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Gene: Ak2 (adenylate kinase 2) Rattus norvegicus
Symbol: Ak2
Name: adenylate kinase 2
Description: Exhibits adenylate kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including animal organ development; purine nucleotide metabolic process; and response to thyroid hormone. Localizes to cytosol; mitochondrial intermembrane space; and nucleus. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2); PARTICIPATES IN adefovir pharmacokinetics pathway; tenofovir pharmacokinetics pathway; de novo purine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; 6-propyl-2-thiouracil; 7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenylate kinase 2, mitochondrial; adenylate monophosphate kinase; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase
Homo sapiens (human) : AK2 (adenylate kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Ak2 (adenylate kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ak2 (adenylate kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AK2 (adenylate kinase 2)
Canis lupus familiaris (dog) : AK2 (adenylate kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ak2 (adenylate kinase 2)
Sus scrofa (pig) : AK2 (adenylate kinase 2)
Chlorocebus sabaeus (African green monkey) : AK2 (adenylate kinase 2)
Heterocephalus glaber (naked mole-rat) : Ak2 (adenylate kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05147,185,474 - 147,204,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05150,910,910 - 150,929,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,156,751 - 148,176,195 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15148,166,789 - 148,183,198 (+)NCBI
Celera5139,827,913 - 139,846,149 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ak2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2077
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.