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Gene: Nppa (natriuretic peptide A) Rattus norvegicus
Symbol: Nppa
Name: natriuretic peptide A
RGD ID: 3193
Description: Exhibits hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of collecting lymphatic vessel constriction; and regulation of ion transport. Localizes to several cellular components, including brush border; mast cell granule; and perinuclear region of cytoplasm. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A); PARTICIPATES IN atrial natriuretic peptide signaling pathway; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANF; ANP; atrial natriuretic factor; atrial natriuretic factor prohormone; atrial natriuretic peptide; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; CDD; Natriuretic peptide precursor A (pronatriodilatin also Anf Pnd); Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); Natriuretic peptide precursor A, (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; natriuretic peptides A; Pnd; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP; RATANF
Homo sapiens (human) : NPPA (natriuretic peptide A)  HGNC  Alliance
Mus musculus (house mouse) : Nppa (natriuretic peptide type A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppa (natriuretic peptide A)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPA (natriuretic peptide A)
Canis lupus familiaris (dog) : NPPA (natriuretic peptide A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppa (natriuretic peptide A)
Sus scrofa (pig) : NPPA (natriuretic peptide A)
Chlorocebus sabaeus (African green monkey) : NPPA (natriuretic peptide A)
Heterocephalus glaber (naked mole-rat) : Nppa (natriuretic peptide A)
more info ...
Allele / Splice: Nppaem4Mcwi  
Genetic Models: SS-Nppaem4Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp49   Strs2   Bp100   Strs6  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map51106.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nppa
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3193
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.