RGD Reference Report - Genetic basis for adverse events after smallpox vaccination. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Genetic basis for adverse events after smallpox vaccination.

Authors: Reif, David M  McKinney, Brett A  Motsinger, Alison A  Chanock, Stephen J  Edwards, Kathryn M  Rock, Michael T  Moore, Jason H  Crowe, James E 
Citation: Reif DM, etal., J Infect Dis. 2008 Jul 1;198(1):16-22. doi: 10.1086/588670.
RGD ID: 42722608
Pubmed: PMID:18454680   (View Abstract at PubMed)
PMCID: PMC2746083   (View Article at PubMed Central)
DOI: DOI:10.1086/588670   (Journal Full-text)

Identifying genetic factors associated with the development of adverse events might allow screening before vaccinia virus administration. Two independent clinical trials of the smallpox vaccine (Aventis Pasteur) were conducted in healthy, vaccinia virus-naive adult volunteers. Volunteers were assessed repeatedly for local and systemic adverse events (AEs) associated with the receipt of vaccine and underwent genotyping for 1,442 singlenucleotide polymorphisms (SNPs). In the first study, 36 SNPs in 26 genes were associated with systemic AEs (P




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IRF1Humansmallpox treatmentIAGP DNA:SNPs,haplotype: :rs839, rs9282763(human)RGD 
Irf1Ratsmallpox treatmentISORGD:735989DNA:SNPs,haplotype: :rs839, rs9282763(human)RGD 
Irf1Mousesmallpox treatmentISORGD:735989DNA:SNPs,haplotype: :rs839, rs9282763(human)RGD 
MTHFRHumansmallpox treatmentIAGP DNA:SNP:exon:rs1801133(human)RGD 
MthfrRatsmallpox treatmentISORGD:733483DNA:SNP:exon:rs1801133(human)RGD 
MthfrMousesmallpox treatmentISORGD:733483DNA:SNP:exon:rs1801133(human)RGD 


Genes (Rattus norvegicus)
Irf1  (interferon regulatory factor 1) Mthfr  (methylenetetrahydrofolate reductase)

Genes (Mus musculus)
Irf1  (interferon regulatory factor 1) Mthfr  (methylenetetrahydrofolate reductase)

Genes (Homo sapiens)
IRF1  (interferon regulatory factor 1) MTHFR  (methylenetetrahydrofolate reductase)