HDAC1 (histone deacetylase 1) - Rat Genome Database
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Gene: HDAC1 (histone deacetylase 1) Homo sapiens
Symbol: HDAC1
Name: histone deacetylase 1
RGD ID: 1320330
Description: Exhibits several functions, including DNA-binding transcription factor binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Contributes to nucleosomal DNA binding activity. Involved in several processes, including covalent chromatin modification; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Localizes to NuRD complex; Sin3 complex; and cytosol. Biomarker of several diseases, including autoimmune disease (multiple); cervix uteri carcinoma in situ; pancreatic ductal carcinoma; prostate carcinoma in situ; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686H12203; GON-10; HD1; KDAC1; reduced potassium dependency, yeast homolog-like 1; RPD3; RPD3L1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HDAC1P1   HDAC1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl132,292,083 - 32,333,635 (+)EnsemblGRCh38hg38GRCh38
GRCh38132,292,083 - 32,333,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,757,684 - 32,799,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,530,295 - 32,571,811 (+)NCBINCBI36hg18NCBI36
Build 34132,426,800 - 32,468,317NCBI
Celera131,028,175 - 31,069,691 (+)NCBI
Cytogenetic Map1p35.2-p35.1NCBI
HuRef130,873,184 - 30,914,532 (+)NCBIHuRef
CHM1_1132,873,153 - 32,914,668 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rh2  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (EXP)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
aspartame  (ISO)
benomyl  (EXP)
benzamide  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
captan  (ISO)
carbamazepine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP,ISO)
entinostat  (EXP)
enzyme inhibitor  (EXP)
fenvalerate  (ISO)
fingolimod hydrochloride  (EXP)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
gamma-mangostin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucaric acid  (ISO)
glucose  (ISO)
glyphosate  (EXP)
guggulsterone  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
indole-3-methanol  (ISO)
L-methionine  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nicotinamide  (ISO)
nicotine  (EXP)
oleanolic acid  (EXP)
oxybenzone  (ISO)
paracetamol  (EXP)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
potassium chloride  (ISO)
progesterone  (EXP)
resveratrol  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
sulforaphane  (EXP)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
theophylline  (EXP)
thiophenes  (EXP)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (EXP)
vorinostat  (EXP,ISO)
warfarin  (ISO)
withaferin A  (EXP)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP-dependent chromatin remodeling  (HDA)
beta-catenin-TCF complex assembly  (TAS)
blood coagulation  (TAS)
cellular response to oxidative stress  (ISO)
cellular response to tumor necrosis factor  (ISO)
chromatin organization  (TAS)
chromatin remodeling  (IC)
circadian regulation of gene expression  (ISS)
circadian rhythm  (ISO)
DNA methylation-dependent heterochromatin assembly  (IGI)
embryonic digit morphogenesis  (ISS)
endoderm development  (IEA,ISO)
epidermal cell differentiation  (ISS)
eyelid development in camera-type eye  (ISS)
fungiform papilla formation  (ISS)
hair follicle placode formation  (ISS)
hippocampus development  (IEA,ISO)
histone deacetylation  (IMP)
histone H3 deacetylation  (IBA,IDA,IEA,ISO)
histone H4 deacetylation  (IBA,IDA)
negative regulation by host of viral transcription  (IMP)
negative regulation of androgen receptor signaling pathway  (IDA)
negative regulation of apoptotic process  (ISS,TAS)
negative regulation of canonical Wnt signaling pathway  (IGI,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of myotube differentiation  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO,TAS)
negative regulation of transcription, DNA-templated  (IMP,ISO,ISS)
neuron differentiation  (IEA,ISO)
odontogenesis of dentin-containing tooth  (ISS)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
positive regulation of signaling receptor activity  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IDA)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type B pancreatic cell apoptotic process  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
protein deacetylation  (IDA)
regulation of amyloid-beta clearance  (IC)
regulation of endopeptidase activity  (IMP)
regulation of megakaryocyte differentiation  (TAS)
regulation of signal transduction by p53 class mediator  (TAS)
regulation of transcription by RNA polymerase II  (IGI)
response to amphetamine  (ISO)
response to caffeine  (ISO)
response to drug  (ISO)
response to hyperoxia  (ISO)
response to lipopolysaccharide  (ISO)
transcription initiation from RNA polymerase II promoter  (TAS)

Cellular Component


References - curated
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3. GOA_HUMAN data from the GO Consortium
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12. Lin Z, etal., Clin Cancer Res. 2009 Jan 15;15(2):570-7.
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15. Park JH, etal., J Clin Invest. 2008 Jun;118(6):2316-24.
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17. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Stypula-Cyrus Y, etal., PLoS One. 2013 May 28;8(5):e64600. doi: 10.1371/journal.pone.0064600. Print 2013.
23. Waltregny D, etal., Eur J Histochem. 2004 Jul-Sep;48(3):273-90.
24. Wang W, etal., Oncol Rep. 2009 Jun;21(6):1439-47.
25. Weichert W, etal., Br J Cancer. 2008 Feb 12;98(3):604-10. Epub 2008 Jan 22.
26. Weichert W, etal., Neoplasia. 2008 Sep;10(9):1021-7.
27. Zhang Z, etal., Breast Cancer Res Treat. 2005 Nov;94(1):11-6.
28. Zhao L, etal., Circulation. 2012 Jul 24;126(4):455-67. doi: 10.1161/CIRCULATIONAHA.112.103176. Epub 2012 Jun 18.
29. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
Additional References at PubMed
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PMID:14752048   PMID:14968110   PMID:14976551   PMID:14981544   PMID:14988403   PMID:15003538   PMID:15016378   PMID:15016876   PMID:15044952   PMID:15051733   PMID:15060175   PMID:15077161  
PMID:15120635   PMID:15136563   PMID:15138260   PMID:15140878   PMID:15148359   PMID:15155736   PMID:15173318   PMID:15192014   PMID:15194748   PMID:15199155   PMID:15207703   PMID:15235594  
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PMID:17643391   PMID:17646674   PMID:17663720   PMID:17670825   PMID:17704056   PMID:17707923   PMID:17785205   PMID:17786334   PMID:17827154   PMID:17850504   PMID:17872950   PMID:17894944  
PMID:17895379   PMID:17897615   PMID:17906119   PMID:17910034   PMID:17922035   PMID:17932104   PMID:17934516   PMID:17935135   PMID:17938259   PMID:17939992   PMID:17956988   PMID:17961987  
PMID:17967891   PMID:17980157   PMID:17996965   PMID:18003922   PMID:18004079   PMID:18029348   PMID:18037904   PMID:18059533   PMID:18067919   PMID:18093978   PMID:18156491   PMID:18172012  
PMID:18182442   PMID:18193082   PMID:18206970   PMID:18241676   PMID:18245468   PMID:18247378   PMID:18271930   PMID:18279852   PMID:18316616   PMID:18326024   PMID:18333962   PMID:18342621  
PMID:18347167   PMID:18362831   PMID:18372343   PMID:18391013   PMID:18408217   PMID:18413351   PMID:18439917   PMID:18451879   PMID:18485871   PMID:18501190   PMID:18552382   PMID:18585351  
PMID:18588874   PMID:18619497   PMID:18634613   PMID:18644863   PMID:18644983   PMID:18671804   PMID:18708058   PMID:18722353   PMID:18765668   PMID:18789002   PMID:18806873   PMID:18822204  
PMID:18850004   PMID:18850007   PMID:18851995   PMID:18854154   PMID:18854353   PMID:18936100   PMID:18948152   PMID:18974119   PMID:19011633   PMID:19015268   PMID:19029947   PMID:19041848  
PMID:19049980   PMID:19057576   PMID:19061646   PMID:19062177   PMID:19064572   PMID:19070599   PMID:19081374   PMID:19081376   PMID:19099586   PMID:19101520   PMID:19124609   PMID:19166851  
PMID:19182791   PMID:19218564   PMID:19235719   PMID:19244234   PMID:19252524   PMID:19303885   PMID:19339282   PMID:19339613   PMID:19343227   PMID:19351825   PMID:19383825   PMID:19394292  
PMID:19416910   PMID:19433865   PMID:19438744   PMID:19454010   PMID:19470756   PMID:19497860   PMID:19503603   PMID:19505873   PMID:19531758   PMID:19561124   PMID:19561196   PMID:19581286  
PMID:19581932   PMID:19617623   PMID:19644445   PMID:19648967   PMID:19683447   PMID:19686092   PMID:19703393   PMID:19729656   PMID:19738201   PMID:19738286   PMID:19740981   PMID:19759913  
PMID:19786833   PMID:19793920   PMID:19800870   PMID:19801684   PMID:19802013   PMID:19819149   PMID:19819974   PMID:19822520   PMID:19828482   PMID:19855430   PMID:19912635   PMID:19995069  
PMID:20001970   PMID:20022962   PMID:20037816   PMID:20049841   PMID:20072153   PMID:20075864   PMID:20081843   PMID:20124407   PMID:20127688   PMID:20144149   PMID:20154723   PMID:20185822  
PMID:20331966   PMID:20332121   PMID:20360311   PMID:20363964   PMID:20379614   PMID:20385359   PMID:20388487   PMID:20398369   PMID:20415600   PMID:20438716   PMID:20464640   PMID:20471948  
PMID:20473547   PMID:20478393   PMID:20484017   PMID:20498639   PMID:20508642   PMID:20523938   PMID:20561418   PMID:20562920   PMID:20585571   PMID:20585871   PMID:20590529   PMID:20596014  
PMID:20603076   PMID:20609223   PMID:20613874   PMID:20633551   PMID:20663877   PMID:20680269   PMID:20693977   PMID:20702731   PMID:20731616   PMID:20802485   PMID:20821348   PMID:20826751  
PMID:20850016   PMID:20856864   PMID:20935208   PMID:20967026   PMID:21030595   PMID:21045206   PMID:21059642   PMID:21081666   PMID:21106524   PMID:21108932   PMID:21123453   PMID:21127047  
PMID:21143702   PMID:21148070   PMID:21176959   PMID:21179169   PMID:21179472   PMID:21182205   PMID:21184735   PMID:21252314   PMID:21258344   PMID:21262769   PMID:21262773   PMID:21293853  
PMID:21301206   PMID:21344388   PMID:21420382   PMID:21423269   PMID:21438903   PMID:21454521   PMID:21455583   PMID:21457345   PMID:21466904   PMID:21502505   PMID:21527555   PMID:21532573  
PMID:21549307   PMID:21565167   PMID:21566081   PMID:21566083   PMID:21617866   PMID:21622623   PMID:21636851   PMID:21637537   PMID:21638299   PMID:21654808   PMID:21661415   PMID:21666599  
PMID:21669392   PMID:21669397   PMID:21670149   PMID:21685935   PMID:21718540   PMID:21725353   PMID:21725604   PMID:21846774   PMID:21873635   PMID:21900881   PMID:21907836   PMID:21937684  
PMID:21952639   PMID:21957129   PMID:21972094   PMID:21972143   PMID:21974802   PMID:21982637   PMID:21983014   PMID:21983900   PMID:21988832   PMID:21996064   PMID:22028823   PMID:22036763  
PMID:22037263   PMID:22056872   PMID:22075476   PMID:22077140   PMID:22100169   PMID:22113938   PMID:22114073   PMID:22116549   PMID:22156779   PMID:22180294   PMID:22184063   PMID:22211246  
PMID:22222205   PMID:22242125   PMID:22266186   PMID:22274925   PMID:22286234   PMID:22308472   PMID:22325352   PMID:22344732   PMID:22355045   PMID:22366686   PMID:22393235   PMID:22411829  
PMID:22416134   PMID:22419072   PMID:22439931   PMID:22496786   PMID:22498736   PMID:22542627   PMID:22615382   PMID:22641068   PMID:22689669   PMID:22720776   PMID:22731250   PMID:22733990  
PMID:22750444   PMID:22778253   PMID:22796363   PMID:22797919   PMID:22822071   PMID:22863883   PMID:22865885   PMID:22879913   PMID:22926524   PMID:22927334   PMID:22939629   PMID:22939983  
PMID:22972034   PMID:22982681   PMID:22989952   PMID:23011797   PMID:23014989   PMID:23022380   PMID:23060449   PMID:23104175   PMID:23110995   PMID:23140481   PMID:23185513   PMID:23217559  
PMID:23242655   PMID:23246564   PMID:23251689   PMID:23273982   PMID:23280436   PMID:23362263   PMID:23437037   PMID:23443559   PMID:23563092   PMID:23612983   PMID:23621261   PMID:23629966  
PMID:23658227   PMID:23677067   PMID:23690335   PMID:23708667   PMID:23714156   PMID:23752268   PMID:23770133   PMID:23791785   PMID:23803414   PMID:23898169   PMID:23926105   PMID:23932364  
PMID:23939379   PMID:24015760   PMID:24036913   PMID:24048479   PMID:24051437   PMID:24058639   PMID:24068740   PMID:24086750   PMID:24116224   PMID:24169447   PMID:24176859   PMID:24190971  
PMID:24239178   PMID:24249678   PMID:24307847   PMID:24316511   PMID:24344198   PMID:24376786   PMID:24457600   PMID:24463822   PMID:24475290   PMID:24514149   PMID:24550390   PMID:24722339  
PMID:24748658   PMID:24763403   PMID:24771265   PMID:24821727   PMID:24830600   PMID:24840043   PMID:24939842   PMID:24981860   PMID:25086032   PMID:25123934   PMID:25150861   PMID:25173798  
PMID:25189618   PMID:25241761   PMID:25247294   PMID:25270209   PMID:25279705   PMID:25314079   PMID:25341045   PMID:25405810   PMID:25437307   PMID:25445594   PMID:25482492   PMID:25483064  
PMID:25514493   PMID:25593344   PMID:25665578   PMID:25688158   PMID:25762635   PMID:25794974   PMID:25796446   PMID:25801958   PMID:25808664   PMID:25812002   PMID:25840828   PMID:25860111  
PMID:25862862   PMID:25885317   PMID:25942572   PMID:25950477   PMID:25996657   PMID:26024595   PMID:26028330   PMID:26030138   PMID:26035691   PMID:26116233   PMID:26123998   PMID:26152200  
PMID:26186194   PMID:26221039   PMID:26255936   PMID:26264872   PMID:26290249   PMID:26299517   PMID:26344197   PMID:26352599   PMID:26460487   PMID:26468294   PMID:26496610   PMID:26502922  
PMID:26527279   PMID:26539911   PMID:26549023   PMID:26549030   PMID:26549310   PMID:26588579   PMID:26598521   PMID:26639180   PMID:26655721   PMID:26678539   PMID:26679995   PMID:26697414  
PMID:26758364   PMID:26759222   PMID:26764010   PMID:26794444   PMID:26797758   PMID:26812044   PMID:26816381   PMID:26841866   PMID:26864203   PMID:26912629   PMID:26949739   PMID:26980768  
PMID:27012186   PMID:27018948   PMID:27025967   PMID:27029072   PMID:27030811   PMID:27060025   PMID:27086779   PMID:27092878   PMID:27098840   PMID:27109927   PMID:27114453   PMID:27171263  
PMID:27173435   PMID:27183383   PMID:27195665   PMID:27197203   PMID:27248496   PMID:27283770   PMID:27320013   PMID:27333946   PMID:27342975   PMID:27358484   PMID:27420561   PMID:27422033  
PMID:27501845   PMID:27506904   PMID:27517492   PMID:27550312   PMID:27593931   PMID:27616479   PMID:27635759   PMID:27637333   PMID:27672210   PMID:27684187   PMID:27694949   PMID:27705803  
PMID:27743347   PMID:27773593   PMID:27886239   PMID:27990641   PMID:28004751   PMID:28030834   PMID:28046085   PMID:28065597   PMID:28102109   PMID:28107582   PMID:28179136   PMID:28192407  
PMID:28242625   PMID:28302793   PMID:28319113   PMID:28411180   PMID:28424407   PMID:28450117   PMID:28473661   PMID:28481362   PMID:28489564   PMID:28514442   PMID:28533418   PMID:28579617  
PMID:28581483   PMID:28617441   PMID:28624794   PMID:28655764   PMID:28667074   PMID:28672879   PMID:28679560   PMID:28716899   PMID:28767587   PMID:28779562   PMID:28870936   PMID:28938863  
PMID:28977666   PMID:28986522   PMID:29058807   PMID:29059365   PMID:29084956   PMID:29128334   PMID:29140459   PMID:29229926   PMID:29263092   PMID:29277783   PMID:29369542   PMID:29378950  
PMID:29384474   PMID:29448109   PMID:29453984   PMID:29459360   PMID:29472538   PMID:29507620   PMID:29507755   PMID:29509190   PMID:29537214   PMID:29561664   PMID:29564676   PMID:29568061  
PMID:29645094   PMID:29656858   PMID:29676528   PMID:29679567   PMID:29738697   PMID:29803790   PMID:29844126   PMID:29845934   PMID:29846670   PMID:29853494   PMID:29911972   PMID:29917299  
PMID:29997244   PMID:30021884   PMID:30060952   PMID:30071534   PMID:30110629   PMID:30135474   PMID:30196744   PMID:30209338   PMID:30242288   PMID:30279482   PMID:30280780   PMID:30344098  
PMID:30415952   PMID:30442713   PMID:30462309   PMID:30463877   PMID:30463901   PMID:30463940   PMID:30500418   PMID:30542118   PMID:30585266   PMID:30592280   PMID:30612578   PMID:30642670  
PMID:30669676   PMID:30670829   PMID:30737378   PMID:30760870   PMID:30776024   PMID:30782261   PMID:30804502   PMID:30818224   PMID:30872677   PMID:30945288   PMID:30948266   PMID:31048545  
PMID:31067491   PMID:31071955   PMID:31091453   PMID:31111958   PMID:31119861   PMID:31130994   PMID:31165775   PMID:31177123   PMID:31180492   PMID:31204933   PMID:31222845   PMID:31226417  
PMID:31239290   PMID:31256937   PMID:31267705   PMID:31358016   PMID:31400279   PMID:31409898   PMID:31435636   PMID:31502386   PMID:31504778   PMID:31527615   PMID:31558698   PMID:31586073  
PMID:31704828   PMID:31722399   PMID:31744547   PMID:31746377   PMID:31753913   PMID:31761932   PMID:31799598   PMID:31856871   PMID:31874856   PMID:31913353   PMID:31964588   PMID:31980649  
PMID:32015101   PMID:32101746   PMID:32129710   PMID:32152128   PMID:32275661   PMID:32324261   PMID:32366868   PMID:32416067   PMID:32525044   PMID:32557953   PMID:32591593   PMID:32632107  
PMID:32780723   PMID:32814053   PMID:32934238   PMID:32938908   PMID:33212149  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl132,292,083 - 32,333,635 (+)EnsemblGRCh38hg38GRCh38
GRCh38132,292,083 - 32,333,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,757,684 - 32,799,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,530,295 - 32,571,811 (+)NCBINCBI36hg18NCBI36
Build 34132,426,800 - 32,468,317NCBI
Celera131,028,175 - 31,069,691 (+)NCBI
Cytogenetic Map1p35.2-p35.1NCBI
HuRef130,873,184 - 30,914,532 (+)NCBIHuRef
CHM1_1132,873,153 - 32,914,668 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394129,409,897 - 129,436,439 (-)NCBIGRCm39mm39
GRCm39 Ensembl4129,409,897 - 129,436,506 (-)Ensembl
GRCm384129,516,104 - 129,542,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,516,104 - 129,542,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,193,348 - 129,219,890 (-)NCBIGRCm37mm9NCBIm37
MGSCv364129,018,408 - 129,044,950 (-)NCBImm8
Celera1782,795,228 - 82,797,813 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25141,853,992 - 141,881,057 (-)NCBI
Rnor_6.0 Ensembl5147,716,664 - 147,743,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05147,716,664 - 147,743,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05151,445,686 - 151,472,652 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,672,515 - 148,699,810 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15148,682,553 - 148,709,849 (-)NCBI
Celera5140,329,254 - 140,356,320 (-)NCBICelera
Cytogenetic Map5q36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545210,636,366 - 10,670,864 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,636,366 - 10,668,873 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1132,585,791 - 32,626,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,585,791 - 32,626,410 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0131,578,373 - 31,619,970 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1268,901,339 - 68,936,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,901,651 - 68,936,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,482,127 - 65,517,259 (-)NCBI
ROS_Cfam_1.0269,467,855 - 69,503,012 (-)NCBI
UMICH_Zoey_3.1266,304,797 - 66,339,911 (-)NCBI
UNSW_CanFamBas_1.0267,300,918 - 67,335,502 (-)NCBI
UU_Cfam_GSD_1.0268,299,008 - 68,334,559 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505849,495,732 - 49,526,636 (+)NCBI
SpeTri2.0NW_00493647415,320,635 - 15,351,418 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl688,749,634 - 88,785,412 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,749,611 - 88,785,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,882,080 - 82,907,607 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120100,529,782 - 100,575,953 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462476415,510,655 - 15,552,020 (+)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,798,652 - 32,798,885UniSTSGRCh37
Build 36132,571,239 - 32,571,472RGDNCBI36
Celera131,069,119 - 31,069,352RGD
Cytogenetic Map1p34UniSTS
HuRef130,913,960 - 30,914,193UniSTS
GeneMap99-GB4 RH Map190.73UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,799,026 - 32,799,206UniSTSGRCh37
Build 36132,571,613 - 32,571,793RGDNCBI36
Celera131,069,493 - 31,069,673RGD
Cytogenetic Map1p34UniSTS
Cytogenetic Map1p35.1UniSTS
HuRef130,914,334 - 30,914,514UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,799,010 - 32,799,132UniSTSGRCh37
Build 36132,571,597 - 32,571,719RGDNCBI36
Celera131,069,477 - 31,069,599RGD
Cytogenetic Map1p34UniSTS
Cytogenetic Map1p35.1UniSTS
HuRef130,914,318 - 30,914,440UniSTS
GeneMap99-GB4 RH Map194.68UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,797,699 - 32,798,646UniSTSGRCh37
GRCh371217,725,971 - 217,726,223UniSTSGRCh37
Build 361215,792,594 - 215,792,846RGDNCBI36
Celera131,068,166 - 31,069,113UniSTS
Celera1190,949,751 - 190,950,003RGD
Cytogenetic Map1p34UniSTS
Cytogenetic Map1q41UniSTS
HuRef130,913,007 - 30,913,954UniSTS
GeneMap99-GB4 RH Map1707.33UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,798,696 - 32,799,387UniSTSGRCh37
Build 36132,571,283 - 32,571,974RGDNCBI36
Celera131,069,163 - 31,069,854RGD
HuRef130,914,004 - 30,914,695UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,796,439 - 32,797,132UniSTSGRCh37
Celera131,066,906 - 31,067,599UniSTS
Cytogenetic Map1p34UniSTS
HuRef130,911,747 - 30,912,440UniSTS
GeneMap99-GB4 RH Map194.68UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p34UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR449Ahsa-miR-449aMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19252524
MIR449Ahsa-miR-449aMirtarbaseexternal_infoImmunoblotFunctional MTI (Weak)20948989
MIR449Bhsa-miR-449b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21418558

Predicted Target Of
Summary Value
Count of predictions:2737
Count of miRNA genes:910
Interacting mature miRNAs:1097
Transcripts:ENST00000373541, ENST00000373548, ENST00000428704, ENST00000463172, ENST00000471488, ENST00000472928, ENST00000476391, ENST00000481281, ENST00000482310, ENST00000484305, ENST00000490081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2438 2884 1720 617 1925 459 4002 1764 3136 415 1458 1611 174 1 1204 2434 6 1
Low 1 107 6 7 26 6 355 433 598 4 1 2 1 354 1
Below cutoff


Nucleotide Sequences
RefSeq Transcripts NG_047018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB457577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL109945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY627042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000373548   ⟹   ENSP00000362649
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,292,083 - 32,333,626 (+)Ensembl
RefSeq Acc Id: ENST00000428704   ⟹   ENSP00000407859
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,292,140 - 32,329,140 (+)Ensembl
RefSeq Acc Id: ENST00000463172
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,292,137 - 32,327,445 (+)Ensembl
RefSeq Acc Id: ENST00000471488
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,331,536 - 32,333,079 (+)Ensembl
RefSeq Acc Id: ENST00000472928
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,292,161 - 32,327,677 (+)Ensembl
RefSeq Acc Id: ENST00000476391
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,329,480 - 32,333,635 (+)Ensembl
RefSeq Acc Id: ENST00000481281
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,292,135 - 32,327,674 (+)Ensembl
RefSeq Acc Id: ENST00000482310
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,327,274 - 32,331,582 (+)Ensembl
RefSeq Acc Id: ENST00000484305
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,330,149 - 32,330,875 (+)Ensembl
RefSeq Acc Id: ENST00000490081
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,327,189 - 32,331,781 (+)Ensembl
RefSeq Acc Id: NM_004964   ⟹   NP_004955
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38132,292,083 - 32,333,626 (+)NCBI
GRCh37132,757,708 - 32,799,227 (+)NCBI
Build 36132,530,295 - 32,571,811 (+)NCBI Archive
HuRef130,873,184 - 30,914,532 (+)ENTREZGENE
CHM1_1132,873,153 - 32,914,668 (+)NCBI
RefSeq Acc Id: XM_011541309   ⟹   XP_011539611
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38132,292,103 - 32,333,628 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_004955   ⟸   NM_004964
- UniProtKB: Q13547 (UniProtKB/Swiss-Prot),   Q6IT96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011539611   ⟸   XM_011541309
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000362649   ⟸   ENST00000373548
RefSeq Acc Id: ENSP00000407859   ⟸   ENST00000428704
Protein Domains

RGD ID:6854834
Promoter ID:EPDNEW_H582
Type:initiation region
Description:histone deacetylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H584  EPDNEW_H583  
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38132,292,104 - 32,292,164EPDNEW
RGD ID:6854990
Promoter ID:EPDNEW_H583
Type:initiation region
Description:histone deacetylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H582  EPDNEW_H584  
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38132,292,240 - 32,292,300EPDNEW
RGD ID:6854838
Promoter ID:EPDNEW_H584
Type:multiple initiation site
Description:histone deacetylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H582  EPDNEW_H583  
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38132,329,419 - 32,329,479EPDNEW
RGD ID:6785700
Promoter ID:HG_KWN:1820
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000373541,   OTTHUMT00000019815,   OTTHUMT00000019817,   OTTHUMT00000020042,   OTTHUMT00000020043,   OTTHUMT00000099439
Human AssemblyChrPosition (strand)Source
Build 36132,529,666 - 32,530,507 (+)MPROMDB
RGD ID:6850600
Promoter ID:EP73094
Type:initiation region
Description:Histone deacetylase 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Human AssemblyChrPosition (strand)Source
Build 36132,530,428 - 32,530,488EPD
RGD ID:6785702
Promoter ID:HG_KWN:1822
SO ACC ID:SO:0000170
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000019819,   OTTHUMT00000020044
Human AssemblyChrPosition (strand)Source
Build 36132,565,369 - 32,565,869 (+)MPROMDB
RGD ID:6785703
Promoter ID:HG_KWN:1823
SO ACC ID:SO:0000170
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000019816,   OTTHUMT00000020045
Human AssemblyChrPosition (strand)Source
Build 36132,567,001 - 32,568,852 (+)MPROMDB
RGD ID:6785705
Promoter ID:HG_KWN:1824
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell_12Hour,   Jurkat,   K562,   Lymphoblastoid
Human AssemblyChrPosition (strand)Source
Build 36132,569,026 - 32,570,052 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p35.2-35.1(chr1:31122108-32402160)x3 copy number gain See cases [RCV000051802] Chr1:31122108..32402160 [GRCh38]
Chr1:31594955..32867761 [GRCh37]
Chr1:31367542..32640348 [NCBI36]
GRCh38/hg38 1p35.2-35.1(chr1:30766758-33359428)x1 copy number loss See cases [RCV000053802] Chr1:30766758..33359428 [GRCh38]
Chr1:31239605..33825029 [GRCh37]
Chr1:31012192..33597616 [NCBI36]
NM_004964.3(HDAC1):c.461A>G (p.Asn154Ser) single nucleotide variant Inborn genetic diseases [RCV000190771] Chr1:32327044 [GRCh38]
Chr1:32792645 [GRCh37]
pathogenic|likely pathogenic
GRCh38/hg38 1p35.3-35.1(chr1:28424867-33122854)x1 copy number loss See cases [RCV000135447] Chr1:28424867..33122854 [GRCh38]
Chr1:28751378..33588455 [GRCh37]
Chr1:28623965..33361042 [NCBI36]
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
GRCh37/hg19 1p35.1(chr1:32608682-32953541)x3 copy number gain not provided [RCV000684559] Chr1:32608682..32953541 [GRCh37]
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
GRCh37/hg19 1p35.2-34.3(chr1:31562164-37421958)x3 copy number gain not provided [RCV000748949] Chr1:31562164..37421958 [GRCh37]
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
uncertain significance
NM_004964.3(HDAC1):c.564C>T (p.Tyr188=) single nucleotide variant not provided [RCV000966125] Chr1:32327605 [GRCh38]
Chr1:32793206 [GRCh37]
GRCh37/hg19 1p35.2-35.1(chr1:32139063-32940848)x4 copy number gain not provided [RCV000846712] Chr1:32139063..32940848 [GRCh37]
uncertain significance
GRCh37/hg19 1p35.2-35.1(chr1:30819875-34380419)x3 copy number gain not provided [RCV001005079] Chr1:30819875..34380419 [GRCh37]
likely pathogenic
NM_004964.3(HDAC1):c.702C>T (p.Asp234=) single nucleotide variant not provided [RCV000888897] Chr1:32329133 [GRCh38]
Chr1:32794734 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4852 AgrOrtholog
Ensembl Genes ENSG00000116478 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000362649 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000407859 UniProtKB/TrEMBL
Ensembl Transcript ENST00000373548 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000428704 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000116478 GTEx
Human Proteome Map HDAC1 Human Proteome Map
InterPro His_deacetylse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
OMIM 601241 OMIM
Pfam Hist_deacetyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29226 PharmGKB
PIRSF His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary D3DPP9 UniProtKB/TrEMBL
  Q92534 UniProtKB/Swiss-Prot