Bw146 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bw146 (Body weight QTL 146) Rattus norvegicus

Symbol: Bw146
Name: Body weight QTL 146
RGD ID: 8657050
Trait: body mass   (VT:0001259)    
Measurement Type: body weight gain   (CMO:0000420)    
LOD Score: 19.84
P Value: 0.001
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8598,972,960 - 143,972,960RGD_MAPPER_PIPELINE
mRatBN7.25108,938,288 - 153,938,288RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05113,059,816 - 120,566,842RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05117,002,345 - 124,443,926RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45114,362,878 - 122,384,169RGD_MAPPER_PIPELINERGSC3.4
Cross Type: intercross
Strains Crossed: W-LeprfaNin F344/Nin 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Lepr is a candidate Gene for Bw146


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146Ratabdominal obesity-metabolic syndrome  IAGP 8657042 RGD 
Bw146RatWeight Gain  IAGP 8657042 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146Ratincreased body weight  IDA 8657042 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146Ratbody weight gain  IDA 8657042 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146Ratcontrol condition  IDA 8657042 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146Ratwhole body digital scale  IDA 8657042 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146RatF344/Nin  IEA 8657042 RGD 
Bw146RatW-LeprfaNin  IEA 8657042 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bw146Ratbody mass  IDA 8657042 RGD 


#
Reference Title
Reference Citation
1. Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor. Kalashikam RR, etal., PLoS One. 2013 Oct 21;8(10):e77679. doi: 10.1371/journal.pone.0077679. eCollection 2013.


1 to 20 of 921 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1560251Caap1caspase activity and apoptosis inhibitor 15109313253109414323Rat
40937684LOC120102920uncharacterized LOC1201029205109330329109338769Rat
621245Plaaphospholipase A2, activating protein5109428600109460373Rat
1359704Ift74intraflagellar transport 745109460372109563839Rat
1591722Lrrc19leucine rich repeat containing 195109494891109507948Rat
2325363Mir872microRNA 8725109539086109539166Rat
620980TekTEK receptor tyrosine kinase5109607077109733805Rat
1563332Eqtnequatorin5109734495109762048Rat
1311787Mysm1myb-like, SWIRM and MPN domains 15109761345109826652Rat
40989424LOC120103252small nucleolar RNA SNORA705109807447109807582Rat
41394229LOC120102921uncharacterized LOC1201029215109883550109887133Rat
2943JunJun proto-oncogene, AP-1 transcription factor subunit5109894175109897268Rat
6494360LOC100911221uncharacterized LOC1009112215109897523109949196Rat
7593337LOC102550339uncharacterized LOC1025503395110107244110110709Rat
40929618LOC120102923uncharacterized LOC1201029235110179996110186201Rat
41402458LOC120102924uncharacterized LOC1201029245110208856110225659Rat
41145702LOC120103235U1 spliceosomal RNA5110355813110355974Rat
1359429FggyFGGY carbohydrate kinase domain containing5110398866110786019Rat
9417869LOC103692418uncharacterized LOC1036924185110605125110712729Rat
41241770LOC120102925uncharacterized LOC1201029255110819794110824522Rat

1 to 20 of 921 rows
1 to 20 of 1315 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10262D5Rhm31335119564714119564847Ratregion
10263D5Rhm41455119592239119592384Ratregion
10324D5Lev191835124411616124411799Ratregion
10453D5Mcw15128924597128924722Ratregion
10453D5Mcw15129098900129099033Ratregion
10454D5Wox121185128924607128924723Ratregion
10454D5Wox121185129098910129099034Ratregion
10455D5Wox21145147939831147939945Ratregion
10490D5Uwm51715147340163147340334Ratregion
10491D5Wox142255147340196147340421Ratregion
10496D5Mco182005150175116150175316Ratregion
10826D5Mgh231285109897808109897936Ratregion
10827D5Lev152925109894810109895102Ratregion
10860D5Wox151195141899404141899523Ratregion
11090D5Rhm21685114659557114659726Ratregion
33804D5Mit62125117817033117817245Ratregion
34136D5Mgh212185144377876144378094Ratregion
34168D5Mgh221615151005994151006154Ratregion
34210D5Mgh141505143608201143608494Ratregion
34210D5Mgh141505143608344143608494Ratregion
1 to 20 of 1315 rows

Flank 1: (D5Rat256)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25108,938,288 - 108,938,528 (+)MAPPER
Rnor_6.05113,059,816 - 113,060,055NCBI
Rnor_5.05117,002,345 - 117,002,584UniSTS
RGSC_v3.45114,362,878 - 114,363,117RGD
RGSC_v3.45114,362,879 - 114,363,118UniSTS
RGSC_v3.15114,368,104 - 114,368,343RGD
Celera5107,574,771 - 107,575,010UniSTS
FHH x ACI Map552.45RGD
FHH x ACI Map552.45UniSTS
Peak: (D5Wox37)
Rat AssemblyChrPosition (strand)Source
GRCr85121,472,814 - 121,473,106 (+)Marker Load Pipeline
Rnor_6.05120,566,555 - 120,566,842NCBI
Rnor_5.05124,443,639 - 124,443,926UniSTS
RGSC_v3.45122,383,882 - 122,384,169UniSTS
Celera5114,880,222 - 114,880,509UniSTS
Cytogenetic Map5q33UniSTS
Flank 2: (D5Wox37)
Rat AssemblyChrPosition (strand)Source
GRCr85121,472,814 - 121,473,106 (+)Marker Load Pipeline
Rnor_6.05120,566,555 - 120,566,842NCBI
Rnor_5.05124,443,639 - 124,443,926UniSTS
RGSC_v3.45122,383,882 - 122,384,169UniSTS
Celera5114,880,222 - 114,880,509UniSTS
Cytogenetic Map5q33UniSTS


1 to 10 of 84 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat

1 to 10 of 84 rows


Note Type Note Reference
qtl_general measurement method: 3 month old rats were weighed using an electronic balance 8657042
qtl_general animals used: 305 F2 rats; 77 obese, 151 carrier and 77 lean rats 8657042
qtl_general software used: R/QTL package 8657042
qtl_general body weights, kinky tail and morphological characteristics were used to identify the phenotypes 8657042
qtl_general obese rats weighed more than carrier and lean rats and carrier weighed more than their lean counterparts 8657042
qtl_general spans 4.43cM 8657042