Chuk (component of inhibitor of nuclear factor kappa B kinase complex) - Rat Genome Database

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Gene: Chuk (component of inhibitor of nuclear factor kappa B kinase complex) Rattus norvegicus
Analyze
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
RGD ID: 1306661
Description: Contributes to IkappaB kinase activity. Involved in several processes, including Rho protein signal transduction; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy. Biomarker of colitis. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH (+)-Tetrandrine; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conserved helix-loop-helix ubiquitous kinase; Ikbka; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; LOC309361
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-Tetrandrine  (EXP)
(R)-mevalonic acid  (ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-phenylprop-2-enal  (EXP)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-ribose  (ISO)
alpinumisoflavone  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP)
aristolochic acid  (ISO)
arjunolic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auranofin  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
Berbamine  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celastrol  (EXP)
celecoxib  (ISO)
cerium trichloride  (ISO)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-ribofuranose  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (EXP,ISO)
etoposide  (ISO)
Evodiamine  (ISO)
filipin III  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glutathione  (ISO)
graphene oxide  (ISO)
homoeriodictyol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (ISO)
ionomycin  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
monosodium L-glutamate  (EXP,ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
Neferine  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
ozone  (EXP)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
phenobarbital  (ISO)
phenylbutazone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
resiquimod  (ISO)
resveratrol  (ISO)
rocaglamide  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
testosterone  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
thiopental  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
Tylophorine  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wedelolactone  (EXP)
Xanthorrhizol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
1. Alameda JP, etal., PLoS One. 2011;6(7):e21984. doi: 10.1371/journal.pone.0021984. Epub 2011 Jul 6.
2. Bruno ME, etal., Arch Biochem Biophys. 2002 Oct 15;406(2):153-64.
3. Canicio J, etal., J Biol Chem. 2001 Jun 8;276(23):20228-33. Epub 2001 Mar 28.
4. Chung S, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L192-203. Epub 2010 May 14.
5. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
6. Fontan E, etal., FEBS J. 2007 May;274(10):2540-51. Epub 2007 Apr 10.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GOA data from the GO Consortium
9. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
10. Ho RC, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C794-801. Epub 2005 May 11.
11. Lee JY, etal., Free Radic Res. 2005 Apr;39(4):399-409.
12. Lim JH, etal., Cell Microbiol. 2008 Nov;10(11):2247-56. Epub 2008 Jul 16.
13. Luo JL, etal., Nature. 2007 Apr 5;446(7136):690-4. Epub 2007 Mar 18.
14. MGD data from the GO Consortium
15. OMIM Disease Annotation Pipeline
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Pipeline to import SMPDB annotations from SMPDB into RGD
19. Rattan R, etal., Free Radic Biol Med. 2003 Nov 1;35(9):1037-50.
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Shukla S, etal., Oncotarget. 2015 Oct 13;6(31):31216-32. doi: 10.18632/oncotarget.5157.
23. Shukla S, etal., PLoS One. 2015 Sep 17;10(9):e0138710. doi: 10.1371/journal.pone.0138710. eCollection 2015.
24. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
25. Tando Y, etal., Digestion. 2002;66(4):237-45. doi: 10.1159/000068364.
26. Van Gammeren D, etal., FASEB J. 2009 Feb;23(2):362-70. doi: 10.1096/fj.08-114249. Epub 2008 Sep 30.
27. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
28. Wu L, etal., J Hypertens. 2006 Jan;24(1):123-30.
Additional References at PubMed
PMID:9520446   PMID:11536016   PMID:11747812   PMID:12477932   PMID:14743216   PMID:14960276   PMID:15485831   PMID:15684432   PMID:16079150   PMID:19386987   PMID:20434986   PMID:20442316  
PMID:20614026   PMID:22982470   PMID:23016877   PMID:23091055   PMID:23487264   PMID:23776175   PMID:24784232   PMID:24928390   PMID:26514923   PMID:30341167   PMID:30988283   PMID:32746986  


Genomics

Comparative Map Data
Chuk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
CHUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,186,319 - 100,229,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10100,188,300 - 100,229,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,948,057 - 101,989,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBINCBI36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBI
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,811 - 102,274,037 (-)NCBICHM1_1
Chuk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBImm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
Chuk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,067,203 - 6,102,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,066,026 - 6,102,066 (-)NCBIChiLan1.0ChiLan1.0
CHUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110100,276,290 - 100,317,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,280,490 - 100,316,918 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01096,794,228 - 96,835,449 (-)NCBIMhudiblu_PPA_v0panPan3
CHUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,964,670 - 13,001,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,965,479 - 13,001,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,147,837 - 13,184,707 (-)NCBI
ROS_Cfam_1.02813,433,260 - 13,470,158 (-)NCBI
ROS_Cfam_1.0 Ensembl2813,433,260 - 13,470,130 (-)Ensembl
UMICH_Zoey_3.12812,980,085 - 13,016,958 (-)NCBI
UNSW_CanFamBas_1.02813,017,918 - 13,055,038 (-)NCBI
UU_Cfam_GSD_1.02813,152,231 - 13,189,348 (-)NCBI
Chuk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,995,060 - 34,039,500 (+)NCBI
SpeTri2.0NW_00493663633,933 - 78,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,307,610 - 111,351,712 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0
Chuk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473712,022,081 - 12,052,128 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH133833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,959,637 - 242,959,854 (+)MAPPERmRatBN7.2
Rnor_6.01263,848,928 - 263,849,144NCBIRnor6.0
Rnor_5.01271,293,920 - 271,294,136UniSTSRnor5.0
RGSC_v3.41249,158,055 - 249,158,271UniSTSRGSC3.4
Celera1238,777,125 - 238,777,341UniSTS
RH 3.4 Map11617.52UniSTS
Cytogenetic Map1q54UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:269
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000030782
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 57 41 19 41 1 1 74 35 35 11 1
Low 11 7 10 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000030782   ⟹   ENSRNOP00000034134
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096055   ⟹   ENSRNOP00000095574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117849   ⟹   ENSRNOP00000080169
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,964,114 - 242,994,755 (-)Ensembl
RefSeq Acc Id: NM_001107588   ⟹   NP_001101058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,959,540 - 242,995,065 (-)NCBI
Rnor_6.01263,848,830 - 263,884,354 (-)NCBI
Rnor_5.01271,293,821 - 271,329,346 (-)NCBI
RGSC_v3.41249,122,845 - 249,158,369 (+)RGD
Celera1238,777,027 - 238,812,551 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231481   ⟹   XP_006231543
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,959,539 - 242,995,040 (-)NCBI
Rnor_6.01263,848,829 - 263,884,351 (-)NCBI
Rnor_5.01271,293,821 - 271,329,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760419   ⟹   XP_008758641
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,962,269 - 242,995,066 (-)NCBI
Rnor_6.01263,851,572 - 263,884,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589269   ⟹   XP_017444758
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,963,495 - 242,995,000 (-)NCBI
Rnor_6.01263,852,836 - 263,884,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080030   ⟹   XP_038935958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,962,269 - 242,994,816 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101058   ⟸   NM_001107588
- UniProtKB: G3V926 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231543   ⟸   XM_006231481
- Peptide Label: isoform X3
- UniProtKB: B5DF32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758641   ⟸   XM_008760419
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017444758   ⟸   XM_017589269
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000034134   ⟸   ENSRNOT00000030782
RefSeq Acc Id: XP_038935958   ⟸   XM_039080030
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000095574   ⟸   ENSRNOT00000096055
RefSeq Acc Id: ENSRNOP00000080169   ⟸   ENSRNOT00000117849
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V926-F1-model_v2 AlphaFold G3V926 1-745 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690934
Promoter ID:EPDNEW_R1459
Type:initiation region
Name:Chuk_1
Description:conserved helix-loop-helix ubiquitous kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,884,331 - 263,884,391EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 249127250 249127251 C A snv FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306661 AgrOrtholog
BioCyc Gene G2FUF-55612 BioCyc
Ensembl Genes ENSRNOG00000022485 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034134 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000080169 ENTREZGENE
  ENSRNOP00000095574 ENTREZGENE
Ensembl Transcript ENSRNOT00000030782 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000096055 ENTREZGENE
  ENSRNOT00000117849 ENTREZGENE
InterPro IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:309361 UniProtKB/TrEMBL
NCBI Gene 309361 ENTREZGENE
Pfam IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Chuk PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART IKKbetaNEMObind UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt B5DF32 ENTREZGENE, UniProtKB/TrEMBL
  G3V926 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Chuk  component of inhibitor of nuclear factor kappa B kinase complex  Chuk  conserved helix-loop-helix ubiquitous kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Chuk  conserved helix-loop-helix ubiquitous kinase   Chuk_predicted  conserved helix-loop-helix ubiquitous kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Chuk_predicted  conserved helix-loop-helix ubiquitous kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED