Myh7 (myosin heavy chain 7) - Rat Genome Database

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Gene: Myh7 (myosin heavy chain 7) Rattus norvegicus
Analyze
Symbol: Myh7
Name: myosin heavy chain 7
RGD ID: 62030
Description: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Involved in cellular response to hydrogen peroxide; cellular response to organonitrogen compound; and muscle contraction. Located in myosin filament and sarcomere. Part of muscle myosin complex. Biomarker of congestive heart failure; hypertension; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; myocarditis pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta myosin heavy chain; Bmyo; myHC-beta; myHC-slow; Myhcb; myosin heavy chain cardiac muscle fetal; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain slow isoform; myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin heavy chain, polypeptide 7, cardiac muscle, fetal ; myosin heavy polypeptide 7 cardiac muscle beta; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; myosin-7
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bss103  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,446,550 - 28,469,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,446,550 - 28,468,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,292,350 - 30,313,937 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01531,439,549 - 31,461,136 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01529,682,125 - 29,703,795 (-)NCBIRnor_WKY
Rnor_6.01533,605,769 - 33,657,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,634,422 - 33,656,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,512,803 - 37,544,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,072,928 - 33,094,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,024,223 - 28,045,877 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenosine deaminase deficiency  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
atrial fibrillation  (ISO)
atrial heart septal defect  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant hyaline body myopathy  (ISO)
autosomal recessive hyaline body myopathy  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Camptocormia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
combined immunodeficiency  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
congenital heart disease  (ISO)
congenital myopathy  (ISO)
congenital myopathy 4A  (ISO)
congenital structural myopathy  (ISO)
congestive heart failure  (IEP)
coronary stenosis  (ISO)
craniosynostosis  (ISO)
Craniosynostosis 4  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
distal myopathy  (ISO)
distal myopathy 1  (ISO)
Dyspnea  (ISO)
Ebstein anomaly  (ISO)
Endotoxemia  (IEP)
familial hypertrophic cardiomyopathy  (ISO)
first-degree atrioventricular block  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
heart disease  (ISO)
Hereditary Motor Neuropathy with Myopathic Features  (ISO)
hyaline body myopathy  (ISO)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 14  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
hypoplastic left heart syndrome  (ISO)
hypothyroidism  (IEP)
intrinsic cardiomyopathy  (ISO)
Leber congenital amaurosis  (ISO)
Left Ventricular Hypertrophy  (IEP,ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
lymphopenia  (ISO)
lysinuric protein intolerance  (ISO)
muscular disease  (ISO)
myocardial infarction  (IEP,ISO)
myopathy  (ISO)
neuromuscular disease  (ISO)
restrictive cardiomyopathy  (ISO)
scapuloperoneal myopathy  (ISO)
severe combined immunodeficiency  (ISO)
Specific Granule Deficiency  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
Candesartan cilexetil  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
dantrolene  (EXP)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
enalapril  (EXP)
etoposide  (ISO)
fasudil  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
gefitinib  (EXP)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
indoxyl sulfate  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
KN-93  (EXP)
L-ascorbic acid  (ISO)
lead nitrate  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
milrinone  (EXP)
mitoxantrone  (ISO)
monocrotaline  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
Paeonol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenylephrine  (EXP,ISO)
Plantamajoside  (EXP,ISO)
potassium dichromate  (ISO)
prazosin  (EXP)
progesterone  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
pyrrolidine dithiocarbamate  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
sunitinib  (EXP,ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trans-piceid  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
verapamil  (ISO)
Y-27632  (EXP)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
muscle myosin complex  (IDA)
myofibril  (IDA,ISO)
myosin complex  (IEA,ISO)
myosin filament  (IBA,IDA,IEA,ISO)
myosin II complex  (IBA)
sarcomere  (IDA)
stress fiber  (IEA,ISO)
Z disc  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prognostic significance of beta-myosin heavy chain mutations is reflective of their hypertrophic expressivity in patients with hypertrophic cardiomyopathy. Abchee A and Marian AJ, J Investig Med. 1997 Apr;45(4):191-6.
2. Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. Budde BS, etal., PLoS One. 2007 Dec 26;2(12):e1362.
3. Interpreting cardiac muscle force-length dynamics using a novel functional model. Campbell KB, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1535-45.
4. Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy. Cheng TH, etal., J Biomed Sci. 2005;12(1):123-33.
5. Novel mutations in sarcomeric protein genes in dilated cardiomyopathy. Daehmlow S, etal., Biochem Biophys Res Commun. 2002 Oct 18;298(1):116-20.
6. Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping. Dechesne CA, etal., J Cell Biol. 1987 Dec;105(6 Pt 2):3031-7.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. Haddad F, etal., J Biol Chem. 2003 Sep 26;278(39):37132-8. Epub 2003 Jul 7.
10. Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. Izumo S, etal., J Clin Invest. 1987 Mar;79(3):970-7.
11. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
12. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. Kamisago M, etal., N Engl J Med 2000 Dec 7;343(23):1688-96.
13. Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy. Karkkainen S, etal., Eur J Heart Fail. 2004 Dec;6(7):861-8.
14. Complete nucleotide sequence of full length cDNA for rat beta cardiac myosin heavy chain. Kraft R, etal., Nucleic Acids Res 1989 Sep 25;17(18):7529-30.
15. Myosin storage myopathy: slow skeletal myosin (MYH7) mutation in two isolated cases. Laing NG, etal., Neurology. 2005 Feb 8;64(3):527-9.
16. Cardiac muscle protein gene expression in the endotoxin-treated rat. Macallan DC and Griffin GE, Clin Sci (Lond). 1994 Nov;87(5):539-46.
17. Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability. Mahdavi V, etal., Eur Heart J 1984 Dec;5 Suppl F:181-91.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes. O'Neill L, etal., Cardioscience. 1991 Mar;2(1):1-5.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. Perrot A, etal., J Mol Med. 2005 Jun;83(6):468-77. Epub 2005 Apr 22.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics. Rundell VL, etal., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H896-903. Epub 2004 Oct 7.
28. Antiplatelet therapy attenuates subcellular remodelling in congestive heart failure. Sanganalmath SK, etal., J Cell Mol Med. 2008 Sep-Oct;12(5A):1728-38. Epub 2007 Dec 14.
29. Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. Schuyler GT and Yarbrough LR, Basic Res Cardiol. 1990 Sep-Oct;85(5):481-94.
30. Myosin storage myopathy associated with a heterozygous missense mutation in MYH7. Tajsharghi H, etal., Ann Neurol. 2003 Oct;54(4):494-500.
31. Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Taylor KC, etal., Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3806-15. doi: 10.1073/pnas.1505813112. Epub 2015 Jul 6.
32. Impact of MYH6 variants in hypoplastic left heart syndrome. Tomita-Mitchell A, etal., Physiol Genomics. 2016 Dec 1;48(12):912-921. doi: 10.1152/physiolgenomics.00091.2016. Epub 2016 Oct 27.
33. Comprehensive analysis of the beta-myosin heavy chain gene in 389 unrelated patients with hypertrophic cardiomyopathy. Van Driest SL, etal., J Am Coll Cardiol. 2004 Aug 4;44(3):602-10.
34. Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression. Wang B, etal., Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):935-41.
35. Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats. Wetzel K, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R607-10.
36. Expression of smooth muscle myosin heavy chain B in cardiac vessels of normotensive and hypertensive rats. Wetzel U, etal., Circ Res. 1998 Jul 27;83(2):204-9.
37. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
38. Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy. Zhang Y, etal., IUBMB Life. 2016 Jan;68(1):13-22. doi: 10.1002/iub.1456. Epub 2015 Nov 24.
Additional References at PubMed
PMID:2614840   PMID:7045682   PMID:7883988   PMID:8482409   PMID:8514894   PMID:9884344   PMID:11832337   PMID:12933346   PMID:12941647   PMID:15621050   PMID:15650152   PMID:16088376  
PMID:16754800   PMID:17138609   PMID:17307996   PMID:17347271   PMID:17363698   PMID:17906105   PMID:17982008   PMID:18631005   PMID:18978355   PMID:19336582   PMID:20833952   PMID:21126233  
PMID:21149577   PMID:21372011   PMID:21884692   PMID:22206666   PMID:24012810   PMID:24047955   PMID:24137001   PMID:24781449   PMID:25139234   PMID:25865156   PMID:26316108   PMID:26342069  
PMID:29753027   PMID:32987653  


Genomics

Comparative Map Data
Myh7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,446,550 - 28,469,888 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,446,550 - 28,468,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,292,350 - 30,313,937 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01531,439,549 - 31,461,136 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01529,682,125 - 29,703,795 (-)NCBIRnor_WKY
Rnor_6.01533,605,769 - 33,657,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,634,422 - 33,656,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,512,803 - 37,544,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,072,928 - 33,094,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1528,024,223 - 28,045,877 (-)NCBICelera
Cytogenetic Map15p13NCBI
MYH7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,412,740 - 23,435,660 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1423,412,740 - 23,435,660 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,881,949 - 23,904,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,951,787 - 22,974,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,951,788 - 22,974,690NCBI
Celera143,744,643 - 3,767,558 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,998,386 - 4,019,919 (-)NCBIHuRef
CHM1_11423,880,619 - 23,902,164 (-)NCBICHM1_1
T2T-CHM13v2.01417,613,744 - 17,636,658 (-)NCBIT2T-CHM13v2.0
Myh7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,208,141 - 55,232,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,208,141 - 55,232,083 (-)EnsemblGRCm39 Ensembl
GRCm381454,970,684 - 54,994,626 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,970,684 - 54,994,626 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,589,525 - 55,613,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,924,897 - 53,948,620 (-)NCBIMGSCv36mm8
Celera1452,776,617 - 52,800,228 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
LOC100978529
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11424,060,434 - 24,083,484 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,231,344 - 4,254,295 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,325,814 - 22,348,763 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,325,812 - 22,348,763 (-)Ensemblpanpan1.1panPan2
MYH7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,660,155 - 3,677,650 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,629,585 - 3,792,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,578,091 - 3,599,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,767,766 - 3,789,981 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,736,980 - 3,815,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,459,417 - 3,479,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,520,889 - 3,540,771 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,782,913 - 3,802,783 (-)NCBIUU_Cfam_GSD_1.0
LOC101972165
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,397,460 - 35,421,544 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722969,384 - 991,129 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936722967,443 - 991,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103231480
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,783,610 - 23,804,981 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366746111,909 - 30,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Myh7
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000024186
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH140569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,466,373 - 28,466,572 (+)MAPPERmRatBN7.2
Rnor_6.01533,654,246 - 33,654,444NCBIRnor6.0
Rnor_5.01537,540,845 - 37,541,043UniSTSRnor5.0
RGSC_v3.41533,092,752 - 33,092,950UniSTSRGSC3.4
Celera1528,044,034 - 28,044,232UniSTS
RH 3.4 Map15259.6UniSTS
Cytogenetic Map15p13UniSTS
MARC_5445-5446:996690391:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,447,551 - 28,448,793 (+)MAPPERmRatBN7.2
Rnor_6.01533,635,424 - 33,636,665NCBIRnor6.0
Rnor_5.01537,522,023 - 37,523,264UniSTSRnor5.0
RGSC_v3.41533,073,930 - 33,075,171UniSTSRGSC3.4
Celera1528,025,225 - 28,026,466UniSTS
Cytogenetic Map15p13UniSTS
Myh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,449,124 - 28,449,397 (+)MAPPERmRatBN7.2
Rnor_6.01533,636,997 - 33,637,269NCBIRnor6.0
Rnor_5.01537,523,596 - 37,523,868UniSTSRnor5.0
Celera1528,026,798 - 28,027,070UniSTS
Cytogenetic Map15p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 27
Medium 16 8 10 1 5 8
Low 26 11 16 11 1 58 11 29 3
Below cutoff 2 6 5 3 5 14 18 11 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY191158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024186   ⟹   ENSRNOP00000024186
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,446,550 - 28,468,217 (-)Ensembl
Rnor_6.0 Ensembl1533,634,422 - 33,656,089 (-)Ensembl
RefSeq Acc Id: NM_017240   ⟹   NP_058936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,446,550 - 28,468,217 (-)NCBI
Rnor_6.01533,634,422 - 33,656,089 (-)NCBI
Rnor_5.01537,512,803 - 37,544,317 (-)NCBI
RGSC_v3.41533,072,928 - 33,094,595 (-)RGD
Celera1528,024,223 - 28,045,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251951   ⟹   XP_006252013
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,446,556 - 28,469,888 (-)NCBI
Rnor_6.01533,634,420 - 33,657,761 (-)NCBI
Rnor_5.01537,512,803 - 37,544,317 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058936   ⟸   NM_017240
- UniProtKB: P02564 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252013   ⟸   XM_006251951
- Peptide Label: isoform X1
- UniProtKB: G3V8B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024186   ⟸   ENSRNOT00000024186
Protein Domains
IQ   Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02564-F1-model_v2 AlphaFold P02564 1-1935 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62030 AgrOrtholog
BioCyc Gene G2FUF-13751 BioCyc
Ensembl Genes ENSRNOG00000016983 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024186 ENTREZGENE
  ENSRNOP00000024186.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024186 ENTREZGENE
  ENSRNOT00000024186.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.4820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29557 UniProtKB/Swiss-Prot
NCBI Gene 29557 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOSIN-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myh7 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tropomyosin UniProtKB/Swiss-Prot
UniProt G3V8B0 ENTREZGENE, UniProtKB/TrEMBL
  MYH7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Myh7  myosin heavy chain 7  Myh7  myosin, heavy chain 7, cardiac muscle, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-18 Myh7  myosin, heavy chain 7, cardiac muscle, beta  Bmyo  Beta myosin heavy chain  Data Merged 737654 APPROVED
2008-10-23 Myh7  myosin, heavy chain 7, cardiac muscle, beta  Myh7  myosin, heavy polypeptide 7, cardiac muscle, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Myh7  myosin, heavy polypeptide 7, cardiac muscle, beta    myosin heavy chain, polypeptide 7  Name updated 1299863 APPROVED
2002-06-10 Bmyo  Beta myosin heavy chain      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Myh7  myosin heavy chain, polypeptide 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cardiac tissue 729162
gene_function component of myosin 631748
gene_process involved in slow type muscle contraction 631748
gene_transcript proximal promoter region contains a putative repressor element beta e1, muscle CAT (MCAT)-binding site, an A/T-rich site, the CCAC box and the beta e3 element 631748