 5

Sequence


RefSeq Acc Id: XM_038440691   ⟹   XP_038296619
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02827,675,675 - 27,693,147 (+)NCBI
RefSeq Acc Id: XM_038515290   ⟹   XP_038371218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12827,230,205 - 27,247,650 (+)NCBI
RefSeq Acc Id: XM_038578898   ⟹   XP_038434826
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02827,438,556 - 27,456,027 (+)NCBI
RefSeq Acc Id: XM_038643108   ⟹   XP_038499036
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02827,249,644 - 27,267,077 (+)NCBI
RefSeq Acc Id: XM_535023   ⟹   XP_535023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12827,139,028 - 27,156,457 (+)NCBI
Dog10K_Boxer_Tasha2827,289,546 - 27,307,018 (+)NCBI
Sequence:
RefSeq Acc Id: XP_535023   ⟸   XM_535023
- UniProtKB: A0A8C0PF93 (UniProtKB/TrEMBL),   A0A8I3QQI4 (UniProtKB/TrEMBL),   A0A8C0TS39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038371218   ⟸   XM_038515290
RefSeq Acc Id: XP_038499036   ⟸   XM_038643108
RefSeq Acc Id: XP_038296619   ⟸   XM_038440691
- UniProtKB: A0A8C0PF93 (UniProtKB/TrEMBL),   A0A8I3QQI4 (UniProtKB/TrEMBL),   A0A8C0TS39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434826   ⟸   XM_038578898
- UniProtKB: A0A8C0KII8 (UniProtKB/TrEMBL),   A0A8C0TS39 (UniProtKB/TrEMBL)
Protein Domains
PLAT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011815 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030025195 UniProtKB/TrEMBL
  ENSCAFG00040024900 UniProtKB/TrEMBL
  ENSCAFG00845030995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018780.5 UniProtKB/TrEMBL
  ENSCAFT00000062020.2 UniProtKB/TrEMBL
  ENSCAFT00000078730.2 UniProtKB/TrEMBL
  ENSCAFT00000081128.2 UniProtKB/TrEMBL
  ENSCAFT00000086324.2 UniProtKB/TrEMBL
  ENSCAFT00000086903.2 UniProtKB/TrEMBL
  ENSCAFT00030046638.1 UniProtKB/TrEMBL
  ENSCAFT00040046406.1 UniProtKB/TrEMBL
  ENSCAFT00040046410.1 UniProtKB/TrEMBL
  ENSCAFT00845055092.1 UniProtKB/TrEMBL
  ENSCAFT00845055098.1 UniProtKB/TrEMBL
  ENSCAFT00845055101 ENTREZGENE
  ENSCAFT00845055101.1 UniProtKB/TrEMBL
  ENSCAFT00845055110.1 UniProtKB/TrEMBL
  ENSCAFT00845055113.1 UniProtKB/TrEMBL
  ENSCAFT00845055122.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Lipase UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/TrEMBL
  Lipase_N UniProtKB/TrEMBL
  Lipase_panc UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  TAG_lipase UniProtKB/TrEMBL
NCBI Gene PNLIP ENTREZGENE
PANTHER FI22312P1 UniProtKB/TrEMBL
  INACTIVE PANCREATIC LIPASE-RELATED PROTEIN 1 UniProtKB/TrEMBL
  PANCREATIC TRIACYLGLYCEROL LIPASE UniProtKB/TrEMBL
  PTHR11610 UniProtKB/TrEMBL
Pfam Lipase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PIRSF Lipoprotein_lipase_LIPH UniProtKB/TrEMBL
PRINTS PANCLIPASE UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/TrEMBL
PROSITE PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0KII8 ENTREZGENE
  A0A8C0PF93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TS39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z6M0_CANLF UniProtKB/TrEMBL
  A0A8I3Q8D7_CANLF UniProtKB/TrEMBL
  A0A8I3QDI3_CANLF UniProtKB/TrEMBL
  A0A8I3QDJ3_CANLF UniProtKB/TrEMBL
  A0A8I3QQI4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QW49_CANLF UniProtKB/TrEMBL
  A0A8I3S7X4_CANLF UniProtKB/TrEMBL
  A0A8P0P2G3_CANLF UniProtKB/TrEMBL
  A0A8P0P472_CANLF UniProtKB/TrEMBL
  A0A8P0PC14_CANLF UniProtKB/TrEMBL
  A0A8P0T830_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0T704 UniProtKB/TrEMBL
VGNC ID VGNC:44745 ENTREZGENE