Gene: Nppa (natriuretic peptide A) Rattus norvegicus
Symbol: Nppa
Name: natriuretic peptide A
Description: ENCODES a protein that exhibits hormone activity; peptide hormone receptor binding; signaling receptor binding; INVOLVED IN cell growth involved in cardiac muscle cell development; cellular response to mechanical stimulus; cGMP biosynthetic process; PARTICIPATES IN atrial natriuretic peptide signaling pathway; ASSOCIATED WITH Acute Kidney Injury; Cardiomegaly; diabetes mellitus, experimental; FOUND IN cytoplasm; mast cell granule; nucleus; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; 1-octadec-9-enoylglycero-3-phosphate
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANF; ANP; atrial natriuretic factor; atrial natriuretic peptide; Natriuretic peptide precursor A (pronatriodilatin also Anf Pnd); Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); Natriuretic peptide precursor A, (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; natriuretic peptides A; Pnd; prepronatriodilatin; RATANF
Homo sapiens (human) : NPPA (natriuretic peptide A)  HGNC  Alliance
Mus musculus (house mouse) : Nppa (natriuretic peptide type A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppa (natriuretic peptide A)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPA (natriuretic peptide A)
Canis lupus familiaris (dog) : NPPA (natriuretic peptide A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppa (natriuretic peptide A)
more info ...
Allele / Splice: Nppaem4Mcwi  
Genetic Models: SS-Nppaem4Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp49   Strs2   Bp100   Strs6  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map51106.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nppa
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3193
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-04-10
Status: ACTIVE