(20S)-ginsenoside Rh2 decreases expression ISO HDAC1 (Homo sapiens) 6480464 ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 (S)-nicotine increases expression ISO HDAC1 (Homo sapiens) 6480464 Nicotine results in increased expression of HDAC1 mRNA CTD PMID:24709674 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of HDAC1 mRNA and Nicotine results in increased expression of HDAC1 protein CTD PMID:34245815 (S)-nicotine multiple interactions EXP 6480464 SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA] and SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein] CTD PMID:34245815 1,2-dimethylhydrazine decreases expression ISO Hdac1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of HDAC1 mRNA CTD PMID:22206623 15-deoxy-Delta(12,14)-prostaglandin J2 decreases expression ISO HDAC1 (Homo sapiens) 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA CTD PMID:21957481 17alpha-ethynylestradiol increases expression ISO Hdac1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of HDAC1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter] more ... CTD PMID:16489025 more ... 17beta-estradiol decreases expression ISO HDAC1 (Homo sapiens) 6480464 Estradiol results in decreased expression of HDAC1 mRNA CTD PMID:16029874 and PMID:23373633 17beta-estradiol increases expression ISO HDAC1 (Homo sapiens) 6480464 Estradiol results in increased expression of HDAC1 mRNA CTD PMID:22952798 and PMID:30684530 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Hdac1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of HDAC1 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HDAC1 mRNA CTD PMID:22493514 and PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNA and Tetrachlorodibenzodioxin affects the reaction [HDAC1 protein binds to CYP1A1 promoter] CTD PMID:17652329 and PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [IL1B protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [HDAC1 protein binds to IL6 promoter] more ... CTD PMID:16489025 and PMID:20511231 2,4,6-tribromophenol increases expression ISO HDAC1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 3,3',4,4',5-pentachlorobiphenyl affects expression ISO Hdac1 (Mus musculus) 6480464 3 more ... CTD PMID:37080397 3,3'-diindolylmethane multiple interactions ISO Hdac1 (Mus musculus) 6480464 3 more ... CTD PMID:24200994 3,4-methylenedioxymethamphetamine increases expression ISO Hdac1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of HDAC1 mRNA CTD PMID:20188158 4-phenylbutyric acid multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein CTD PMID:18497984 5-aza-2'-deoxycytidine multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Decitabine inhibits the reaction [HDAC1 protein binds to ABCG2 promoter] more ... CTD PMID:16043219 more ... 5-fluorouracil multiple interactions ISO Hdac1 (Mus musculus) 6480464 [HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]] more ... CTD PMID:25178657 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HDAC1 mRNA CTD PMID:30047161 7,12-dimethyltetraphene increases expression ISO Hdac1 (Mus musculus) 6480464 9 more ... CTD PMID:24792773 7,12-dimethyltetraphene multiple interactions ISO Hdac1 (Mus musculus) 6480464 Butyric Acid affects the reaction [9 more ... CTD PMID:24792773 acetylsalicylic acid increases expression ISO HDAC1 (Homo sapiens) 6480464 Aspirin results in increased expression of HDAC1 mRNA CTD PMID:15456535 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of HDAC1 mRNA CTD PMID:28959563 aldehydo-D-glucose multiple interactions ISO Hdac1 (Mus musculus) 6480464 Glucose promotes the reaction [HDAC1 protein binds to TUG1 promoter] CTD PMID:32467232 all-trans-retinoic acid multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Thiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA] CTD PMID:16140955 all-trans-retinoic acid increases expression ISO HDAC1 (Homo sapiens) 6480464 Tretinoin results in increased expression of HDAC1 mRNA CTD PMID:16140955 allethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC1 mRNA more ... CTD PMID:33051911 more ... alpha-mangostin increases expression ISO HDAC1 (Homo sapiens) 6480464 mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 amitrole increases expression EXP 6480464 Amitrole results in increased expression of HDAC1 mRNA CTD PMID:30047161 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of HDAC1 protein CTD PMID:16483693 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HDAC1 mRNA CTD PMID:16483693 amphetamine multiple interactions EXP 6480464 Amphetamine promotes the reaction [HDAC1 protein binds to FOS promoter] CTD PMID:18632938 amphetamine multiple interactions ISO Hdac1 (Mus musculus) 6480464 HDAC1 gene mutant form promotes the reaction [Amphetamine results in increased expression of FOS mRNA] CTD PMID:18632938 andrographolide decreases expression ISO HDAC1 (Homo sapiens) 6480464 andrographolide results in decreased expression of HDAC1 protein CTD PMID:28651835 antirheumatic drug decreases expression ISO HDAC1 (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of HDAC1 mRNA CTD PMID:24449571 arsenous acid multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [[Arsenic Trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein] which binds to CDKN1A promoter more ... CTD PMID:18210215 more ... aspartame multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 benomyl decreases activity ISO HDAC1 (Homo sapiens) 6480464 Benomyl results in decreased activity of HDAC1 protein CTD PMID:25543211 benzamide decreases activity ISO HDAC1 (Homo sapiens) 6480464 benzamide analog results in decreased activity of HDAC1 protein CTD PMID:19362838 benzo[a]pyrene decreases expression ISO HDAC1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of HDAC1 mRNA CTD PMID:16269432 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of HDAC1 protein CTD PMID:26358852 benzo[a]pyrene multiple interactions ISO Hdac1 (Mus musculus) 6480464 Benzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter] more ... CTD PMID:14625279 and PMID:17682057 benzo[b]fluoranthene decreases expression ISO HDAC1 (Homo sapiens) 6480464 benzo(b)fluoranthene results in decreased expression of HDAC1 mRNA CTD PMID:16269432 beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of HDAC1 protein CTD PMID:19389873 bisphenol A multiple interactions EXP 6480464 HDAC1 mutant form inhibits the reaction [bisphenol A results in decreased expression of SLC12A5 mRNA] CTD PMID:23440186 bisphenol A affects splicing ISO HDAC1 (Homo sapiens) 6480464 bisphenol A affects the splicing of HDAC1 mRNA CTD PMID:33670352 bisphenol A affects expression ISO HDAC1 (Homo sapiens) 6480464 bisphenol A affects the expression of HDAC1 mRNA CTD PMID:30903817 bisphenol A affects methylation ISO Hdac1 (Mus musculus) 6480464 bisphenol A affects the methylation of HDAC1 promoter CTD PMID:27334623 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HDAC1 mRNA CTD PMID:30816183 more ... bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HDAC1 mRNA CTD PMID:25181051 more ... butyric acid multiple interactions ISO Hdac1 (Mus musculus) 6480464 Butyric Acid affects the reaction [9 more ... CTD PMID:24792773 butyric acid multiple interactions EXP 6480464 Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA] CTD PMID:37414240 butyric acid multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Butyric Acid inhibits the reaction [HDAC1 protein binds to CYP1A1 enhancer] and Butyric Acid inhibits the reaction [Oxalic Acid results in increased expression of HDAC1 mRNA] CTD PMID:27830268 and PMID:37414240 C.I. Natural Red 20 multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein and shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter] CTD PMID:37268198 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of HDAC1 mRNA CTD PMID:19167457 caffeine increases expression EXP 6480464 Caffeine results in increased expression of HDAC1 mRNA CTD PMID:24717552 calcium oxalate multiple interactions EXP 6480464 [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA and Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA] CTD PMID:37414240 captan increases expression ISO Hdac1 (Mus musculus) 6480464 Captan results in increased expression of HDAC1 mRNA CTD PMID:31558096 carbamazepine affects expression ISO HDAC1 (Homo sapiens) 6480464 Carbamazepine affects the expression of HDAC1 mRNA CTD PMID:25979313 Chlamydocin decreases activity ISO HDAC1 (Homo sapiens) 6480464 chlamydocin analog results in decreased activity of HDAC1 protein CTD PMID:16439135 chlorpyrifos decreases methylation EXP 6480464 Chlorpyrifos results in decreased methylation of HDAC1 gene CTD PMID:32905263 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of HDAC1 mRNA CTD PMID:30290214 choline multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC1 gene CTD PMID:20938992 chromium atom multiple interactions ISO Hdac1 (Mus musculus) 6480464 Chromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]] more ... CTD PMID:14625279 and PMID:17682057 chromium(6+) multiple interactions ISO HDAC1 (Homo sapiens) 6480464 chromium hexavalent ion promotes the reaction [HDAC1 protein binds to CDH1 promoter] CTD PMID:23518002 ciprofibrate increases expression ISO Hdac1 (Mus musculus) 6480464 ciprofibrate results in increased expression of HDAC1 mRNA CTD PMID:12771043 cisplatin multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Cisplatin inhibits the reaction [[HDAC1 protein co-treated with TP63 protein modified form] binds to BBC3 promoter] CTD PMID:21527555 cobalt dichloride multiple interactions ISO HDAC1 (Homo sapiens) 6480464 cobaltous chloride inhibits the reaction [HDAC1 protein binds to HIF1A promoter] CTD PMID:19714248 copper atom multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of HDAC1 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of HDAC1 mRNA CTD PMID:30911355 cortisol increases expression ISO HDAC1 (Homo sapiens) 6480464 Hydrocortisone results in increased expression of HDAC1 mRNA CTD PMID:34454011 cortisol multiple interactions ISO HDAC1 (Homo sapiens) 6480464 HDAC1 protein affects the reaction [Hydrocortisone results in decreased expression of CYP11A1 mRNA] and SF1 protein inhibits the reaction [Hydrocortisone results in increased expression of HDAC1 mRNA] CTD PMID:34454011 coumarin increases phosphorylation ISO HDAC1 (Homo sapiens) 6480464 coumarin results in increased phosphorylation of HDAC1 protein CTD PMID:35688186 CU-O LINKAGE decreases phosphorylation ISO HDAC1 (Homo sapiens) 6480464 cupric oxide results in decreased phosphorylation of HDAC1 protein CTD PMID:25470785 curcumin decreases expression ISO HDAC1 (Homo sapiens) 6480464 Curcumin analog results in decreased expression of HDAC1 mRNA more ... CTD PMID:17927689 more ... curcumin decreases expression ISO Hdac1 (Mus musculus) 6480464 Curcumin analog results in decreased expression of HDAC1 protein CTD PMID:29228771 curcumin affects localization ISO HDAC1 (Homo sapiens) 6480464 Curcumin affects the localization of HDAC1 protein CTD PMID:17927689 curcumin multiple interactions ISO HDAC1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein] more ... CTD PMID:17927689 cyclosporin A decreases expression ISO HDAC1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of HDAC1 mRNA CTD PMID:20106945 and PMID:25562108 cyhalothrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC1 mRNA more ... CTD PMID:33051911 more ... cypermethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC1 mRNA more ... CTD PMID:33051911 more ... D-glucose multiple interactions ISO Hdac1 (Mus musculus) 6480464 Glucose promotes the reaction [HDAC1 protein binds to TUG1 promoter] CTD PMID:32467232 decabromodiphenyl ether increases expression ISO HDAC1 (Homo sapiens) 6480464 decabromobiphenyl ether results in increased expression of HDAC1 protein CTD PMID:31675489 deoxynivalenol affects phosphorylation ISO Hdac1 (Mus musculus) 6480464 deoxynivalenol affects the phosphorylation of HDAC1 protein CTD PMID:23352502 dexamethasone multiple interactions EXP 6480464 HDAC1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA] CTD PMID:17884810 dexamethasone multiple interactions ISO Hdac1 (Mus musculus) 6480464 [HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of CDON mRNA] more ... CTD PMID:27645313 diarsenic trioxide multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [[Arsenic Trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein] which binds to CDKN1A promoter more ... CTD PMID:18210215 more ... dibenz[a,h]anthracene increases expression ISO Hdac1 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 dibutyl phthalate decreases expression ISO Hdac1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of HDAC1 mRNA CTD PMID:17361019 and PMID:21266533 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of HDAC1 protein CTD PMID:22711276 dioxygen multiple interactions EXP 6480464 Valproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein] and vorinostat inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein] CTD PMID:22711276 doxorubicin multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Doxorubicin promotes the reaction [HDAC1 protein binds to BIRC5 promoter] CTD PMID:17124180 doxorubicin decreases expression ISO HDAC1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of HDAC1 mRNA CTD PMID:29803840 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of HDAC1 mRNA CTD PMID:28865727 endosulfan increases expression ISO HDAC1 (Homo sapiens) 6480464 Endosulfan results in increased expression of HDAC1 mRNA and Endosulfan results in increased expression of HDAC1 protein CTD PMID:29054638 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of HDAC1 mRNA CTD PMID:29391264 entinostat increases expression ISO HDAC1 (Homo sapiens) 6480464 entinostat results in increased expression of HDAC1 mRNA CTD PMID:27188386 enzyme inhibitor multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HDAC1 protein CTD PMID:23301498 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HDAC1 mRNA CTD PMID:34454011 ethylene glycol multiple interactions EXP 6480464 [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA and Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA] CTD PMID:37414240 fenvalerate multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC1 mRNA more ... CTD PMID:33051911 more ... fingolimod hydrochloride affects binding ISO HDAC1 (Homo sapiens) 6480464 Fingolimod Hydrochloride metabolite binds to HDAC1 protein CTD PMID:24859201 fingolimod hydrochloride multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein] and SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein] CTD PMID:24859201 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of HDAC1 mRNA CTD PMID:24793618 folic acid multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC1 gene CTD PMID:20938992 folic acid decreases expression ISO Hdac1 (Mus musculus) 6480464 Folic Acid results in decreased expression of HDAC1 mRNA CTD PMID:25629700 FR900359 affects phosphorylation ISO HDAC1 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of HDAC1 protein CTD PMID:37730182 furan increases methylation EXP 6480464 furan results in increased methylation of HDAC1 gene CTD PMID:22079235 genistein decreases expression ISO HDAC1 (Homo sapiens) 6480464 Genistein results in decreased expression of HDAC1 protein CTD PMID:23593078 genistein multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Genistein promotes the reaction [HDAC1 protein binds to COMT promoter] and sulforaphane inhibits the reaction [Genistein promotes the reaction [HDAC1 protein binds to COMT promoter]] CTD PMID:30684530 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HDAC1 mRNA CTD PMID:22061828 gentamycin increases expression ISO Hdac1 (Mus musculus) 6480464 Gentamicins results in increased expression of HDAC1 protein CTD PMID:19141081 and PMID:23558232 glucaric acid multiple interactions ISO Hdac1 (Mus musculus) 6480464 Glucaric Acid affects the reaction [9 more ... CTD PMID:24792773 glucose multiple interactions ISO Hdac1 (Mus musculus) 6480464 Glucose promotes the reaction [HDAC1 protein binds to TUG1 promoter] CTD PMID:32467232 glyphosate decreases expression ISO HDAC1 (Homo sapiens) 6480464 Glyphosate results in decreased expression of HDAC1 mRNA CTD PMID:31295307 guggulsterone decreases expression ISO HDAC1 (Homo sapiens) 6480464 pregna-4 more ... CTD PMID:23593078 hesperidin multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] CTD PMID:34800614 Honokiol multiple interactions ISO HDAC1 (Homo sapiens) 6480464 honokiol binds to and results in decreased activity of HDAC1 protein CTD PMID:34973135 hydrogen peroxide decreases expression ISO HDAC1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of HDAC1 mRNA CTD PMID:12419474 hydrogen peroxide increases expression ISO HDAC1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of HDAC1 mRNA and Hydrogen Peroxide results in increased expression of HDAC1 protein CTD PMID:27655674 hydrogen peroxide multiple interactions ISO Hdac1 (Mus musculus) 6480464 Hydrogen Peroxide promotes the reaction [[HDAC1 protein binds to CTCF promoter] which results in decreased expression of CTCF] and Hydrogen Peroxide promotes the reaction [HDAC1 protein binds to CTCF promoter] CTD PMID:24558376 hydroquinone increases expression ISO HDAC1 (Homo sapiens) 6480464 hydroquinone results in increased expression of HDAC1 mRNA and hydroquinone results in increased expression of HDAC1 protein CTD PMID:27220438 and PMID:30448557 hydroquinone multiple interactions ISO HDAC1 (Homo sapiens) 6480464 trichostatin A inhibits the reaction [hydroquinone results in increased expression of HDAC1 mRNA] CTD PMID:27220438 indirubin multiple interactions ISO Hdac1 (Mus musculus) 6480464 [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein] more ... CTD PMID:18344322 indole-3-methanol multiple interactions ISO Hdac1 (Mus musculus) 6480464 indole-3-carbinol inhibits the reaction [enterotoxin B and staphylococcal results in increased expression of HDAC1 mRNA] CTD PMID:24200994 ivermectin decreases expression ISO HDAC1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of HDAC1 protein CTD PMID:32959892 L-methionine multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC1 gene CTD PMID:20938992 lead(0) affects expression ISO HDAC1 (Homo sapiens) 6480464 Lead affects the expression of HDAC1 mRNA CTD PMID:28903495 lead(0) multiple interactions EXP 6480464 [HDAC1 protein co-treated with HDAC2 protein] inhibits the reaction [Lead results in decreased expression of NOTCH2 protein] and Lead promotes the reaction [HDAC1 protein binds to HDAC2 protein] CTD PMID:29301062 lipopolysaccharide multiple interactions ISO Hdac1 (Mus musculus) 6480464 Lipopolysaccharides inhibits the reaction [HDAC1 protein binds to CCL20 promoter] and Lipopolysaccharides inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter] CTD PMID:26259605 lithium chloride multiple interactions ISO Hdac1 (Mus musculus) 6480464 Lithium Chloride inhibits the reaction [HDAC1 protein binds to GCG promoter] and Lithium Chloride inhibits the reaction [HDAC1 protein binds to GIP promoter] CTD PMID:19582394 lovastatin increases expression ISO Hdac1 (Mus musculus) 6480464 Lovastatin results in increased expression of HDAC1 mRNA CTD PMID:20493250 manganese atom multiple interactions EXP 6480464 Manganese promotes the reaction [RELA protein binds to HDAC1 protein] and Manganese promotes the reaction [YY1 protein binds to HDAC1 protein] CTD PMID:24469401 manganese atom multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein] and Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] CTD PMID:34800614 manganese(0) multiple interactions EXP 6480464 Manganese promotes the reaction [RELA protein binds to HDAC1 protein] and Manganese promotes the reaction [YY1 protein binds to HDAC1 protein] CTD PMID:24469401 manganese(0) multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein] and Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] CTD PMID:34800614 manganese(II) chloride multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein] and Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] CTD PMID:34800614 methimazole increases expression EXP 6480464 Methimazole results in increased expression of HDAC1 mRNA CTD PMID:30047161 methotrexate decreases expression ISO HDAC1 (Homo sapiens) 6480464 Methotrexate results in decreased expression of HDAC1 mRNA CTD PMID:24449571 methoxyacetic acid decreases activity ISO HDAC1 (Homo sapiens) 6480464 methoxyacetic acid results in decreased activity of HDAC1 protein CTD PMID:15103026 methoxyacetic acid decreases activity ISO Hdac1 (Mus musculus) 6480464 methoxyacetic acid results in decreased activity of HDAC1 protein CTD PMID:32496642 methylmercury chloride decreases expression ISO Hdac1 (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of HDAC1 mRNA CTD PMID:20061341 mocetinostat decreases expression ISO HDAC1 (Homo sapiens) 6480464 mocetinostat results in decreased expression of HDAC1 protein CTD PMID:26378038 monosodium L-glutamate multiple interactions ISO Hdac1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO HDAC1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein] more ... CTD PMID:17395887 and PMID:17927689 N-ethyl-N-nitrosourea increases expression ISO Hdac1 (Mus musculus) 6480464 Ethylnitrosourea results in increased expression of HDAC1 CTD PMID:21154115 N-nitrosodiethylamine multiple interactions ISO Hdac1 (Mus musculus) 6480464 AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of HDAC1 mRNA] CTD PMID:19996281 N-nitrosodiethylamine increases expression ISO Hdac1 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of HDAC1 mRNA CTD PMID:12771043 N-nitrosodiethylamine decreases expression ISO Hdac1 (Mus musculus) 6480464 Diethylnitrosamine results in decreased expression of HDAC1 mRNA CTD PMID:19996281 N-Vinyl-2-pyrrolidone multiple interactions EXP 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of HDAC1 mRNA CTD PMID:22037397 nicotinamide multiple interactions ISO Hdac1 (Mus musculus) 6480464 Niacinamide affects the reaction [9 more ... CTD PMID:24792773 nicotine increases expression ISO HDAC1 (Homo sapiens) 6480464 Nicotine results in increased expression of HDAC1 mRNA CTD PMID:24709674 nicotine multiple interactions EXP 6480464 SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA] and SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein] CTD PMID:34245815 nicotine increases expression EXP 6480464 Nicotine results in increased expression of HDAC1 mRNA and Nicotine results in increased expression of HDAC1 protein CTD PMID:34245815 oleanolic acid decreases expression ISO HDAC1 (Homo sapiens) 6480464 Oleanolic Acid results in decreased expression of HDAC1 protein CTD PMID:20726234 oxalic acid increases expression ISO HDAC1 (Homo sapiens) 6480464 Oxalic Acid results in increased expression of HDAC1 mRNA CTD PMID:37414240 oxalic acid multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Butyric Acid inhibits the reaction [Oxalic Acid results in increased expression of HDAC1 mRNA] CTD PMID:37414240 oxybenzone increases expression EXP 6480464 oxybenzone results in increased expression of HDAC1 protein CTD PMID:31368502 paracetamol decreases expression ISO HDAC1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of HDAC1 mRNA CTD PMID:21420995 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of HDAC1 mRNA CTD PMID:33387578 pelargonidin decreases expression ISO Hdac1 (Mus musculus) 6480464 pelargonidin results in decreased expression of HDAC1 protein CTD PMID:31181187 pentachlorophenol increases expression ISO Hdac1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of HDAC1 mRNA CTD PMID:23892564 phenethyl isothiocyanate multiple interactions EXP 6480464 phenethyl isothiocyanate inhibits the reaction [Freund's Adjuvant results in increased expression of HDAC1 protein] CTD PMID:32289289 potassium chloride multiple interactions ISO Hdac1 (Mus musculus) 6480464 Potassium Chloride inhibits the reaction [HDAC1 protein binds to BDNF promoter] CTD PMID:14593183 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of HDAC1 mRNA CTD PMID:30047161 progesterone decreases expression ISO HDAC1 (Homo sapiens) 6480464 Progesterone results in decreased expression of HDAC1 mRNA CTD PMID:18037150 pyrethrins increases expression EXP 6480464 Pyrethrins results in increased expression of HDAC1 mRNA CTD PMID:34896426 resveratrol decreases expression ISO HDAC1 (Homo sapiens) 6480464 resveratrol results in decreased expression of HDAC1 protein CTD PMID:23593078 resveratrol multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [[resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]] which results in increased acetylation of and results in increased activity of TP53 protein more ... CTD PMID:19810103 and PMID:25875864 resveratrol increases expression ISO Hdac1 (Mus musculus) 6480464 resveratrol results in increased expression of HDAC1 mRNA CTD PMID:22610192 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of HDAC1 protein CTD PMID:35544339 Shikonin multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [shikonin results in increased acetylation of HDAC1 protein] which results in increased expression of ATF3 protein and shikonin promotes the reaction [HDAC1 protein binds to ATF3 promoter] CTD PMID:37268198 sodium arsenate increases expression ISO Hdac1 (Mus musculus) 6480464 sodium arsenate results in increased expression of HDAC1 protein CTD PMID:26193056 sodium arsenite multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Estradiol inhibits the reaction [sodium arsenite results in increased expression of HDAC1 mRNA] and sodium arsenite inhibits the reaction [Estradiol results in increased expression of HDAC1 mRNA] CTD PMID:22952798 sodium arsenite increases expression ISO HDAC1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of HDAC1 mRNA CTD PMID:22952798 and PMID:34032870 Soman increases expression EXP 6480464 Soman results in increased expression of HDAC1 mRNA CTD PMID:19281266 sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of HDAC1 mRNA CTD PMID:30047161 sulforaphane multiple interactions ISO HDAC1 (Homo sapiens) 6480464 sulforaphane inhibits the reaction [Estradiol promotes the reaction [HDAC1 protein binds to COMT promoter]] more ... CTD PMID:30684530 sulforaphane decreases expression ISO HDAC1 (Homo sapiens) 6480464 sulforaphane results in decreased expression of HDAC1 mRNA CTD PMID:30684530 sulindac sulfide decreases expression ISO HDAC1 (Homo sapiens) 6480464 sulindac sulfide results in decreased expression of HDAC1 mRNA CTD PMID:16184548 sunitinib decreases expression ISO HDAC1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of HDAC1 mRNA CTD PMID:31533062 taiwanin C decreases expression ISO HDAC1 (Homo sapiens) 153305910 taiwanin C decreases expression of HDAC1 protein in Chondrocyte Cells RGD tamoxifen multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Tamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter] CTD PMID:20208560 tangeretin decreases expression ISO Hdac1 (Mus musculus) 6480464 tangeretin metabolite results in decreased expression of HDAC1 protein and tangeretin results in decreased expression of HDAC1 protein CTD PMID:37517432 Tanshinone I multiple interactions ISO Hdac1 (Mus musculus) 6480464 [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein] more ... CTD PMID:18344322 temozolomide increases expression ISO HDAC1 (Homo sapiens) 6480464 Temozolomide results in increased expression of HDAC1 mRNA CTD PMID:31758290 tert-butyl hydroperoxide decreases expression ISO HDAC1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of HDAC1 mRNA CTD PMID:12419474 tetrachloromethane increases expression ISO Hdac1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of HDAC1 mRNA CTD PMID:27396813 theophylline increases activity ISO HDAC1 (Homo sapiens) 6480464 Theophylline results in increased activity of HDAC1 protein CTD PMID:12070353 theophylline increases expression ISO HDAC1 (Homo sapiens) 6480464 Theophylline results in increased expression of HDAC1 protein CTD PMID:12070353 and PMID:15337792 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of HDAC1 mRNA CTD PMID:34492290 thiophenes multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Thiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA] CTD PMID:16140955 Trapoxin B decreases activity ISO HDAC1 (Homo sapiens) 6480464 trapoxin B results in decreased activity of HDAC1 protein CTD PMID:15930892 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of HDAC1 mRNA CTD PMID:33387578 trichostatin A decreases activity ISO HDAC1 (Homo sapiens) 6480464 trichostatin A results in decreased activity of HDAC1 protein CTD PMID:15103026 more ... trichostatin A decreases activity ISO Hdac1 (Mus musculus) 6480464 trichostatin A results in decreased activity of HDAC1 protein CTD PMID:32496642 trichostatin A multiple interactions ISO HDAC1 (Homo sapiens) 6480464 trichostatin A inhibits the reaction [hydroquinone results in increased expression of HDAC1 mRNA] CTD PMID:27220438 trichostatin A decreases expression ISO HDAC1 (Homo sapiens) 6480464 trichostatin A results in decreased expression of HDAC1 protein CTD PMID:23285096 Triptolide increases expression EXP 6480464 triptolide results in increased expression of HDAC1 mRNA CTD PMID:23639586 triptonide increases expression ISO Hdac1 (Mus musculus) 6480464 triptonide results in increased expression of HDAC1 mRNA CTD PMID:33045310 valproic acid decreases activity ISO HDAC1 (Homo sapiens) 6480464 Valproic Acid results in decreased activity of HDAC1 protein CTD PMID:15103026 valproic acid decreases activity ISO Hdac1 (Mus musculus) 6480464 Valproic Acid results in decreased activity of HDAC1 protein CTD PMID:32496642 valproic acid decreases methylation ISO HDAC1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of HDAC1 gene CTD PMID:29501571 valproic acid decreases expression ISO Hdac1 (Mus musculus) 6480464 Valproic Acid results in decreased expression of HDAC1 mRNA CTD PMID:31445079 valproic acid multiple interactions EXP 6480464 Valproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein] CTD PMID:22711276 valproic acid increases expression ISO HDAC1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of HDAC1 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO HDAC1 (Homo sapiens) 6480464 Valproic Acid affects the expression of HDAC1 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO HDAC1 (Homo sapiens) 6480464 [Valproic Acid co-treated with arsenic trioxide] results in decreased expression of HDAC1 mRNA CTD PMID:25815518 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of HDAC1 mRNA CTD PMID:18042343 and PMID:23555832 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of HDAC1 protein CTD PMID:27474498 vitamin E increases expression ISO HDAC1 (Homo sapiens) 6480464 Vitamin E results in increased expression of HDAC1 mRNA CTD PMID:19244175 vorinostat multiple interactions ISO HDAC1 (Homo sapiens) 6480464 vorinostat inhibits the reaction [monomethylarsonous acid results in increased expression of HDAC1 mRNA] CTD PMID:23891734 vorinostat decreases expression ISO HDAC1 (Homo sapiens) 6480464 Vorinostat results in decreased expression of HDAC1 mRNA and Vorinostat results in decreased expression of HDAC1 protein CTD PMID:28963909 vorinostat multiple interactions EXP 6480464 vorinostat inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein] CTD PMID:22711276 vorinostat decreases activity ISO HDAC1 (Homo sapiens) 6480464 vorinostat results in decreased activity of HDAC1 protein CTD PMID:15930892 warfarin increases expression ISO Hdac1 (Mus musculus) 6480464 Warfarin results in increased expression of HDAC1 mRNA CTD PMID:20493250 withaferin A decreases expression ISO HDAC1 (Homo sapiens) 6480464 withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 zileuton decreases expression EXP 6480464 zileuton results in decreased expression of HDAC1 mRNA CTD PMID:12883083 zinc atom multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Zinc binds to and results in increased activity of HDAC1 protein CTD PMID:16439135 zinc atom multiple interactions ISO Hdac1 (Mus musculus) 6480464 [zinc chloride results in increased abundance of Zinc] which results in decreased expression of HDAC1 mRNA CTD PMID:31588059 zinc dichloride multiple interactions ISO Hdac1 (Mus musculus) 6480464 [zinc chloride results in increased abundance of Zinc] which results in decreased expression of HDAC1 mRNA CTD PMID:31588059 zinc(0) multiple interactions ISO HDAC1 (Homo sapiens) 6480464 Zinc binds to and results in increased activity of HDAC1 protein CTD PMID:16439135 zinc(0) multiple interactions ISO Hdac1 (Mus musculus) 6480464 [zinc chloride results in increased abundance of Zinc] which results in decreased expression of HDAC1 mRNA CTD PMID:31588059