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Gene: HDAC2 (histone deacetylase 2) Homo sapiens
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Symbol: HDAC2
Name: histone deacetylase 2
Description: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HD2; KDAC2; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1-associated factor 1
Orthologs:
Mus musculus (house mouse) : Hdac2 (histone deacetylase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac2 (histone deacetylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac2 (histone deacetylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC2 (histone deacetylase 2)
Canis lupus familiaris (dog) : HDAC2 (histone deacetylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac2 (histone deacetylase 2)
Sus scrofa (pig) : HDAC2 (histone deacetylase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386113,933,028 - 113,971,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376114,257,320 - 114,292,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,364,019 - 114,399,047 (-)NCBINCBI36hg18NCBI36
Build 346114,368,619 - 114,398,967NCBI
Celera6114,998,693 - 115,033,733 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6111,834,121 - 111,869,161 (-)NCBIHuRef
CHM1_16114,520,179 - 114,555,225 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HDAC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312509
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.