Nppa (natriuretic peptide A) - Rat Genome Database

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Gene: Nppa (natriuretic peptide A) Rattus norvegicus
Symbol: Nppa
Name: natriuretic peptide A
RGD ID: 3193
Description: Enables hormone activity. Involved in several processes, including positive regulation of cell communication; regulation of monoatomic cation transmembrane transport; and response to peptide hormone. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in brush border; mast cell granule; and perinuclear region of cytoplasm. Is active in glycinergic synapse. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A); PARTICIPATES IN atrial natriuretic peptide signaling pathway; INTERACTS WITH (R)-noradrenaline; 1-octadec-9-enoylglycero-3-phosphate; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ANF; ANP; atrial natriuretic factor; atrial natriuretic factor prohormone; atrial natriuretic peptide; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; CDD; Natriuretic peptide precursor A (pronatriodilatin also Anf Pnd); Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); Natriuretic peptide precursor A, (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; natriuretic peptides A; Pnd; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP; RATANF
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nppaem4Mcwi  
Genetic Models: SS-Nppaem4Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp49   Strs2   Bp100   Strs6  
Candidate Gene For: Bp49 Cm24 Lanf1 Bp155
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85163,712,184 - 163,713,493 (+)NCBIGRCr8
mRatBN7.25158,429,042 - 158,430,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,145,793 - 161,147,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,973,730 - 162,975,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,930,077 - 162,931,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
aortic valve insufficiency  (ISO)
atrial standstill 1  (ISO)
atrial standstill 2  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IDA,ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (IDA,ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Diabetic Cardiomyopathies  (IDA)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (IEP)
Familial Atrial Fibrillation 6  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
heart disease  (ISO)
Hypercapnia  (ISO)
hypertension  (IEP,ISO,ISS)
hypertrophic cardiomyopathy  (IEP,ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
intrinsic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (IEP,ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Side Effects of Drugs and Substances  (IEP)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (IEP)
obesity  (ISO)
Pain  (ISO)
patent ductus arteriosus  (ISO)
peritonitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
renal hypertension  (IEP,ISO)
Right Ventricular Hypertrophy  (IDA)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IDA,ISO)
Urination Disorders  (ISO)
vascular dementia  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP)
2-Hydroxy-4-trifluoromethyl benzoic acid  (EXP)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
8-(3-chlorostyryl)caffeine  (EXP)
8-(4-chlorophenylthio)-cGMP  (EXP)
acetic acid  (ISO)
aconitine  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (EXP,ISO)
aldrithiol  (EXP)
all-trans-retinoic acid  (ISO)
alprenolol  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
angiotensin II  (EXP,ISO)
argipressin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
atropine  (EXP)
bellidifolin  (EXP,ISO)
benazepril  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
betaxolol  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (EXP)
bromochloroacetic acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (EXP)
candesartan  (EXP)
candoxatrilat  (EXP)
capsazepine  (EXP)
carbon monoxide  (EXP)
carvedilol  (EXP,ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chelerythrine  (EXP)
choline  (ISO)
cilazapril monohydrate  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
cucurbitacin I  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyanamide  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP)
D-mannitol  (ISO)
dantrolene  (EXP)
daunorubicin  (EXP)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
digoxin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
enalapril  (EXP,ISO)
ethanol  (EXP)
fasudil  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (EXP,ISO)
furosemide  (ISO)
gefitinib  (EXP)
gentamycin  (EXP)
glucose  (EXP)
glycerol  (ISO)
graphite  (ISO)
GSK2181236A  (EXP)
Guanabenz  (EXP)
GW 501516  (EXP)
haloperidol  (EXP)
HET0016  (EXP)
hydrogen peroxide  (EXP)
Ile(5)-angiotensin II  (EXP)
indinavir  (ISO)
indole-3-acetic acid  (EXP)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP,ISO)
irbesartan  (ISO)
isoprenaline  (EXP,ISO)
kenpaullone  (EXP)
KT 5720  (EXP)
L-methionine  (ISO)
labetalol  (ISO)
lamivudine  (ISO)
leptomycin B  (EXP)
lipopolysaccharide  (EXP)
lisinopril dihydrate  (ISO)
losartan  (EXP)
lovastatin  (ISO)
LY294002  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
manidipine  (EXP)
mercury dichloride  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
metoprolol  (EXP)
mevalonic acid  (EXP)
mifepristone  (EXP,ISO)
milrinone  (EXP)
monocrotaline  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
naloxone  (ISO)
nifedipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
NSC 23766  (ISO)
ochratoxin A  (EXP)
omapatrilat  (ISO)
ouabain  (EXP)
paricalcitol  (EXP)
pentobarbital  (EXP)
phenformin  (EXP)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
Plantamajoside  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
quinapril hydrochloride  (EXP)
resveratrol  (EXP,ISO)
ruthenium red  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP)
sildenafil citrate  (EXP)
simvastatin  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
spermine  (ISO)
spironolactone  (EXP,ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
torasemide  (EXP)
trans-cinnamic acid  (EXP)
trans-piceid  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
U-73122  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
verapamil  (ISO)
Vinpocetine  (EXP)
xestospongin C  (EXP)
Y-27632  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA)
cardiac muscle hypertrophy in response to stress  (ISO)
cell growth involved in cardiac muscle cell development  (IEP)
cellular response to angiotensin  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to mechanical stimulus  (IEP)
cGMP biosynthetic process  (IBA,IEA,IMP,ISO)
cGMP-mediated signaling  (IBA,IDA)
female pregnancy  (ISO,ISS)
heart development  (TAS)
multicellular organismal-level water homeostasis  (TAS)
negative regulation of blood pressure  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (IMP)
negative regulation of collecting lymphatic vessel constriction  (IDA)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of systemic arterial blood pressure  (IBA,IDA)
neuropeptide signaling pathway  (IBA,IEA,ISO)
positive regulation of cardiac muscle contraction  (IEA,ISO)
positive regulation of cGMP-mediated signaling  (IDA)
positive regulation of heart rate  (IEA,ISO)
positive regulation of histamine secretion by mast cell  (IDA)
positive regulation of potassium ion export across plasma membrane  (IDA,IEA,ISO)
protein folding  (IEA,ISO)
receptor guanylyl cyclase signaling pathway  (IBA,IDA,IEA,ISO,ISS)
regulation of atrial cardiac muscle cell membrane repolarization  (IEA,ISO)
regulation of blood pressure  (IEA,ISO,ISS,TAS)
regulation of body fluid levels  (TAS)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (IDA)
response to 3-methylcholanthrene  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to stress  (IEA)
sodium ion export across plasma membrane  (ISO)
synaptic signaling via neuropeptide  (EXP,IDA,IMP)
vasodilation  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Al-Attas OS, etal., Environ Sci Pollut Res Int. 2015 Jul;22(13):10083-93. doi: 10.1007/s11356-015-4212-5. Epub 2015 Feb 18.
3. Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy. Aziz MT, etal., Diabetol Metab Syndr. 2013 Mar 12;5(1):13. doi: 10.1186/1758-5996-5-13.
4. Augmentation of insulin-stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats. Bai GY, etal., Peptides. 2006 Nov;27(11):2756-63. Epub 2006 Jul 10.
5. Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth. Baldini PM, etal., Mol Cell Biochem. 2005 Apr;272(1-2):19-28.
6. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
7. ANP but not BNP reflects early left diastolic dysfunction in type 1 diabetics with myocardial dysinnervation. Bayerle-Eder M, etal., Horm Metab Res. 2003 May;35(5):301-7.
8. Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells. Bkaily G, etal., J Mol Cell Cardiol. 1993 Nov;25(11):1305-16.
9. Scar myofibroblasts of the infarcted rat heart express natriuretic peptides. Calderone A, etal., J Cell Physiol. 2006 Apr;207(1):165-73.
10. Ventricular function and natriuretic peptides in sequentially combined models of hypertension. Cavallero S, etal., Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1290-9. doi: 10.1152/ajpheart.00911.2009. Epub 2010 Feb 5.
11. Distribution patterns of PCNA and ANP in perinatal stages of the developing rat heart. Cayli S, etal., Acta Histochem 2002;104(3):271-7.
12. Encapsulated transgene cells attenuate hypertension, cardiac hypertrophy and enhance renal function in Goldblatt hypertensive rats. Chen LG, etal., J Gene Med. 2004 Jul;6(7):786-97.
13. Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy. Christoffersen TE, etal., Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1635-41. Epub 2005 Nov 4.
14. Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats. Chujo K, etal., J Biosci Bioeng. 2010 Jun;109(6):526-30. doi: 10.1016/j.jbiosc.2009.11.021. Epub 2009 Dec 23.
15. Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.
16. Cyclical stretch induces structural changes in atrial myocytes. De Jong AM, etal., J Cell Mol Med. 2013 Jun;17(6):743-53. doi: 10.1111/jcmm.12064. Epub 2013 Apr 26.
17. The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release. de Plater GM, etal., Toxicon. 1998 Jun;36(6):847-57.
18. Pro-A-type natriuretic peptide and pro-adrenomedullin predict progression of chronic kidney disease: the MMKD Study. Dieplinger B, etal., Kidney Int. 2009 Feb;75(4):408-14. doi: 10.1038/ki.2008.560. Epub 2008 Dec 3.
19. Identifying multiple causative genes at a single GWAS locus. Flister MJ, etal., Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Association of the ScaI atrial natriuretic peptide gene polymorphism with nonfatal myocardial infarction and extent of coronary artery disease. Gruchala M, etal., Am Heart J. 2003 Jan;145(1):125-31.
23. [Effects of buyang huanwu decoction on the sarcoplasmic reticulum calcium uptake in abdominal aortic constriction induced myocardial hypertrophic rats]. Gu YP, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):627-31.
24. Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. Gutkowska J, etal., J Physiol. 2009 Oct 1;587(Pt 19):4725-36. Epub 2009 Aug 12.
25. Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease. Hassan A, etal., Neurology. 2001 Nov 13;57(9):1726-8.
26. Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure. Hystad ME, etal., Acta Physiol Scand. 2001 Apr;171(4):395-403.
27. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Jankowski M, etal., Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11765-70.
28. Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Jeffs B, etal., Nat Genet 1997 Aug;16(4):364-7
29. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
30. Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia. Jin H, etal., J Clin Invest. 1990 Jan;85(1):115-20.
31. Effects of Atrial Natriuretic Peptide After Prolonged Hypothermic Storage of the Isolated Rat Heart. Kanamitsu H, etal., Artif Organs. 2013 Jul 4. doi: 10.1111/aor.12120.
32. Identification of rat gamma atrial natriuretic polypeptide and characterization of the cDNA encoding its precursor. Kangawa K, etal., Nature 1984 Nov 8-14;312(5990):152-5.
33. Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure. Kao YH, etal., Int J Cardiol. 2013 Aug 7. pii: S0167-5273(13)01322-3. doi: 10.1016/j.ijcard.2013.07.111.
34. Altered regulation of nitric oxide and natriuretic peptide system in cisplatin-induced nephropathy. Kim CS, etal., Regul Pept. 2012 Feb 10;174(1-3):65-70. doi: 10.1016/j.regpep.2011.12.001. Epub 2011 Dec 28.
35. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
36. Association of 2238T>C polymorphism of the atrial natriuretic peptide gene with coronary artery disease in Afro-Caribbeans with type 2 diabetes. Larifla L, etal., Am J Hypertens. 2012 May;25(5):524-7. doi: 10.1038/ajh.2011.233. Epub 2011 Dec 15.
37. Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway. Maayah ZH, etal., Arch Toxicol. 2014 Mar;88(3):725-38. doi: 10.1007/s00204-013-1159-5. Epub 2013 Nov 19.
38. Potent and direct presynaptic modulation of glycinergic transmission in rat spinal neurons by atrial natriuretic peptide. Maeda M, etal., Brain Res Bull. 2013 Oct;99:19-26. doi: 10.1016/j.brainresbull.2013.09.003. Epub 2013 Sep 21.
39. Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence. Maki M, etal., Nature 1984 Jun 21-27;309(5970):722-4.
40. The presence of ANP in rat peritoneal mast cells. Martynova MG, etal., Cell Res. 2005 Oct;15(10):811-6.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. Moffatt P, etal., J Biol Chem. 2007 Dec 14;282(50):36454-62. Epub 2007 Oct 19.
43. Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide. Morikawa S, etal., J Am Coll Cardiol. 2009 Mar 24;53(12):1040-6. doi: 10.1016/j.jacc.2008.10.061.
44. Increased human brain natriuretic peptide in congestive heart failure. Mukoyama M, etal., N Engl J Med. 1990 Sep 13;323(11):757-8.
45. Central nervous system-specific glycosylation of the type A natriuretic peptide receptor. Muller D, etal., Endocrinology 2002 Jan;143(1):23-9.
46. NT-proANP and BNP in renovascular and in severe and mild essential hypertension. Mussalo H, etal., Kidney Blood Press Res. 2003;26(1):34-41.
47. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. Nakagawa O, etal., J Clin Invest. 1995 Sep;96(3):1280-7.
48. The genetic contribution of the natriuretic peptide system to cardiovascular diseases. Nakayama T Endocr J. 2005 Feb;52(1):11-21.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. Nicolaidou P, etal., Pediatr Int. 2003 Feb;45(1):35-8.
51. Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Nishikimi T, etal., Regul Pept. 2009 Apr 10;154(1-3):44-53. doi: 10.1016/j.regpep.2009.02.006. Epub 2009 Feb 15.
52. Alterations in atrial natriuretic peptide and its receptor levels in long-term, streptozotocin-induced, diabetes in rats. Obineche E, etal., Ann N Y Acad Sci. 2006 Nov;1084:223-34.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis. Panizo S, etal., Nephrol Dial Transplant. 2013 Sep 7.
55. Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites. Pereira NL, etal., Circ Cardiovasc Genet. 2015 Feb;8(1):141-9. doi: 10.1161/CIRCGENETICS.114.000624. Epub 2014 Dec 1.
56. Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats. Prunier F, etal., Eur J Heart Fail. 2005 Aug;7(5):739-47.
57. Immunocytochemical localization of proANF 1-30, proANF 31-67 and atrial natriuretic factor in the kidney. Ramirez G, etal., Kidney Int. 1992 Feb;41(2):334-41. doi: 10.1038/ki.1992.46.
58. GOA pipeline RGD automated data pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. Atrial natriuretic peptide in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy. Rollin R, etal., Mol Vis. 2004 Jul 15;10:450-7.
62. Downregulation of the atrial natriuretic peptide/natriuretic peptide receptor-C system in the early stages of diabetic retinopathy in the rat. Rollin R, etal., Mol Vis. 2005 Mar 18;11:216-24.
63. Acute antihypertrophic actions of bradykinin in the rat heart: importance of cyclic GMP. Rosenkranz AC, etal., Hypertension 2002 Oct;40(4):498-503.
64. Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies. Roussel R, etal., Diabetes. 2004 May;53(5):1394-8.
65. Altered structure, regulation, and function of the gene encoding the atrial natriuretic peptide in the stroke-prone spontaneously hypertensive rat. Rubattu S, etal., Circ Res 1999 Nov 12;85(10):900-5.
66. The gene encoding atrial natriuretic peptide and the risk of human stroke. Rubattu S, etal., Circulation. 1999 Oct 19;100(16):1722-6. doi: 10.1161/01.cir.100.16.1722.
67. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease Rubattu S, etal., Nat Genet 1996 Aug;13(4):429-34
68. Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans. Rubattu S, etal., Stroke. 2004 Apr;35(4):814-8. Epub 2004 Mar 11.
69. Permeability and contractile responses of collecting lymphatic vessels elicited by atrial and brain natriuretic peptides. Scallan JP, etal., J Physiol. 2013 Oct 15;591(Pt 20):5071-81. doi: 10.1113/jphysiol.2013.260042. Epub 2013 Jul 29.
70. A polymorphism in the gene for the atrial natriuretic peptide and diabetic nephropathy. Diabetic Nephropathy Study Group. Schmidt S, etal., Nephrol Dial Transplant. 1998 Jul;13(7):1807-10.
71. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
72. Nuclear Translocation of Calpain-2 Mediates Apoptosis of Hypertrophied Cardiomyocytes in Transverse Aortic Constriction Rat. Sheng JJ, etal., J Cell Physiol. 2015 Nov;230(11):2743-54. doi: 10.1002/jcp.24999.
73. Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides. Sorci G, etal., Brain Res. 1995 Jun 12;683(1):51-8.
74. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
75. Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats. Vesely DL, etal., Metabolism. 1999 Jun;48(6):771-8.
76. Inverse association of long-acting natriuretic peptide with metabolic syndrome in congestive heart failure patients. Wang JH, etal., Diabetol Metab Syndr. 2013 Apr 8;5(1):19. doi: 10.1186/1758-5996-5-19.
77. Atrial natriuretic peptides elevate cyclic GMP levels in primary cultures of rat ependymal cells. Wellard J, etal., Neurochem Res. 2003 Feb;28(2):225-33.
78. A-type natriuretic peptide receptor in the spontaneously hypertensive rat kidney. Woodard GE, etal., Peptides 2002 Sep;23(9):1637-47.
79. Cloning and sequence analysis of the cDNA for the rat atrial natriuretic factor precursor. Yamanaka M, etal., Nature 1984 Jun 21-27;309(5970):719-22.
80. Plasma brain natriuretic peptide levels in normotensive noninsulin-dependent diabetic patients with microalbuminuria. Yano Y, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2353-6.
81. Cosegregation analysis of natriuretic peptide genes and blood pressure in the spontaneously hypertensive rat. Ye P and West MJ, Clin Exp Pharmacol Physiol 2003 Dec;30(12):930-6.
82. Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis. Yokota N, etal., Nephron. 1993;65(3):454-9.
83. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
84. Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. Zang MX, etal., J Cell Biochem. 2004 Dec 15;93(6):1255-66.
85. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Zhang Y, etal., Biochim Biophys Acta. 2014 Feb;1842(2):232-44. doi: 10.1016/j.bbadis.2013.11.018. Epub 2013 Nov 23.
86. Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. Zhang Y, etal., IUBMB Life. 2016 Jan;68(1):13-22. doi: 10.1002/iub.1456. Epub 2015 Nov 24.
87. Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin. Zhang Y, etal., Mol Med Rep. 2020 Jan;21(1):393-404. doi: 10.3892/mmr.2019.10810. Epub 2019 Nov 11.
88. Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats. Zhu YB, etal., Chin Med J (Engl). 2013 Feb;126(4):747-50.
Additional References at PubMed
PMID:1652217   PMID:1660465   PMID:1672777   PMID:2951736   PMID:2962707   PMID:2966345   PMID:2967498   PMID:2985557   PMID:6230082   PMID:6232612   PMID:6233494   PMID:6234658  
PMID:6238331   PMID:6419347   PMID:6547996   PMID:8889548   PMID:12020441   PMID:12022755   PMID:12413399   PMID:12477932   PMID:12527142   PMID:12540777   PMID:12738802   PMID:12829435  
PMID:14575315   PMID:14766980   PMID:14985074   PMID:15117337   PMID:15117952   PMID:15452027   PMID:15539631   PMID:15569826   PMID:16377580   PMID:16814407   PMID:16859700   PMID:16870210  
PMID:16909307   PMID:17038494   PMID:17332063   PMID:17434981   PMID:17522368   PMID:17537544   PMID:18378355   PMID:18823659   PMID:19101594   PMID:19539681   PMID:19546173   PMID:19570884  
PMID:19646991   PMID:19799869   PMID:19896516   PMID:20071611   PMID:20353436   PMID:20384792   PMID:20559433   PMID:20691705   PMID:20801128   PMID:21056071   PMID:21237168   PMID:21287975  
PMID:21552198   PMID:21635224   PMID:22399583   PMID:22437503   PMID:22962310   PMID:23551170   PMID:23578746   PMID:23749889   PMID:23913708   PMID:23956981   PMID:24137001   PMID:24333928  
PMID:24403064   PMID:24689065   PMID:25123163   PMID:25126708   PMID:25218476   PMID:25451332   PMID:25669688   PMID:25846103   PMID:25865156   PMID:26254181   PMID:26446774   PMID:26660905  
PMID:27208702   PMID:27228659   PMID:27559042   PMID:29021616   PMID:30623208   PMID:30633838   PMID:31386893   PMID:31541683   PMID:35509154   PMID:37924963  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85163,712,184 - 163,713,493 (+)NCBIGRCr8
mRatBN7.25158,429,042 - 158,430,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,145,793 - 161,147,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,973,730 - 162,975,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,930,077 - 162,931,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38111,845,709 - 11,847,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,845,709 - 11,848,345 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,905,766 - 11,907,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,828,363 - 11,830,422 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,840,041 - 11,842,101NCBI
Celera111,019,389 - 11,021,472 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,060,823 - 11,062,905 (-)NCBIHuRef
CHM1_1111,893,660 - 11,895,736 (-)NCBICHM1_1
T2T-CHM13v2.0111,389,795 - 11,391,868 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394148,085,179 - 148,086,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)EnsemblGRCm39 Ensembl
GRCm384148,000,722 - 148,002,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,374,855 - 147,376,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,844,546 - 146,845,867 (+)NCBIMGSCv36mm8
Celera4150,267,117 - 150,268,440 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.66NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554862,060,735 - 2,063,003 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,061,196 - 2,062,805 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,021,064 - 215,023,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,825,072 - 11,827,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1284,406,317 - 84,408,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505834,846,575 - 34,848,291 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl671,918,845 - 71,921,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,919,557 - 71,921,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,829,057 - 65,830,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120119,942,412 - 119,946,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,944,532 - 119,945,917 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,811,217 - 23,814,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248181,147,974 - 1,148,927 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,147,654 - 1,149,722 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nppa
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:121
Interacting mature miRNAs:132
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
631498Bp100Blood pressure QTL 1004.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5158418175158429042Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,427,876 - 158,428,037 (+)MAPPERmRatBN7.2
Rnor_6.05164,807,242 - 164,807,402NCBIRnor6.0
Rnor_5.05168,465,144 - 168,465,304UniSTSRnor5.0
RGSC_v3.45165,073,352 - 165,073,513RGDRGSC3.4
RGSC_v3.45165,073,353 - 165,073,513UniSTSRGSC3.4
RGSC_v3.15165,083,540 - 165,083,701RGD
Celera5156,709,720 - 156,709,880UniSTS
RH 3.4 Map51105.1UniSTS
RH 3.4 Map51105.1RGD
RH 2.0 Map51108.0RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,430,406 - 158,430,550 (+)MAPPERmRatBN7.2
Rnor_6.05164,809,772 - 164,809,913NCBIRnor6.0
Rnor_5.05168,467,674 - 168,467,815UniSTSRnor5.0
RGSC_v3.45165,075,883 - 165,076,024UniSTSRGSC3.4
RGSC_v3.15165,086,070 - 165,086,213RGD
Celera5156,712,250 - 156,712,391UniSTS
RH 3.4 Map51104.0UniSTS
RH 3.4 Map51104.0RGD
RH 2.0 Map597.2RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,429,113 - 158,429,626 (+)MAPPERmRatBN7.2
Rnor_6.05164,808,479 - 164,808,991NCBIRnor6.0
Rnor_5.05168,466,381 - 168,466,893UniSTSRnor5.0
RGSC_v3.45165,074,590 - 165,075,102UniSTSRGSC3.4
Celera5156,710,957 - 156,711,469UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,429,401 - 158,429,667 (+)MAPPERmRatBN7.2
Rnor_6.05164,808,767 - 164,809,032NCBIRnor6.0
Rnor_5.05168,466,669 - 168,466,934UniSTSRnor5.0
RGSC_v3.45165,074,878 - 165,075,143UniSTSRGSC3.4
Celera5156,711,245 - 156,711,510UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,428,778 - 158,429,130 (+)MAPPERmRatBN7.2
Rnor_6.05164,808,144 - 164,808,495NCBIRnor6.0
Rnor_5.05168,466,046 - 168,466,397UniSTSRnor5.0
RGSC_v3.45165,074,255 - 165,074,606UniSTSRGSC3.4
Celera5156,710,622 - 156,710,973UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,429,171 - 158,429,665 (+)MAPPERmRatBN7.2
Rnor_6.05164,808,537 - 164,809,030NCBIRnor6.0
Rnor_5.05168,466,439 - 168,466,932UniSTSRnor5.0
RGSC_v3.45165,074,648 - 165,075,141UniSTSRGSC3.4
Celera5156,711,015 - 156,711,508UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map51107.4UniSTS
RH 3.4 Map51104.1UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map51106.6UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,429,613 - 158,430,158 (+)MAPPERmRatBN7.2
Rnor_6.05164,808,979 - 164,809,523NCBIRnor6.0
Rnor_5.05168,466,881 - 168,467,425UniSTSRnor5.0
RGSC_v3.45165,075,090 - 165,075,634UniSTSRGSC3.4
Celera5156,711,457 - 156,712,001UniSTS
RH 3.4 Map51106.8UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,429,341 - 158,429,558 (+)MAPPERmRatBN7.2
Rnor_6.05164,808,707 - 164,808,923NCBIRnor6.0
Rnor_5.05168,466,609 - 168,466,825UniSTSRnor5.0
Celera5156,711,185 - 156,711,401UniSTS
Cytogenetic Map5q36UniSTS

Related Rat Strains
The following Strains have been annotated to Nppa

Genetic Models
This gene Nppa is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 40
Medium 3 7 8
Low 30 14 16 14 8 8 61 14 16 1 8
Below cutoff 3 1 1 4 9 18 1


RefSeq Acc Id: ENSRNOT00000011005   ⟹   ENSRNOP00000011005
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)Ensembl
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117878   ⟹   ENSRNOP00000076789
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5158,429,042 - 158,430,328 (+)Ensembl
RefSeq Acc Id: NM_012612   ⟹   NP_036744
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr85163,712,184 - 163,713,493 (+)NCBI
mRatBN7.25158,429,042 - 158,430,351 (+)NCBI
Rnor_6.05164,808,407 - 164,809,716 (+)NCBI
Rnor_5.05168,466,309 - 168,467,618 (+)NCBI
RGSC_v3.45165,074,518 - 165,075,827 (+)RGD
Celera5156,710,885 - 156,712,194 (+)RGD
RefSeq Acc Id: NP_036744   ⟸   NM_012612
- Peptide Label: precursor
- UniProtKB: P01161 (UniProtKB/Swiss-Prot),   B0BMW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011005   ⟸   ENSRNOT00000011005
RefSeq Acc Id: ENSRNOP00000076789   ⟸   ENSRNOT00000117878

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01161-F1-model_v2 AlphaFold P01161 1-152 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694254
Promoter ID:EPDNEW_R4779
Type:single initiation site
Description:natriuretic peptide A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,808,398 - 164,808,458EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3193 AgrOrtholog
BioCyc Gene G2FUF-39201 BioCyc
Ensembl Genes ENSRNOG00000008176 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00060026671 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011005 ENTREZGENE
  ENSRNOT00000011005.6 UniProtKB/Swiss-Prot
  ENSRNOT00000117878.1 UniProtKB/TrEMBL
  ENSRNOT00060046218 UniProtKB/Swiss-Prot
InterPro Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natriuretic_peptide_atrial UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24602 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nppa PhenoGen
  NATPEPTIDES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008176 RatGTEx
  ENSRNOG00060026671 RatGTEx
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216750
UniProt A0A8I5Y501_RAT UniProtKB/TrEMBL
  ANF_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-20 Nppa  natriuretic peptide precursor A  Nppa  natriuretic peptide precursor type A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nppa  natriuretic peptide precursor type A      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Nppa  natriuretic peptide precursor type A      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease present in the liver and spleen 70434
gene_disease associated with cardiomyocyte hypertrophy 625709
gene_expression controls fluid volume homeostasis 70434
gene_expression expressed in the left ventricles of heart 625709
gene_process binds membrane receptors 70434
gene_process mediates estrogen action 69504
gene_process regulates hydromineral homeostasis 69504
gene_process prevents cardiac hypertrophy 69504
gene_process induces vasorelaxation, natriuresis, diuresis 69504
gene_product 122kDa protein 70434
gene_protein precursor protein contains 152 amino acid residues 728984
gene_regulation activated by 17-beta-estradiol 69504
gene_regulation angiotensin II increases the left ventricular mRNA expression and is repressed by bradykinin 625709