MTHFR (methylenetetrahydrofolate reductase) - Rat Genome Database

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Gene: MTHFR (methylenetetrahydrofolate reductase) Sus scrofa
Analyze
Symbol: MTHFR
Name: methylenetetrahydrofolate reductase
RGD ID: 14257034
Description: ENCODES a protein that exhibits flavin adenine dinucleotide binding (ortholog); methylenetetrahydrofolate reductase (NAD(P)H) activity (ortholog); NADP binding (ortholog); INVOLVED IN heterochromatin organization (ortholog); homocysteine metabolic process (ortholog); methionine biosynthetic process (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; altered folate mediated one-carbon metabolic pathway; folate cycle metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH choline; cyanocob(III)alamin; deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5,10-methylenetetrahydrofolate reductase (NADPH)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,863,637 - 71,881,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,863,637 - 71,882,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,776,804 - 65,791,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic disease  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anemia  (ISO)
angle-closure glaucoma  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
aphthous stomatitis  (ISO)
Arsenic Poisoning  (ISO)
Arterial Occlusive Diseases  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Banti's Syndrome  (ISO)
bipolar disorder  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Budd-Chiari syndrome  (ISO)
cardia cancer  (ISO)
cardiovascular system disease  (ISO)
carotid stenosis  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
cervix uteri carcinoma in situ  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
clubfoot  (ISO)
Cognitive Dysfunction  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
Conotruncal Cardiac Defects  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Crohn's disease  (ISO)
Cytomegalovirus Infections  (ISO)
depressive disorder  (ISO)
Developmental Disabilities  (ISO)
dextro-looped transposition of the great arteries  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
Down syndrome  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Diabetes Mellitus  (ISO)
eye disease  (ISO)
factor VIII deficiency  (ISO)
Familial Atrial Fibrillation 6  (ISO)
familial Mediterranean fever  (ISO)
Female Infertility  (ISO)
Folate-Sensitive Neural Tube Defects  (ISO)
follicular lymphoma  (ISO)
gastrointestinal stromal tumor  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
Helicobacter Infections  (ISO)
Hematologic Neoplasms  (ISO)
hematopoietic system disease  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
hyperhomocysteinemia  (ISO)
hyperthyroidism  (ISO)
hypopituitarism  (ISO)
hypothyroidism  (ISO)
inflammatory bowel disease  (ISO)
Inherited Blood Coagulation Disease  (ISO)
intellectual disability  (ISO)
intracranial sinus thrombosis  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
leukopenia  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Lung Neoplasms  (ISO)
lung small cell carcinoma  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
Malnutrition  (ISO)
Maxillofacial Abnormalities  (ISO)
Meniere's disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Methylenetetrahydrofolate Reductase Deficiency  (ISO)
Microsatellite Instability  (ISO)
Microvascular Angina  (ISO)
migraine  (ISO)
migraine with aura  (ISO)
mitral valve disease  (ISO)
Mthfr Deficiency, Thermolabile Type  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
nephrosclerosis  (ISO)
nervous system disease  (ISO)
neural tube defect  (ISO)
neutropenia  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
non-Hodgkin lymphoma  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
osteonecrosis  (ISO)
osteosarcoma  (ISO)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
Parkinson's disease  (ISO)
peripheral artery disease  (ISO)
portal vein thrombosis  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary embolism  (ISO)
rectal benign neoplasm  (ISO)
renal artery disease  (ISO)
renal cell carcinoma  (ISO)
retinal disease  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sickle cell anemia  (ISO)
skin disease  (ISO)
smallpox  (ISO)
spina bifida  (ISO)
spinal cord disease  (ISO)
sporadic breast cancer  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
tetralogy of Fallot  (ISO)
thrombocytopenia  (ISO)
thrombophilia  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (ISO)
Thrombotic Microangiopathies  (ISO)
thyrotoxicosis  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Vascular Calcification  (ISO)
vascular dementia  (ISO)
vascular disease  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

References
Additional References at PubMed
PMID:12297544   PMID:12370778   PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MTHFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,863,637 - 71,881,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,863,637 - 71,882,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,776,804 - 65,791,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,785,723 - 11,805,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,785,723 - 11,806,455 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,845,780 - 11,866,021 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,768,374 - 11,788,702 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,780,944 - 11,800,248NCBI
Celera110,959,433 - 10,979,782 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,000,872 - 11,021,217 (-)NCBIHuRef
CHM1_1111,833,709 - 11,854,054 (-)NCBICHM1_1
T2T-CHM13v2.0111,329,802 - 11,350,048 (-)NCBIT2T-CHM13v2.0
Mthfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,123,534 - 148,144,019 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,123,534 - 148,144,008 (+)EnsemblGRCm39 Ensembl
GRCm384148,039,077 - 148,059,562 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,039,077 - 148,059,551 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,413,186 - 147,433,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,885,022 - 146,903,349 (+)NCBIMGSCv36mm8
Celera4150,305,674 - 150,326,065 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.67NCBI
Mthfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,748,346 - 163,768,141 (+)NCBIGRCr8
mRatBN7.25158,465,248 - 158,484,999 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,465,296 - 158,483,797 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05164,844,642 - 164,864,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,845,925 - 164,860,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,502,556 - 168,522,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,112,850 - 165,126,885 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,123,406 - 165,137,073 (+)NCBI
Celera5156,747,024 - 156,766,742 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mthfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,096,379 - 2,112,240 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,096,379 - 2,112,240 (+)NCBIChiLan1.0ChiLan1.0
MTHFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,418,108 - 216,434,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,063,577 - 215,079,672 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,548,196 - 10,568,174 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,766,334 - 11,785,645 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,766,334 - 11,785,419 (-)Ensemblpanpan1.1panPan2
MTHFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,445,526 - 84,457,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,380,919 - 84,536,818 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,977,302 - 80,990,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,109,058 - 85,123,378 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,109,070 - 85,122,016 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,858,180 - 81,870,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,857,476 - 82,872,293 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,920,334 - 83,933,329 (+)NCBIUU_Cfam_GSD_1.0
Mthfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,798,656 - 34,813,131 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474623,291 - 638,193 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474623,438 - 637,849 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,987,667 - 120,003,611 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,990,133 - 120,002,950 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,855,633 - 23,871,475 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,187,869 - 1,199,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,184,736 - 1,202,708 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MTHFR
590 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003127574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003127575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005664995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005664996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002344905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF398932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK231743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK349221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU695168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU855519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GACC01000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01033826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM187757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000037878   ⟹   ENSSSCP00000047921
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl671,864,740 - 71,881,820 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000042716   ⟹   ENSSSCP00000051768
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl671,863,637 - 71,879,544 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000060759   ⟹   ENSSSCP00000032858
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl671,864,737 - 71,881,536 (-)Ensembl
RefSeq Acc Id: XM_003127574   ⟹   XP_003127622
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,882,118 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003127575   ⟹   XP_003127623
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,880,547 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005664995   ⟹   XP_005665052
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,881,854 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005664996   ⟹   XP_005665053
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,881,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021095342   ⟹   XP_020951001
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,880,550 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021095343   ⟹   XP_020951002
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,880,550 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021095344   ⟹   XP_020951003
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,881,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021095345   ⟹   XP_020951004
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,881,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021095346   ⟹   XP_020951005
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,881,761 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344905
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1671,863,637 - 71,880,553 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003127622 (Get FASTA)   NCBI Sequence Viewer  
  XP_003127623 (Get FASTA)   NCBI Sequence Viewer  
  XP_005665052 (Get FASTA)   NCBI Sequence Viewer  
  XP_005665053 (Get FASTA)   NCBI Sequence Viewer  
  XP_020951001 (Get FASTA)   NCBI Sequence Viewer  
  XP_020951002 (Get FASTA)   NCBI Sequence Viewer  
  XP_020951003 (Get FASTA)   NCBI Sequence Viewer  
  XP_020951004 (Get FASTA)   NCBI Sequence Viewer  
  XP_020951005 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF68431 (Get FASTA)   NCBI Sequence Viewer  
  AAL17644 (Get FASTA)   NCBI Sequence Viewer  
  AAL17645 (Get FASTA)   NCBI Sequence Viewer  
  AAN40870 (Get FASTA)   NCBI Sequence Viewer  
  AAN40871 (Get FASTA)   NCBI Sequence Viewer  
  ADX01258 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000032858.3
  ENSSSCP00000047921
  ENSSSCP00000047921.3
  ENSSSCP00000051768
  ENSSSCP00000051768.2
  ENSSSCP00015002279.1
  ENSSSCP00025033853.1
  ENSSSCP00030020144.1
  ENSSSCP00035007191.1
  ENSSSCP00035007193.1
  ENSSSCP00035007197.1
  ENSSSCP00035007206.1
  ENSSSCP00035007209.1
  ENSSSCP00035007212.1
  ENSSSCP00040026757.1
  ENSSSCP00045004222.1
  ENSSSCP00045004229.1
  ENSSSCP00045004241.1
  ENSSSCP00045004253.1
  ENSSSCP00045004260.1
  ENSSSCP00050016503.1
  ENSSSCP00055031077.1
  ENSSSCP00055031149.1
  ENSSSCP00055031265.1
  ENSSSCP00055031397.1
  ENSSSCP00055031468.1
  ENSSSCP00060044866.1
  ENSSSCP00065024254.1
  ENSSSCP00065024256.1
  ENSSSCP00065024267.1
  ENSSSCP00065024274.1
  ENSSSCP00065024276.1
GenBank Protein JAA53593 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_003127622   ⟸   XM_003127574
- Peptide Label: isoform X5
- UniProtKB: F1RF82 (UniProtKB/TrEMBL),   A0A8D0HXW3 (UniProtKB/TrEMBL),   A0A287AUY4 (UniProtKB/TrEMBL),   A0A8D1C5P6 (UniProtKB/TrEMBL),   A0A8D0HX37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005665052   ⟸   XM_005664995
- Peptide Label: isoform X5
- UniProtKB: F1RF82 (UniProtKB/TrEMBL),   A0A8D0HXW3 (UniProtKB/TrEMBL),   A0A287AUY4 (UniProtKB/TrEMBL),   A0A8D1C5P6 (UniProtKB/TrEMBL),   A0A8D0HX37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005665053   ⟸   XM_005664996
- Peptide Label: isoform X5
- UniProtKB: F1RF82 (UniProtKB/TrEMBL),   A0A8D0HXW3 (UniProtKB/TrEMBL),   A0A287AUY4 (UniProtKB/TrEMBL),   A0A8D1C5P6 (UniProtKB/TrEMBL),   A0A8D0HX37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951003   ⟸   XM_021095344
- Peptide Label: isoform X4
- UniProtKB: A0A8D0YSM6 (UniProtKB/TrEMBL),   A0A8D1YN60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951005   ⟸   XM_021095346
- Peptide Label: isoform X4
- UniProtKB: A0A8D0YSM6 (UniProtKB/TrEMBL),   A0A8D1YN60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951004   ⟸   XM_021095345
- Peptide Label: isoform X4
- UniProtKB: A0A8D0YSM6 (UniProtKB/TrEMBL),   A0A8D1YN60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951002   ⟸   XM_021095343
- Peptide Label: isoform X2
- UniProtKB: A0A8D1R6C5 (UniProtKB/TrEMBL),   K9IVF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951001   ⟸   XM_021095342
- Peptide Label: isoform X1
- UniProtKB: A0A8D1R6C5 (UniProtKB/TrEMBL),   K9IVF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003127623   ⟸   XM_003127575
- Peptide Label: isoform X3
- UniProtKB: A0A287B634 (UniProtKB/TrEMBL),   A0A8D1YQU9 (UniProtKB/TrEMBL),   A0A8D1R6C5 (UniProtKB/TrEMBL),   K9IVF1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000032858   ⟸   ENSSSCT00000060759
Ensembl Acc Id: ENSSSCP00000051768   ⟸   ENSSSCT00000042716
Ensembl Acc Id: ENSSSCP00000047921   ⟸   ENSSSCT00000037878
Protein Domains
MTHFR SAM-binding regulatory


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003428 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015004258 UniProtKB/TrEMBL
  ENSSSCG00025056470 UniProtKB/TrEMBL
  ENSSSCG00030032403 UniProtKB/TrEMBL
  ENSSSCG00035015740 UniProtKB/TrEMBL
  ENSSSCG00040047043 UniProtKB/TrEMBL
  ENSSSCG00045003756 UniProtKB/TrEMBL
  ENSSSCG00050029574 UniProtKB/TrEMBL
  ENSSSCG00055019907 UniProtKB/TrEMBL
  ENSSSCG00060074975 UniProtKB/TrEMBL
  ENSSSCG00065040810 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000037878 ENTREZGENE
  ENSSSCT00000037878.3 UniProtKB/TrEMBL
  ENSSSCT00000042716 ENTREZGENE
  ENSSSCT00000042716.3 UniProtKB/TrEMBL
  ENSSSCT00000060759.3 UniProtKB/TrEMBL
  ENSSSCT00015005685.1 UniProtKB/TrEMBL
  ENSSSCT00025078098.1 UniProtKB/TrEMBL
  ENSSSCT00030044832.1 UniProtKB/TrEMBL
  ENSSSCT00035020087.1 UniProtKB/TrEMBL
  ENSSSCT00035020092.1 UniProtKB/TrEMBL
  ENSSSCT00035020102.1 UniProtKB/TrEMBL
  ENSSSCT00035020114.1 UniProtKB/TrEMBL
  ENSSSCT00035020119.1 UniProtKB/TrEMBL
  ENSSSCT00035020125.1 UniProtKB/TrEMBL
  ENSSSCT00040063415.1 UniProtKB/TrEMBL
  ENSSSCT00045006232.1 UniProtKB/TrEMBL
  ENSSSCT00045006241.1 UniProtKB/TrEMBL
  ENSSSCT00045006254.1 UniProtKB/TrEMBL
  ENSSSCT00045006270.1 UniProtKB/TrEMBL
  ENSSSCT00045006280.1 UniProtKB/TrEMBL
  ENSSSCT00050039817.1 UniProtKB/TrEMBL
  ENSSSCT00055039080.1 UniProtKB/TrEMBL
  ENSSSCT00055039172.1 UniProtKB/TrEMBL
  ENSSSCT00055039310.1 UniProtKB/TrEMBL
  ENSSSCT00055039468.1 UniProtKB/TrEMBL
  ENSSSCT00055039557.1 UniProtKB/TrEMBL
  ENSSSCT00060102897.1 UniProtKB/TrEMBL
  ENSSSCT00065055798.1 UniProtKB/TrEMBL
  ENSSSCT00065055803.1 UniProtKB/TrEMBL
  ENSSSCT00065055818.1 UniProtKB/TrEMBL
  ENSSSCT00065055831.1 UniProtKB/TrEMBL
  ENSSSCT00065055837.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.220 UniProtKB/TrEMBL
InterPro FAD-linked_oxidoreductase-like UniProtKB/TrEMBL
  Fadh2_euk UniProtKB/TrEMBL
  Mehydrof_redctse UniProtKB/TrEMBL
  MTHFR_C UniProtKB/TrEMBL
KEGG Report ssc:397180 UniProtKB/TrEMBL
NCBI Gene MTHFR ENTREZGENE
PANTHER METHYLENETETRAHYDROFOLATE REDUCTASE UniProtKB/TrEMBL
  METHYLENETETRAHYDROFOLATE REDUCTASE UniProtKB/TrEMBL
Pfam MTHFR UniProtKB/TrEMBL
  MTHFR_C UniProtKB/TrEMBL
Superfamily-SCOP SSF51730 UniProtKB/TrEMBL
UniProt A0A286ZMK3_PIG UniProtKB/TrEMBL
  A0A287AUY4 ENTREZGENE
  A0A287B634 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0HX37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0HXW3 ENTREZGENE
  A0A8D0I168_PIG UniProtKB/TrEMBL
  A0A8D0YSM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YSN5_PIG UniProtKB/TrEMBL
  A0A8D1C5P6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R6C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R9C6_PIG UniProtKB/TrEMBL
  A0A8D1WU44_PIG UniProtKB/TrEMBL
  A0A8D1YN60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1YQU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1YU06_PIG UniProtKB/TrEMBL
  F1RF82 ENTREZGENE, UniProtKB/TrEMBL
  K9IVF1 ENTREZGENE, UniProtKB/TrEMBL
  Q8HX87_PIG UniProtKB/TrEMBL
  Q8HX95_PIG UniProtKB/TrEMBL
  Q9N0Y5_PIG UniProtKB/TrEMBL
  V5IV96_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287AUY4 UniProtKB/TrEMBL
  A0A8D0HXW3 UniProtKB/TrEMBL
VGNC ID VGNC:90451 ENTREZGENE