Hdac1 (histone deacetylase 1) - Rat Genome Database

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Gene: Hdac1 (histone deacetylase 1) Mus musculus
Analyze
Symbol: Hdac1
Name: histone deacetylase 1
RGD ID: 1320331
MGI Page MGI
Description: Enables several functions, including E-box binding activity; Krueppel-associated box domain binding activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including eyelid development in camera-type eye; fungiform papilla formation; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of signal transduction; nervous system development; and positive regulation of oligodendrocyte differentiation. Located in heterochromatin; neuronal cell body; and nucleus. Part of NuRD complex and transcription repressor complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HDAC1 (histone deacetylase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HD1; Hdac1-ps; MGC102534; MGC118085; MommeD; MommeD5; RP; RPD3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18132   Gm18139   Gm18142   Gm4864   Hdac1-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,409,897 - 129,436,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,409,897 - 129,436,506 (-)EnsemblGRCm39 Ensembl
GRCm384129,516,104 - 129,542,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,516,104 - 129,542,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,193,348 - 129,219,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,018,408 - 129,044,950 (-)NCBIMGSCv36mm8
Celera1782,795,228 - 82,797,813 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rh2  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-mangostin  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
benomyl  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (EXP,ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium oxalate  (ISO)
captan  (EXP)
carbamazepine  (ISO)
Chlamydocin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium atom  (EXP)
chromium(6+)  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucaric acid  (EXP)
glucose  (EXP)
glyphosate  (ISO)
guggulsterone  (ISO)
hesperidin  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indirubin  (EXP)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (EXP)
lovastatin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP,ISO)
methylmercury chloride  (EXP)
mocetinostat  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
oleanolic acid  (ISO)
oxalic acid  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
pelargonidin  (EXP)
pentachlorophenol  (EXP)
phenethyl isothiocyanate  (ISO)
potassium chloride  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
pyrethrins  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
Shikonin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
taiwanin C  (ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
Tanshinone I  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
Trapoxin B  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
Triptolide  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
warfarin  (EXP)
withaferin A  (ISO)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to oxidative stress  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
chromatin organization  (TAS)
chromatin remodeling  (ISO)
circadian regulation of gene expression  (IDA)
circadian rhythm  (IDA)
DNA methylation-dependent constitutive heterochromatin formation  (IEA,ISO)
embryonic digit morphogenesis  (IGI)
endoderm development  (IDA,IMP)
epidermal cell differentiation  (IGI)
eyelid development in camera-type eye  (IGI)
fungiform papilla formation  (IGI)
hair follicle placode formation  (IGI)
heterochromatin formation  (IBA)
hippocampus development  (IGI)
negative regulation by host of viral transcription  (IEA,ISO)
negative regulation of androgen receptor signaling pathway  (IEA,ISO)
negative regulation of apoptotic process  (IGI)
negative regulation of canonical NF-kappaB signal transduction  (IGI)
negative regulation of canonical Wnt signaling pathway  (IGI,ISO)
negative regulation of cell migration  (NAS)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO,NAS)
negative regulation of gene expression  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IGI)
negative regulation of myotube differentiation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of stem cell population maintenance  (NAS)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,ISO,NAS)
negative regulation of transforming growth factor beta receptor signaling pathway  (NAS)
neuron differentiation  (IGI)
odontogenesis of dentin-containing tooth  (IGI)
oligodendrocyte differentiation  (IGI)
positive regulation of cell population proliferation  (IGI,ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of DNA-templated transcription  (ISO,NAS)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of oligodendrocyte differentiation  (IGI,ISO)
positive regulation of protein modification process  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell population maintenance  (NAS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type B pancreatic cell apoptotic process  (ISO)
protein deacetylation  (ISO)
regulation of cell fate specification  (NAS)
regulation of stem cell differentiation  (NAS)
regulation of transcription by RNA polymerase II  (ISO)
response to amphetamine  (ISO)
response to caffeine  (ISO)
response to hyperoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Function
chromatin binding  (IDA,ISO)
core promoter sequence-specific DNA binding  (ISO)
deacetylase activity  (ISO)
DNA binding  (IDA)
DNA-binding transcription factor binding  (IPI,ISO,TAS)
E-box binding  (IDA)
enzyme binding  (ISO)
histone deacetylase activity  (IBA,IDA,ISO,TAS)
histone deacetylase binding  (IEA,ISO)
histone decrotonylase activity  (IDA,ISO)
histone H3K14 deacetylase activity, hydrolytic mechanism  (IEA)
histone H3K4 deacetylase activity, hydrolytic mechanism  (IEA)
histone H3K9 deacetylase activity, hydrolytic mechanism  (IEA)
histone H4K12 deacetylase activity, hydrolytic mechanism  (IEA)
histone H4K16 deacetylase activity, hydrolytic mechanism  (IEA)
histone H4K5 deacetylase activity, hydrolytic mechanism  (IEA)
histone H4K8 deacetylase activity, hydrolytic mechanism  (IEA)
Krueppel-associated box domain binding  (IPI)
metal ion binding  (IEA)
NF-kappaB binding  (IEA,ISO)
p53 binding  (IEA,ISO)
promoter-specific chromatin binding  (IDA)
protein binding  (IPI,ISO)
protein lysine deacetylase activity  (ISO)
protein lysine delactylase activity  (ISS)
protein-containing complex binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II core promoter sequence-specific DNA binding  (IEA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IPI,ISO)
transcription cis-regulatory region binding  (IDA)
transcription corepressor activity  (IDA,ISO)
transcription corepressor binding  (IEA,ISO)
transcription factor binding  (ISO)
tubulin deacetylase activity  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal coat appearance  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair medulla  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal head development  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal nail color  (IAGP)
abnormal nail matrix morphology  (IAGP)
abnormal nail morphology  (IAGP)
abnormal periorbital region morphology  (IAGP)
abnormal sebaceous gland morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal tail morphology  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal vibrissa morphology  (IAGP)
abnormal zigzag hair morphology  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
aneuploidy  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
cardiovascular system phenotype  (IEA)
chromosomal instability  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body size  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased exploration in new environment  (IEA)
decreased fibroblast proliferation  (IAGP)
decreased heart rate variability  (IEA)
decreased mean corpuscular hemoglobin  (IEA)
decreased megakaryocyte cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased thymocyte number  (IAGP)
dilated hair follicle infundibulum  (IAGP)
dilated heart ventricle  (IAGP)
distended abdomen  (IAGP)
distorted hair follicle pattern  (IAGP)
early cellular replicative senescence  (IAGP)
ectopic melanocytes  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged chest  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
epidermal hyperplasia  (IAGP)
epithelioid cyst  (IAGP)
hyperkeratosis  (IAGP)
increased apoptosis  (IAGP)
increased B cell apoptosis  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased foot pad pigmentation  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased single-positive T cell number  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell proliferation  (IAGP)
increased tail pigmentation  (IAGP)
increased thymocyte apoptosis  (IAGP)
increased thymocyte number  (IAGP)
increased tumor incidence  (IAGP)
internal hemorrhage  (IAGP)
irregular heartbeat  (IAGP)
lethargy  (IAGP)
Meibomian gland hyperplasia  (IAGP)
narrow eye opening  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
short hair  (IAGP)
short vibrissae  (IAGP)
thick epidermis  (IAGP)
thin epidermis stratum granulosum  (IAGP)
thrombocytopenia  (IAGP)
thymus hypoplasia  (IAGP)
trisomy  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. Bardai FH, etal., J Biol Chem. 2012 Oct 12;287(42):35444-53. doi: 10.1074/jbc.M112.394544. Epub 2012 Aug 23.
2. The nucleosome remodeling and deacetylase complex in development and disease. Basta J and Rauchman M, Transl Res. 2014 May 10. pii: S1931-5244(14)00166-2. doi: 10.1016/j.trsl.2014.05.003.
3. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Ecsedy JA, etal., Mol Cell Biol 2003 Feb;23(3):950-60.
4. The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia. Gruhn B, etal., Leuk Res. 2013 Oct;37(10):1200-7. doi: 10.1016/j.leukres.2013.07.016. Epub 2013 Aug 12.
5. Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Halkidou K, etal., Prostate. 2004 May 1;59(2):177-89.
6. Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation. Hsieh CH, etal., Mol Carcinog. 2017 Mar;56(3):1055-1067. doi: 10.1002/mc.22570. Epub 2016 Oct 4.
7. Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Jia H, etal., Hum Mol Genet. 2012 Dec 15;21(24):5280-93. doi: 10.1093/hmg/dds379. Epub 2012 Sep 10.
8. Histone deacetylase expression in white matter oligodendrocytes after stroke. Kassis H, etal., Neurochem Int. 2014 Nov;77:17-23. doi: 10.1016/j.neuint.2014.03.006. Epub 2014 Mar 19.
9. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
10. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Ke X, etal., Physiol Genomics. 2006 Mar 13;25(1):16-28. Epub 2005 Dec 27.
11. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Khabele D, etal., Cancer Biol Ther. 2007 May;6(5):795-801. Epub 2007 Feb 14.
12. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Kim JY, etal., Nat Neurosci. 2010 Feb;13(2):180-9. doi: 10.1038/nn.2471. Epub 2009 Dec 27.
13. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
14. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. Lagger G, etal., EMBO J 2002 Jun 3;21(11):2672-81.
15. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Lin Z, etal., Clin Cancer Res. 2009 Jan 15;15(2):570-7.
16. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Lundh M, etal., Diabetologia. 2012 Sep;55(9):2421-31. doi: 10.1007/s00125-012-2615-0. Epub 2012 Jul 7.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Noh H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F729-39. doi: 10.1152/ajprenal.00086.2009. Epub 2009 Jun 24.
19. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
20. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. Park JH, etal., J Clin Invest. 2008 Jun;118(6):2316-24.
21. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
22. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. Mouse MP Annotation Import Pipeline RGD automated import pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. Stypula-Cyrus Y, etal., PLoS One. 2013 May 28;8(5):e64600. doi: 10.1371/journal.pone.0064600. Print 2013.
29. Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells. Waltregny D, etal., Eur J Histochem. 2004 Jul-Sep;48(3):273-90.
30. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.
31. Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer. Wang W, etal., Oncol Rep. 2009 Jun;21(6):1439-47.
32. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Weichert W, etal., Br J Cancer. 2008 Feb 12;98(3):604-10. Epub 2008 Jan 22.
33. Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Weichert W, etal., Neoplasia. 2008 Sep;10(9):1021-7.
34. Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*. Zhang Z, etal., Breast Cancer Res Treat. 2005 Nov;94(1):11-6.
35. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Zhao L, etal., Circulation. 2012 Jul 24;126(4):455-67. doi: 10.1161/CIRCULATIONAHA.112.103176. Epub 2012 Jun 18.
36. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
Additional References at PubMed
PMID:8917507   PMID:9139821   PMID:9271381   PMID:9651585   PMID:9702189   PMID:9823308   PMID:10204490   PMID:10349636   PMID:10357820   PMID:10409740   PMID:10570134   PMID:10615135  
PMID:10673037   PMID:10688671   PMID:10922068   PMID:10984530   PMID:11022042   PMID:11042159   PMID:11076861   PMID:11115394   PMID:11285237   PMID:11302704   PMID:11327722   PMID:11358320  
PMID:11477107   PMID:11564889   PMID:11641275   PMID:11684023   PMID:11788710   PMID:11836251   PMID:11909966   PMID:11923873   PMID:11931769   PMID:12040188   PMID:12198164   PMID:12198165  
PMID:12398767   PMID:12477932   PMID:12520002   PMID:12574125   PMID:12616525   PMID:12711221   PMID:12799438   PMID:12900441   PMID:12972616   PMID:14519686   PMID:14593184   PMID:14610273  
PMID:14643676   PMID:14645126   PMID:14673164   PMID:14749395   PMID:15060137   PMID:15060165   PMID:15060175   PMID:15140878   PMID:15226430   PMID:15337766   PMID:15367668   PMID:15496408  
PMID:15509593   PMID:15528197   PMID:15537544   PMID:15601857   PMID:15608638   PMID:15711539   PMID:15713663   PMID:15722557   PMID:15782199   PMID:15796905   PMID:15831478   PMID:15890782  
PMID:15907476   PMID:15917248   PMID:15919722   PMID:15919778   PMID:15920471   PMID:15935060   PMID:15978719   PMID:16085498   PMID:16103876   PMID:16107708   PMID:16109736   PMID:16109738  
PMID:16141072   PMID:16141073   PMID:16288735   PMID:16377629   PMID:16407282   PMID:16407974   PMID:16416968   PMID:16428440   PMID:16431920   PMID:16462733   PMID:16484221   PMID:16582105  
PMID:16602821   PMID:16611996   PMID:16678101   PMID:16728531   PMID:16805913   PMID:16873063   PMID:16940178   PMID:17056544   PMID:17071620   PMID:17150957   PMID:17182846   PMID:17220375  
PMID:17226765   PMID:17255939   PMID:17274640   PMID:17304221   PMID:17322895   PMID:17392792   PMID:17442941   PMID:17487425   PMID:17568773   PMID:17626016   PMID:17634443   PMID:17639084  
PMID:17682057   PMID:17707228   PMID:17707923   PMID:17905753   PMID:17963697   PMID:17967808   PMID:18003922   PMID:18206970   PMID:18241125   PMID:18288092   PMID:18454139   PMID:18486321  
PMID:18501342   PMID:18550396   PMID:18622014   PMID:18622015   PMID:18651664   PMID:18824292   PMID:18851995   PMID:18983969   PMID:19015268   PMID:19099580   PMID:19124609   PMID:19144721  
PMID:19181930   PMID:19235719   PMID:19362090   PMID:19379700   PMID:19380719   PMID:19398579   PMID:19412887   PMID:19416910   PMID:19422799   PMID:19424149   PMID:19463978   PMID:19483677  
PMID:19497860   PMID:19501046   PMID:19503085   PMID:19523849   PMID:19531374   PMID:19553468   PMID:19605684   PMID:19654328   PMID:19796622   PMID:19805123   PMID:19906951   PMID:19927129  
PMID:20028735   PMID:20081843   PMID:20097764   PMID:20188178   PMID:20194438   PMID:20211142   PMID:20362541   PMID:20362542   PMID:20404188   PMID:20496471   PMID:20571512   PMID:20579762  
PMID:20596014   PMID:20599664   PMID:20702731   PMID:20720167   PMID:20937823   PMID:20967026   PMID:20979029   PMID:21041482   PMID:21059642   PMID:21093383   PMID:21103394   PMID:21108932  
PMID:21127047   PMID:21169561   PMID:21177534   PMID:21267068   PMID:21270520   PMID:21270677   PMID:21292776   PMID:21311748   PMID:21321941   PMID:21364650   PMID:21367693   PMID:21423190  
PMID:21423191   PMID:21448134   PMID:21454521   PMID:21490601   PMID:21511710   PMID:21521687   PMID:21589869   PMID:21677750   PMID:21680841   PMID:21731673   PMID:21873635   PMID:21874024  
PMID:21931736   PMID:21937600   PMID:21953612   PMID:21960634   PMID:21972143   PMID:22075476   PMID:22083510   PMID:22119903   PMID:22156375   PMID:22223663   PMID:22242125   PMID:22266280  
PMID:22297846   PMID:22307625   PMID:22325351   PMID:22333916   PMID:22334647   PMID:22439931   PMID:22441348   PMID:22496552   PMID:22560079   PMID:22610404   PMID:22770845   PMID:22865885  
PMID:22915496   PMID:22922362   PMID:22984288   PMID:22984607   PMID:22989952   PMID:23014989   PMID:23086144   PMID:23087373   PMID:23213415   PMID:23287868   PMID:23327920   PMID:23376422  
PMID:23436026   PMID:23440245   PMID:23449471   PMID:23456364   PMID:23475113   PMID:23498780   PMID:23506836   PMID:23516383   PMID:23548937   PMID:23564453   PMID:23575838   PMID:23616648  
PMID:23624624   PMID:23664640   PMID:23698124   PMID:23744762   PMID:23792463   PMID:23835259   PMID:23852118   PMID:23888963   PMID:23892436   PMID:23937658   PMID:24025402   PMID:24027299  
PMID:24040068   PMID:24190971   PMID:24200994   PMID:24240174   PMID:24335282   PMID:24335310   PMID:24413057   PMID:24449838   PMID:24457600   PMID:24483844   PMID:24525021   PMID:24550390  
PMID:24681565   PMID:24736997   PMID:24760871   PMID:24770533   PMID:24796935   PMID:24808536   PMID:24821725   PMID:24947680   PMID:24958871   PMID:24982181   PMID:25011550   PMID:25043739  
PMID:25178657   PMID:25187418   PMID:25203139   PMID:25333902   PMID:25412078   PMID:25648995   PMID:25758227   PMID:25868580   PMID:25904100   PMID:25971728   PMID:26129908   PMID:26152200  
PMID:26167872   PMID:26174178   PMID:26196676   PMID:26206133   PMID:26238735   PMID:26283270   PMID:26291311   PMID:26329601   PMID:26365490   PMID:26406915   PMID:26416882   PMID:26447190  
PMID:26586441   PMID:26663087   PMID:26733201   PMID:26776516   PMID:26814051   PMID:26816381   PMID:26832969   PMID:26951610   PMID:26974661   PMID:27048565   PMID:27068467   PMID:27122033  
PMID:27171263   PMID:27185875   PMID:27260837   PMID:27333946   PMID:27352031   PMID:27534825   PMID:27635759   PMID:27668390   PMID:27721407   PMID:27806305   PMID:27857213   PMID:27871855  
PMID:27886239   PMID:27913583   PMID:27941310   PMID:28028172   PMID:28139683   PMID:28185240   PMID:28186506   PMID:28276480   PMID:28300292   PMID:28337219   PMID:28378742   PMID:28485501  
PMID:28533418   PMID:28554894   PMID:28566502   PMID:28663197   PMID:28791750   PMID:28892081   PMID:28964722   PMID:29035278   PMID:29084956   PMID:29113455   PMID:29184203   PMID:29207042  
PMID:29328071   PMID:29448109   PMID:29490983   PMID:29548672   PMID:29641990   PMID:29660306   PMID:29712641   PMID:29950483   PMID:30070635   PMID:30086304   PMID:30115891   PMID:30179675  
PMID:30186101   PMID:30196744   PMID:30228260   PMID:30279482   PMID:30457570   PMID:30550785   PMID:30592280   PMID:30595499   PMID:30709655   PMID:30726206   PMID:30776024   PMID:30814129  
PMID:30911105   PMID:30916347   PMID:30926862   PMID:30973865   PMID:31077711   PMID:31097476   PMID:31223056   PMID:31271872   PMID:31278362   PMID:31304633   PMID:31356635   PMID:31361780  
PMID:31450981   PMID:31533525   PMID:31600191   PMID:31883829   PMID:31943063   PMID:32098917   PMID:32102981   PMID:32113161   PMID:32227584   PMID:32409664   PMID:32424276   PMID:32482889  
PMID:32641996   PMID:32647127   PMID:33181265   PMID:33221374   PMID:33498747   PMID:33526073   PMID:33564072   PMID:33621930   PMID:33795231   PMID:33798452   PMID:33831416   PMID:33849645  
PMID:33907245   PMID:33961623   PMID:34075040   PMID:34161765   PMID:34180153   PMID:34284046   PMID:34321999   PMID:34333051   PMID:34450266   PMID:34450641   PMID:34668144   PMID:34709266  
PMID:34815344   PMID:34890513   PMID:35167946   PMID:35420781   PMID:35443136   PMID:35575026   PMID:35760306   PMID:35871293   PMID:35954222   PMID:36130284   PMID:36282138   PMID:36356658  
PMID:36414418   PMID:36537660   PMID:36604795   PMID:36675131   PMID:36951067   PMID:37028517   PMID:37244179   PMID:37441600   PMID:37563109   PMID:37640195   PMID:37921375   PMID:38229308  
PMID:38254102   PMID:38355793   PMID:38523117   PMID:38573853   PMID:38604490   PMID:38679196   PMID:38812060   PMID:39224519  


Genomics

Comparative Map Data
Hdac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,409,897 - 129,436,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,409,897 - 129,436,506 (-)EnsemblGRCm39 Ensembl
GRCm384129,516,104 - 129,542,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,516,104 - 129,542,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,193,348 - 129,219,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,018,408 - 129,044,950 (-)NCBIMGSCv36mm8
Celera1782,795,228 - 82,797,813 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
HDAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,292,083 - 32,333,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,292,083 - 32,333,635 (+)EnsemblGRCh38hg38GRCh38
GRCh37132,757,684 - 32,799,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,530,295 - 32,571,811 (+)NCBINCBI36Build 36hg18NCBI36
Build 34132,426,800 - 32,468,317NCBI
Celera131,028,175 - 31,069,691 (+)NCBICelera
Cytogenetic Map1p35.2-p35.1NCBI
HuRef130,873,184 - 30,914,532 (+)NCBIHuRef
CHM1_1132,873,153 - 32,914,668 (+)NCBICHM1_1
T2T-CHM13v2.0132,150,000 - 32,191,544 (+)NCBIT2T-CHM13v2.0
Hdac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,138,328 - 147,165,387 (-)NCBIGRCr8
mRatBN7.25141,853,992 - 141,881,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,853,989 - 141,881,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,555,355 - 144,582,392 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,325,182 - 146,352,217 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,321,706 - 146,348,843 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,716,664 - 147,743,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,716,664 - 147,743,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,445,686 - 151,472,652 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,672,515 - 148,699,810 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,682,553 - 148,709,849 (-)NCBI
Celera5140,329,254 - 140,356,320 (-)NCBICelera
Cytogenetic Map5q36NCBI
Hdac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,636,366 - 10,670,864 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,636,366 - 10,668,873 (+)NCBIChiLan1.0ChiLan1.0
HDAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,493,301 - 194,535,079 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,614,643 - 193,656,280 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,578,373 - 31,619,970 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1132,585,791 - 32,626,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,585,791 - 32,626,410 (+)Ensemblpanpan1.1panPan2
HDAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,901,339 - 68,936,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,901,651 - 68,936,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,482,127 - 65,517,259 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,467,855 - 69,503,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,467,851 - 69,502,759 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,304,797 - 66,339,911 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,300,918 - 67,335,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,299,008 - 68,334,559 (-)NCBIUU_Cfam_GSD_1.0
Hdac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,495,732 - 49,526,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,320,729 - 15,350,860 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,320,635 - 15,351,418 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl688,749,634 - 88,785,411 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,749,611 - 88,785,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,882,080 - 82,907,607 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,529,782 - 100,575,953 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,530,369 - 100,558,556 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,112,046 - 16,155,022 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,510,866 - 15,552,025 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,510,655 - 15,552,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1173
Count of miRNA genes:559
Interacting mature miRNAs:687
Transcripts:ENSMUST00000102597, ENSMUST00000125718, ENSMUST00000132909, ENSMUST00000139305, ENSMUST00000142984, ENSMUST00000145628, ENSMUST00000150105
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
Hdac1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
cM Map459.0UniSTS
RH127908  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384129,515,743 - 129,515,936UniSTSGRCm38
MGSCv374129,192,987 - 129,193,180UniSTSGRCm37
Cytogenetic Map4D2.2UniSTS
AW215397  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384129,515,602 - 129,515,711UniSTSGRCm38
GRCm38X101,708,517 - 101,708,626UniSTSGRCm38
MGSCv37X98,903,856 - 98,903,965UniSTSGRCm37
MGSCv374129,192,846 - 129,192,955UniSTSGRCm37
Celera4127,857,443 - 127,857,552UniSTS
CeleraX88,626,619 - 88,626,728UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map4D2.2UniSTS
cM MapX34.0UniSTS
Whitehead/MRC_RH41685.06UniSTS
UniSTS:235037  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384129,525,044 - 129,525,247UniSTSGRCm38
MGSCv374129,202,288 - 129,202,491UniSTSGRCm37
Celera4127,866,588 - 127,866,791UniSTS
Cytogenetic Map4D2.2UniSTS
RH70655  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381778,492,809 - 78,493,031UniSTSGRCm38
GRCm384129,516,608 - 129,517,500UniSTSGRCm38
MGSCv374129,193,852 - 129,194,744UniSTSGRCm37
MGSCv371778,892,149 - 78,892,371UniSTSGRCm37
Celera1782,797,079 - 82,797,301UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map4D2.2UniSTS
Hdac1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
Hdac1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000102597   ⟹   ENSMUSP00000099657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,409,897 - 129,436,506 (-)Ensembl
GRCm38.p6 Ensembl4129,516,104 - 129,542,713 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,416,284 - 129,422,792 (-)Ensembl
GRCm38.p6 Ensembl4129,522,491 - 129,528,999 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,416,619 - 129,418,335 (-)Ensembl
GRCm38.p6 Ensembl4129,522,826 - 129,524,542 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139305
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,422,308 - 129,436,484 (-)Ensembl
GRCm38.p6 Ensembl4129,528,515 - 129,542,691 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,411,876 - 129,416,583 (-)Ensembl
GRCm38.p6 Ensembl4129,518,083 - 129,522,790 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,410,061 - 129,411,311 (-)Ensembl
GRCm38.p6 Ensembl4129,516,268 - 129,517,518 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150105
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4129,416,431 - 129,418,377 (-)Ensembl
GRCm38.p6 Ensembl4129,522,638 - 129,524,584 (-)Ensembl
RefSeq Acc Id: NM_008228   ⟹   NP_032254
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394129,409,897 - 129,436,516 (-)NCBI
GRCm384129,516,104 - 129,542,646 (-)ENTREZGENE
MGSCv374129,193,348 - 129,219,890 (-)RGD
Celera4127,857,945 - 127,869,238 (-)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032254 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB68398 (Get FASTA)   NCBI Sequence Viewer  
  AAH92070 (Get FASTA)   NCBI Sequence Viewer  
  AAI08372 (Get FASTA)   NCBI Sequence Viewer  
  CAA66870 (Get FASTA)   NCBI Sequence Viewer  
  EDL38458 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000099657
  ENSMUSP00000099657.5
GenBank Protein O09106 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032254   ⟸   NM_008228
- UniProtKB: P97476 (UniProtKB/Swiss-Prot),   O09106 (UniProtKB/Swiss-Prot),   Q58E49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099657   ⟸   ENSMUST00000102597
Protein Domains
Histone deacetylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09106-F1-model_v2 AlphaFold O09106 1-482 view protein structure

Promoters
RGD ID:6835459
Promoter ID:MM_KWN:39793
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B6
Transcripts:OTTMUST00000022296
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364129,194,281 - 129,195,337 (-)MPROMDB
RGD ID:6835455
Promoter ID:MM_KWN:39794
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000022294
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364129,199,876 - 129,201,027 (-)MPROMDB
RGD ID:6835456
Promoter ID:MM_KWN:39795
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000022293,   OTTMUST00000022295
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364129,201,436 - 129,202,777 (-)MPROMDB
RGD ID:6835454
Promoter ID:MM_KWN:39796
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000022292
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364129,206,759 - 129,207,259 (-)MPROMDB
RGD ID:6835453
Promoter ID:MM_KWN:39797
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000022290,   OTTMUST00000022291
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364129,219,809 - 129,220,309 (-)MPROMDB
RGD ID:6884768
Promoter ID:EPDNEW_M5835
Type:initiation region
Name:Hdac1_1
Description:Mus musculus histone deacetylase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384129,542,660 - 129,542,720EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108086 AgrOrtholog
Ensembl Genes ENSMUSG00000028800 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000102597 ENTREZGENE
  ENSMUST00000102597.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HDAC_PDAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:433759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108086 ENTREZGENE
NCBI Gene 433759 ENTREZGENE
PANTHER HISTONE DEACETYLASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hdac1 PhenoGen
PIRSF His_deacetylse_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HDAC1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P97476 ENTREZGENE
  Q58E49 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97476 UniProtKB/Swiss-Prot