Pitx3 (paired-like homeodomain 3) - Rat Genome Database

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Gene: Pitx3 (paired-like homeodomain 3) Rattus norvegicus
Analyze
Symbol: Pitx3
Name: paired-like homeodomain 3
RGD ID: 3332
Description: Enables DNA-binding transcription factor activity. Involved in several processes, including cellular response to glial cell derived neurotrophic factor; positive regulation of cell proliferation in midbrain; and response to methamphetamine hydrochloride. Located in chromatin. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3); INTERACTS WITH 17beta-estradiol 3-benzoate; 5-azacytidine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein PITX3; homeobox protein PTX3; paired-like homeodomain transcription factor 3; pituitary homeobox 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,942,550 - 254,955,325 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1254,942,608 - 254,955,336 (-)EnsemblGRCr8
mRatBN7.21245,001,106 - 245,013,881 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,001,164 - 245,013,892 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,122,834 - 253,135,529 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,817,740 - 259,830,442 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,469,560 - 252,482,261 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,886,766 - 265,899,947 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,887,230 - 265,899,958 (-)Ensemblrn6Rnor6.0
Rnor_5.01273,317,125 - 273,330,306 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,355,785 - 251,368,502 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,784,495 - 240,797,213 (-)NCBICelera
RGSC_v3.11251,616,353 - 251,629,068 (-)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
nucleus  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. Addison PK, etal., Br J Ophthalmol. 2005 Feb;89(2):138-41.
2. Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Ardayfio P, etal., Neurobiol Dis. 2008 Sep;31(3):406-12. doi: 10.1016/j.nbd.2008.05.017. Epub 2008 Jun 4.
3. Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. Bidinost C, etal., Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1274-80.
4. A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter. Cazorla P, etal., J Neurochem. 2000 May;74(5):1829-37.
5. Morphine administration modulates expression of Argonaute 2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function. Garcia-Perez D, etal., Br J Pharmacol. 2013 Apr;168(8):1889-901. doi: 10.1111/bph.12083.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Green AL, etal., Neuropharmacology. 2017 Oct;125:189-196. doi: 10.1016/j.neuropharm.2017.07.020. Epub 2017 Jul 22.
9. Immunocytochemical expression of dopamine-related transcription factors Pitx3 and Nurr1 in prenatally stressed adult rats. Katunar MR, etal., J Neurosci Res. 2009 Mar;87(4):1014-22. doi: 10.1002/jnr.21911.
10. Ontogenetic expression of dopamine-related transcription factors and tyrosine hydroxylase in prenatally stressed rats. Katunar MR, etal., Neurotox Res. 2010 Jul;18(1):69-81. doi: 10.1007/s12640-009-9132-z. Epub 2009 Nov 20.
11. Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain. Krasnova IN, etal., PLoS One. 2011 Apr 25;6(4):e19179. doi: 10.1371/journal.pone.0019179.
12. Signaling of glial cell line-derived neurotrophic factor and its receptor GFRalpha1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. Lei Z, etal., J Neuropathol Exp Neurol. 2011 Sep;70(9):736-47.
13. Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function. Leo D, etal., Exp Neurol. 2007 Feb;203(2):472-80. Epub 2006 Oct 27.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Rieger DK, etal., Genomics. 2001 Feb 15;72(1):61-72.
21. Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3. Roybon L, etal., J Neurosci. 2008 Apr 2;28(14):3644-56. doi: 10.1523/JNEUROSCI.0311-08.2008.
22. A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Semina EV, etal., Nat Genet 1998 Jun;19(2):167-70.
23. A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Smidt MP, etal., Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13305-10.
24. Anterior segment mesenchymal dysgenesis in a large Australian family is associated with the recurrent 17 bp duplication in PITX3. Summers KM, etal., Mol Vis. 2008;14:2010-5. Epub 2008 Nov 5.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. Wada K, etal., PLoS One. 2014 Oct 27;9(10):e111432. doi: 10.1371/journal.pone.0111432. eCollection 2014.
Additional References at PubMed
PMID:11299318   PMID:14973278   PMID:15950611   PMID:16190884   PMID:17184956   PMID:17761882   PMID:17919745   PMID:18646205   PMID:19007884   PMID:19144721   PMID:19334279   PMID:19515692  
PMID:20175877   PMID:23863478   PMID:30634592  


Genomics

Comparative Map Data
Pitx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,942,550 - 254,955,325 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1254,942,608 - 254,955,336 (-)EnsemblGRCr8
mRatBN7.21245,001,106 - 245,013,881 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,001,164 - 245,013,892 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,122,834 - 253,135,529 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,817,740 - 259,830,442 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,469,560 - 252,482,261 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,886,766 - 265,899,947 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,887,230 - 265,899,958 (-)Ensemblrn6Rnor6.0
Rnor_5.01273,317,125 - 273,330,306 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,355,785 - 251,368,502 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,784,495 - 240,797,213 (-)NCBICelera
RGSC_v3.11251,616,353 - 251,629,068 (-)NCBI
Cytogenetic Map1q54NCBI
PITX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,230,189 - 102,241,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,230,189 - 102,241,512 (-)Ensemblhg38GRCh38
GRCh3710103,989,946 - 104,001,269 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,979,936 - 103,991,221 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410103,979,935 - 103,991,221NCBI
Celera1097,730,869 - 97,742,153 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,622,237 - 97,633,522 (-)NCBIHuRef
CHM1_110104,273,459 - 104,284,755 (-)NCBICHM1_1
T2T-CHM13v2.010103,115,176 - 103,126,499 (-)NCBIT2T-CHM13v2.0
Pitx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,123,720 - 46,136,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,124,124 - 46,136,765 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381946,135,281 - 46,148,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,135,685 - 46,148,326 (-)Ensemblmm10GRCm38
MGSCv371946,210,175 - 46,222,815 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361946,188,996 - 46,201,636 (-)NCBIMGSCv36mm8
Celera1946,899,486 - 46,912,129 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Pitx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,130,244 - 8,140,292 (+)Ensembl
ChiLan1.0NW_0049554858,130,244 - 8,140,292 (+)NCBIChiLan1.0ChiLan1.0
PITX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,117,326 - 114,132,913 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,122,647 - 114,138,234 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,833,330 - 98,846,292 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,301,528 - 102,302,943 (-)NCBIPanPan1.1PanPan1.1panPan2
PITX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,760,741 - 14,775,584 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,761,094 - 14,762,716 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2814,932,709 - 14,949,677 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02815,234,082 - 15,251,065 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,234,605 - 15,248,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,779,199 - 14,796,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,818,353 - 14,829,717 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,951,115 - 14,968,074 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pitx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,004,580 - 32,016,313 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,607,819 - 3,620,917 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,607,883 - 3,619,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,230,965 - 113,241,360 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114113,230,194 - 113,241,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,084,113 - 123,095,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PITX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,266,257 - 95,278,333 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,266,582 - 95,268,139 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604856,368,363 - 56,370,376 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,650,381 - 1,651,699 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248311,649,585 - 1,651,729 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pitx3
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:59
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000026013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1223262787260522016Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat

Markers in Region
AF005772  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81254,942,586 - 254,942,680 (+)Marker Load Pipeline
mRatBN7.21245,001,141 - 245,001,236 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,208 - 265,887,302NCBIRnor6.0
Rnor_5.01273,317,567 - 273,317,661UniSTSRnor5.0
RGSC_v3.41251,355,763 - 251,355,857UniSTSRGSC3.4
Celera1240,784,473 - 240,784,567UniSTS
Cytogenetic Map1q54UniSTS
Pitx3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,002,596 - 245,002,838 (+)MAPPERmRatBN7.2
Rnor_6.01265,888,663 - 265,888,904NCBIRnor6.0
Rnor_5.01273,319,022 - 273,319,263UniSTSRnor5.0
RGSC_v3.41251,357,218 - 251,357,459UniSTSRGSC3.4
Celera1240,785,928 - 240,786,169UniSTS
Cytogenetic Map1q54UniSTS
RH142219  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81254,942,653 - 254,942,845 (+)Marker Load Pipeline
mRatBN7.21245,001,209 - 245,001,401 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,276 - 265,887,467NCBIRnor6.0
Rnor_5.01273,317,635 - 273,317,826UniSTSRnor5.0
RGSC_v3.41251,355,831 - 251,356,022UniSTSRGSC3.4
Celera1240,784,541 - 240,784,732UniSTS
RH 3.4 Map9495.9UniSTS
Cytogenetic Map1q54UniSTS
D1Bda64  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81254,943,248 - 254,943,938 (+)Marker Load Pipeline
mRatBN7.21245,001,804 - 245,002,494 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,871 - 265,888,560NCBIRnor6.0
Rnor_5.01273,318,230 - 273,318,919UniSTSRnor5.0
RGSC_v3.41251,356,426 - 251,357,115UniSTSRGSC3.4
Celera1240,785,136 - 240,785,825UniSTS
Cytogenetic Map1q54UniSTS
UniSTS:144187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,001,811 - 245,002,023 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,878 - 265,888,089NCBIRnor6.0
Rnor_5.01273,318,237 - 273,318,448UniSTSRnor5.0
RGSC_v3.41251,356,433 - 251,356,644UniSTSRGSC3.4
Celera1240,785,143 - 240,785,354UniSTS
Cytogenetic Map1q54UniSTS
UniSTS:256827  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81254,943,209 - 254,943,920 (+)Marker Load Pipeline
mRatBN7.21245,001,765 - 245,002,476 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,832 - 265,888,542NCBIRnor6.0
Rnor_5.01273,318,191 - 273,318,901UniSTSRnor5.0
RGSC_v3.41251,356,387 - 251,357,097UniSTSRGSC3.4
Celera1240,785,097 - 240,785,807UniSTS
Cytogenetic Map1q54UniSTS
Pitx3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,001,811 - 245,002,022 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,878 - 265,888,088NCBIRnor6.0
Rnor_5.01273,318,237 - 273,318,447UniSTSRnor5.0
RGSC_v3.41251,356,433 - 251,356,643UniSTSRGSC3.4
Celera1240,785,143 - 240,785,353UniSTS
Cytogenetic Map1q54UniSTS
Pitx3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,001,507 - 245,002,845 (+)MAPPERmRatBN7.2
Rnor_6.01265,887,574 - 265,888,911NCBIRnor6.0
Rnor_5.01273,317,933 - 273,319,270UniSTSRnor5.0
Celera1240,784,839 - 240,786,176UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 11 42 87 31 30 15 1 15 6 137 66 8 67 37 61 15 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000026013   ⟹   ENSRNOP00000026013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,942,608 - 254,955,336 (-)Ensembl
mRatBN7.2 Ensembl1245,001,164 - 245,013,892 (-)Ensembl
Rnor_6.0 Ensembl1265,887,230 - 265,899,958 (-)Ensembl
RefSeq Acc Id: NM_019247   ⟹   NP_062120
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,942,608 - 254,955,325 (-)NCBI
mRatBN7.21245,001,164 - 245,013,881 (-)NCBI
Rnor_6.01265,887,230 - 265,899,947 (-)NCBI
Rnor_5.01273,317,125 - 273,330,306 (-)NCBI
RGSC_v3.41251,355,785 - 251,368,502 (-)RGD
Celera1240,784,495 - 240,797,213 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231478   ⟹   XP_006231540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,942,550 - 254,948,262 (-)NCBI
mRatBN7.21245,001,106 - 245,006,844 (-)NCBI
Rnor_6.01265,886,766 - 265,892,917 (-)NCBI
Rnor_5.01273,317,125 - 273,330,306 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062120 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231540 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA09455 (Get FASTA)   NCBI Sequence Viewer  
  EDL94336 (Get FASTA)   NCBI Sequence Viewer  
  EDL94337 (Get FASTA)   NCBI Sequence Viewer  
  EDL94338 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026013
  ENSRNOP00000026013.2
GenBank Protein P81062 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062120   ⟸   NM_019247
- UniProtKB: P81062 (UniProtKB/Swiss-Prot),   A6JHL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231540   ⟸   XM_006231478
- Peptide Label: isoform X1
- UniProtKB: P81062 (UniProtKB/Swiss-Prot),   A6JHL3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026013   ⟸   ENSRNOT00000026013
Protein Domains
Homeobox   OAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81062-F1-model_v2 AlphaFold P81062 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3332 AgrOrtholog
BioCyc Gene G2FUF-55526 BioCyc
Ensembl Genes ENSRNOG00000019194 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026013 ENTREZGENE
  ENSRNOT00000026013.4 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_Pitx/unc30 UniProtKB/Swiss-Prot
  OAR_dom UniProtKB/Swiss-Prot
KEGG Report rno:29609 UniProtKB/Swiss-Prot
NCBI Gene 29609 ENTREZGENE
PANTHER PITUITARY HOMEOBOX 3 UniProtKB/Swiss-Prot
  PITUITARY HOMEOBOX HOMOLOG PTX1 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
  OAR UniProtKB/Swiss-Prot
PhenoGen Pitx3 PhenoGen
PIRSF Homeobox_protein_Pitx/Unc30 UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
  OAR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019194 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
TIGR TC218469
UniProt A6JHL3 ENTREZGENE, UniProtKB/TrEMBL
  A6JHL4_RAT UniProtKB/TrEMBL
  P81062 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Pitx3  paired-like homeodomain 3  Pitx3  paired-like homeodomain transcription factor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pitx3  paired-like homeodomain transcription factor 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed specifically in neurons of the mesencephalic dopaminergic (mesDA) system 69932