Bp100 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp100 (Blood pressure QTL 100) Rattus norvegicus

Symbol: Bp100
Name: Blood pressure QTL 100
RGD ID: 631498
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: 4.9
P Value: 0.001
Variance: 13.5
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25158,418,175 - 158,429,042RGD_MAPPER_PIPELINE
Rnor_6.05164,797,538 - 164,808,407RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05168,455,640 - 168,466,309RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45165,063,650 - 165,074,518RGDRGSC3.4
RGSC_v3.15165,073,838 - 165,084,713RGD
Cross Type: backcross
Strains Crossed: SHR WKY 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
SHR  (IEA)
WKY  (IEA)

References

References - curated
1. Zhang L, etal., Clin Exp Pharmacol Physiol 1997 Jun;24(6):442-4.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3194Nppbnatriuretic peptide B5164796176164797538Rat
3193Nppanatriuretic peptide A5164808407164809716Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
42768D5Rat2602495164803790164804026Ratregion
11001D5Wox101615164807242164807402Ratregion
5032517Nppa3525164808144164808495Ratregion
Position Markers

Flank 1: (Nppa)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,429,042 - 158,430,351 (+)NCBI
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)Ensembl
Rnor_6.05164,808,407 - 164,809,716 (+)NCBI
Rnor_5.05168,466,309 - 168,467,618 (+)NCBI
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBI
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBI
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
Peak: (Nppb)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,416,813 - 158,418,175 (+)NCBI
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)Ensembl
Rnor_6.05164,796,176 - 164,797,538 (+)NCBI
Rnor_5.05168,454,278 - 168,455,640 (+)NCBI
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBI
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBI
Cytogenetic Map5q36NCBI
Flank 2: (Nppb)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25158,416,813 - 158,418,175 (+)NCBI
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)Ensembl
Rnor_6.05164,796,176 - 164,797,538 (+)NCBI
Rnor_5.05168,454,278 - 168,455,640 (+)NCBI
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBI
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBI
Cytogenetic Map5q36NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5149568588167739697Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149832180164807402Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5150360936167946134Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5157212422167739539Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5157319671171194163Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5157319671173707219Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5161084664173707219Rat
631498Bp100Blood pressure QTL 1004.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5164797538164808407Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Bp100

RGD Curation Notes
Note Type Note Reference
qtl_cross_type backcross  
qtl_gene closely linked to the natriuretic peptide gene region but both the Nppa and Nppb genes have no effect on the blood pressure 619655