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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2920
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irf1
Name: interferon regulatory factor 1
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irf1multiple interactionsISOIRF1 (Homo sapiens)6480464CTDDactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of IRF1 mRNA]PMID:16085646 PMID:16636311
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