Slc2a7 (solute carrier family 2 member 7) - Rat Genome Database

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Gene: Slc2a7 (solute carrier family 2 member 7) Rattus norvegicus
Analyze
Symbol: Slc2a7
Name: solute carrier family 2 member 7 (Ensembl:solute carrier family 2 (facilitated glucose transporter), member 7)
RGD ID: 1583902
Description: Predicted to enable D-glucose transmembrane transporter activity and fructose transmembrane transporter activity. Predicted to be involved in fructose transmembrane transport and glucose transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Orthologous to human SLC2A7 (solute carrier family 2 member 7); INTERACTS WITH acrylamide; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glucose transporter type 7; GLUT-7; LOC100362644; LOC691471; similar to intestinal facilitative glucose transporter 7; solute carrier family 2 (facilitated glucose transporter), member 7; solute carrier family 2, facilitated glucose transporter member 7
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,624,793 - 160,643,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,624,793 - 160,643,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,341,254 - 163,360,451 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,163,127 - 165,182,312 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,119,812 - 165,139,016 (+)NCBIRnor_WKY
Rnor_6.05167,195,981 - 167,211,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,195,981 - 167,211,391 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,826,294 - 170,839,549 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,287,943 - 167,318,833 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5158,885,103 - 158,901,022 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IEA)
membrane  (IBA)
plasma membrane  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28083649  


Genomics

Comparative Map Data
Slc2a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,624,793 - 160,643,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,624,793 - 160,643,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,341,254 - 163,360,451 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,163,127 - 165,182,312 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,119,812 - 165,139,016 (+)NCBIRnor_WKY
Rnor_6.05167,195,981 - 167,211,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,195,981 - 167,211,391 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,826,294 - 170,839,549 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,287,943 - 167,318,833 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5158,885,103 - 158,901,022 (+)NCBICelera
Cytogenetic Map5q36NCBI
SLC2A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818,992,534 - 9,026,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl19,002,973 - 9,026,423 (-)EnsemblGRCh38hg38GRCh38
GRCh3719,063,032 - 9,086,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,985,946 - 9,008,991 (-)NCBINCBI36Build 36hg18NCBI36
Build 3418,997,624 - 9,020,670NCBI
Celera18,172,056 - 8,195,080 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef18,213,158 - 8,236,183 (-)NCBIHuRef
CHM1_119,053,282 - 9,076,303 (-)NCBICHM1_1
T2T-CHM13v2.018,536,635 - 8,560,063 (-)NCBIT2T-CHM13v2.0
Slc2a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,233,293 - 150,253,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,233,429 - 150,252,939 (+)EnsemblGRCm39 Ensembl
GRCm384150,148,834 - 150,169,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,148,972 - 150,168,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,523,081 - 149,542,591 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,992,772 - 149,012,282 (+)NCBIMGSCv36mm8
Celera4152,423,736 - 152,443,348 (+)NCBICelera
Cytogenetic Map4E2NCBI
SLC2A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.118,994,787 - 9,017,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,994,787 - 9,017,922 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v017,760,357 - 7,784,105 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Slc2a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,717,310 - 32,735,227 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,205,532 - 3,221,030 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366233,205,237 - 3,221,639 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,484,227 - 69,503,732 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,483,736 - 69,503,758 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC2A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,724,595 - 122,749,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,725,001 - 122,748,899 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605426,742,129 - 26,771,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Slc2a7
325 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000055520
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
D5Got113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25160,621,260 - 160,621,545 (+)MAPPERmRatBN7.2
Rnor_6.05167,184,438 - 167,184,722NCBIRnor6.0
Rnor_5.05170,818,262 - 170,818,546UniSTSRnor5.0
RGSC_v3.45167,296,841 - 167,297,126RGDRGSC3.4
RGSC_v3.45167,296,842 - 167,297,126UniSTSRGSC3.4
RGSC_v3.15167,307,030 - 167,307,314RGD
RH 3.4 Map51118.9UniSTS
RH 3.4 Map51118.9RGD
RH 2.0 Map51108.4RGD
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 17
Below cutoff 12 3 3 3 4 2 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055520   ⟹   ENSRNOP00000052384
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,624,793 - 160,643,514 (+)Ensembl
Rnor_6.0 Ensembl5167,195,981 - 167,211,391 (+)Ensembl
RefSeq Acc Id: XM_039111576   ⟹   XP_038967504
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,624,793 - 160,643,994 (+)NCBI
RefSeq Acc Id: XM_039111577   ⟹   XP_038967505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,624,793 - 160,643,994 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380621 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967504 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967505 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A4ZYQ5 (Get FASTA)   NCBI Sequence Viewer  
  ABP68403 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000052384   ⟸   ENSRNOT00000055520
RefSeq Acc Id: XP_038967504   ⟸   XM_039111576
- Peptide Label: isoform X1
- UniProtKB: F1M868 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967505   ⟸   XM_039111577
- Peptide Label: isoform X2
Protein Domains
MFS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A4ZYQ5-F1-model_v2 AlphaFold A4ZYQ5 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583902 AgrOrtholog
BioCyc Gene G2FUF-39079 BioCyc
Ensembl Genes ENSRNOG00000036951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052384 ENTREZGENE
  ENSRNOP00000052384.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055520 ENTREZGENE
  ENSRNOT00000055520.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GLUT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Slc2a7 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc2a7 PhenoGen
PRINTS SUGRTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4ZYQ5 ENTREZGENE
  F1M868 ENTREZGENE, UniProtKB/TrEMBL
  GTR7_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a7  solute carrier family 2 member 7  Slc2a7  solute carrier family 2 (facilitated glucose transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-18 Slc2a7  solute carrier family 2 (facilitated glucose transporter), member 7  LOC100362644  solute carrier family 2 (facilitated glucose transporter), member 7  Data Merged 737654 APPROVED
2010-05-06 LOC100362644  solute carrier family 2 (facilitated glucose transporter), member 7      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-09 Slc2a7  solute carrier family 2 (facilitated glucose transporter), member 7   LOC691471  similar to intestinal facilitative glucose transporter 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691471  similar to intestinal facilitative glucose transporter 7      Symbol and Name status set to provisional 70820 PROVISIONAL