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Gene: Chuk (component of inhibitor of nuclear factor kappa B kinase complex) Rattus norvegicus
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Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Description: Contributes to IkappaB kinase activity. Involved in several processes, including Rho protein signal transduction; response to cholecystokinin; and response to lipopolysaccharide. Localizes to the IkappaB kinase complex and intracellular membrane-bounded organelle. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in cocoon syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH (+)-Tetrandrine; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: conserved helix-loop-helix ubiquitous kinase; Ikbka; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; LOC309361
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)Ensembl
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Chuk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306661
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.