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Gene: Irf1 (interferon regulatory factor 1) Mus musculus
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Symbol: Irf1
Name: interferon regulatory factor 1
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; regulation of T cell activation; and regulation of gene expression. Localizes to cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human IRF1 (interferon regulatory factor 1); PARTICIPATES IN interleukin-6 signaling pathway; Jak-Stat signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-alpha-viniferin; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU020929; Irf-1
Orthologs:
Homo sapiens (human) : IRF1 (interferon regulatory factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irf1 (interferon regulatory factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf1 (interferon regulatory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF1 (interferon regulatory factor 1)
Canis lupus familiaris (dog) : IRF1 (interferon regulatory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf1 (interferon regulatory factor 1)
Sus scrofa (pig) : IRF1 (interferon regulatory factor 1)
Chlorocebus sabaeus (African green monkey) : IRF1 (interferon regulatory factor 1)
Heterocephalus glaber (naked mole-rat) : Irf1 (interferon regulatory factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1153,770,014 - 53,778,374 (+)EnsemblGRCm38mm10GRCm38
GRCm381153,770,014 - 53,778,374 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371153,583,516 - 53,591,876 (+)NCBIGRCm37mm9NCBIm37
MGSCv361153,613,501 - 53,620,746 (+)NCBImm8
Celera1158,349,840 - 58,358,199 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Irf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10815
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.