RGD Reference Report - Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients. - Rat Genome Database

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Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients.

Authors: Laing, ME  Dicker, P  Moloney, FJ  Ho, WL  Murphy, GM  Conlon, P  Whitehead, AS  Shields, DC 
Citation: Laing ME, etal., Transplantation. 2007 Jul 15;84(1):113-6.
RGD ID: 6893580
Pubmed: PMID:17627246   (View Abstract at PubMed)
DOI: DOI:10.1097/01.tp.0000266069.41882.28   (Journal Full-text)

The relative risk of developing cutaneous squamous cell carcinoma (SCC) is significantly increased after organ transplantation. We investigated the genetic association of SCC in two pathways associated with cancer risks, with the potential for modification by vitamin supplementation. A total of 367 renal transplant recipients (117 with SCC and 250 without any skin cancer) were genotyped for key polymorphisms in the folate pathway (methylene tetrahydrofolate reductase; MTHFR:C677T), and the vitamin D pathway (vitamin D receptor: Intron8G/T;). Individuals carrying the MTHFR 677T allele had a marked increase in risk of SCC (adjusted odds ratio=2.54, P=0.002, after adjustment for age, ender, skin type, sun exposure score, and immunosuppression duration; lower 95% confidence boundary odds ratio of 1.41). In contrast, vitamin D receptor polymorphisms were not significantly associated. Folate-sensitive pathways may play a critical role in the elevated rate of SCC in renal transplant recipients.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MTHFRHumansquamous cell carcinoma susceptibilityIAGP DNA:transition:cds:g.677C>T (human)RGD 
MthfrRatsquamous cell carcinoma susceptibilityISOMTHFR (Homo sapiens)DNA:transition:cds:g.677C>T (human)RGD 
MthfrMousesquamous cell carcinoma susceptibilityISOMTHFR (Homo sapiens)DNA:transition:cds:g.677C>T (human)RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MTHFRHumanAbnormal skin morphology susceptibilityIAGP DNA:transition:cds:g.677C>TRGD 

Genes (Rattus norvegicus)
Mthfr  (methylenetetrahydrofolate reductase)

Genes (Mus musculus)
Mthfr  (methylenetetrahydrofolate reductase)

Genes (Homo sapiens)
MTHFR  (methylenetetrahydrofolate reductase)