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Gene: Ide (insulin degrading enzyme) Rattus norvegicus
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Symbol: Ide
Name: insulin degrading enzyme
RGD ID: 2861
Description: Exhibits several functions, including ATP binding activity; metalloendopeptidase activity; and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; and proteolysis involved in cellular protein catabolic process. Localizes to several cellular components, including cell surface; cytosolic proteasome complex; and peroxisomal matrix. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-nitrofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: INSDEGM; insulin protease; insulin-degrading enzyme; insulinase; insulysin
Orthologs:
Homo sapiens (human) : IDE (insulin degrading enzyme)  HGNC  Alliance
Mus musculus (house mouse) : Ide (insulin degrading enzyme)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ide (insulin degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : IDE (insulin degrading enzyme)
Canis lupus familiaris (dog) : IDE (insulin degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ide (insulin degrading enzyme)
Sus scrofa (pig) : IDE (insulin degrading enzyme)
Chlorocebus sabaeus (African green monkey) : IDE (insulin degrading enzyme)
Heterocephalus glaber (naked mole-rat) : Ide (insulin degrading enzyme)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ide
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2861
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.