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Gene: Irf1 (interferon regulatory factor 1) Rattus norvegicus
Symbol: Irf1
Name: interferon regulatory factor 1
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and response to peptide hormone. Localizes to the nucleus. Used to study endometrial adenocarcinoma. Biomarker of allergic conjunctivitis; lung disease; respiratory syncytial virus infectious disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human IRF1 (interferon regulatory factor 1); PARTICIPATES IN Jak-Stat signaling pathway; nuclear factor kappa B signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: IRF-1
Homo sapiens (human) : IRF1 (interferon regulatory factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Irf1 (interferon regulatory factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf1 (interferon regulatory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF1 (interferon regulatory factor 1)
Canis lupus familiaris (dog) : IRF1 (interferon regulatory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf1 (interferon regulatory factor 1)
Sus scrofa (pig) : IRF1 (interferon regulatory factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01039,109,530 - 39,116,532 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01038,891,468 - 38,898,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,220,600 - 39,227,602 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,229,846 - 39,236,848 (+)NCBI
Celera1037,260,559 - 37,267,561 (+)NCBICelera
Cytogenetic Map10q22NCBI
RH 3.4 Map10405.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Irf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2920
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.