Adra2a (adrenoceptor alpha 2A) - Rat Genome Database

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Gene: Adra2a (adrenoceptor alpha 2A) Rattus norvegicus
Analyze
Symbol: Adra2a
Name: adrenoceptor alpha 2A
RGD ID: 2056
Description: Enables alpha2-adrenergic receptor activity. Involved in several processes, including negative regulation of secretion by cell; negative regulation of uterine smooth muscle contraction; and response to morphine. Located in axon terminus and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study anxiety disorder and depressive disorder. Biomarker of alcohol dependence; hypertension; morphine dependence; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrenergic alpha 2A receptor; adrenergic receptor, alpha 2a; Adrenergic, alpha 2A, receptor; adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha-2D adrenergic receptor; CA2-47; RATRG20; RG20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Adra2aem1Mcwi  
Genetic Models: SS-Adra2aem1Mcwi-/- SS-Adra2aem1Mcwi
Is Marker For: Strains:   F344.GK-(D1Swe8-D1Gpam-1)/Swe  
Candidate Gene For: Lnnr2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81263,066,780 - 263,069,580 (+)NCBIGRCr8
mRatBN7.21253,061,480 - 253,064,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1253,060,218 - 253,064,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1261,250,961 - 261,253,761 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,957,040 - 267,959,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,612,912 - 260,615,708 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methoxyidazoxan  (ISO)
2-phenylethylamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitraz  (EXP,ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atenolol  (ISO)
atrazine  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brimonidine tartrate  (EXP,ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyanazine  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
entinostat  (ISO)
fipronil  (EXP)
folic acid  (ISO)
glycidol  (EXP)
idazoxan  (EXP)
indapamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
malathion  (ISO)
medetomidine  (ISO)
methylisothiazolinone  (ISO)
morphine  (EXP)
Moxonidine  (ISO)
naloxone  (EXP)
nickel atom  (EXP)
niclosamide  (ISO)
oxcarbazepine  (EXP)
oxymetazoline  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phentolamine  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium dichromate  (ISO)
prazosin  (EXP,ISO)
pregabalin  (ISO)
progesterone  (ISO)
reserpine  (EXP)
Rilmenidine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
synephrine  (ISO)
Talipexole dihydrochloride  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topiramate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
xylazine  (EXP)
Xylometazoline  (ISO)
yohimbine  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activation of protein kinase B activity  (IEA,ISO)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adrenergic receptor signaling pathway  (ISO)
cellular response to hormone stimulus  (ISO)
DNA replication  (IMP)
fear response  (ISO)
female pregnancy  (IMP)
G protein-coupled receptor signaling pathway  (IMP,ISO)
glucose homeostasis  (IMP,ISO)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of insulin secretion  (ISO)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP,ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of uterine smooth muscle contraction  (IMP)
phospholipase C-activating adrenergic receptor signaling pathway  (ISO)
platelet activation  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of wound healing  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of vasoconstriction  (IEA)
response to alcohol  (IEP)
response to morphine  (IEP)
thermoception  (IDA)
vasodilation  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway. Bavencoffe A, etal., J Biol Chem. 2010 Mar 26;285(13):9410-9. Epub 2010 Jan 28.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Naloxone-precipitated withdrawal in morphine-dependent rats increases the expression of alpha 2a-adrenoceptor mRNA in brain. Busquets X, etal., Brain Res Mol Brain Res. 1997 Apr;45(1):154-8. doi: 10.1016/s0169-328x(96)00307-5.
4. Molecular cloning, sequencing and expression of an alpha 2-adrenergic receptor complementary DNA from rat brain. Chalberg SC, etal., Mol Cell Biochem 1990 Sep 21;97(2):161-72.
5. Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. Cheon KA, etal., Biol Psychiatry. 2009 Apr 1;65(7):564-70. Epub 2009 Jan 15.
6. Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse. Clarke TK, etal., Addict Biol. 2012 Jan;17(1):202-8. doi: 10.1111/j.1369-1600.2010.00263.x. Epub 2010 Nov 11.
7. Pancreatic beta-cell alpha2A adrenoceptor and phospholipid changes in hyperlipidemic rats. Clement L, etal., Lipids 2002 May;37(5):501-6.
8. Αlpha 2a-Adrenoceptor Gene Expression and Early Life Stress-Mediated Propensity to Alcohol Drinking in Outbred Rats. Comasco E, etal., Int J Environ Res Public Health. 2015 Jun 25;12(7):7154-71. doi: 10.3390/ijerph120707154.
9. Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. Comings DE, etal., Psychiatr Genet 2000 Mar;10(1):39-42.
10. Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. De Felice M, etal., Pain. 2011 Dec;152(12):2701-9. Epub 2011 Jul 13.
11. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Dwyer JM, etal., Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. Epub 2010 Jan 5.
12. Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia. Fuchigami T, etal., Neuroscience. 2011 Oct 27;194:160-9. Epub 2011 Aug 16.
13. The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat. Gal A, etal., Eur J Pharmacol. 2009 Aug 1;615(1-3):193-200. Epub 2009 May 15.
14. Different roles of alpha2-adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat. Gaspar R, etal., Neurochem Int. 2007 Oct;51(5):311-8. Epub 2007 Jul 1.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Alpha-2A-adrenergic receptors are present on neurons in the central nucleus of the amygdala that project to the dorsal vagal complex in the rat. Glass MJ, etal., Synapse 2002 Dec 15;46(4):258-68.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular carcinoma tumorigenesis in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH). Jia Y, etal., Exp Mol Pathol. 2018 Aug;105(1):144-149. doi: 10.1016/j.yexmp.2018.07.005. Epub 2018 Jul 17.
19. Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain. Kreider ML, etal., Brain Res Dev Brain Res. 2004 Sep 17;152(2):233-9.
20. Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2. Kubota K, etal., Bone 2002 Oct;31(4):465-71.
21. Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype. Lanier SM, etal., J Biol Chem 1991 Jun 5;266(16):10470-8.
22. Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain. Leiphart JW, etal., Neurosci Lett. 2003 Sep 25;349(1):5-8.
23. Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways. Leong J, etal., Life Sci. 2010 May 8;86(19-20):740-6. Epub 2010 Mar 17.
24. Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? Li JL, etal., Hypertension. 2006 Jun;47(6):1140-6. Epub 2006 Apr 24.
25. Yohimbine protects against endotoxin-induced acute lung injury by blockade of alpha 2A adrenergic receptor in rats. Lin Y, etal., Chin Med J (Engl). 2011 Apr;124(7):1069-74.
26. Gender effects on adrenergic receptor expression and lipolysis in white adipose tissue of rats. Llado I, etal., Obes Res 2002 Apr;10(4):296-305.
27. Alpha 2 adrenergic receptors on GABAergic, putative sleep-promoting basal forebrain neurons. Manns ID, etal., Eur J Neurosci 2003 Aug;18(3):723-7.
28. Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. Merenäkk L, etal., Psychopharmacology (Berl). 2011 May;215(1):13-22. doi: 10.1007/s00213-010-2109-z. Epub 2010 Dec 8.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes. Milner TA, etal., J Comp Neurol. 1998 Jun 8;395(3):310-27.
31. Adrenal alpha(2)-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat. Moura E, etal., Neurobiol Aging. 2012 May;33(5):969-78. Epub 2010 Aug 5.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Philipp M, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95.
34. Tobacco smoking and the ADRA2A C-1291G polymorphism. Prestes AP, etal., J Neural Transm (Vienna). 2007;114(11):1503-6. doi: 10.1007/s00702-007-0769-6. Epub 2007 Jul 6.
35. GOA pipeline RGD automated data pipeline
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Rosengren AH, etal., Science. 2010 Jan 8;327(5962):217-20. Epub 2009 Nov 19.
38. The alpha-2A-adrenergic receptor gene affects rat resistance to cold anesthesia. Shishkina GT, etal., Dokl Biol Sci 2003 Jan-Feb;388:68-9.
39. Effects of antisense oligodeoxynucleotide to the alpha2A-adrenoceptors on the plasma corticosterone level and on elevated plus-maze behavior in rats. Shishkina GT, etal., Psychoneuroendocrinology 2002 Jul;27(5):593-601.
40. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. Stevenson J, etal., J Child Psychol Psychiatry. 2005 Oct;46(10):1081-8.
41. The involvement of peripheral alpha 2-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain. Tomic MA, etal., Anesth Analg. 2007 Nov;105(5):1474-81, table of contents.
42. Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety. Uzsoki B, etal., Neurosci Lett. 2011 Jul 25;499(3):219-23. Epub 2011 Jun 6.
43. Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat. Wong ES, etal., J Pharmacol Exp Ther. 2010 Dec;335(3):659-64. Epub 2010 Sep 13.
44. Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina. Wypijewski K, etal., Mol Cell Biochem 1995 Mar 23;144(2):181-90.
45. alpha(2a) and alpha(2c) adrenoceptors on spinal neurons controlling penile erection. Yaici ED, etal., Neuroscience 2002;114(4):945-60.
46. Alpha-adrenergic receptor (alpha(2 A )) is colocalized in basal forebrain cholinergic neurons: a light and electron microscopic double immunolabeling study. Zaborszky L, etal., J Neurocytol. 2004 May;33(3):265-76.
47. Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsis. Zhang F, etal., J Mol Med (Berl). 2010 Mar;88(3):289-96. Epub 2009 Nov 6.
48. Increased cardiac norepinephrine release in spontaneously hypertensive rats: role of presynaptic alpha-2A adrenoceptors. Zugck C, etal., J Hypertens 2003 Jul;21(7):1363-9.
Additional References at PubMed
PMID:1354394   PMID:2174879   PMID:2823383   PMID:9249478   PMID:10948191   PMID:10948198   PMID:10952463   PMID:11927164   PMID:12529373   PMID:15105370   PMID:15218143   PMID:15653687  
PMID:16531006   PMID:16605244   PMID:17215105   PMID:17510509   PMID:17655843   PMID:17680988   PMID:18225740   PMID:18226963   PMID:18250367   PMID:18491035   PMID:18924139   PMID:18977208  
PMID:19120051   PMID:19120135   PMID:19139607   PMID:19180644   PMID:19427365   PMID:19430535   PMID:19477270   PMID:19822802   PMID:20371702   PMID:20884323   PMID:21333691   PMID:21562737  
PMID:21575605   PMID:21963947   PMID:22038538   PMID:23063894   PMID:23916734   PMID:24216055   PMID:24304869   PMID:24939293   PMID:25009274   PMID:25407049   PMID:26418907   PMID:26676573  
PMID:27365174   PMID:27452863   PMID:30264294   PMID:30929926   PMID:31542234   PMID:37548252  


Genomics

Comparative Map Data
Adra2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81263,066,780 - 263,069,580 (+)NCBIGRCr8
mRatBN7.21253,061,480 - 253,064,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1253,060,218 - 253,064,365 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1261,250,961 - 261,253,761 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,957,040 - 267,959,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,612,912 - 260,615,708 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
ADRA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810111,077,029 - 111,080,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10111,077,029 - 111,080,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,836,787 - 112,840,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,826,911 - 112,830,560 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410112,826,910 - 112,830,560NCBI
Celera10106,568,388 - 106,572,263 (+)NCBICelera
Cytogenetic Map10q25.2ENTREZGENE
HuRef10106,465,554 - 106,469,429 (+)NCBIHuRef
CHM1_110113,118,624 - 113,122,499 (+)NCBICHM1_1
T2T-CHM13v2.010111,960,874 - 111,964,752 (+)NCBIT2T-CHM13v2.0
Adra2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391954,033,690 - 54,037,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1954,032,582 - 54,037,413 (+)EnsemblGRCm39 Ensembl
GRCm381954,045,259 - 54,048,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1954,044,151 - 54,048,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv371954,119,672 - 54,123,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361954,098,545 - 54,102,294 (+)NCBIMGSCv36mm8
Celera1956,240,003 - 56,243,840 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1949.04NCBI
Adra2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485385,800 - 387,240 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485384,405 - 387,332 (-)NCBIChiLan1.0ChiLan1.0
ADRA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,957,240 - 122,972,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,963,626 - 122,966,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,669,860 - 107,673,685 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110111,119,153 - 111,122,369 (+)NCBIpanpan1.1PanPan1.1panPan2
ADRA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,366,989 - 22,392,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,892,610 - 22,893,893 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBIUU_Cfam_GSD_1.0
Adra2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,720,233 - 23,724,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,838,176 - 1,839,630 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,837,785 - 1,841,019 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,403,894 - 132,405,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19104,015,577 - 104,019,364 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9104,016,580 - 104,017,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604865,215,363 - 65,219,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,264,099 - 35,265,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adra2a
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:135
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000071541
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1600384Niddm66Non-insulin dependent diabetes mellitus QTL 660.000005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1252645447253439819Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat

Markers in Region
D1Smu2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21253,050,519 - 253,050,648 (+)MAPPERmRatBN7.2
Rnor_6.01274,755,723 - 274,755,851NCBIRnor6.0
Rnor_5.01282,168,252 - 282,168,380UniSTSRnor5.0
Celera1248,764,527 - 248,764,655UniSTS
RH139989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21253,063,937 - 253,064,117 (+)MAPPERmRatBN7.2
Rnor_6.01274,768,741 - 274,768,920NCBIRnor6.0
Rnor_5.01282,180,933 - 282,181,112UniSTSRnor5.0
Celera1248,777,941 - 248,778,120UniSTS
RH 3.4 Map11683.4UniSTS


Related Rat Strains
The following Strains have been annotated to Adra2a
F344.GK-(D1Swe8-D1Gpam-1)/Swe    


Genetic Models
This gene Adra2a is modified in the following models/strains:
SS-Adra2aem1Mcwi-/-     SS-Adra2aem1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 90 27
Low 13 48 94 18 69 18 30 24 160 114 90 47 18
Below cutoff 72 107 103 103 6 21 28 10 6

Sequence


Ensembl Acc Id: ENSRNOT00000071541   ⟹   ENSRNOP00000066242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1253,060,218 - 253,064,365 (+)Ensembl
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)Ensembl
RefSeq Acc Id: NM_012739   ⟹   NP_036871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81263,066,780 - 263,069,580 (+)NCBI
mRatBN7.21253,061,480 - 253,064,280 (+)NCBI
Rnor_6.01274,766,283 - 274,769,083 (+)NCBI
Rnor_5.01282,178,475 - 282,181,275 (+)NCBI
Celera1248,775,483 - 248,778,283 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036871   ⟸   NM_012739
- UniProtKB: P22909 (UniProtKB/Swiss-Prot),   M0R9R3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066242   ⟸   ENSRNOT00000071541

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22909-F1-model_v2 AlphaFold P22909 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2056 AgrOrtholog
BioCyc Gene G2FUF-55371 BioCyc
Ensembl Genes ENSRNOG00000047545 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028819 UniProtKB/Swiss-Prot
  ENSRNOG00060016882 UniProtKB/Swiss-Prot
  ENSRNOG00065010837 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071541.2 UniProtKB/Swiss-Prot
  ENSRNOT00055049903 UniProtKB/Swiss-Prot
  ENSRNOT00060028861 UniProtKB/Swiss-Prot
  ENSRNOT00065017573 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRA2A_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25083 UniProtKB/Swiss-Prot
NCBI Gene 25083 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  ALPHA-2A ADRENERGIC RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADRA2A RGD
PhenoGen Adra2a PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCA2AR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047545 RatGTEx
  ENSRNOG00055028819 RatGTEx
  ENSRNOG00060016882 RatGTEx
  ENSRNOG00065010837 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt ADA2A_RAT UniProtKB/Swiss-Prot
  M0R9R3 ENTREZGENE
  P22909 ENTREZGENE
UniProt Secondary M0R9R3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adra2a  adrenergic, alpha-2A-, receptor  Adra2a  adrenergic receptor, alpha 2a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adra2a  adrenergic receptor, alpha 2a    Adrenergic, alpha 2A, receptor  Name updated 625702 APPROVED
2002-06-10 Adra2a  Adrenergic, alpha 2A, receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the dendrite plasmalemma in neurons of the central nucleus of the amygdala (CeA) 631769
gene_expression protein detected in spinal cord neurons 631768
gene_process may mediate penile erection 631768
gene_process may play a role in autonomic stress responses and feeding behavior 631769
gene_process may regulate anxiety-related behavior 631770