RGD Reference Report - Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer.

Authors: Halkidou, K  Gaughan, L  Cook, S  Leung, HY  Neal, DE  Robson, CN 
Citation: Halkidou K, etal., Prostate. 2004 May 1;59(2):177-89.
RGD ID: 2306219
Pubmed: PMID:15042618   (View Abstract at PubMed)
DOI: DOI:10.1002/pros.20022   (Journal Full-text)

BACKGROUND: Histone deacetylase 1 (HDAC1) is a co-repressor involved in differentiation and proliferation control. It is upregulated in malignant compared to benign tissue, and targets a number of transcription factors including p53. METHODS: By immunohistochemistry, HDAC1 protein expression was investigated in human prostate specimens and the CWR22 mouse xenograft model. Flow cytometry and deconvolution immunofluorescence were also performed. RESULTS: HDAC1 was upregulated in pre-malignant and malignant lesions, with the highest increase in expression in hormone refractory (HR) cancer. Using the CWR22 xenograft model we showed androgen dependent regulation of HDAC1. HDAC1 overexpression led to a significant increase in proliferation and a shift towards the undifferentiated cytokeratin (CK) profile in a PC3M derivative clone constitutively expressing HDAC1. CONCLUSION: This study underlines the importance of HDAC1 in cell proliferation and the development of prostate cancer (CaP) and proposes a mechanism for HDAC1 nuclear recruitment. HDAC1 may constitute a crucial therapeutic target particularly in the most lethal phase of androgen independence.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate carcinoma in situ  IEP 2306219protein:increased expression:prostate glandRGD 
prostate carcinoma in situ  ISOHDAC1 (Homo sapiens)2306219; 2306219protein:increased expression:prostate glandRGD 
Prostatic Neoplasms  IEP 2306219protein:increased expression:prostate glandRGD 
Prostatic Neoplasms  ISOHDAC1 (Homo sapiens)2306219; 2306219protein:increased expression:prostate glandRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hdac1  (histone deacetylase 1)

Genes (Mus musculus)
Hdac1  (histone deacetylase 1)

Genes (Homo sapiens)
HDAC1  (histone deacetylase 1)


Additional Information