Adra2a (adrenoceptor alpha 2A) - Rat Genome Database

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Gene: Adra2a (adrenoceptor alpha 2A) Rattus norvegicus
Analyze
Symbol: Adra2a
Name: adrenoceptor alpha 2A
RGD ID: 2056
Description: Exhibits alpha2-adrenergic receptor activity. Involved in several processes, including glucose homeostasis; negative regulation of secretion by cell; and negative regulation of uterine smooth muscle contraction. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and integral component of synaptic membrane. Used to study anxiety disorder and mental depression. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adrenergic alpha 2A receptor; adrenergic receptor, alpha 2a; Adrenergic, alpha 2A, receptor; adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha-2D adrenergic receptor; CA2-47; RATRG20; RG20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adra2aem1Mcwi  
Genetic Models: SS-Adra2aem1Mcwi-/- SS-Adra2aem1Mcwi
Is Marker For: Strains:   F344.GK-(D1Swe8-D1Gpam-1)/Swe  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21253,061,480 - 253,064,280 (+)NCBI
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methoxyidazoxan  (ISO)
2-phenylethylamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitraz  (EXP,ISO)
arsenous acid  (ISO)
atenolol  (ISO)
atrazine  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
brimonidine tartrate  (EXP,ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyanazine  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
entinostat  (ISO)
fipronil  (EXP)
folic acid  (ISO)
glycidol  (EXP)
idazoxan  (EXP)
indapamide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
medetomidine  (ISO)
methylisothiazolinone  (ISO)
Moxonidine  (ISO)
nickel atom  (EXP)
oxcarbazepine  (EXP)
oxymetazoline  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phentolamine  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium dichromate  (ISO)
prazosin  (EXP,ISO)
pregabalin  (ISO)
progesterone  (ISO)
reserpine  (EXP)
Rilmenidine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
synephrine  (ISO)
Talipexole dihydrochloride  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topiramate  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
xylazine  (EXP)
Xylometazoline  (ISO)
yohimbine  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activation of protein kinase B activity  (ISO)
acute inflammatory response  (IMP)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting adrenergic receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adrenergic receptor signaling pathway  (ISO)
cellular response to hormone stimulus  (ISO)
DNA replication  (IMP)
fear response  (ISO)
female pregnancy  (IMP)
G protein-coupled receptor signaling pathway  (IMP,ISO)
glucose homeostasis  (IMP,ISO)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of insulin secretion  (ISO)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP,ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of uterine smooth muscle contraction  (IMP)
phospholipase C-activating adrenergic receptor signaling pathway  (ISO)
platelet activation  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of epidermal growth factor-activated receptor activity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of wound healing  (ISO)
receptor transactivation  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of vasoconstriction  (IEA)
signal transduction  (IEP)
thermoception  (IDA)
vasodilation  (IDA)

References

References - curated
1. Bavencoffe A, etal., J Biol Chem. 2010 Mar 26;285(13):9410-9. Epub 2010 Jan 28.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Chalberg SC, etal., Mol Cell Biochem 1990 Sep 21;97(2):161-72.
4. Cheon KA, etal., Biol Psychiatry. 2009 Apr 1;65(7):564-70. Epub 2009 Jan 15.
5. Clement L, etal., Lipids 2002 May;37(5):501-6.
6. Comings DE, etal., Psychiatr Genet 2000 Mar;10(1):39-42.
7. De Felice M, etal., Pain. 2011 Dec;152(12):2701-9. Epub 2011 Jul 13.
8. Dwyer JM, etal., Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. Epub 2010 Jan 5.
9. Fuchigami T, etal., Neuroscience. 2011 Oct 27;194:160-9. Epub 2011 Aug 16.
10. Gal A, etal., Eur J Pharmacol. 2009 Aug 1;615(1-3):193-200. Epub 2009 May 15.
11. Gaspar R, etal., Neurochem Int. 2007 Oct;51(5):311-8. Epub 2007 Jul 1.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Glass MJ, etal., Synapse 2002 Dec 15;46(4):258-68.
14. GOA data from the GO Consortium
15. Kreider ML, etal., Brain Res Dev Brain Res. 2004 Sep 17;152(2):233-9.
16. Kubota K, etal., Bone 2002 Oct;31(4):465-71.
17. Lanier SM, etal., J Biol Chem 1991 Jun 5;266(16):10470-8.
18. Leiphart JW, etal., Neurosci Lett. 2003 Sep 25;349(1):5-8.
19. Leong J, etal., Life Sci. 2010 May 8;86(19-20):740-6. Epub 2010 Mar 17.
20. Li JL, etal., Hypertension. 2006 Jun;47(6):1140-6. Epub 2006 Apr 24.
21. Lin Y, etal., Chin Med J (Engl). 2011 Apr;124(7):1069-74.
22. Llado I, etal., Obes Res 2002 Apr;10(4):296-305.
23. Manns ID, etal., Eur J Neurosci 2003 Aug;18(3):723-7.
24. MGD data from the GO Consortium
25. Milner TA, etal., J Comp Neurol. 1998 Jun 8;395(3):310-27.
26. Moura E, etal., Neurobiol Aging. 2012 May;33(5):969-78. Epub 2010 Aug 5.
27. NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Philipp M, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95.
29. RGD automated data pipeline
30. RGD automated import pipeline for gene-chemical interactions
31. Rosengren AH, etal., Science. 2010 Jan 8;327(5962):217-20. Epub 2009 Nov 19.
32. Shishkina GT, etal., Dokl Biol Sci 2003 Jan-Feb;388:68-9.
33. Shishkina GT, etal., Psychoneuroendocrinology 2002 Jul;27(5):593-601.
34. Stevenson J, etal., J Child Psychol Psychiatry. 2005 Oct;46(10):1081-8.
35. Tomic MA, etal., Anesth Analg. 2007 Nov;105(5):1474-81, table of contents.
36. Uzsoki B, etal., Neurosci Lett. 2011 Jul 25;499(3):219-23. Epub 2011 Jun 6.
37. Wong ES, etal., J Pharmacol Exp Ther. 2010 Dec;335(3):659-64. Epub 2010 Sep 13.
38. Wypijewski K, etal., Mol Cell Biochem 1995 Mar 23;144(2):181-90.
39. Yaici ED, etal., Neuroscience 2002;114(4):945-60.
40. Zaborszky L, etal., J Neurocytol. 2004 May;33(3):265-76.
41. Zhang F, etal., J Mol Med (Berl). 2010 Mar;88(3):289-96. Epub 2009 Nov 6.
42. Zugck C, etal., J Hypertens 2003 Jul;21(7):1363-9.
Additional References at PubMed
PMID:1354394   PMID:2174879   PMID:2823383   PMID:9249478   PMID:10948191   PMID:10948198   PMID:10952463   PMID:11927164   PMID:12529373   PMID:15105370   PMID:15218143   PMID:15653687  
PMID:16531006   PMID:16605244   PMID:17215105   PMID:17510509   PMID:17655843   PMID:17680988   PMID:18225740   PMID:18226963   PMID:18250367   PMID:18491035   PMID:18924139   PMID:18977208  
PMID:19120051   PMID:19120135   PMID:19139607   PMID:19180644   PMID:19427365   PMID:19430535   PMID:19477270   PMID:19822802   PMID:20371702   PMID:20884323   PMID:21333691   PMID:21562737  
PMID:21575605   PMID:21963947   PMID:22038538   PMID:23063894   PMID:23916734   PMID:24216055   PMID:24304869   PMID:24939293   PMID:25009274   PMID:25407049   PMID:26121187   PMID:26418907  
PMID:26676573   PMID:27365174   PMID:27452863   PMID:30264294   PMID:30929926   PMID:31542234  


Genomics

Candidate Gene Status
Adra2a is a candidate Gene for QTL Lnnr2
Comparative Map Data
Adra2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21253,061,480 - 253,064,280 (+)NCBI
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
ADRA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10111,077,029 - 111,080,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3810111,077,029 - 111,080,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710112,836,787 - 112,840,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,826,911 - 112,830,560 (+)NCBINCBI36hg18NCBI36
Build 3410112,826,910 - 112,830,560NCBI
Celera10106,568,388 - 106,572,263 (+)NCBI
Cytogenetic Map10q25.2ENTREZGENE
HuRef10106,465,554 - 106,469,429 (+)NCBIHuRef
CHM1_110113,118,624 - 113,122,499 (+)NCBICHM1_1
Adra2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391954,033,690 - 54,037,413 (+)NCBIGRCm39mm39
GRCm39 Ensembl1954,032,582 - 54,037,413 (+)Ensembl
GRCm381954,045,259 - 54,048,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1954,044,151 - 54,048,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv371954,119,672 - 54,123,472 (+)NCBIGRCm37mm9NCBIm37
MGSCv361954,098,545 - 54,102,294 (+)NCBImm8
Celera1956,240,003 - 56,243,840 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1949.04NCBI
Adra2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485385,800 - 387,240 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485384,405 - 387,332 (-)NCBIChiLan1.0ChiLan1.0
ADRA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110111,119,153 - 111,122,369 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v010107,669,860 - 107,673,685 (+)NCBIMhudiblu_PPA_v0panPan3
ADRA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12822,366,989 - 22,392,163 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2822,367,780 - 22,370,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,520,055 - 22,522,948 (+)NCBI
ROS_Cfam_1.02822,892,378 - 22,895,274 (+)NCBI
UMICH_Zoey_3.12822,451,483 - 22,454,353 (+)NCBI
UNSW_CanFamBas_1.02822,458,352 - 22,461,267 (+)NCBI
UU_Cfam_GSD_1.02822,592,510 - 22,595,401 (+)NCBI
Adra2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,720,233 - 23,724,342 (-)NCBI
SpeTri2.0NW_0049364861,837,785 - 1,841,019 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,469,527 - 121,470,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,469,572 - 121,470,924 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214132,403,894 - 132,405,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19104,015,577 - 104,019,364 (+)NCBI
ChlSab1.1 Ensembl9104,016,580 - 104,017,932 (+)Ensembl
Adra2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473735,262,779 - 35,265,566 (-)NCBI

Position Markers
D1Smu2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01274,755,723 - 274,755,851NCBIRnor6.0
Rnor_5.01282,168,252 - 282,168,380UniSTSRnor5.0
Celera1248,764,527 - 248,764,655UniSTS
RH139989  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01274,768,741 - 274,768,920NCBIRnor6.0
Rnor_5.01282,180,933 - 282,181,112UniSTSRnor5.0
Celera1248,777,941 - 248,778,120UniSTS
RH 3.4 Map11683.4UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1249206242281795785Rat
1581544Rf52Renal function QTL 520.05total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1252948438281795785Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1252955158280632620Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1255728828282763074Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1258132568282763074Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1258709726281795785Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1259295704282763074Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1266793821279986079Rat
1600384Niddm66Non-insulin dependent diabetes mellitus QTL 660.000005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1274353782275138914Rat


Related Rat Strains
The following Strains have been annotated to Adra2a


Genetic Models
This gene Adra2a is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:135
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000071541
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 30 9
Low 1 16 22 6 19 6 6 8 44 35 29 9 6
Below cutoff 22 27 27 27 2 3 3 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071541   ⟹   ENSRNOP00000066242
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)Ensembl
RefSeq Acc Id: NM_012739   ⟹   NP_036871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21253,061,480 - 253,064,280 (+)NCBI
Rnor_6.01274,766,283 - 274,769,083 (+)NCBI
Rnor_5.01282,178,475 - 282,181,275 (+)NCBI
Celera1248,775,483 - 248,778,283 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036871   ⟸   NM_012739
- UniProtKB: P22909 (UniProtKB/Swiss-Prot),   M0R9R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066242   ⟸   ENSRNOT00000071541

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2056 AgrOrtholog
Ensembl Genes ENSRNOG00000047545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066242 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071541 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRA2A_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25083 UniProtKB/Swiss-Prot
NCBI Gene 25083 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADRA2A RGD
PhenoGen Adra2a PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCA2AR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt ADA2A_RAT UniProtKB/Swiss-Prot
  M0R9R3 ENTREZGENE
  P22909 ENTREZGENE
UniProt Secondary M0R9R3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adra2a  adrenergic, alpha-2A-, receptor  Adra2a  adrenergic receptor, alpha 2a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adra2a  adrenergic receptor, alpha 2a    Adrenergic, alpha 2A, receptor  Name updated 625702 APPROVED
2002-06-10 Adra2a  Adrenergic, alpha 2A, receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the dendrite plasmalemma in neurons of the central nucleus of the amygdala (CeA) 631769
gene_expression protein detected in spinal cord neurons 631768
gene_process may mediate penile erection 631768
gene_process may play a role in autonomic stress responses and feeding behavior 631769
gene_process may regulate anxiety-related behavior 631770