Myh7 (myosin heavy chain 7) - Rat Genome Database

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Gene: Myh7 (myosin heavy chain 7) Rattus norvegicus
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Symbol: Myh7
Name: myosin heavy chain 7
RGD ID: 62030
Description: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; cellular response to angiotensin; and cellular response to hydrogen peroxide. Located in myosin filament and sarcomere. Part of muscle myosin complex. Biomarker of congestive heart failure; hypertension; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; myocarditis pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta myosin heavy chain; Bmyo; myHC-beta; myHC-slow; Myhcb; myosin heavy chain cardiac muscle fetal; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain slow isoform; myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin heavy chain, polypeptide 7, cardiac muscle, fetal; myosin heavy polypeptide 7 cardiac muscle beta; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; myosin-7
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bss103  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,416,525 - 32,439,851 (-)NCBIGRCr8
GRCr8 Ensembl1532,416,527 - 32,438,194 (-)EnsemblGRCr8 Ensembl
mRatBN7.21528,446,550 - 28,469,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,446,550 - 28,468,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,292,350 - 30,313,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,439,549 - 31,461,136 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,682,125 - 29,703,795 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,605,769 - 33,657,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,634,422 - 33,656,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,512,803 - 37,544,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,072,928 - 33,094,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,024,223 - 28,045,877 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
atrial fibrillation  (ISO)
atrial heart septal defect  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant hyaline body myopathy  (ISO)
autosomal recessive hyaline body myopathy  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Camptocormia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
Chest Pain  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital heart disease  (ISO)
congenital myopathy  (ISO)
congenital myopathy 1A  (ISO)
congenital myopathy 4A  (ISO)
congenital structural myopathy  (ISO)
congestive heart failure  (IEP,ISO)
coronary stenosis  (ISO)
craniosynostosis  (ISO)
craniosynostosis 4  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
distal myopathy  (ISO)
distal myopathy 1  (ISO)
Dyspnea  (ISO)
Ebstein anomaly  (ISO)
Endotoxemia  (IEP)
familial hypertrophic cardiomyopathy  (ISO)
Familial Ventricular Tachycardia  (ISO)
first-degree atrioventricular block  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
heart disease  (ISO)
hyaline body myopathy  (ISO)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 14  (ISO)
hypertrophic cardiomyopathy 2  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
hypoplastic left heart syndrome  (ISO)
hypothyroidism  (IEP)
intrinsic cardiomyopathy  (ISO)
Leber congenital amaurosis  (ISO)
Left Ventricular Hypertrophy  (IEP,ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
lysinuric protein intolerance  (ISO)
Metabolic Side Effects of Drugs and Substances  (IEP)
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency  (ISO)
microcephalic osteodysplastic primordial dwarfism type I  (ISO)
myocardial infarction  (IEP,ISO)
myopathy  (ISO)
neuromuscular disease  (ISO)
pericarditis  (ISO)
restrictive cardiomyopathy  (ISO)
scapuloperoneal myopathy  (ISO)
severe combined immunodeficiency  (ISO)
Specific Granule Deficiency  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
ATP  (ISO)
bellidifolin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
dantrolene  (EXP)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
ellagic acid  (EXP)
enalapril  (EXP)
etoposide  (ISO)
fasudil  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
gefitinib  (EXP)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
indole-3-acetic acid  (EXP)
indoxyl sulfate  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
KN-93  (EXP)
L-ascorbic acid  (ISO)
lead nitrate  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
maneb  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
milrinone  (EXP)
mitoxantrone  (ISO)
monocrotaline  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
Paeonol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenylephrine  (EXP,ISO)
Plantamajoside  (EXP,ISO)
potassium dichromate  (ISO)
prazosin  (EXP)
progesterone  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
pyrrolidine dithiocarbamate  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Spiruchostatin A  (EXP)
streptozocin  (EXP)
sunitinib  (EXP,ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trans-piceid  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
verapamil  (ISO)
Y-27632  (EXP)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
muscle myosin complex  (IDA,IEA)
myofibril  (IDA,IEA,ISO)
myosin complex  (IEA,ISO)
myosin filament  (IBA,IDA,IEA,ISO)
myosin II complex  (IBA)
sarcomere  (IDA,IEA)
stress fiber  (IEA,ISO)
Z disc  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prognostic significance of beta-myosin heavy chain mutations is reflective of their hypertrophic expressivity in patients with hypertrophic cardiomyopathy. Abchee A and Marian AJ, J Investig Med. 1997 Apr;45(4):191-6.
2. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Al-Attas OS, etal., Environ Sci Pollut Res Int. 2015 Jul;22(13):10083-93. doi: 10.1007/s11356-015-4212-5. Epub 2015 Feb 18.
3. Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. Budde BS, etal., PLoS One. 2007 Dec 26;2(12):e1362.
4. Interpreting cardiac muscle force-length dynamics using a novel functional model. Campbell KB, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1535-45.
5. Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy. Cheng TH, etal., J Biomed Sci. 2005;12(1):123-33.
6. Novel mutations in sarcomeric protein genes in dilated cardiomyopathy. Daehmlow S, etal., Biochem Biophys Res Commun. 2002 Oct 18;298(1):116-20.
7. Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping. Dechesne CA, etal., J Cell Biol. 1987 Dec;105(6 Pt 2):3031-7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. Haddad F, etal., J Biol Chem. 2003 Sep 26;278(39):37132-8. Epub 2003 Jul 7.
11. Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. Izumo S, etal., J Clin Invest. 1987 Mar;79(3):970-7.
12. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
13. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. Kamisago M, etal., N Engl J Med 2000 Dec 7;343(23):1688-96.
14. Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy. Karkkainen S, etal., Eur J Heart Fail. 2004 Dec;6(7):861-8.
15. Complete nucleotide sequence of full length cDNA for rat beta cardiac myosin heavy chain. Kraft R, etal., Nucleic Acids Res 1989 Sep 25;17(18):7529-30.
16. Myosin storage myopathy: slow skeletal myosin (MYH7) mutation in two isolated cases. Laing NG, etal., Neurology. 2005 Feb 8;64(3):527-9.
17. Cardiac muscle protein gene expression in the endotoxin-treated rat. Macallan DC and Griffin GE, Clin Sci (Lond). 1994 Nov;87(5):539-46.
18. Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability. Mahdavi V, etal., Eur Heart J 1984 Dec;5 Suppl F:181-91.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes. O'Neill L, etal., Cardioscience. 1991 Mar;2(1):1-5.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. Perrot A, etal., J Mol Med. 2005 Jun;83(6):468-77. Epub 2005 Apr 22.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics. Rundell VL, etal., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H896-903. Epub 2004 Oct 7.
29. Antiplatelet therapy attenuates subcellular remodelling in congestive heart failure. Sanganalmath SK, etal., J Cell Mol Med. 2008 Sep-Oct;12(5A):1728-38. Epub 2007 Dec 14.
30. Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. Schuyler GT and Yarbrough LR, Basic Res Cardiol. 1990 Sep-Oct;85(5):481-94.
31. Myosin storage myopathy associated with a heterozygous missense mutation in MYH7. Tajsharghi H, etal., Ann Neurol. 2003 Oct;54(4):494-500.
32. Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Taylor KC, etal., Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3806-15. doi: 10.1073/pnas.1505813112. Epub 2015 Jul 6.
33. Myosin filament assembly requires a cluster of four positive residues located in the rod domain. Thompson RC, etal., FEBS Lett. 2012 Sep 21;586(19):3008-12. doi: 10.1016/j.febslet.2012.06.019. Epub 2012 Jun 21.
34. Impact of MYH6 variants in hypoplastic left heart syndrome. Tomita-Mitchell A, etal., Physiol Genomics. 2016 Dec 1;48(12):912-921. doi: 10.1152/physiolgenomics.00091.2016. Epub 2016 Oct 27.
35. Comprehensive analysis of the beta-myosin heavy chain gene in 389 unrelated patients with hypertrophic cardiomyopathy. Van Driest SL, etal., J Am Coll Cardiol. 2004 Aug 4;44(3):602-10.
36. Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression. Wang B, etal., Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):935-41.
37. Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats. Wetzel K, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R607-10.
38. Expression of smooth muscle myosin heavy chain B in cardiac vessels of normotensive and hypertensive rats. Wetzel U, etal., Circ Res. 1998 Jul 27;83(2):204-9.
39. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
40. Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. Zhang Y, etal., IUBMB Life. 2016 Jan;68(1):13-22. doi: 10.1002/iub.1456. Epub 2015 Nov 24.
Additional References at PubMed
PMID:2614840   PMID:7045682   PMID:7883988   PMID:8482409   PMID:8514894   PMID:9884344   PMID:11832337   PMID:12933346   PMID:12941647   PMID:15621050   PMID:15650152   PMID:16088376  
PMID:16754800   PMID:17138609   PMID:17307996   PMID:17347271   PMID:17363698   PMID:17906105   PMID:17982008   PMID:18631005   PMID:18978355   PMID:19336582   PMID:20833952   PMID:21126233  
PMID:21149577   PMID:21372011   PMID:21884692   PMID:22206666   PMID:24012810   PMID:24047955   PMID:24137001   PMID:24781449   PMID:25139234   PMID:25865156   PMID:26316108   PMID:26342069  
PMID:29753027   PMID:32987653   PMID:35352799  


Genomics

Comparative Map Data
Myh7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,416,525 - 32,439,851 (-)NCBIGRCr8
GRCr8 Ensembl1532,416,527 - 32,438,194 (-)EnsemblGRCr8 Ensembl
mRatBN7.21528,446,550 - 28,469,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,446,550 - 28,468,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,292,350 - 30,313,937 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,439,549 - 31,461,136 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,682,125 - 29,703,795 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,605,769 - 33,657,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,634,422 - 33,656,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,512,803 - 37,544,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,072,928 - 33,094,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,024,223 - 28,045,877 (-)NCBICelera
Cytogenetic Map15p13NCBI
MYH7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,412,740 - 23,435,660 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,412,740 - 23,435,660 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,881,949 - 23,904,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,951,787 - 22,974,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,951,788 - 22,974,690NCBI
Celera143,744,643 - 3,767,558 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,998,386 - 4,019,919 (-)NCBIHuRef
CHM1_11423,880,619 - 23,902,164 (-)NCBICHM1_1
T2T-CHM13v2.01417,613,744 - 17,636,658 (-)NCBIT2T-CHM13v2.0
Myh7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,208,141 - 55,232,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,208,141 - 55,232,083 (-)EnsemblGRCm39 Ensembl
GRCm381454,970,684 - 54,994,626 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,970,684 - 54,994,626 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,589,525 - 55,613,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,924,897 - 53,948,620 (-)NCBIMGSCv36mm8
Celera1452,776,617 - 52,800,228 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
LOC100978529
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,843,945 - 24,866,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,060,435 - 24,083,484 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,231,344 - 4,254,295 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,325,814 - 22,348,763 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,325,812 - 22,348,763 (-)Ensemblpanpan1.1panPan2
MYH7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,660,155 - 3,677,650 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,629,585 - 3,792,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,578,091 - 3,599,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,767,766 - 3,789,981 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,736,980 - 3,815,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,459,417 - 3,479,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,520,889 - 3,540,771 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,782,913 - 3,802,783 (-)NCBIUU_Cfam_GSD_1.0
LOC101972165
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,397,460 - 35,421,544 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722969,384 - 991,129 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722967,443 - 991,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103231480
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,783,610 - 23,804,981 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,783,557 - 23,799,771 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366746111,909 - 30,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Myh7
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000024186
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH140569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,466,373 - 28,466,572 (+)MAPPERmRatBN7.2
Rnor_6.01533,654,246 - 33,654,444NCBIRnor6.0
Rnor_5.01537,540,845 - 37,541,043UniSTSRnor5.0
RGSC_v3.41533,092,752 - 33,092,950UniSTSRGSC3.4
Celera1528,044,034 - 28,044,232UniSTS
RH 3.4 Map15259.6UniSTS
Cytogenetic Map15p13UniSTS
MARC_5445-5446:996690391:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,447,551 - 28,448,793 (+)MAPPERmRatBN7.2
Rnor_6.01533,635,424 - 33,636,665NCBIRnor6.0
Rnor_5.01537,522,023 - 37,523,264UniSTSRnor5.0
RGSC_v3.41533,073,930 - 33,075,171UniSTSRGSC3.4
Celera1528,025,225 - 28,026,466UniSTS
Cytogenetic Map15p13UniSTS
Myh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,449,124 - 28,449,397 (+)MAPPERmRatBN7.2
Rnor_6.01533,636,997 - 33,637,269NCBIRnor6.0
Rnor_5.01537,523,596 - 37,523,868UniSTSRnor5.0
Celera1528,026,798 - 28,027,070UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 11 49 111 58 57 26 25 26 6 177 97 11 91 38 60 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY191158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024186   ⟹   ENSRNOP00000024186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,416,527 - 32,438,194 (-)Ensembl
mRatBN7.2 Ensembl1528,446,550 - 28,468,217 (-)Ensembl
Rnor_6.0 Ensembl1533,634,422 - 33,656,089 (-)Ensembl
RefSeq Acc Id: NM_017240   ⟹   NP_058936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,416,527 - 32,438,194 (-)NCBI
mRatBN7.21528,446,550 - 28,468,217 (-)NCBI
Rnor_6.01533,634,422 - 33,656,089 (-)NCBI
Rnor_5.01537,512,803 - 37,544,317 (-)NCBI
RGSC_v3.41533,072,928 - 33,094,595 (-)RGD
Celera1528,024,223 - 28,045,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251951   ⟹   XP_006252013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,416,525 - 32,439,851 (-)NCBI
mRatBN7.21528,446,556 - 28,469,888 (-)NCBI
Rnor_6.01533,634,420 - 33,657,761 (-)NCBI
Rnor_5.01537,512,803 - 37,544,317 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063274187   ⟹   XP_063130257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,416,525 - 32,439,794 (-)NCBI
RefSeq Acc Id: NP_058936   ⟸   NM_017240
- UniProtKB: Q63351 (UniProtKB/Swiss-Prot),   P02563 (UniProtKB/Swiss-Prot),   P02564 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252013   ⟸   XM_006251951
- Peptide Label: isoform X1
- UniProtKB: Q63351 (UniProtKB/Swiss-Prot),   P02563 (UniProtKB/Swiss-Prot),   G3V8B0 (UniProtKB/TrEMBL),   A6KGY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024186   ⟸   ENSRNOT00000024186
RefSeq Acc Id: XP_063130257   ⟸   XM_063274187
- Peptide Label: isoform X1
- UniProtKB: Q63351 (UniProtKB/Swiss-Prot),   P02563 (UniProtKB/Swiss-Prot),   A6KGY1 (UniProtKB/TrEMBL),   G3V8B0 (UniProtKB/TrEMBL)
Protein Domains
IQ   Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02564-F1-model_v2 AlphaFold P02564 1-1935 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62030 AgrOrtholog
BioCyc Gene G2FUF-13751 BioCyc
Ensembl Genes ENSRNOG00000016983 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024186 ENTREZGENE
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot
  1.20.5.340 UniProtKB/Swiss-Prot
  1.20.5.370 UniProtKB/Swiss-Prot
  1.20.5.4820 UniProtKB/Swiss-Prot
  1.20.58.530 UniProtKB/Swiss-Prot
  2.30.30.360 UniProtKB/Swiss-Prot
  3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.2420 UniProtKB/Swiss-Prot
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  Myosin_head_motor_dom UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_S1_N UniProtKB/Swiss-Prot
  Myosin_tail UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  XRCC4-like_C UniProtKB/Swiss-Prot
KEGG Report rno:29557 UniProtKB/Swiss-Prot
NCBI Gene 29557 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/Swiss-Prot
  MYOSIN-6 UniProtKB/Swiss-Prot
  MYOSIN-7 UniProtKB/Swiss-Prot
Pfam Myosin_head UniProtKB/Swiss-Prot
  Myosin_N UniProtKB/Swiss-Prot
  Myosin_tail_1 UniProtKB/Swiss-Prot
PhenoGen Myh7 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot
  PS50096 UniProtKB/Swiss-Prot
  SH3_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016983 RatGTEx
SMART MYSc UniProtKB/Swiss-Prot
Superfamily-SCOP Myosin rod fragments UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  Tropomyosin UniProtKB/Swiss-Prot
UniProt A6KGY1 ENTREZGENE, UniProtKB/TrEMBL
  G3V8B0 ENTREZGENE, UniProtKB/TrEMBL
  MYH6_RAT UniProtKB/Swiss-Prot
  MYH7_RAT UniProtKB/Swiss-Prot
  P02563 ENTREZGENE
  P02564 ENTREZGENE
  Q63351 ENTREZGENE
UniProt Secondary Q63351 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Myh7  myosin heavy chain 7  Myh7  myosin, heavy chain 7, cardiac muscle, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-18 Myh7  myosin, heavy chain 7, cardiac muscle, beta  Bmyo  Beta myosin heavy chain  Data merged from RGD:2216 737654 APPROVED
2008-10-23 Myh7  myosin, heavy chain 7, cardiac muscle, beta  Myh7  myosin, heavy polypeptide 7, cardiac muscle, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Myh7  myosin, heavy polypeptide 7, cardiac muscle, beta    myosin heavy chain, polypeptide 7  Name updated 1299863 APPROVED
2002-06-10 Bmyo  Beta myosin heavy chain      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Myh7  myosin heavy chain, polypeptide 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cardiac tissue 729162
gene_function component of myosin 631748
gene_process involved in slow type muscle contraction 631748
gene_transcript proximal promoter region contains a putative repressor element beta e1, muscle CAT (MCAT)-binding site, an A/T-rich site, the CCAC box and the beta e3 element 631748