Mthfr (methylenetetrahydrofolate reductase) - Rat Genome Database

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Gene: Mthfr (methylenetetrahydrofolate reductase) Mus musculus
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Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
RGD ID: 1551392
MGI Page MGI
Description: Exhibits methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in methionine biosynthetic process. Predicted to localize to cytosol and synapse. Is expressed in several structures, including central nervous system; cranium; heart; sensory organ; and testis. Used to study neural tube defect. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase); PARTICIPATES IN altered folate cycle metabolic pathway; altered folate mediated one-carbon metabolic pathway; folate cycle metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5,10-methylenetetrahydrofolate reductase; AI323986
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Mthfr-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,123,534 - 148,144,019 (+)NCBIGRCm39mm39
GRCm39 Ensembl4148,123,534 - 148,144,008 (+)Ensembl
GRCm384148,039,077 - 148,059,562 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,039,077 - 148,059,551 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,413,186 - 147,433,671 (+)NCBIGRCm37mm9NCBIm37
MGSCv364146,885,022 - 146,903,349 (+)NCBImm8
Celera4150,305,674 - 150,326,065 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic disease  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anemia  (ISO)
angle-closure glaucoma  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
aphthous stomatitis  (ISO)
Arsenic Poisoning  (ISO)
Arterial Occlusive Diseases  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Banti's Syndrome  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Budd-Chiari syndrome  (ISO)
cardia cancer  (ISO)
cardiovascular system disease  (ISO)
carotid stenosis  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
clubfoot  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
Conotruncal Cardiac Defects  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Crohn's disease  (ISO)
Cytomegalovirus Infections  (IMP,ISO)
Developmental Disabilities  (ISO)
dextro-looped transposition of the great arteries  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
Down syndrome  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
eye disease  (ISO)
factor VIII deficiency  (ISO)
Familial Atrial Fibrillation 6  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Female Infertility  (ISO)
Folate-Sensitive Neural Tube Defects  (ISO)
follicular lymphoma  (ISO)
Gastrointestinal Diseases  (ISO)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Graves' disease  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hematopoietic system disease  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
homocystinuria  (ISO,ISS)
hyperhomocysteinemia  (ISO)
hyperthyroidism  (ISO)
hypopituitarism  (ISO)
hypothyroidism  (ISO)
inflammatory bowel disease  (ISO)
Inherited Blood Coagulation Disease  (ISO)
intellectual disability  (ISO)
intracranial sinus thrombosis  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
leukopenia  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Lung Neoplasms  (ISO)
lung small cell carcinoma  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
Malnutrition  (ISO)
Maxillofacial Abnormalities  (ISO)
Meniere's disease  (ISO)
mental depression  (ISO)
Methylenetetrahydrofolate Reductase Deficiency  (ISO)
Microsatellite Instability  (ISO)
Microvascular Angina  (ISO)
migraine  (ISO)
migraine with aura  (ISO)
mitral valve disease  (ISO)
Mthfr Deficiency, Thermolabile Type  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nephrosclerosis  (ISO)
nervous system disease  (ISO)
neural tube defect  (IEA,ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
non-Hodgkin lymphoma  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
peripheral artery disease  (ISO)
portal vein thrombosis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary embolism  (ISO)
rectal benign neoplasm  (ISO)
renal artery disease  (ISO)
renal cell carcinoma  (ISO)
retinal disease  (IMP)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sickle cell anemia  (ISO)
skin disease  (ISO)
smallpox  (ISO)
spina bifida  (ISO)
spinal cord disease  (ISO)
sporadic breast cancer  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
tetralogy of Fallot  (ISO)
thrombocytopenia  (ISO)
thrombophilia  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
thyrotoxicosis  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Calcification  (ISO)
vascular disease  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
3-chloropropane-1,2-diol  (ISO)
5,10-methylenetetrahydrofolic acid  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methyltetrahydrofolic acid  (ISO)
7-Hydroxymethotrexate  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
ancitabine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
bifenthrin  (EXP)
bisphenol A  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
dibenz[a,h]anthracene  (EXP)
epoxiconazole  (ISO)
floxuridine  (ISO)
folic acid  (EXP,ISO)
gold atom  (EXP)
gold(0)  (EXP)
GW 4064  (EXP)
homocysteine  (EXP,ISO)
indole-3-methanol  (ISO)
L-methionine  (EXP)
maneb  (EXP)
methotrexate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
olanzapine  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
pentanal  (ISO)
pirinixic acid  (EXP)
raloxifene  (ISO)
riboflavin  (ISO)
ritodrine  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (EXP)
tributylstannane  (EXP)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vigabatrin  (EXP)

References

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Additional References at PubMed
PMID:8875901   PMID:9173930   PMID:9188671   PMID:9205124   PMID:9570950   PMID:9680386   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11080594   PMID:11181567  
PMID:11217851   PMID:12370778   PMID:12477932   PMID:12520002   PMID:12551843   PMID:12829522   PMID:14577615   PMID:14610273   PMID:14630804   PMID:14637162   PMID:14681479   PMID:15097236  
PMID:15217352   PMID:15514261   PMID:15548731   PMID:15782199   PMID:15979267   PMID:16141072   PMID:16141073   PMID:16274753   PMID:16397891   PMID:16602821   PMID:16772436   PMID:17079455  
PMID:17349292   PMID:17689540   PMID:17937387   PMID:18065414   PMID:18356316   PMID:18615588   PMID:18799693   PMID:19176749   PMID:19204075   PMID:19215022   PMID:19560954   PMID:20444942  
PMID:20638879   PMID:20813139   PMID:21169404   PMID:21193302   PMID:21490592   PMID:21677750   PMID:21697299   PMID:21769670   PMID:21821099   PMID:21873635   PMID:22259189   PMID:22365888  
PMID:22521626   PMID:23449672   PMID:23896051   PMID:24048573   PMID:24169962   PMID:24384392   PMID:25188266   PMID:25202269   PMID:25733650   PMID:25766590   PMID:25956258   PMID:26166573  
PMID:26235956   PMID:26646559   PMID:26937386   PMID:27183385   PMID:28069796   PMID:28087280   PMID:28384716   PMID:28396257   PMID:29141214   PMID:29329322   PMID:29360980   PMID:30055159  
PMID:30288696   PMID:30345292   PMID:30552741   PMID:30768359   PMID:31026769   PMID:31133774   PMID:31361376   PMID:31525435   PMID:31794432  


Genomics

Comparative Map Data
Mthfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,123,534 - 148,144,019 (+)NCBIGRCm39mm39
GRCm39 Ensembl4148,123,534 - 148,144,008 (+)Ensembl
GRCm384148,039,077 - 148,059,562 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,039,077 - 148,059,551 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,413,186 - 147,433,671 (+)NCBIGRCm37mm9NCBIm37
MGSCv364146,885,022 - 146,903,349 (+)NCBImm8
Celera4150,305,674 - 150,326,065 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.67NCBI
MTHFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,785,723 - 11,806,455 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,785,723 - 11,806,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,845,780 - 11,866,021 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,768,374 - 11,788,702 (-)NCBINCBI36hg18NCBI36
Build 34111,780,944 - 11,800,248NCBI
Celera110,959,433 - 10,979,782 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,000,872 - 11,021,217 (-)NCBIHuRef
CHM1_1111,833,709 - 11,854,054 (-)NCBICHM1_1
Mthfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,465,248 - 158,484,999 (+)NCBI
Rnor_6.0 Ensembl5164,845,925 - 164,860,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05164,844,642 - 164,864,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,502,556 - 168,522,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,112,850 - 165,126,885 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,123,406 - 165,137,073 (+)NCBI
Celera5156,747,024 - 156,766,742 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mthfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,096,379 - 2,112,240 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,096,379 - 2,112,240 (+)NCBIChiLan1.0ChiLan1.0
MTHFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,766,334 - 11,785,645 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,766,334 - 11,785,419 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0110,548,196 - 10,568,174 (-)NCBIMhudiblu_PPA_v0panPan3
MTHFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,445,526 - 84,457,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,380,919 - 84,536,818 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,977,302 - 80,990,296 (+)NCBI
ROS_Cfam_1.0285,109,058 - 85,123,378 (+)NCBI
UMICH_Zoey_3.1281,858,180 - 81,870,539 (+)NCBI
UNSW_CanFamBas_1.0282,857,476 - 82,872,293 (+)NCBI
UU_Cfam_GSD_1.0283,920,334 - 83,933,329 (+)NCBI
Mthfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,798,656 - 34,813,131 (-)NCBI
SpeTri2.0NW_004936474623,438 - 637,849 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,863,636 - 71,881,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,863,637 - 71,882,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,776,804 - 65,791,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,987,667 - 120,003,611 (+)NCBI
ChlSab1.1 Ensembl20119,990,133 - 120,002,950 (+)Ensembl
Vero_WHO_p1.0NW_02366605423,855,633 - 23,871,475 (+)NCBI
Mthfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,184,736 - 1,202,708 (+)NCBI

Position Markers
AI323986  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,059,172 - 148,059,302UniSTSGRCm38
MGSCv374147,433,281 - 147,433,411UniSTSGRCm37
Celera4150,325,675 - 150,325,805UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.4UniSTS
Whitehead/MRC_RH41918.76UniSTS
Mthfr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,053,649 - 148,055,035UniSTSGRCm38
MGSCv374147,427,758 - 147,429,144UniSTSGRCm37
Celera4150,320,186 - 150,321,538UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137890537151570093Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137946694150592401Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144973265148822969Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4167
Count of miRNA genes:783
Interacting mature miRNAs:1058
Transcripts:ENSMUST00000069604, ENSMUST00000097788, ENSMUST00000125978, ENSMUST00000141283, ENSMUST00000145115, ENSMUST00000152498, ENSMUST00000156113
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001161798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF398931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF398934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF404270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF404271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF404272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF404273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF404274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB726553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000069604   ⟹   ENSMUSP00000069774
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,041,191 - 148,059,551 (+)Ensembl
RefSeq Acc Id: ENSMUST00000097788   ⟹   ENSMUSP00000095395
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,039,077 - 148,056,206 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125978
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,041,602 - 148,043,956 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141283   ⟹   ENSMUSP00000116239
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,039,159 - 148,044,554 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,040,810 - 148,043,448 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152498   ⟹   ENSMUSP00000117095
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,041,287 - 148,059,551 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156113   ⟹   ENSMUSP00000116840
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4148,052,678 - 148,059,548 (+)Ensembl
RefSeq Acc Id: NM_001161798   ⟹   NP_001155270
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,125,646 - 148,144,019 (+)NCBI
GRCm384148,041,189 - 148,059,562 (+)NCBI
MGSCv374147,413,186 - 147,433,671 (+)RGD
Celera4150,305,674 - 150,326,065 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010840   ⟹   NP_034970
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,123,534 - 148,144,019 (+)NCBI
GRCm384148,039,077 - 148,059,562 (+)NCBI
MGSCv374147,413,186 - 147,433,671 (+)RGD
Celera4150,305,674 - 150,326,065 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027809
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,125,646 - 148,144,019 (+)NCBI
GRCm384148,041,189 - 148,059,562 (+)NCBI
MGSCv374147,413,186 - 147,433,671 (+)RGD
Celera4150,305,674 - 150,326,065 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034970   ⟸   NM_010840
- Peptide Label: isoform b
- UniProtKB: Q9WU20 (UniProtKB/Swiss-Prot),   Q497H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001155270   ⟸   NM_001161798
- Peptide Label: isoform a
- UniProtKB: A2A7F7 (UniProtKB/TrEMBL),   Q3UDB2 (UniProtKB/TrEMBL),   Q497H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117095   ⟸   ENSMUST00000152498
RefSeq Acc Id: ENSMUSP00000069774   ⟸   ENSMUST00000069604
RefSeq Acc Id: ENSMUSP00000095395   ⟸   ENSMUST00000097788
RefSeq Acc Id: ENSMUSP00000116840   ⟸   ENSMUST00000156113
RefSeq Acc Id: ENSMUSP00000116239   ⟸   ENSMUST00000141283

Promoters
RGD ID:6835715
Promoter ID:MM_KWN:40796
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000030879,   ENSMUST00000094479,   NM_010840,   OTTMUST00000023687,   OTTMUST00000023694,   OTTMUST00000023695,   OTTMUST00000023696,   OTTMUST00000023697,   UC008VTV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,411,806 - 147,413,957 (+)MPROMDB
RGD ID:6835709
Promoter ID:MM_KWN:40797
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001161798,   NR_027809,   OTTMUST00000023692,   UC008VTY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,414,361 - 147,415,452 (+)MPROMDB
RGD ID:6835712
Promoter ID:MM_KWN:40798
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000023689
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,425,851 - 147,426,657 (+)MPROMDB
RGD ID:6885492
Promoter ID:EPDNEW_M6197
Type:initiation region
Name:Mthfr_2
Description:Mus musculus methylenetetrahydrofolate reductase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6198  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,039,169 - 148,039,229EPDNEW
RGD ID:6885494
Promoter ID:EPDNEW_M6198
Type:multiple initiation site
Name:Mthfr_1
Description:Mus musculus methylenetetrahydrofolate reductase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6197  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,041,189 - 148,041,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106639 AgrOrtholog
Ensembl Genes ENSMUSG00000029009 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069774 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000095395 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116239 UniProtKB/TrEMBL
  ENSMUSP00000116840 UniProtKB/TrEMBL
  ENSMUSP00000117095 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069604 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000097788 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000141283 UniProtKB/TrEMBL
  ENSMUST00000152498 UniProtKB/TrEMBL
  ENSMUST00000156113 UniProtKB/TrEMBL
InterPro FAD-linked_oxidoreductase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fadh2_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mehydrof_redctse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:106639 ENTREZGENE
NCBI Gene 17769 ENTREZGENE
Pfam MTHFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MTHFR RGD
PhenoGen Mthfr PhenoGen
Superfamily-SCOP SSF51730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs fadh2_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A7F7 ENTREZGENE, UniProtKB/TrEMBL
  A2A7F9_MOUSE UniProtKB/TrEMBL
  F6Z4F8_MOUSE UniProtKB/TrEMBL
  F7BGN3_MOUSE UniProtKB/TrEMBL
  MTHR_MOUSE UniProtKB/Swiss-Prot
  Q3UDB2 ENTREZGENE, UniProtKB/TrEMBL
  Q3V399_MOUSE UniProtKB/TrEMBL
  Q497H7 ENTREZGENE, UniProtKB/TrEMBL
  Q8BHN2_MOUSE UniProtKB/TrEMBL
  Q8CJA5_MOUSE UniProtKB/TrEMBL
  Q8CJA6_MOUSE UniProtKB/TrEMBL
  Q8CJA7_MOUSE UniProtKB/TrEMBL
  Q8CJA8_MOUSE UniProtKB/TrEMBL
  Q8CJA9_MOUSE UniProtKB/TrEMBL
  Q9WU20 ENTREZGENE
UniProt Secondary Q8CDE4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-12 Mthfr  methylenetetrahydrofolate reductase    5,10-methylenetetrahydrofolate reductase  Symbol and/or name change 5135510 APPROVED