Xpnpep1 (X-prolyl aminopeptidase 1)

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Gene: Xpnpep1 (X-prolyl aminopeptidase 1) Rattus norvegicus

Analyze

Symbol:

Xpnpep1

Name:

X-prolyl aminopeptidase 1

RGD ID:

621274

Description:

Enables aminopeptidase activity. Involved in proteolysis. Located in cytoplasm. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

aminoacylproline aminopeptidase; cytoplasmic aminopeptidase P; cytosolic aminopeptidase P; sAmp; soluble aminopeptidase P; X-Pro aminopeptidase 1, soluble; X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; X-prolyl aminopeptidase 1, soluble; xaa-Pro aminopeptidase 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	XPNPEP1 (X-prolyl aminopeptidase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Xpnpep1 (X-prolyl aminopeptidase (aminopeptidase P) 1, soluble)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Xpnpep1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	XPNPEP1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	XPNPEP1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Xpnpep1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	XPNPEP1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	XPNPEP1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Xpnpep1 (X-prolyl aminopeptidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	XPNPEP1 (X-prolyl aminopeptidase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Xpnpep1 (X-prolyl aminopeptidase (aminopeptidase P) 1, soluble)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	xpnpep1 (X-prolyl aminopeptidase (aminopeptidase P) 1, soluble)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ApepP	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FRA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y45G5AM.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	app-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	252,001,366 - 252,052,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	252,001,367 - 252,051,479 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	260,189,774 - 260,239,893 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	266,895,833 - 266,945,952 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	259,547,854 - 259,598,654 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	273,708,217 - 273,758,247 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	273,708,212 - 273,758,442 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	281,121,567 - 281,171,473 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	259,089,652 - 259,139,681 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	259,355,566 - 259,405,597 (-)	NCBI
Celera	1	247,726,460 - 247,776,301 (-)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

flutamide (EXP)

folic acid (ISO)

gallic acid (ISO)

haloperidol (ISO)

indometacin (ISO)

inulin (ISO)

isobutanol (ISO)

ivermectin (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

Salinomycin (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

thapsigargin (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bradykinin catabolic process (ISO,ISS)

negative regulation of programmed cell death (ISO,ISS)

proteolysis (IDA,ISO)

Cellular Component

cellular anatomical entity (IEA)

cytoplasm (IDA)

cytosol (ISO)

Molecular Function

aminopeptidase activity (IDA,ISO)

manganese ion binding (ISO,ISS)

metal ion binding (IEA)

metalloaminopeptidase activity (IEA,ISO,ISS)

protein binding (ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

kallikrein-kinin cascade pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P.	Czirjak G, etal., Biochim Biophys Acta 1999 Mar 19;1444(3):326-36.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	The kallikrein-kinin system: current and future pharmacological targets.	Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11106490	PMID:12874451	PMID:15489334	PMID:17515839	PMID:18515364	PMID:20431301	PMID:22082260	PMID:22871113	PMID:23376485	PMID:23533145	PMID:26683993

Genomics

Comparative Map Data

Xpnpep1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	252,001,366 - 252,052,077 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	252,001,367 - 252,051,479 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	260,189,774 - 260,239,893 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	266,895,833 - 266,945,952 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	259,547,854 - 259,598,654 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	273,708,217 - 273,758,247 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	273,708,212 - 273,758,442 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	281,121,567 - 281,171,473 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	259,089,652 - 259,139,681 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	259,355,566 - 259,405,597 (-)	NCBI
Celera	1	247,726,460 - 247,776,301 (-)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

XPNPEP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	109,864,766 - 109,923,511 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	109,864,766 - 109,923,553 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	111,624,524 - 111,683,269 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	111,614,514 - 111,673,192 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	111,614,513 - 111,673,192	NCBI
Celera	10	105,356,208 - 105,414,975 (-)	NCBI		Celera
Cytogenetic Map	10	q25.1	NCBI
HuRef	10	105,255,598 - 105,314,375 (-)	NCBI		HuRef
CHM1_1	10	111,906,232 - 111,965,041 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	110,748,625 - 110,807,363 (-)	NCBI		T2T-CHM13v2.0

Xpnpep1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	52,919,710 - 53,027,093 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	52,920,357 - 53,028,645 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	52,931,279 - 53,038,662 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	52,931,926 - 53,040,214 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	53,065,673 - 53,113,032 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	53,044,495 - 53,091,854 (-)	NCBI		MGSCv36	mm8
Celera	19	55,173,619 - 55,221,048 (-)	NCBI		Celera
Cytogenetic Map	19	D2	NCBI

Xpnpep1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	1,436,834 - 1,501,463 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955485	1,436,834 - 1,501,408 (+)	NCBI	ChiLan1.0	ChiLan1.0

XPNPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	121,749,204 - 121,807,967 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	106,457,390 - 106,516,111 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	109,908,285 - 109,967,100 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	109,908,285 - 109,967,094 (-)	Ensembl	panpan1.1		panPan2

XPNPEP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	21,267,588 - 21,322,044 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	21,246,467 - 21,321,953 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	21,410,929 - 21,465,285 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	21,782,248 - 21,836,736 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	21,760,215 - 21,836,755 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	21,343,307 - 21,397,639 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	21,342,664 - 21,397,127 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	21,482,813 - 21,537,258 (-)	NCBI		UU_Cfam_GSD_1.0

Xpnpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	24,708,158 - 24,759,708 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	801,328 - 853,147 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936486	801,563 - 853,107 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XPNPEP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	120,315,910 - 120,367,780 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	120,316,578 - 120,367,995 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	131,108,925 - 131,204,866 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

XPNPEP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	102,792,424 - 102,840,479 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	102,782,895 - 102,784,895 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
ChlSab1.1 Ensembl	9	102,782,895 - 102,784,895 (-)	NCBI	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	63,982,600 - 64,043,409 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xpnpep1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624737	36,343,159 - 36,402,940 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Xpnpep1
526 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	26
Count of miRNA genes:	26
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000033148
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	213707201	252085212	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	218748008	257976495	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	218753816	256448513	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	222363780	260522016	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	223201027	260522016	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	224054293	260122809	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	224054293	260122809	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	224569538	260122809	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	225126575	260522016	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	228581588	259647894	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	232156370	259647894	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233190394	258625266	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	233948574	260522016	Rat
631690	Scl5	Serum cholesterol level QTL 5	2.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	236125214	260522016	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	0.00000487	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	237147813	260522016	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	238699859	259647894	Rat
1598839	Rf56	Renal function QTL 56			renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	245907761	257976495	Rat

Markers in Region

RH129041

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	252,001,395 - 252,001,585 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	252,001,395 - 252,002,084 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	273,708,246 - 273,708,934	NCBI	Rnor6.0
Rnor_6.0	1	273,708,246 - 273,708,435	NCBI	Rnor6.0
Rnor_5.0	1	281,121,596 - 281,122,284	UniSTS	Rnor5.0
Rnor_5.0	1	281,121,596 - 281,121,785	UniSTS	Rnor5.0
RGSC_v3.4	1	259,089,680 - 259,090,368	UniSTS	RGSC3.4
RGSC_v3.4	1	259,089,680 - 259,089,869	UniSTS	RGSC3.4
Celera	1	247,726,489 - 247,726,678	UniSTS
Celera	1	247,726,489 - 247,727,177	UniSTS
RH 3.4 Map	1	1664.5	UniSTS
Cytogenetic Map	1	q55	UniSTS

RH129233

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	252,001,560 - 252,001,776 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	273,708,411 - 273,708,626	NCBI	Rnor6.0
Rnor_5.0	1	281,121,761 - 281,121,976	UniSTS	Rnor5.0
RGSC_v3.4	1	259,089,845 - 259,090,060	UniSTS	RGSC3.4
Celera	1	247,726,654 - 247,726,869	UniSTS
RH 3.4 Map	1	1665.7	UniSTS
Cytogenetic Map	1	q55	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001398660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_131913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF038591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000033148 ⟹ ENSRNOP00000031325

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	252,001,367 - 252,044,548 (-)	Ensembl
Rnor_6.0 Ensembl	1	273,708,217 - 273,758,247 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088016 ⟹ ENSRNOP00000069329

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	252,001,367 - 252,051,479 (-)	Ensembl
Rnor_6.0 Ensembl	1	273,708,212 - 273,758,442 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111011 ⟹ ENSRNOP00000079124

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	252,001,367 - 252,051,479 (-)	Ensembl

RefSeq Acc Id:

NM_131913 ⟹ NP_571988

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	252,001,366 - 252,051,513 (-)	NCBI
Rnor_6.0	1	273,708,217 - 273,758,247 (-)	NCBI
Rnor_5.0	1	281,121,567 - 281,171,473 (-)	NCBI
RGSC_v3.4	1	259,089,652 - 259,139,681 (-)	RGD
Celera	1	247,726,460 - 247,776,301 (-)	NCBI

Sequence:

show sequence

GCGAATGGCAGCCTCCAGAAAGCCGCCGCGAGTAAGACCACAGGATGGCTCCGAAGGTGACCTC
AGAGCTTCTGCGGCAGCTGCGACAAGCTATGAGGAACTCGGAGTGCGTGGCAGAACCCATCCAG
GCCTACATCATCCCATCGGGAGACGCCCACCAGAGTGAGTACATTGCACCCTGTGACTGTCGGA
GGGCGTTCGTCTCCGGCTTCGATGGCTCTGCAGGCACAGCTATCATCACGGAGGAGCATGCGGC
CATGTGGACGGATGGGCGCTACTTTCTCCAAGCTGCCAAGCAGATGGACAACAACTGGACCCTC
ATGAAGATGGGTCTGAAGGACACACCGACTCAGGAGGACTGGCTGGTGAGTGTGCTTCCGGAAG
GATCCAGGGTTGGTGTGGACCCTCTCATCATTCCCACAGATTACTGGAAGAAGATGGCCAAGGT
ACTTCGAAGTGCTGGTCACCACCTCGTGCCTGTGAAGGAGAACCTTGTGGATAAGATCTGGACA
GACCGGCCAGAGCGCCCTTGCAAGCCCCTCCTCACACTGGGTCTGGATTATACAGGCATCTCGT
GGAAGGAGAAGGTTGCAGACCTTCGGTTGAAAATGGCGGAGAGGAGCATCGTGTGGTTTGTGGT
CACTGCCCTAGACGAGATTGCATGGCTGTTCAATCTCCGAGGGTCAGATGTGGAGCACAACCCG
GTGTTTTTCTCCTACGCAATCATAGGACTAGAGAGGATCATGCTCTTCATCGACGGGGACCGCA
TTGATGCGCCTGGTGTGAAACAGCACCTGCTCCTTGACTTGGGCCTGGAGGCAGAATATAAAAT
CCAGGTGCTGCCTTACAAGTCCATCCTGAGTGAACTCAAGACCCTGTGTGCTGACCTGTCCCCG
AGGGAGAAGGTGTGGGTCAGTGACAAAGCCAGCTATGCTGTGAGCGAGGCCATCCCCAAGGATC
ATCGGTGCTGTATGCCTTATACGCCCATCTGCATTGCCAAAGCCGTGAAGAACTCCGCCGAGTC
AGCAGGCATGAGGCGGGCTCATATTAAAGATGCCGTTGCCCTCTGCGAGCTCTTCAACTGGCTG
GAGCAAGAGGTCCCCAAAGGTGGCGTAACGGAGATCTCTGCAGCTGACAAGGCTGAGGAATTTC
GAAGACAACAGGCTGACTTTGTGGACCTGAGCTTCCCAACGATTTCCAGCACGGGACCCAACGG
CGCCATCATTCACTACGCGCCGATCCCTGAGACGAATAGGACCCTGTCCCTGGATGAGGTGTAT
CTCATTGACTCCGGTGCTCAGTACAAGGATGGAACTACAGACGTTACCCGGACCATGCACTTCG
GGACCCCTACTGCCTATGAGAAGGAGTGTTTCACGTATGTACTGAAAGGCCACATTGCTGTGAG
CGCGGCTGTTTTCCCAACGGGAACCAAAGGCCACCTTCTAGACTCCTTTGCCCGGTCAGCCCTG
TGGGATTCCGGCCTGGATTACCTGCACGGAACAGGACACGGCGTCGGGTCTTTCCTGAATGTTC
ACGAGGGCCCTTGTGGCATCAGTTATAAAACGTTCTCTGACGAGCCCTTGGAAGCCGGCATGAT
CGTCACTGATGAGCCAGGGTATTATGAAGATGGGGCGTTTGGGATCCGCATCGAGAACGTTGTT
TTGGTGGTCCCTGCGAAGACCAAGTATAATTTCAATAACCGAGGAAGCCTGACCTTTGAACCTC
TAACTTTGGTTCCCATCCAGACCAAAATGATAGATGTGGATGCTCTTACAGATAAAGAGTGTGA
CTGGCTCAACAGCTACCACCAGACCTGCAGGGATGTGATTGGGAAGGAGCTGCAGACTCAAGGC
CGCCAGGAAGCTCTCGAGTGGCTCCTCAGAGAGACAGAGCCCATCTCCAGGCAGCATTGATACC
GTCTAGCGTTTGTTTTTGTAGGATGCTCTGGGGAAGGAAGACACATGGCAGACCCTGACTTCTT
TCTCCTCACCTCCTCCTCCTCCCCAACTCCCCTTTTTACTTTTAGACACTAAGAAGGGCAGAAA
CTCTTCTTATCCACTTTGATATTTTCTTGCAAACAGTCTTTTATGAATTTTTAATTGTTGAGAA
TGAGCCAGGAATAAAACTGCTACACCAGAAGGAGGGGCCTCACAAAGCGAAGCCTTGACAAGGG
GGAGATACCCGAGCCCTCTGGCCAGCGGTGGCCAGCGGTGACTGCTCTGCGATGGTCTCCTTCC
AGGTGCTGGTACCTCAGTCGCGGTCACCCTGACGTTCATGAGACCCTCCTATGATCAGTGAATA
AAATACTAAACTCGGAAGAGATGAGTGCCTATGGTGTGTACAGATAACCCTCTGATTTTGTGGG
TTTCTGAGCGGCC

hide sequence

RefSeq Acc Id:

XM_039084351 ⟹ XP_038940279

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	252,001,367 - 252,052,076 (-)	NCBI

RefSeq Acc Id:

XM_039084410 ⟹ XP_038940338

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	252,001,367 - 252,047,416 (-)	NCBI

RefSeq Acc Id:

XM_039084472 ⟹ XP_038940400

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	252,001,367 - 252,052,077 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001385589	(Get FASTA)	NCBI Sequence Viewer
	NP_571988	(Get FASTA)	NCBI Sequence Viewer
	XP_038940279	(Get FASTA)	NCBI Sequence Viewer
	XP_038940338	(Get FASTA)	NCBI Sequence Viewer
	XP_038940400	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB95331	(Get FASTA)	NCBI Sequence Viewer
	AAH61758	(Get FASTA)	NCBI Sequence Viewer
	EDL94409	(Get FASTA)	NCBI Sequence Viewer
	EDL94410	(Get FASTA)	NCBI Sequence Viewer
	EDL94411	(Get FASTA)	NCBI Sequence Viewer
	O54975	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_571988 ⟸ NM_131913

- UniProtKB:

O54975 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPKVTSELLRQLRQAMRNSECVAEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAI
ITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDY
WKKMAKVLRSAGHHLVPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAER
SIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERIMLFIDGDRIDAPGVKQHLLLDLG
LEAEYKIQVLPYKSILSELKTLCADLSPREKVWVSDKASYAVSEAIPKDHRCCMPYTPICIAKA
VKNSAESAGMRRAHIKDAVALCELFNWLEQEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTI
SSTGPNGAIIHYAPIPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVL
KGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDE
PLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDA
LTDKECDWLNSYHQTCRDVIGKELQTQGRQEALEWLLRETEPISRQH

hide sequence

RefSeq Acc Id:

ENSRNOP00000031325 ⟸ ENSRNOT00000033148

RefSeq Acc Id:

ENSRNOP00000069329 ⟸ ENSRNOT00000088016

RefSeq Acc Id:	XP_038940400 ⟸ XM_039084472
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6G2V2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940279 ⟸ XM_039084351
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038940338 ⟸ XM_039084410
- Peptide Label:	isoform X2
- UniProtKB:	O54975 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:

ENSRNOP00000079124 ⟸ ENSRNOT00000111011

Protein Domains

Creatinase N-terminal Peptidase M24 Peptidase M24 C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54975-F1-model_v2	AlphaFold	O54975	1-623	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690987

Promoter ID:

EPDNEW_R1512

Type:

multiple initiation site

Name:

Xpnpep1_1

Description:

X-prolyl aminopeptidase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	273,758,256 - 273,758,316	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621274	AgrOrtholog
BioCyc Gene	G2FUF-55406	BioCyc
Ensembl Genes	ENSRNOG00000012084	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000031325	ENTREZGENE
	ENSRNOP00000031325.4	UniProtKB/TrEMBL
	ENSRNOP00000069329	ENTREZGENE
	ENSRNOP00000069329.1	UniProtKB/TrEMBL
	ENSRNOP00000079124	ENTREZGENE
	ENSRNOP00000079124.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033148	ENTREZGENE
	ENSRNOT00000033148.4	UniProtKB/TrEMBL
	ENSRNOT00000088016	ENTREZGENE
	ENSRNOT00000088016.2	UniProtKB/TrEMBL
	ENSRNOT00000111011	ENTREZGENE
	ENSRNOT00000111011.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.350.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.230.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5600093	IMAGE-MGC_LOAD
InterPro	Creatin/AminoP/Spt16_NTD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Creatinase/aminopeptidase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Creatinase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M24	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M24B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M24_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M24B_aminopep-P_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:170751	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72323	IMAGE-MGC_LOAD
NCBI Gene	170751	ENTREZGENE
PANTHER	XAA-PRO AMINOPEPTIDASE 1	UniProtKB/Swiss-Prot
	XAA-PRO AMINOPEPTIDASE 1	UniProtKB/Swiss-Prot
	XAA-PRO AMINOPEPTIDASE 1	UniProtKB/TrEMBL
	XAA-PRO AMINOPEPTIDASE 1	UniProtKB/TrEMBL
Pfam	Creatinase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Creatinase_N_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M24	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M24_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Xpnpep1	PhenoGen
PROSITE	PROLINE_PEPTIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53092	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55920	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JV31	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G2V2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QGG3_RAT	UniProtKB/TrEMBL
	O54975	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-13	Xpnpep1	X-prolyl aminopeptidase 1	Xpnpep1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Xpnpep1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble		cytoplasmic aminopeptidase P	Name updated	1299863	APPROVED
2002-08-07	Xpnpep1	cytoplasmic aminopeptidase P			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed ubiquitously with highest expression in testis	634520

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations