Eau7 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eau7 (Experimental allergic uveoretinitis QTL 7) Rattus norvegicus

Symbol: Eau7
Name: Experimental allergic uveoretinitis QTL 7
RGD ID: 2298480
Trait: uvea integrity trait   (VT:0010551)    
Measurement Type: experimental autoimmune uveitis score   (CMO:0001504)    
LOD Score: Not Available
P Value: 0.0049
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81035,509,383 - 80,509,383RGD_MAPPER_PIPELINE
mRatBN7.21027,957,626 - 34,490,668RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01035,669,573 - 36,185,929RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01035,428,387 - 35,954,931RGDRnor5.0
RGSC_v3.41035,713,561 - 36,254,741RGDRGSC3.4
Cross Type: intercross
Strains Crossed: F344/NHsd LEW/NHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Csf1r is a candidate Gene for Eau7
Fabp6 is a candidate Gene for Eau7
Il3 is a candidate Gene for Eau7
Il4 is a candidate Gene for Eau7
Il5 is a candidate Gene for Eau7
Il9r is a candidate Gene for Eau7
Irf1 is a candidate Gene for Eau7
Slc22a5 is a candidate Gene for Eau7
Slc22a4 is a candidate Gene for Eau7
Il12b is a candidate Gene for Eau7
Mapk9 is a candidate Gene for Eau7
Scgb3a2 is a candidate Gene for Eau7


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7RatExperimental Autoimmune Uveitis  IDA 2296064 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7Ratabnormal uvea morphology  IDA 2296064induced by peptide R16RGD 
Eau7Ratdecreased susceptibility to experimental autoimmune uveoretinitis  IDA 2296064decreased susceptibility due to F alleleRGD 
Eau7Rateye inflammation  IDA 2296064 RGD 
Eau7Ratincreased susceptibility to experimental autoimmune uveoretinitis susceptibilityIDA 2296064due to L alleleRGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7Ratexperimental autoimmune uveitis score  IDA 2296064 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7RatFreund's complete adjuvant  IDA 2296064 RGD 
Eau7RatR16 peptide of interphotoreceptor retinoid-binding protein  IDA 2296064 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7Ratex vivo light microscopy  IDA 2296064 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7RatF344/NHsd  IEA 2296064 RGD 
Eau7RatLEW/NHsd  IEA 2296064 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Eau7Ratuvea integrity trait  IDA 2296064 RGD 


#
Reference Title
Reference Citation
1. Common genetic determinants of uveitis shared with other autoimmune disorders. Mattapallil MJ, etal., J Immunol. 2008 May 15;180(10):6751-9.

Related QTL Description Reference
Pia15 maps to same region RGD:2296064
Eae3 maps to same region RGD:2296064



1 to 20 of 126 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1561041C1qtnf2C1q and TNF related 2102794194827958926Rat
11396808LOC108352074uncharacterized LOC108352074102797451527983092Rat
1561384Ccnjlcyclin J-like102799568228053428Rat
2592Fabp6fatty acid binding protein 6102806360328068276Rat
41108829Trnap-agg70transfer RNA proline (anticodon AGG) 70102809977528099855Rat
11369295LOC10835207560S ribosomal protein L34 pseudogene102810055028100901Rat
1589937Atp5if1-ps2ATP synthase inhibitory factor subunit 1, pseudogene 2102811183328112277Rat
1589910Rps2-ps35ribosomal protein S2, pseudogene 35102814493228146035Rat
1305891Pwwp2aPWWP domain containing 2A102815550928195255Rat
1359604Ttc1tetratricopeptide repeat domain 1102820232528227464Rat
2054Adra1badrenoceptor alpha 1B102825502528373418Rat
11412952LOC108352076uncharacterized LOC108352076102827573428366956Rat
7714490LOC102549660uncharacterized LOC102549660102864248628659252Rat
11485485LOC108352079uncharacterized LOC108352079102864501128668249Rat
1562355Atp6v1g1l1ATPase H+ transporting V1 subunit G1 like 1102866397428664273Rat
41019890LOC120095318uncharacterized LOC120095318102868818128689960Rat
41331781LOC120095075uncharacterized LOC120095075102875381828755862Rat
41159125Nop16-ps3NOP16 nucleolar protein, pseudogene 3102883471928835165Rat
628704Il12binterleukin 12B102888883228903802Rat
1584858Gins4-ps1GINS complex subunit 4, pseudogene 1102893193928933904Rat

1 to 20 of 126 rows
1 to 20 of 104 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
34359D10Mgh11134102929950429299638Ratregion
34677D10Mgh19108103063149230631600Ratregion
33565D10Mit9238103122402631224268Ratregion
35571D10Rat35147103167468831674835Ratregion
36067D10Rat38174103096480030964974Ratregion
37454D10Rat82192103222339032223584Ratregion
36496D10Rat37179103397392133974100Ratregion
36721D10Rat40165102898094628981111Ratregion
35040D10Rat39177102962646529626644Ratregion
38162D10Rat129210103389769133897901Ratregion
39102D10Rat71193102887565028875843Ratregion
42908D10Rat253129102930956729309696Ratregion
42910D10Rat250213103351360133513811Ratregion
41732D10Rat224145103252655932526706Ratregion
44714D10Got44135102906082629060961Ratregion
44715D10Wox26153102965946229659617Ratregion
44716D10Got50211103049313930493350Ratregion
44717D10Got45199102857817828578377Ratregion
44718D10Got47210103010782530108035Ratregion
44719D10Got51146103034131630341462Ratregion
1 to 20 of 104 rows

Flank 1: (D10Mgh10)
Rat AssemblyChrPosition (strand)Source
GRCr81035,509,383 - 35,509,521 (+)Marker Load Pipeline
Rnor_6.01036,185,929 - 36,186,066NCBI
Rnor_5.01035,954,931 - 35,955,068UniSTS
RGSC_v3.41036,254,741 - 36,254,879RGD
RGSC_v3.41036,254,742 - 36,254,879UniSTS
RGSC_v3.11036,255,791 - 36,255,928RGD
Celera1034,362,292 - 34,362,429UniSTS
RH 3.4 Map10374.6UniSTS
RH 3.4 Map10374.6RGD
RH 2.0 Map10401.0RGD
SHRSP x BN Map1034.04RGD
FHH x ACI Map1033.0199RGD
Cytogenetic Map10q22UniSTS
Peak: (D10Mit9)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21031,224,026 - 31,224,268 (+)MAPPER
Rnor_6.01031,919,397 - 31,919,634NCBI
Rnor_5.01031,740,635 - 31,740,872UniSTS
RGSC_v3.41031,931,622 - 31,931,860RGD
RGSC_v3.41031,931,623 - 31,931,860UniSTS
RGSC_v3.11031,932,672 - 31,932,909RGD
Celera1030,668,756 - 30,668,993UniSTS
RH 3.4 Map10340.71UniSTS
RH 3.4 Map10340.71RGD
RH 2.0 Map10373.7RGD
Cytogenetic Map10 RGD
Flank 2: (D10Arb3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,490,559 - 34,490,668 (+)MAPPER
Rnor_6.01035,669,465 - 35,669,573NCBI
Rnor_5.01035,428,279 - 35,428,387UniSTS
RGSC_v3.41035,713,452 - 35,713,561RGD
RGSC_v3.41035,713,453 - 35,713,561UniSTS
RGSC_v3.11035,714,501 - 35,714,610RGD
Celera1033,839,800 - 33,839,908UniSTS
Cytogenetic Map10q22UniSTS


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat

1 to 10 of 54 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general allele: decreased susceptibility observed in animals homozygous for F allele and animals homozygous for L allele showed increased susceptibility 2296064
qtl_general inducing agent: 30 micrograms of peptide R16, major uveitogenic epitope of bovine IRBP 2296064
qtl_general number of animals used: 1287 2296064
qtl_general allele: LEW allele was responsible for higher incidence of disease 2296064
qtl_general measurement method: after 16-18 days of immunization, eyes were collected and evaluated histopathologically by scoring 0-4, average score of both the eyes taken 2296064