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Gene: Mthfr (methylenetetrahydrofolate reductase) Rattus norvegicus
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
RGD ID: 1309952
Description: Exhibits NADP binding activity; flavin adenine dinucleotide binding activity; and methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in several processes, including carboxylic acid metabolic process; response to interleukin-1; and response to vitamin. Localizes to cytosol and synapse. Biomarker of hyperthyroidism; hypothyroidism; and liver benign neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase); PARTICIPATES IN altered folate cycle metabolic pathway; altered folate mediated one-carbon metabolic pathway; folate cycle metabolic pathway; INTERACTS WITH 2-acetamidofluorene; 3-chloropropane-1,2-diol; ammonium chloride.
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5,10-methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase (NADPH); LOC362657; methylenetetrahydrofolate reductase (NAD(P)H)
Homo sapiens (human) : MTHFR (methylenetetrahydrofolate reductase)  HGNC  Alliance
Mus musculus (house mouse) : Mthfr (methylenetetrahydrofolate reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mthfr (methylenetetrahydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTHFR (methylenetetrahydrofolate reductase)
Canis lupus familiaris (dog) : MTHFR (methylenetetrahydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mthfr (methylenetetrahydrofolate reductase)
Sus scrofa (pig) : MTHFR (methylenetetrahydrofolate reductase)
Chlorocebus sabaeus (African green monkey) : MTHFR (methylenetetrahydrofolate reductase)
Heterocephalus glaber (naked mole-rat) : Mthfr (methylenetetrahydrofolate reductase)
more info ...
Allele / Splice: Mthfrem1Mcwi  
Genetic Models: SS-Mthfrem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,844,642 - 164,864,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,845,925 - 164,860,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,502,556 - 168,522,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,112,850 - 165,126,885 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,123,406 - 165,137,073 (+)NCBI
Celera5156,747,024 - 156,766,742 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mthfr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309952
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.