Mecp2 (methyl CpG binding protein 2) - Rat Genome Database

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Gene: Mecp2 (methyl CpG binding protein 2) Rattus norvegicus
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Symbol: Mecp2
Name: methyl CpG binding protein 2
RGD ID: 3075
Description: Enables several functions, including DNA binding activity; histone deacetylase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including central nervous system development; positive regulation of dense core granule transport; and regulation of dendrite extension. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study Rett syndrome. Biomarker of hepatocellular carcinoma; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: meCP-2 protein; methyl-CpG-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mecp2em1Sage  
Genetic Models: SD-Mecp2em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,931,091 - 153,985,757 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,494,308 - 157,548,973 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X155,166,123 - 155,220,783 (-)NCBIRnor_WKY
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Angelman syndrome  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
bruxism  (ISO)
Cocaine-Related Disorders  (IMP,ISO)
Craniofacial Abnormalities  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
epilepsy  (ISO)
Facial Hypertrichosis  (ISO)
Fetal Growth Retardation  (IEP)
focal epilepsy  (ISO)
gastrointestinal system disease  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hyperalgesia  (ISO)
immunodeficiency 33  (ISO)
intellectual disability  (ISO)
learning disability  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Muscle Hypotonia  (ISO)
Myoclonus  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
non-syndromic X-linked intellectual disability  (ISO)
periventricular nodular heterotopia  (ISO)
pervasive developmental disorder  (ISO)
Psychomotor Disorders  (ISO)
pulmonary fibrosis  (ISO)
respiratory failure  (ISO)
Rett syndrome  (IMP,ISO)
Rett Syndrome, Atypical  (ISO)
Rett Syndrome, Zappella Variant  (ISO)
schizophrenia  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Smith-Magenis syndrome  (ISO)
Splenomegaly  (ISO)
stereotypic movement disorder  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
transient cerebral ischemia  (IEP)
visual epilepsy  (IEP,ISO)
X-Linked Intellectual Developmental Disorders  (ISO)
X-linked intellectual disability-psychosis-macroorchidism syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsenous acid  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bicuculline  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cocaine  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
diarsenic trioxide  (EXP)
dichlorine  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
formaldehyde  (EXP)
genistein  (ISO)
gentamycin  (ISO)
guggulsterone  (ISO)
homocysteine  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
melittin  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
potassium chloride  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
withaferin A  (ISO)
zebularine  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (ISO)
behavioral fear response  (ISO)
biogenic amine metabolic process  (ISO)
brain development  (ISO)
cardiolipin metabolic process  (ISO)
catecholamine secretion  (ISO)
cell population proliferation  (ISO)
cellular response to isoquinoline alkaloid  (IDA)
cellular response to potassium ion  (IDA)
cerebellum development  (IEP,ISO)
cerebral cortex development  (IEP)
chemical synaptic transmission  (ISO)
dendrite development  (ISO)
epigenetic regulation of gene expression  (ISO)
excitatory postsynaptic potential  (ISO)
gene expression  (ISO)
glial cell proliferation  (ISO)
glucocorticoid metabolic process  (ISO)
glutamine metabolic process  (ISO)
heart development  (IEP)
heterochromatin formation  (ISO)
hippocampus development  (IEP)
histone acetylation  (ISO)
histone methylation  (ISO)
inositol metabolic process  (ISO)
learning  (ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
lung alveolus development  (IEP)
memory  (ISO)
mitotic spindle organization  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of astrocyte differentiation  (IDA)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of dendrite extension  (IMP)
negative regulation of dendritic spine development  (IMP)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of gene expression  (IMP,ISO)
negative regulation of locomotion involved in locomotory behavior  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of primary miRNA processing  (IMP)
negative regulation of protein binding  (IMP)
negative regulation of respiratory gaseous exchange  (IMP)
negative regulation of smooth muscle cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IMP,ISO)
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  (ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling posture  (ISO)
neuron differentiation  (IEP,ISO)
neuron maturation  (ISO)
neuron projection development  (ISO)
Notch signaling pathway  (ISO)
olfactory bulb development  (IEP)
oligodendrocyte development  (IEP)
oligodendrocyte differentiation  (IEP)
phosphatidylcholine metabolic process  (ISO)
positive regulation of anterograde dense core granule transport  (IMP)
positive regulation of branching morphogenesis of a nerve  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendrite extension  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of DNA methylation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of glial cell proliferation  (ISO)
positive regulation of histone H3-K9 trimethylation  (ISO)
positive regulation of microtubule nucleation  (ISO)
positive regulation of retrograde dense core granule transport  (IMP)
positive regulation of synaptic plasticity  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
post-embryonic development  (ISO)
principal sensory nucleus of trigeminal nerve development  (IEP)
proprioception  (ISO)
protein localization  (ISO)
regulation of action potential firing threshold  (IMP)
regulation of DNA methylation  (IEP,IMP)
regulation of gene expression  (ISO)
regulation of gene expression by genomic imprinting  (ISO)
regulation of histone H3-K9 methylation  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (ISO)
regulation of synapse organization  (IDA,IMP)
regulation of synaptic plasticity  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
respiratory gaseous exchange by respiratory system  (ISO)
response to cocaine  (IDA,IEP)
response to estradiol  (IEP)
response to hypoxia  (ISO)
response to ionizing radiation  (IEP)
response to lead ion  (IEP)
response to organic cyclic compound  (IEP)
response to other organism  (ISO)
sensory perception of pain  (ISO)
social behavior  (IMP,ISO)
spinal cord development  (IEP)
startle response  (ISO)
striatum development  (IEP)
synapse assembly  (ISO)
thalamus development  (IEP)
trans-synaptic signaling by BDNF  (ISO)
triglyceride metabolic process  (ISO)
ventricular system development  (ISO)
visual learning  (ISO)

Cellular Component
centrosome  (ISO)
chromatin  (IDA)
cytoplasm  (ISO)
cytosol  (IDA,ISO)
glutamatergic synapse  (IDA,IMP)
heterochromatin  (IBA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO)
postsynapse  (IEA)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gross rearrangements of the MECP2 gene are found in both classical and atypical Rett syndrome patients. Archer HL, etal., J Med Genet. 2006 May;43(5):451-6. Epub 2005 Sep 23.
2. Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency. Bie B, etal., Nat Neurosci. 2014 Feb;17(2):223-31. doi: 10.1038/nn.3618. Epub 2014 Jan 19.
3. A critical and cell-autonomous role for MeCP2 in synaptic scaling up. Blackman MP, etal., J Neurosci. 2012 Sep 26;32(39):13529-36.
4. A detailed analysis of the MECP2 gene: prevalence of recurrent mutations and gross DNA rearrangements in Rett syndrome patients. Bourdon V, etal., Hum Genet. 2001 Jan;108(1):43-50.
5. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
6. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Cassel S, etal., Mol Pharmacol. 2006 Aug;70(2):487-92. Epub 2006 May 2.
7. Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations. Chapleau CA, etal., Neurobiol Dis. 2009 Aug;35(2):219-33. doi: 10.1016/j.nbd.2009.05.001. Epub 2009 May 12.
8. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Chen WG, etal., Science. 2003 Oct 31;302(5646):885-9.
9. SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development. Cheng J, etal., J Neurochem. 2014 Mar;128(6):798-806. doi: 10.1111/jnc.12523. Epub 2013 Nov 25.
10. MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Cheng TL, etal., Dev Cell. 2014 Mar 10;28(5):547-60. doi: 10.1016/j.devcel.2014.01.032.
11. MECP2 is highly mutated in X-linked mental retardation. Couvert P, etal., Hum Mol Genet. 2001 Apr 15;10(9):941-6.
12. A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3"-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. Coy JF, etal., Hum Mol Genet 1999 Jul;8(7):1253-62.
13. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
14. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Francis J, etal., Neuroscience. 2002;113(1):79-87.
15. Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain. Galvao TC and Thomas JO, Nucleic Acids Res. 2005 Nov 27;33(20):6603-9. Print 2005.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Guy J, etal., Nat Genet. 2001 Mar;27(3):322-6.
19. MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Im HI, etal., Nat Neurosci. 2010 Sep;13(9):1120-7. doi: 10.1038/nn.2615. Epub 2010 Aug 15.
20. RNAi-induced down-regulation of Mecp2 expression in the rat brain. Jin J, etal., Int J Dev Neurosci. 2008 Aug;26(5):457-65. doi: 10.1016/j.ijdevneu.2008.02.009. Epub 2008 Mar 4.
21. IUGR differentially alters MeCP2 expression and H3K9Me3 of the PPARgamma gene in male and female rat lungs during alveolarization. Joss-Moore LA, etal., Birth Defects Res A Clin Mol Teratol. 2011 Aug;91(8):672-81. doi: 10.1002/bdra.20783. Epub 2011 Mar 21.
22. The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells. Jung BP, etal., J Neurobiol. 2003 Apr;55(1):86-96.
23. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Jung BP, etal., Neuroscience. 2002;115(2):515-24.
24. Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Ke X, etal., Physiol Genomics. 2006 Mar 13;25(1):16-28. Epub 2005 Dec 27.
25. Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. Kimura H and Shiota K, J Biol Chem 2003 Feb 14;278(7):4806-12. Epub 2002 Dec 6.
26. Epigenetic regulation of neonatal cardiomyocytes differentiation. Kou CY, etal., Biochem Biophys Res Commun. 2010 Sep 17;400(2):278-83. doi: 10.1016/j.bbrc.2010.08.064. Epub 2010 Aug 22.
27. Mecp2 organizes juvenile social behavior in a sex-specific manner. Kurian JR, etal., J Neurosci. 2008 Jul 9;28(28):7137-42. doi: 10.1523/JNEUROSCI.1345-08.2008.
28. Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Larimore JL, etal., Neurobiol Dis. 2009 May;34(2):199-211. doi: 10.1016/j.nbd.2008.12.011. Epub 2009 Jan 3.
29. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Lewis JD, etal., Cell 1992 Jun 12;69(6):905-14.
30. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Long SW, etal., Biosci Rep. 2011 Oct 1;31(5):333-43. doi: 10.1042/BSR20100124.
31. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Loree J, etal., Int J Radiat Biol. 2006 Nov;82(11):805-15.
32. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Phosphorylation of methyl-CpG binding protein 2 (MeCP2) regulates the intracellular localization during neuronal cell differentiation. Miyake K and Nagai K, Neurochem Int. 2007 Jan;50(1):264-70. Epub 2006 Oct 18.
35. Gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome. Motil KJ, etal., J Pediatr Gastroenterol Nutr. 2012 Sep;55(3):292-8. doi: 10.1097/MPG.0b013e31824b6159.
36. Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain. Mullaney BC, etal., Neuroscience. 2004;123(4):939-49.
37. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Nan X, etal., Cell. 1997 Feb 21;88(4):471-81.
38. Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Nan X, etal., Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2709-14. Epub 2007 Feb 12.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Aug 1;25(15):3303-3320. doi: 10.1093/hmg/ddw179. Epub 2016 Jun 21.
42. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Dec 15;25(24):5514-5515. doi: 10.1093/hmg/ddw435.
43. Cocaine represses protein phosphatase-1Cbeta through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Pol Bodetto S, etal., Neuropharmacology. 2013 Oct;73:31-40. doi: 10.1016/j.neuropharm.2013.05.005. Epub 2013 May 18.
44. The Rett syndrome protein MeCP2 regulates synaptic scaling. Qiu Z, etal., J Neurosci. 2012 Jan 18;32(3):989-94. doi: 10.1523/JNEUROSCI.0175-11.2012.
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway. Roux JC, etal., Neurobiol Dis. 2012 Feb;45(2):786-95. doi: 10.1016/j.nbd.2011.11.002. Epub 2011 Nov 15.
48. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Schneider JS, etal., Toxicol Lett. 2013 Feb 13;217(1):75-81. doi: 10.1016/j.toxlet.2012.12.004. Epub 2012 Dec 15.
49. Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons. Setoguchi H, etal., J Neurosci Res. 2006 Oct;84(5):969-79.
50. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Sharma D, etal., Mol Endocrinol. 2013 Jul;27(7):1142-52. doi: 10.1210/me.2013-1079. Epub 2013 May 13.
51. Involvement of MeCP2 in Regulation of Myelin-Related Gene Expression in Cultured Rat Oligodendrocytes. Sharma K, etal., J Mol Neurosci. 2015 Oct;57(2):176-84. doi: 10.1007/s12031-015-0597-3. Epub 2015 Jul 5.
52. MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism. Shibayama A, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):50-3.
53. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Tang WY, etal., Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.
54. A novel transcriptional regulator of myelin gene expression: implications for neurodevelopmental disorders. Vora P, etal., Neuroreport. 2010 Oct 6;21(14):917-21. doi: 10.1097/WNR.0b013e32833da500.
55. Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats. Wu Y, etal., J Neurodev Disord. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7. eCollection 2016.
Additional References at PubMed
PMID:8563762   PMID:10888872   PMID:11441023   PMID:11809720   PMID:12949043   PMID:14519686   PMID:14593184   PMID:15006690   PMID:15034150   PMID:15322089   PMID:15342650   PMID:15345242  
PMID:15519245   PMID:15608638   PMID:15757975   PMID:15939091   PMID:15975715   PMID:16087343   PMID:16199017   PMID:16354910   PMID:16399702   PMID:16467389   PMID:16763620   PMID:16782889  
PMID:17046689   PMID:17050729   PMID:17108082   PMID:17237885   PMID:17532643   PMID:17544925   PMID:17546630   PMID:17553988   PMID:17920015   PMID:17997046   PMID:18203756   PMID:18295506  
PMID:18321864   PMID:18334558   PMID:18511691   PMID:18550052   PMID:18571096   PMID:18952054   PMID:19225110   PMID:19382685   PMID:19692427   PMID:20211261   PMID:21435439   PMID:21782149  
PMID:22056649   PMID:22369085   PMID:22658674   PMID:22664934   PMID:22848609   PMID:23200852   PMID:23333245   PMID:23935992   PMID:23960241   PMID:23980619   PMID:24269336   PMID:24936739  
PMID:25409090   PMID:25511996   PMID:25527496   PMID:25617893   PMID:25716866   PMID:25722434   PMID:26093272   PMID:26239616   PMID:26511729   PMID:26842955   PMID:26975406   PMID:27245166  
PMID:27312406   PMID:27350269   PMID:27365498   PMID:27995568   PMID:28074855   PMID:28573530   PMID:28655627   PMID:29090669   PMID:29155278   PMID:29286317   PMID:29476059   PMID:29540297  
PMID:29738885   PMID:29992497   PMID:30053369   PMID:30137367   PMID:31398393   PMID:32634579   PMID:33726573   PMID:33932163   PMID:34686597   PMID:35166074   PMID:35410641   PMID:35985556  


Genomics

Comparative Map Data
Mecp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,931,091 - 153,985,757 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,494,308 - 157,548,973 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X155,166,123 - 155,220,783 (-)NCBIRnor_WKY
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
MECP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,021,573 - 154,097,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,287,024 - 153,363,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
T2T-CHM13v2.0X152,295,254 - 152,371,375 (-)NCBIT2T-CHM13v2.0
Mecp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,070,198 - 73,129,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,070,198 - 73,178,969 (-)EnsemblGRCm39 Ensembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,026,592 - 74,135,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBIMGSCv36mm8
CeleraX65,279,211 - 65,338,021 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.63NCBI
Mecp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580679,109 - 735,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBIChiLan1.0ChiLan1.0
MECP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,458,248 - 153,527,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,465,204 - 153,527,854 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,571,864 - 143,647,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MECP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,866,721 - 121,876,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBIUU_Cfam_GSD_1.0
Mecp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,165,167 - 119,228,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809911,764 - 966,839 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936809902,938 - 967,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MECP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,735,656 - 124,738,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,295,001 - 142,349,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MECP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,445,028 - 128,519,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,453,577 - 128,455,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,318,831 - 66,395,535 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mecp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946628,284 - 685,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946620,581 - 685,339 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mecp2
19 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir132rno-miR-132-3pMirtarbaseexternal_infoWestern blotFunctional MTI17994015

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000056327
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
BE114216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,791,231 - 151,791,428 (-)MAPPERmRatBN7.2
Rnor_6.0X156,703,562 - 156,703,758NCBIRnor6.0
Rnor_5.01152,451,396 - 152,451,592UniSTSRnor5.0
RGSC_v3.4X159,981,891 - 159,982,087UniSTSRGSC3.4
Celera1136,103,616 - 136,103,812UniSTS
Cytogenetic MapXq37UniSTS
Mecp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,788,800 - 151,790,347 (-)MAPPERmRatBN7.2
Rnor_6.0X156,704,643 - 156,706,189NCBIRnor6.0
Rnor_5.01152,452,477 - 152,454,023UniSTSRnor5.0
RGSC_v3.4X159,979,460 - 159,981,006UniSTSRGSC3.4
Celera1136,104,697 - 136,106,243UniSTS
Cytogenetic MapXq37UniSTS
REN88597  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,789,797 - 151,790,042 (-)MAPPERmRatBN7.2
Rnor_6.0X156,704,948 - 156,705,192NCBIRnor6.0
Rnor_5.01152,452,782 - 152,453,026UniSTSRnor5.0
RGSC_v3.4X159,980,457 - 159,980,701UniSTSRGSC3.4
Celera1136,105,002 - 136,105,246UniSTS
Cytogenetic MapXq37UniSTS
REN88598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,789,984 - 151,790,233 (-)MAPPERmRatBN7.2
Rnor_6.0X156,704,757 - 156,705,005NCBIRnor6.0
Rnor_5.01152,452,591 - 152,452,839UniSTSRnor5.0
RGSC_v3.4X159,980,644 - 159,980,892UniSTSRGSC3.4
Celera1136,104,811 - 136,105,059UniSTS
Cytogenetic MapXq37UniSTS
REN88847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,838,647 - 151,838,884 (-)MAPPERmRatBN7.2
Rnor_6.0X156,656,111 - 156,656,347NCBIRnor6.0
Rnor_5.01152,403,946 - 152,404,182UniSTSRnor5.0
RGSC_v3.4X160,029,302 - 160,029,538UniSTSRGSC3.4
Celera1136,055,934 - 136,056,170UniSTS
Cytogenetic MapXq37UniSTS
Mecp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,790,522 - 151,790,830 (-)MAPPERmRatBN7.2
Rnor_6.0X156,704,160 - 156,704,467NCBIRnor6.0
Rnor_5.01152,451,994 - 152,452,301UniSTSRnor5.0
RGSC_v3.4X159,981,182 - 159,981,489UniSTSRGSC3.4
Celera1136,104,214 - 136,104,521UniSTS
Cytogenetic MapXq37UniSTS


Genetic Models
This gene Mecp2 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 19 4 19 4 1 1 74 25 34 11 1
Low 2 17 38 37 37 7 10 10 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085723   ⟹   ENSRNOP00000069913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,789,940 - 151,839,036 (-)Ensembl
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106335   ⟹   ENSRNOP00000094658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118226   ⟹   ENSRNOP00000088700
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,789,930 - 151,792,256 (-)Ensembl
RefSeq Acc Id: NM_022673   ⟹   NP_073164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,789,940 - 151,844,604 (-)NCBI
Rnor_6.0X156,650,389 - 156,705,050 (+)NCBI
Rnor_5.01152,390,961 - 152,461,647 (+)NCBI
RGSC_v3.4X159,980,599 - 160,035,260 (-)RGD
Celera1136,055,782 - 136,105,104 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229567   ⟹   XP_006229629
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,781,177 - 151,844,414 (-)NCBI
Rnor_6.0X156,655,516 - 156,713,813 (+)NCBI
Rnor_5.01152,390,961 - 152,461,647 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601935   ⟹   XP_017457424
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,781,177 - 151,844,413 (-)NCBI
Rnor_6.0X156,655,516 - 156,713,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099534   ⟹   XP_038955462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_073164   ⟸   NM_022673
- UniProtKB: Q00566 (UniProtKB/Swiss-Prot),   A0A0G2JWK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229629   ⟸   XM_006229567
- Peptide Label: isoform X2
- UniProtKB: Q00566 (UniProtKB/Swiss-Prot),   A0A0G2JWK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457424   ⟸   XM_017601935
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000069913   ⟸   ENSRNOT00000085723
RefSeq Acc Id: XP_038955462   ⟸   XM_039099534
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000094658   ⟸   ENSRNOT00000106335
RefSeq Acc Id: ENSRNOP00000088700   ⟸   ENSRNOT00000118226
Protein Domains
MBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00566-F1-model_v2 AlphaFold Q00566 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3075 AgrOrtholog
BioCyc Gene G2FUF-644 BioCyc
Ensembl Genes ENSRNOG00000056659 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069913 ENTREZGENE
  ENSRNOP00000069913.1 UniProtKB/TrEMBL
  ENSRNOP00000088700.1 UniProtKB/TrEMBL
  ENSRNOP00000094658 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085723 ENTREZGENE
  ENSRNOT00000085723.2 UniProtKB/TrEMBL
  ENSRNOT00000106335 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000118226.1 UniProtKB/TrEMBL
InterPro DNA-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Me_CpG-bd_MeCP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MeCP2/MBD4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29386 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29386 ENTREZGENE
PANTHER PTHR15074 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mecp2 PhenoGen
PIRSF Methyl_CpG_bd_MeCP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABA1_RAT UniProtKB/TrEMBL
  MECP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q09GN5_RAT UniProtKB/TrEMBL
UniProt Secondary Q09HV7 UniProtKB/Swiss-Prot
  Q09HV8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mecp2  methyl CpG binding protein 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript 3"-UTR is alternatively polyadenylated 69888