RGD Reference Report - Effect of methionine-loading on methyl group synthesis and activation in rat brain and liver. - Rat Genome Database

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Effect of methionine-loading on methyl group synthesis and activation in rat brain and liver.

Authors: Carl, GF  Benesh, FC  Hudson, JL 
Citation: Carl GF, etal., Biol Psychiatry. 1978 Dec;13(6):661-9.
RGD ID: 6893691
Pubmed: PMID:737254   (View Abstract at PubMed)

Much greater increases in S-adenosylmethionine concentrations are observed in the liver in response to methionine-loading than in the brain due to differences in the methionine adenosyltransferase activities in these tissues. Liver methione adenosyltransferase exhibits a bimodal saturation curve with a nonlinear Line-weaver-Burk plot, indicating that high methionine concentrations are required for saturation. In the brain the methionine adenosyltransferase is saturated in vitro at a methionine concentration less than the normal physiological concentration. The increased S-adenosylmethionine concentrations in the livers of methionine-treated rats also account for the observed inhibition of N5,N10-methylenetetrahydrofolate reductase activity in this tissue. No inhibition of this enzyme is observed in the brain of methionine treated animals. Nor are S-adenosylmethionine concentrations increased significantly in brain. Serine hydroxymethyltransferase activity responds to methionine-loading by decreasing in brain and increasing in liver.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MthfrRatresponse to amino acid  IEP methionineRGD 


Genes (Rattus norvegicus)
Mthfr  (methylenetetrahydrofolate reductase)