Gene: Ide (insulin degrading enzyme) Rattus norvegicus
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Symbol: Ide
Name: insulin degrading enzyme
Description: ENCODES a protein that exhibits amyloid-beta binding; ATP binding; ATPase activity; INVOLVED IN amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; PARTICIPATES IN Alzheimer's disease pathway; ASSOCIATED WITH Alzheimer's disease; Diabetes Mellitus, Experimental ; nonalcoholic fatty liver disease; FOUND IN cell surface; cytosol; cytosolic proteasome complex; INTERACTS WITH 2,6-dinitrotoluene; 2-nitrofluorene; 3-chloropropane-1,2-diol
AGR Description: Exhibits several functions, including ATP binding activity, ATPase activity, and peptide binding activity; involved in several processes, including amyloid-beta clearance by cellular catabolic process, amyloid-beta metabolic process, and protein complex oligomerization; localizes to several cellular components, including the cell surface, cytoplasm, and extracellular space; used to study Alzheimer's disease and type 2 diabetes mellitus; biomarker of Alzheimer's disease and nonalcoholic fatty liver disease; orthologous to human IDE (insulin degrading enzyme).
Merged Description: Exhibits several functions, including ATP binding activity, ATPase activity, and peptide binding activity; involved in several processes, including amyloid-beta clearance by cellular catabolic process, amyloid-beta metabolic process, and protein complex oligomerization; localizes to several cellular components, including the cell surface, cytoplasm, and extracellular space; used to study Alzheimer's disease and type 2 diabetes mellitus; biomarker of Alzheimer's disease and nonalcoholic fatty liver disease; orthologous to human IDE (insulin degrading enzyme); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 2,6-dinitrotoluene; 2-nitrofluorene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: INSDEGM; insulin protease; insulin-degrading enzyme; insulinase; insulysin
Orthologs:
Homo sapiens (human) : IDE (insulin degrading enzyme)  HGNC  Alliance
Mus musculus (house mouse) : Ide (insulin degrading enzyme)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ide (insulin degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : IDE (insulin degrading enzyme)
Canis lupus familiaris (dog) : IDE (insulin degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ide (insulin degrading enzyme)
Sus scrofa (pig) : IDE (insulin degrading enzyme)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ide
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2861
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.