PNLIP (pancreatic lipase) - Rat Genome Database

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Gene: PNLIP (pancreatic lipase) Sus scrofa
Analyze
Symbol: PNLIP
Name: pancreatic lipase
RGD ID: 14083412
Description: ENCODES a protein that exhibits lipase activity (ortholog); triglyceride lipase activity (ortholog); INVOLVED IN intestinal cholesterol absorption (ortholog); lipid metabolic process (ortholog); post-embryonic development (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH obesity (ortholog); Pancreatic Lipase Deficiency (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH organophosphorus compound; orlistat; p-hydroxybenzyl alcohol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: pancreatic triacylglycerol lipase; PL; PTL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,771,920 - 126,789,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,771,920 - 126,789,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,017,775 - 138,032,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:27155580   PMID:27155582  


Genomics

Comparative Map Data
PNLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,771,920 - 126,789,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114126,771,920 - 126,789,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,017,775 - 138,032,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10116,545,931 - 116,567,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3810116,545,931 - 116,567,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710118,305,443 - 118,327,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,295,418 - 118,317,357 (+)NCBINCBI36hg18NCBI36
Build 3410118,295,448 - 118,317,356NCBI
Celera10112,034,704 - 112,056,644 (+)NCBI
Cytogenetic Map10q25.3NCBI
HuRef10111,932,653 - 111,954,591 (+)NCBIHuRef
CHM1_110118,588,590 - 118,610,538 (+)NCBICHM1_1
Pnlip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391958,658,797 - 58,670,231 (+)NCBIGRCm39mm39
GRCm39 Ensembl1958,640,930 - 58,670,220 (+)Ensembl
GRCm381958,670,365 - 58,681,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,652,498 - 58,681,788 (+)EnsemblGRCm38mm10GRCm38
MGSCv371958,744,855 - 58,756,278 (+)NCBIGRCm37mm9NCBIm37
MGSCv361958,723,615 - 58,735,038 (+)NCBImm8
Celera1960,867,340 - 60,878,784 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.46NCBI
Pnlip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21257,774,012 - 257,811,656 (+)NCBI
Rnor_6.0 Ensembl1279,798,187 - 279,811,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01279,798,187 - 279,811,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01287,136,617 - 287,172,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,107,812 - 265,120,969 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11265,318,856 - 265,332,014 (+)NCBI
Celera1253,456,158 - 253,469,343 (+)NCBICelera
Cytogenetic Map1q55NCBI
PNLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110116,568,110 - 116,589,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,568,273 - 116,589,729 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010113,067,443 - 113,158,473 (+)NCBIMhudiblu_PPA_v0panPan3
PNLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,139,028 - 27,156,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,139,230 - 27,212,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,289,546 - 27,307,018 (+)NCBI
ROS_Cfam_1.02827,675,675 - 27,693,147 (+)NCBI
UMICH_Zoey_3.12827,230,205 - 27,247,650 (+)NCBI
UNSW_CanFamBas_1.02827,249,644 - 27,267,077 (+)NCBI
UU_Cfam_GSD_1.02827,438,556 - 27,456,027 (+)NCBI
LOC103216566
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,330,050 - 109,375,687 (+)NCBI
ChlSab1.1 Ensembl9109,352,806 - 109,375,670 (+)Ensembl


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system
High
Medium
Low 2
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011657   ⟹   ENSSSCP00000011355
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14126,771,920 - 126,789,160 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081695   ⟹   ENSSSCP00000072179
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14126,772,911 - 126,789,160 (+)Ensembl
RefSeq Acc Id: NM_001177912   ⟹   NP_001171383
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114126,771,920 - 126,789,097 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001171383 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADD71520 (Get FASTA)   NCBI Sequence Viewer  
  P00591 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001171383   ⟸   NM_001177912
- Peptide Label: precursor
- UniProtKB: D4P6H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011355   ⟸   ENSSSCT00000011657
RefSeq Acc Id: ENSSSCP00000072179   ⟸   ENSSSCT00000081695
Protein Domains
PLAT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011355 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000072179 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011657 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000081695 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_panc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100157809 UniProtKB/TrEMBL
NCBI Gene PNLIP ENTREZGENE
PANTHER PTHR11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PANCLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2RJR8_PIG UniProtKB/TrEMBL
  D4P6H2 ENTREZGENE, UniProtKB/TrEMBL
  F1S4T9_PIG UniProtKB/TrEMBL
  LIPP_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:91597 ENTREZGENE