RGD Reference Report - Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection. - Rat Genome Database

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Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection.

Authors: Saberi, Samaneh  Zendehdel, Kazem  Jahangiri, Sahar  Talebkhan, Yeganeh  Abdirad, Afshin  Mohajerani, Nazanin  Bababeik, Maryam  Karami, Najmeh  Esmaili, Maryam  Oghalaie, Akbar  Hassanpour, Parisa  Amini, Neda  Mohagheghi, Mohammad Ali  Eshagh Hossieni, Mahmoud  Mohammadi, Marjan 
Citation: Saberi S, etal., Iran Biomed J. 2012;16(4):179-84. doi: 10.6091/ibj.1102.2012.
RGD ID: 38501056
Pubmed: PMID:23183616   (View Abstract at PubMed)
PMCID: PMC3600959   (View Article at PubMed Central)
DOI: DOI:10.6091/ibj.1102.2012   (Journal Full-text)


BACKGROUND: Attempts for early detection of gastric cancer have recently focused on host's genetic susceptibility factors and gene-environment interactions. We have, herein, studied the association of MTHFR C677T single nucleotide polymorphism (SNP) and its interaction with Helicobacter pylori infection, smoking, age and gender on the risk of gastric cancer among an Iranian population.
METHODS: Gastric cancer patients (n = 450) and cancer-free controls (n = 780) were studied for serum H. pylori-specific IgG antibodies by ELISA and MTHFR C677T polymorphism (SNP) by PCR-RFLP. Demographic and life style data were collected through patient interviews. Unconditional logistic regression model estimated odds ratio (OR) and the corresponding 95% confidence intervals (CI).
RESULTS: The interactions of MTHFR genotype with H. pylori infection (P = 0.03), age (P = 0.049) and gender (P = 0.007) were statistically significant. Accordingly, MTHFR C677T carriers who were also positive for H. pylori infection exhibited 80% (OR = 1.8, 95% CI = 1.0-2.9) significant excess risk of non-cardia gastric cancer. Furthermore, subjects over the age of 50 or female subjects carrying MTHFR C677T SNP showed 40 (OR = 1.4, 95% CI = 1.0-2.0) and 100 (OR = 2.0, 95% CI = 1.2-3.2) percent increased risk of gastric cancer, respectively.
CONCLUSION: MTHFR C677T SNP seems to increase the risk of gastric cancer and the effect is significantly inflated by interactions with H. pylori infection, age and gender.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Helicobacter Infections susceptibilityIAGP 38501056associated with stomach cancer and DNA:missense mutation:cds:g.677C>T (human)RGD 
Helicobacter Infections susceptibilityISOMTHFR (Homo sapiens)38501056; 38501056associated with stomach cancer and DNA:missense mutation:cds:g.677C>T (human)RGD 
stomach cancer no_associationIAGP 38501056DNA:missense mutation:cds:g.677C>T (human)RGD 
stomach cancer no_associationISOMTHFR (Homo sapiens)38501056; 38501056DNA:missense mutation:cds:g.677C>T (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mthfr  (methylenetetrahydrofolate reductase)

Genes (Mus musculus)
Mthfr  (methylenetetrahydrofolate reductase)

Genes (Homo sapiens)
MTHFR  (methylenetetrahydrofolate reductase)


Additional Information