Pigfal4 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Pigfal4 (Plasma insulin-like growth factor 1 level QTL 4) Rattus norvegicus

Symbol: Pigfal4
Name: Plasma insulin-like growth factor 1 level QTL 4
RGD ID: 8552908
Trait: blood insulin-like growth factor amount   (VT:0010479)    
Measurement Type: plasma insulin-like growth factor 1 level   (CMO:0001299)    
LOD Score: 6.6
P Value: Not Available
Variance: 11.3
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85133,789,363 - 172,190,305RGD_MAPPER_PIPELINE
mRatBN7.25128,506,074 - 166,875,058RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05134,712,342 - 173,707,219RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05138,453,703 - 177,180,328RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45135,084,412 - 173,096,209RGD_MAPPER_PIPELINERGSC3.4
Cross Type: intercross
Strains Crossed: F344/IcoCrlf LOU/NimrOlaHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4Ratdisease of metabolism  IAGP 7794844 RGD 
Pigfal4RatInsulin-Like Growth Factor I Deficiency  IAGP 7794844 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4Ratabnormal circulating insulin-like growth factor I level  IDA 7794844 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4Ratplasma insulin-like growth factor 1 level  IDA 7794844 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4Ratcontrolled calorie content diet  IDA 7794844 RGD 
Pigfal4Ratfasting  IDA 7794844 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4Ratradioimmunoassay  IDA 7794844 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4RatF344/IcoCrlf  IEA 7794844 RGD 
Pigfal4RatLOU/NimrOlaHsd  IEA 7794844 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pigfal4Ratblood insulin-like growth factor amount  IDA 7794844 RGD 


#
Reference Title
Reference Citation
1. QTLs influencing IGF-1 levels in a LOU/CxFischer 344F2 rat population. Tracks towards the metabolic theory of Ageing. Marissal-Arvy N, etal., Growth Horm IGF Res. 2013 Dec;23(6):220-8. doi: 10.1016/j.ghir.2013.08.002. Epub 2013 Aug 19.


1 to 20 of 995 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1310116Cmpk1cytidine/uridine monophosphate kinase 15128480301128507830Rat
1304972StilSTIL, centriolar assembly protein5128520837128573732Rat
1306748Tal1TAL bHLH transcription factor 1, erythroid differentiation factor5128586776128600976Rat
41126986LOC120102952uncharacterized LOC1201029525128612314128619258Rat
620952Pdzk1ip1PDZK1 interacting protein 15128618050128623131Rat
41400278Trnap-agg66transfer RNA proline (anticodon AGG) 665128635289128635369Rat
628719Cyp4x1cytochrome P450, family 4, subfamily x, polypeptide 15128651681128683338Rat
628846Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 85128702130128733476Rat
40981232Mcts1-ps1MCTS1, re-initiation and release factor, pseudogene 15128728574128729067Rat
1562603Cyp4a8-ps1cytochrome P450, family 4, subfamily a, polypeptide 8, pseudogene 15128827304128852403Rat
41096017Pkm-ps4pyruvate kinase M1/2, pseudogene 45128906060128907436Rat
41170167H3f3cl1H3 histone, family 3C like 15128921288128921701Rat
2479Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 25128922355128934188Rat
41339692Cyp4a2-ps1cytochrome P450, family 4, subfamily a, polypeptide 2, pseudogene 15128967020128975566Rat
41245892Pkm-ps5pyruvate kinase M1/2, pseudogene 55128992798128994173Rat
41174391H3f3l2H3.3 histone like 25129008176129008589Rat
41366809Cyp4a2l1cytochrome P450, family 4, subfamily a, polypeptide 2 like 15129010501129021087Rat
40980620Cyp4a2-ps2cytochrome P450, family 4, subfamily a, polypeptide 2, pseudogene 25129053886129062415Rat
1584917Pkm-ps13pyruvate kinase M1/2, pseudogene 135129079590129081630Rat
631356Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 35129097571129115488Rat

1 to 20 of 995 rows
1 to 20 of 1321 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10453D5Mcw15128924597128924722Ratregion
10453D5Mcw15129098900129099033Ratregion
10454D5Wox121185128924607128924723Ratregion
10454D5Wox121185129098910129099034Ratregion
10455D5Wox21145147939831147939945Ratregion
10490D5Uwm51715147340163147340334Ratregion
10491D5Wox142255147340196147340421Ratregion
10496D5Mco182005150175116150175316Ratregion
10517D5Arb142575154137169154137426Ratregion
10860D5Wox151195141899404141899523Ratregion
11001D5Wox101615158427876158428037Ratregion
11002D5Mit151425158430406158430550Ratregion
34136D5Mgh212185144377876144378094Ratregion
34168D5Mgh221615151005994151006154Ratregion
34206D5Mgh151595161165494161165651Ratregion
34210D5Mgh141505143608201143608494Ratregion
34210D5Mgh141505143608344143608494Ratregion
34220D5Mgh131485133529271133529419Ratregion
34248D5Mgh91345165560291165560427Ratregion
34441D5Mgh202225133916727133916949Ratregion
1 to 20 of 1321 rows

Peak: (D5Mgh22)
Rat AssemblyChrPosition (strand)Source
GRCr85156,289,283 - 156,289,444 (+)Marker Load Pipeline
mRatBN7.25151,005,994 - 151,006,154 (+)MAPPER
Rnor_6.05157,212,263 - 157,212,422NCBI
Rnor_5.05160,953,624 - 160,953,783UniSTS
RGSC_v3.45157,584,332 - 157,584,492RGD
RGSC_v3.45157,584,333 - 157,584,492UniSTS
RGSC_v3.15157,594,371 - 157,594,531RGD
Celera5149,394,047 - 149,394,206UniSTS
RH 3.4 Map51033.4RGD
RH 3.4 Map51033.4UniSTS
RH 2.0 Map51032.4RGD


1 to 10 of 69 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat

1 to 10 of 69 rows


Note Type Note Reference
qtl_general number of animals used: 93 F2 males 7794844
qtl_general software package used: ANOVA; MultiQTL software 7794844
qtl_general measurement method: 4 weeks old rats were fed SAFE-A03 chow; at 18 weeks of age they were fasted overnight, decapitated in the morning and blood samples taken; total Igf-1 level determined by radioimmunoassay 7794844
qtl_general confidence interval from 160.00 Mb till end 7794844