Ide (insulin degrading enzyme) - Rat Genome Database

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Gene: Ide (insulin degrading enzyme) Rattus norvegicus
Symbol: Ide
Name: insulin degrading enzyme
RGD ID: 2861
Description: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; and negative regulation of proteolysis. Located in cell surface; extracellular space; and peroxisomal matrix. Part of cytosolic proteasome complex. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-nitrofluorene.
Type: protein-coding
Previously known as: INSDEGM; insulin protease; insulin-degrading enzyme; insulinase; insulysin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21235,002,984 - 235,102,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,391,715 - 243,489,902 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01250,321,195 - 250,419,385 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01243,159,390 - 243,257,588 (-)NCBIRnor_WKY
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-(3,4-dihydroxyphenyl)propanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
ceftriaxone  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glucose  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
nefazodone  (EXP)
notoginsenoside R1  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
scopolin  (ISO)
sodium arsenate  (ISO)
succimer  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts. Baumeister H, etal., FEBS Lett 1993 Feb 15;317(3):250-4.
2. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex. Bennett RG, etal., Diabetes. 1997 Feb;46(2):197-203.
3. Treadmill Running and Rutin Reverse High Fat Diet Induced Cognitive Impairment in Diet Induced Obese Mice. Cheng J, etal., J Nutr Health Aging. 2016;20(5):503-8. doi: 10.1007/s12603-015-0616-7.
4. Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients. da Costa IB, etal., Curr Alzheimer Res. 2017;14(7):760-765. doi: 10.2174/1567205014666170203100734.
5. Insulin-degrading enzyme hydrolyzes ATP. Del Carmen Camberos M and Cresto JC, Exp Biol Med (Maywood). 2007 Feb;232(2):281-92.
6. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). Edbauer D, etal., J Biol Chem 2002 Apr 19;277(16):13389-93.
7. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Fakhrai-Rad H, etal., Hum Mol Genet 2000 Sep 1;9(14):2149-58.
8. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Farris W, etal., Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.
9. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Florez JC, etal., Diabetes. 2006 Jan;55(1):128-35.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Ghareeb DA, etal., Evid Based Complement Alternat Med. 2015;2015:361847. doi: 10.1155/2015/361847. Epub 2015 Oct 20.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Karamohamed S, etal., Diabetes. 2003 Jun;52(6):1562-7.
14. Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. Kazkayasi I, etal., Pharmacol Rep. 2018 Aug;70(4):677-683. doi: 10.1016/j.pharep.2018.01.008. Epub 2018 Feb 1.
15. Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. Khodadadi D, etal., Neurochem Res. 2018 Aug;43(8):1561-1574. doi: 10.1007/s11064-018-2571-2. Epub 2018 Jun 11.
16. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and invivo models of Alzheimer's disease. Kim DH, etal., Biochem Biophys Res Commun. 2018 Sep 14. pii: S0006-291X(18)31922-3. doi: 10.1016/j.bbrc.2018.09.012.
17. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-a and IL-1ß in an Aß25-35-induced Rat Model of Alzheimer's Disease. Li L, etal., J Alzheimers Dis. 2017;56(4):1403-1417. doi: 10.3233/JAD-160587.
18. The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis. Llovera RE, etal., J Biol Chem. 2008 Jun 20;283(25):17039-48. Epub 2008 Apr 14.
19. Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Marlowe L, etal., Neurodegener Dis. 2006;3(6):320-6.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins. Morita M, etal., Cell Struct Funct. 2000 Oct;25(5):309-15.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Shimizu E, etal., J Immunol. 2008 Nov 1;181(9):6503-13.
27. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Son SM, etal., Autophagy. 2016 May 3;12(5):784-800. doi: 10.1080/15548627.2016.1159375. Epub 2016 Mar 10.
28. ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. Song ES, etal., J Biol Chem. 2004 Dec 24;279(52):54216-20. Epub 2004 Oct 19.
29. Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions. Song ES, etal., J Biol Chem. 2005 May 6;280(18):17701-6. Epub 2005 Mar 3.
30. Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment. Sun J, etal., Curr Alzheimer Res. 2016;13(12):1337-1345.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus. Udrisar DP, etal., Exp Biol Med (Maywood). 2005 Jul;230(7):479-86.
33. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. Vekrellis K, etal., J Neurosci. 2000 Mar 1;20(5):1657-65.
34. Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation. Wang N, etal., Neural Regen Res. 2017 Apr;12(4):654-659. doi: 10.4103/1673-5374.205107.
35. Pioglitazone ameliorates Aß42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3ß activation. Yang S, etal., Mol Med Rep. 2017 May;15(5):2588-2594. doi: 10.3892/mmr.2017.6342. Epub 2017 Mar 16.
36. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. Zhao WQ, etal., J Biol Chem. 2009 Jul 10;284(28):18742-53. doi: 10.1074/jbc.M109.011015. Epub 2009 Apr 30.
Additional References at PubMed
PMID:1445854   PMID:1836994   PMID:7678795   PMID:9231799   PMID:9830016   PMID:15285718   PMID:15489232   PMID:15590928   PMID:15800373   PMID:16511862   PMID:17051221   PMID:17055432  
PMID:17613531   PMID:18226493   PMID:18448515   PMID:18489915   PMID:18602473   PMID:18614015   PMID:19321446   PMID:20082125   PMID:20178365   PMID:20300529   PMID:20364150   PMID:20414044  
PMID:20876579   PMID:21185309   PMID:21448434   PMID:21731629   PMID:22049080   PMID:22509294   PMID:22871113   PMID:23077523   PMID:23520555   PMID:23525105   PMID:23593132   PMID:24847884  
PMID:25247577   PMID:25792373   PMID:26968463   PMID:27930980   PMID:29263141   PMID:30361391   PMID:31505169  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21235,002,984 - 235,102,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,391,715 - 243,489,902 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01250,321,195 - 250,419,385 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01243,159,390 - 243,257,588 (-)NCBIRnor_WKY
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381092,451,684 - 92,574,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1092,451,684 - 92,574,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391937,246,140 - 37,341,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)EnsemblGRCm39 Ensembl
GRCm381937,268,743 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBIMGSCv36mm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955425847,615 - 926,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955425819,461 - 926,440 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan110104,492,478 - 104,617,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,196,295 - 89,320,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,714,343 - 92,833,430 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,716,540 - 92,833,353 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1286,844,480 - 6,967,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721340,597,592 - 40,685,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,230,283 - 2,318,752 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366012,230,477 - 2,318,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14103,992,039 - 104,106,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,992,035 - 104,106,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,505,034 - 113,619,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1985,722,728 - 85,843,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,721,886 - 85,843,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,459,858 - 46,578,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ide
464 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:74
Interacting mature miRNAs:78
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,087,223 - 235,087,370 (+)MAPPERmRatBN7.2
Rnor_6.01255,998,697 - 255,998,843NCBIRnor6.0
Rnor_5.01263,473,778 - 263,473,924UniSTSRnor5.0
RGSC_v3.41241,631,253 - 241,631,399UniSTSRGSC3.4
Celera1232,178,409 - 232,178,555UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,094,902 - 235,095,102 (+)MAPPERmRatBN7.2
Rnor_6.01256,006,376 - 256,006,575NCBIRnor6.0
Rnor_5.01263,481,457 - 263,481,656UniSTSRnor5.0
RGSC_v3.41241,638,933 - 241,639,132UniSTSRGSC3.4
Celera1232,186,089 - 232,186,288UniSTS
RH 3.4 Map11580.3UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,028,590 - 235,028,805 (+)MAPPERmRatBN7.2
Rnor_6.01255,940,070 - 255,940,284NCBIRnor6.0
Rnor_5.01263,415,154 - 263,415,368UniSTSRnor5.0
RGSC_v3.41241,572,626 - 241,572,840UniSTSRGSC3.4
Celera1232,119,774 - 232,119,988UniSTS
RH 3.4 Map11581.7UniSTS
Cytogenetic Map1q53UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023342   ⟹   ENSRNOP00000023342
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,995,351 - 235,102,085 (-)Ensembl
Rnor_6.0 Ensembl1255,915,313 - 256,013,495 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085303   ⟹   ENSRNOP00000074304
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,003,007 - 235,102,085 (-)Ensembl
Rnor_6.0 Ensembl1255,914,447 - 255,976,425 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098836   ⟹   ENSRNOP00000087605
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110995   ⟹   ENSRNOP00000089992
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,995,351 - 235,084,794 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119683   ⟹   ENSRNOP00000088595
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,995,351 - 235,102,085 (-)Ensembl
RefSeq Acc Id: NM_013159   ⟹   NP_037291
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,003,832 - 235,102,023 (-)NCBI
Rnor_6.01255,915,313 - 256,013,495 (-)NCBI
Rnor_5.01263,389,549 - 263,489,002 (-)NCBI
RGSC_v3.41241,547,869 - 241,646,052 (-)RGD
Celera1232,095,058 - 232,193,208 (-)RGD
RefSeq Acc Id: XM_006231313   ⟹   XP_006231375
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,002,984 - 235,102,448 (-)NCBI
Rnor_6.01255,914,465 - 256,014,168 (-)NCBI
Rnor_5.01263,389,549 - 263,489,002 (-)NCBI
RefSeq Acc Id: XM_039102124   ⟹   XP_038958052
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,002,984 - 235,085,070 (-)NCBI
RefSeq Acc Id: XM_039102127   ⟹   XP_038958055
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,002,984 - 235,101,695 (-)NCBI
RefSeq Acc Id: XM_039102130   ⟹   XP_038958058
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21235,023,688 - 235,102,448 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037291   ⟸   NM_013159
- UniProtKB: P35559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231375   ⟸   XM_006231313
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A860 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074304   ⟸   ENSRNOT00000085303
RefSeq Acc Id: ENSRNOP00000023342   ⟸   ENSRNOT00000023342
RefSeq Acc Id: XP_038958055   ⟸   XM_039102127
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A841 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958052   ⟸   XM_039102124
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A841 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958058   ⟸   XM_039102130
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000087605   ⟸   ENSRNOT00000098836
RefSeq Acc Id: ENSRNOP00000089992   ⟸   ENSRNOT00000110995
RefSeq Acc Id: ENSRNOP00000088595   ⟸   ENSRNOT00000119683
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35559-F1-model_v2 AlphaFold P35559 1-1019 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690875
Promoter ID:EPDNEW_R1400
Type:initiation region
Description:insulin degrading enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01256,013,553 - 256,013,613EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2861 AgrOrtholog
BioCyc Gene G2FUF-55806 BioCyc
Ensembl Genes ENSRNOG00000016833 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023342 ENTREZGENE
  ENSRNOP00000023342.3 UniProtKB/TrEMBL
  ENSRNOP00000074304.2 UniProtKB/TrEMBL
  ENSRNOP00000087605.1 UniProtKB/TrEMBL
  ENSRNOP00000088595.1 UniProtKB/TrEMBL
  ENSRNOP00000089992.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023342 ENTREZGENE
  ENSRNOT00000023342.4 UniProtKB/TrEMBL
  ENSRNOT00000085303.2 UniProtKB/TrEMBL
  ENSRNOT00000098836.1 UniProtKB/TrEMBL
  ENSRNOT00000110995.1 UniProtKB/TrEMBL
  ENSRNOT00000119683.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25700 UniProtKB/Swiss-Prot
  NARDILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ide PhenoGen
Superfamily-SCOP SSF63411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217161
UniProt A0A0G2K7Q7_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ide  Insulin degrading enzyme      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function cleaves and removes the beta-amyloid precursor protein intracellular domain 727339