Kcnq4 (potassium voltage-gated channel subfamily Q member 4) - Rat Genome Database

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Gene: Kcnq4 (potassium voltage-gated channel subfamily Q member 4) Rattus norvegicus
Analyze
Symbol: Kcnq4
Name: potassium voltage-gated channel subfamily Q member 4
RGD ID: 61799
Description: Enables potassium channel activity. Involved in negative regulation of dopaminergic synaptic transmission and potassium ion transport. Predicted to be located in basal plasma membrane. Predicted to be part of monoatomic ion channel complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2A and sensorineural hearing loss. Orthologous to human KCNQ4 (potassium voltage-gated channel subfamily Q member 4); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage-gated KQT-like subfamily Q, member 4; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; potassium voltage-gated channel, subfamily Q, member 4; voltage-gated potassium channel subunit Kv7.4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,560,366 - 139,612,212 (-)NCBIGRCr8
mRatBN7.25134,275,145 - 134,326,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,275,934 - 134,326,932 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05139,625,783 - 139,677,300 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,627,576 - 139,677,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,423,596 - 143,443,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,289,211 - 141,339,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5132,831,886 - 132,880,820 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2. Beisel KW, etal., Brain Res Mol Brain Res 2000 Oct 20;82(1-2):137-49.
2. Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Coucke PJ, etal., Hum Mol Genet. 1999 Jul;8(7):1321-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. Hansen HH, etal., J Pharmacol Exp Ther. 2006 Sep;318(3):1006-19. Epub 2006 Jun 14.
6. M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle. Hurley KM, etal., J Neurosci. 2006 Oct 4;26(40):10253-69.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12657673   PMID:16437162   PMID:16803873   PMID:18786918   PMID:20624791   PMID:21747056   PMID:21750731   PMID:24297175   PMID:24558103   PMID:25965962   PMID:27789473   PMID:28189443  
PMID:29775679  


Genomics

Comparative Map Data
Kcnq4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,560,366 - 139,612,212 (-)NCBIGRCr8
mRatBN7.25134,275,145 - 134,326,992 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,275,934 - 134,326,932 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05139,625,783 - 139,677,300 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,627,576 - 139,677,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,423,596 - 143,443,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,289,211 - 141,339,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5132,831,886 - 132,880,820 (-)NCBICelera
Cytogenetic Map5q36NCBI
KCNQ4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,783,787 - 40,840,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,783,787 - 40,840,452 (+)EnsemblGRCh38hg38GRCh38
GRCh37141,249,459 - 41,306,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36141,022,271 - 41,076,947 (+)NCBINCBI36Build 36hg18NCBI36
Build 34140,918,776 - 40,973,453NCBI
Celera139,531,891 - 39,588,392 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef139,389,941 - 39,423,633 (+)NCBIHuRef
CHM1_1141,365,539 - 41,422,020 (+)NCBICHM1_1
T2T-CHM13v2.0140,653,010 - 40,709,692 (+)NCBIT2T-CHM13v2.0
Kcnq4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,553,331 - 120,605,809 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,553,335 - 120,605,809 (-)EnsemblGRCm39 Ensembl
GRCm384120,696,134 - 120,747,491 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4120,696,138 - 120,748,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv374120,370,078 - 120,419,781 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364120,193,773 - 120,246,247 (-)NCBIMGSCv36mm8
Celera4119,415,703 - 119,465,580 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map456.52NCBI
Kcnq4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955537624,217 - 674,330 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955537624,217 - 671,407 (+)NCBIChiLan1.0ChiLan1.0
KCNQ4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21185,977,915 - 186,035,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,119,207 - 185,176,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0140,076,552 - 40,133,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1141,396,117 - 41,452,780 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl141,396,111 - 41,452,780 (+)Ensemblpanpan1.1panPan2
KCNQ4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,203,938 - 2,257,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,205,276 - 2,242,093 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,462,807 - 2,515,471 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,293,829 - 2,346,530 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,293,829 - 2,345,510 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,199,391 - 2,252,017 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,259,444 - 2,320,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,275,224 - 2,327,921 (-)NCBIUU_Cfam_GSD_1.0
Kcnq4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,619,577 - 56,671,314 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647422,444,358 - 22,496,105 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647422,444,359 - 22,496,097 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6170,346,141 - 170,401,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16170,346,135 - 170,401,534 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26157,393,601 - 157,448,978 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNQ4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,083,015 - 92,139,810 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,083,013 - 92,139,728 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,741,206 - 24,797,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624892226,324 - 275,195 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624892226,324 - 275,198 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnq4
180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000014231
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
Kcnq4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25134,276,854 - 134,276,986 (+)MAPPERmRatBN7.2
Rnor_6.05139,627,497 - 139,627,628NCBIRnor6.0
Rnor_5.05143,423,687 - 143,423,818UniSTSRnor5.0
RGSC_v3.45141,289,132 - 141,289,263UniSTSRGSC3.4
Celera5132,831,807 - 132,831,938UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2
Low 3 23 1 7 8 9 68 20 38 11 8
Below cutoff 16 31 16 12 16 4 11 1

Sequence


Ensembl Acc Id: ENSRNOT00000087445   ⟹   ENSRNOP00000073695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5134,275,934 - 134,326,932 (-)Ensembl
Rnor_6.0 Ensembl5139,627,576 - 139,677,300 (-)Ensembl
RefSeq Acc Id: NM_001419575   ⟹   NP_001406504
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,560,366 - 139,612,102 (-)NCBI
mRatBN7.25134,275,145 - 134,326,882 (-)NCBI
RefSeq Acc Id: XM_008764110   ⟹   XP_008762332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,560,366 - 139,612,204 (-)NCBI
mRatBN7.25134,275,145 - 134,326,987 (-)NCBI
Rnor_6.05139,627,576 - 139,677,300 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764111   ⟹   XP_008762333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,560,366 - 139,587,644 (-)NCBI
mRatBN7.25134,275,145 - 134,302,418 (-)NCBI
Rnor_6.05139,625,783 - 139,653,001 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111224   ⟹   XP_038967152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,560,366 - 139,612,205 (-)NCBI
mRatBN7.25134,275,145 - 134,326,988 (-)NCBI
RefSeq Acc Id: XM_039111225   ⟹   XP_038967153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,560,366 - 139,612,204 (-)NCBI
mRatBN7.25134,275,145 - 134,326,987 (-)NCBI
RefSeq Acc Id: XM_039111226   ⟹   XP_038967154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,577,144 - 139,612,212 (-)NCBI
mRatBN7.25134,290,538 - 134,326,992 (-)NCBI
RefSeq Acc Id: XP_008762332   ⟸   XM_008764110
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008762333   ⟸   XM_008764111
- Peptide Label: isoform X4
- UniProtKB: A6IRZ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073695   ⟸   ENSRNOT00000087445
RefSeq Acc Id: XP_038967152   ⟸   XM_039111224
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967153   ⟸   XM_039111225
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038967154   ⟸   XM_039111226
- Peptide Label: isoform X5
RefSeq Acc Id: NP_001406504   ⟸   NM_001419575
- UniProtKB: A0A0G2K666 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JK96-F1-model_v2 AlphaFold Q9JK96 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693994
Promoter ID:EPDNEW_R4516
Type:single initiation site
Name:Kcnq4_1
Description:potassium voltage-gated channel subfamily Q member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05139,677,317 - 139,677,377EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61799 AgrOrtholog
BioCyc Gene G2FUF-40064 BioCyc
Ensembl Genes ENSRNOG00000060435 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087445.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298496 UniProtKB/TrEMBL
NCBI Gene Kcnq4 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnq4 PhenoGen
PRINTS KCHANNEL UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060435 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0G2K666 ENTREZGENE, UniProtKB/TrEMBL
  A6IRZ1 ENTREZGENE, UniProtKB/TrEMBL
  KCNQ4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnq4  potassium voltage-gated channel subfamily Q member 4  Kcnq4  potassium channel, voltage-gated KQT-like subfamily Q, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnq4  potassium channel, voltage-gated KQT-like subfamily Q, member 4  Kcnq4  potassium voltage-gated channel, KQT-like subfamily, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kcnq4  potassium voltage-gated channel, KQT-like subfamily, member 4  Kcnq4  potassium voltage-gated channel, subfamily Q, member 4   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnq4  potassium voltage-gated channel, subfamily Q, member 4       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the inner and outer hair cells; highly expressed in the base of the cochlea and in the apex ofthe outer hair cells 61648