RGD Reference Report - Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy.

Authors: Zhang, Y  Si, Y  Ma, N 
Citation: Zhang Y, etal., IUBMB Life. 2016 Jan;68(1):13-22. doi: 10.1002/iub.1456. Epub 2015 Nov 24.
RGD ID: 11554891
Pubmed: PMID:26597775   (View Abstract at PubMed)
DOI: DOI:10.1002/iub.1456   (Journal Full-text)

The poly(rC)-binding protein 2 (PCBP2) is currently reported to inhibit cardiac hypertrophy. However, how PCBP2 is regulated at transcriptional level remains unknown. Here, we show that Meis1, a PBX1-related homeobox gene, binds to PCBP2 promoter and promotes its transcription. In human failing heart tissues and murine hypertrophic heart tissues, the mRNA and protein levels of Meis1 are markedly downregulated, and the level of Meis1 significantly correlates with levels of Nppa, Myh7, and PCBP2. In neonatal rat cardiomyocytes, angiotensin II (Ang II) treatment induces hypertrophic growth of the cells (increase in cell size, enhanced protein synthesis, and hyperexpression of hypertrophic fetal genes), which are significantly inhibited by Meis1 overexpression or promoted by Meis1 knockdown. Meis1 also reduces Ang II-induced activation of Akt-mTOR pathway. Finally, we show that PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes. (c) 2015 IUBMB Life, 68(1):13-22, 2016.



1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MEIS1HumanCardiomegaly  ISOMeis1 (Mus musculus)mRNA and protein:decreased expression:heart (mouse)RGD 
MYH7HumanCardiomegaly  ISOMyh7 (Mus musculus)mRNA and protein:increased expression:heart (mouse)RGD 
Meis1RatCardiomegaly  ISOMeis1 (Mus musculus)mRNA and protein:decreased expression:heart (mouse)RGD 
Meis1MouseCardiomegaly  IEP mRNA and protein:decreased expression:heart (mouse)RGD 
Myh7MouseCardiomegaly  IEP mRNA and protein:increased expression:heart (mouse)RGD 
Myh7RatCardiomegaly  ISOMyh7 (Mus musculus)mRNA and protein:increased expression:heart (mouse)RGD 
NPPAHumanCardiomegaly  ISONppa (Mus musculus)mRNA and protein:increased expression:heart (mouse)RGD 
NppaRatCardiomegaly  ISONppa (Mus musculus)mRNA and protein:increased expression:heart (mouse)RGD 
NppaMouseCardiomegaly  IEP mRNA and protein:increased expression:heart (mouse)RGD 
MEIS1Humanheart disease  IEP mRNA and protein:decreased expression:heart (human)RGD 
MYH7Humanheart disease  IEP mRNA and protein:increased expression:heart (human)RGD 
Meis1Mouseheart disease  ISOMEIS1 (Homo sapiens)mRNA and protein:decreased expression:heart (human)RGD 
Meis1Ratheart disease  ISOMEIS1 (Homo sapiens)mRNA and protein:decreased expression:heart (human)RGD 
Myh7Ratheart disease  ISOMYH7 (Homo sapiens)mRNA and protein:increased expression:heart (human)RGD 
Myh7Mouseheart disease  ISOMYH7 (Homo sapiens)mRNA and protein:increased expression:heart (human)RGD 
NPPAHumanheart disease  IEP mRNA and protein:increased expression:heart (human)RGD 
NppaRatheart disease  ISONPPA (Homo sapiens)mRNA and protein:increased expression:heart (human)RGD 
NppaMouseheart disease  ISONPPA (Homo sapiens)mRNA and protein:increased expression:heart (human)RGD 
1 to 18 of 18 rows


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Meis1Ratcell growth involved in cardiac muscle cell development  IMP  RGD 


Genes (Rattus norvegicus)
Meis1  (Meis homeobox 1) Myh7  (myosin heavy chain 7) Nppa  (natriuretic peptide A)

Genes (Mus musculus)
Meis1  (Meis homeobox 1) Myh7  (myosin, heavy polypeptide 7, cardiac muscle, beta) Nppa  (natriuretic peptide type A)

Genes (Homo sapiens)
MEIS1  (Meis homeobox 1) MYH7  (myosin heavy chain 7) NPPA  (natriuretic peptide A)