Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Rattus norvegicus
Analyze
Symbol: Il4
Name: interleukin 4
RGD ID: 2898
Description: Predicted to enable cytokine activity. Involved in several processes, including positive regulation of leukocyte migration; regulation of biosynthetic process; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; rhinitis (multiple); and trypanosomiasis. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dichloroethane; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell growth factor 1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BSF-1; IL-4; Il4e12; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,272,003 - 38,277,549 (-)NCBIGRCr8
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Il4RatAcute Experimental Pancreatitis treatmentIEP 10402805 RGD 
Il4RatAcute Hepatitis  IDA 8142397 RGD 
Il4RatAcute Lung Injury treatmentIEP 10402798 RGD 
Il4Ratacute myocardial infarction amelioratesIEP 267358468 RGD 
Il4Ratallergic rhinitis treatmentISOIL4 (Homo sapiens)7829827 RGD 
Il4Ratallergic rhinitis treatmentIEP 11522769 RGD 
Il4Ratallergic rhinitis treatmentISOIL4 (Homo sapiens)7829802 RGD 
Il4Ratallergic rhinitis treatmentISOIL4 (Homo sapiens)7829796 RGD 
Il4Ratalopecia universalis  ISOIL4 (Homo sapiens)7829773protein:increased expression:serumRGD 
Il4RatAlzheimer's disease  ISOIL4 (Homo sapiens)10402788DNA:polymorphisms:promoterRGD 
Il4RatAnaphylaxis  ISOIl4 (Mus musculus)10402796mRNA:increased expression:lung more ...RGD 
Il4RatAnaphylaxis  ISOIL4 (Homo sapiens)14696684associated with cystic echinococcosis and protein:increased expression:bloodRGD 
Il4Ratanogenital venereal wart treatmentISOIL4 (Homo sapiens)7829774 RGD 
Il4Ratanogenital venereal wart  ISOIL4 (Homo sapiens)40400714protein:increased expression:peripheral blood mononuclear cells (human)RGD 
Il4Ratanti-basement membrane glomerulonephritis  IMP 2317673 RGD 
Il4Ratanti-basement membrane glomerulonephritis  IDA 2307059 RGD 
Il4Rataspirin-induced respiratory disease susceptibilityISOIL4 (Homo sapiens)11528633DNA:SNPs:promoter more ...RGD 
Il4Ratasthma  ISOIl4 (Mus musculus)5128557 RGD 
Il4Ratasthma  IEP 2317290protein:increased expression:lungRGD 
Il4Ratasthma treatmentIEP 10402799 RGD 
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Il4Ratfamilial adenomatous polyposis 1  ISOIL4 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
Il4RatHereditary Neoplastic Syndromes  ISOIL4 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
Il4RatNeurodevelopmental Disorders  ISOIL4 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Il4Ratadult T-cell leukemia/lymphoma  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23962110
Il4Ratallergic contact dermatitis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12484431 and PMID:21804303
Il4Ratallergic disease  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16095146 and PMID:21625544
Il4Ratallergic rhinitis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36127783
Il4Ratasthma  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18357729
Il4Ratatopic dermatitis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11886533 more ...
Il4Ratautistic disorder  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16360218
Il4Ratautoimmune disease  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7871386 more ...
Il4Ratautoimmune hepatitis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21227906
Il4RatBovine Tuberculosis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17387165
Il4Ratcardiomyopathy  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7578376
Il4RatChemical and Drug Induced Liver Injury  ISOIL4 (Homo sapiens)11554173CTD more ...CTDPMID:21094227 more ...
Il4RatChromosome Breakage  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27634759
Il4Ratcolitis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:24314293
Il4Ratcutaneous leishmaniasis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20102417
Il4Ratdermatitis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31330126
Il4Ratdrug allergy  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15867870 and PMID:20485159
Il4RatDrug Eruptions  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19351467
Il4RatExperimental Arthritis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:10444273
Il4RatFibrosis  ISOIL4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24286936
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Il4Ratatopic dermatitis  ISSIl4 (Mus musculus)13592920OMIM:603165MouseDO 
Il4RatSjogren's syndrome  ISSIl4 (Mus musculus)13592920OMIM:270150MouseDO 
Il4Rattype 1 diabetes mellitus  ISSIl4 (Mus musculus)13592920OMIM:222100MouseDO 

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Il4Rat(+)-trans-(S)-allethrin multiple interactionsISOIL4 (Homo sapiens)6480464[bioallethrin co-treated with Piperonyl Butoxide] results in increased expression of IL4 proteinCTDPMID:10414782
Il4Rat(+)-trans-(S)-allethrin affects expressionISOIL4 (Homo sapiens)6480464bioallethrin affects the expression of IL4 proteinCTDPMID:9860237
Il4Rat(-)-matairesinol multiple interactionsISOIl4 (Mus musculus)6480464matairesinol inhibits the reaction [Antigens and Dermatophagoides results in increased expression of IL4 mRNA]CTDPMID:27085937
Il4Rat(20S)-ginsenoside Rh1 decreases expressionISOIl4 (Mus musculus)6480464ginsenoside Rh1 results in decreased expression of IL4CTDPMID:22855946
Il4Rat(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid multiple interactionsISOIl4 (Mus musculus)6480464zopolrestat inhibits the reaction [Antigens and Plant results in increased expression of IL4 mRNA]CTDPMID:21334316
Il4Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNACTDPMID:23830814
Il4Rat1,2-dibutyrin multiple interactionsISOIl4 (Mus musculus)6480464[dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 proteinCTDPMID:29198882
Il4Rat1,2-dichloroethane decreases secretionEXP 6480464ethylene dichloride results in decreased secretion of IL4 proteinCTDPMID:24228488
Il4Rat1,2-dichloroethane multiple interactionsEXP 6480464azoximer bromide inhibits the reaction [ethylene dichloride results in decreased secretion of IL4 protein]CTDPMID:24228488
Il4Rat1,3,5-trinitrobenzene increases expressionISOIl4 (Mus musculus)6480464sym-trinitrobenzene results in increased expression of IL4 mRNACTDPMID:15890784
Il4Rat1,4-phenylenediamine increases expressionISOIl4 (Mus musculus)64804644-phenylenediamine results in increased expression of IL4 mRNACTDPMID:11531941
Il4Rat1,4-phenylenediamine increases secretionISOIl4 (Mus musculus)64804644-phenylenediamine results in increased secretion of IL4 proteinCTDPMID:22245253
Il4Rat1-chloro-2,4,6-trinitrobenzene multiple interactionsISOIL4 (Homo sapiens)64804644-cyano-4-(2 more ...CTDPMID:18854230
Il4Rat1-chloro-2,4,6-trinitrobenzene increases expressionISOIl4 (Mus musculus)6480464Picryl Chloride results in increased expression of IL4 more ...CTDPMID:12188032 more ...
Il4Rat1-chloro-2,4,6-trinitrobenzene multiple interactionsISOIl4 (Mus musculus)6480464[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein more ...CTDPMID:12188032 more ...
Il4Rat1-chloro-2,4,6-trinitrobenzene increases expressionISOIL4 (Homo sapiens)6480464Picryl Chloride results in increased expression of IL4 proteinCTDPMID:18854230
Il4Rat1-chloro-2,4-dinitrobenzene affects expressionISOIl4 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of IL4 mRNACTDPMID:22302311
Il4Rat1-chloro-2,4-dinitrobenzene decreases expressionISOIl4 (Mus musculus)6480464Dinitrochlorobenzene results in decreased expression of IL4 mRNA and Dinitrochlorobenzene results in decreased expression of IL4 proteinCTDPMID:34651546
Il4Rat1-chloro-2,4-dinitrobenzene increases secretionISOIl4 (Mus musculus)6480464Dinitrochlorobenzene results in increased secretion of IL4 proteinCTDPMID:26017682
Il4Rat1-chloro-2,4-dinitrobenzene increases expressionISOIl4 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of IL4 mRNA and Dinitrochlorobenzene results in increased expression of IL4 proteinCTDPMID:15588918 more ...

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Biological Process
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Il4Ratactivated T cell proliferation acts_upstream_ofISOIl4 (Mus musculus)1624291 PMID:10485657 and PMID:9841920RGDPMID:10485657 and PMID:9841920
Il4RatB cell activation acts_upstream_ofISOIl4 (Mus musculus)1624291 PMID:8566034RGDPMID:8566034
Il4RatB cell activation involved_inIEAUniProtKB-KW:KW-00751600115GO_REF:0000043UniProtGO_REF:0000043
Il4RatB cell costimulation acts_upstream_of_or_withinISOIl4 (Mus musculus)1624291 PMID:18762567RGDPMID:18762567
Il4RatB cell proliferation acts_upstream_ofISOIl4 (Mus musculus)1624291 PMID:10979977 and PMID:14607964RGDPMID:10979977 and PMID:14607964
Il4Ratcell surface receptor signaling pathway via JAK-STAT involved_inISOIL4 (Homo sapiens)1624291UniProtKB:P42226 and PMID:12574355RGDPMID:12574355
Il4Ratcellular response to mercury ion  IEP 2317279 RGD 
Il4Ratcellular response to mercury ion  IEP 2317674 RGD 
Il4Ratcholesterol metabolic process involved_inISOIl4 (Mus musculus)1624291 PMID:11971948RGDPMID:11971948
Il4Ratdefense response to protozoan acts_upstream_of_or_withinISOIl4 (Mus musculus)1624291 PMID:7927664RGDPMID:7927664
Il4Ratdendritic cell differentiation involved_inISOIL4 (Homo sapiens)1624291 PMID:21149635RGDPMID:21149635
Il4Ratextrinsic apoptotic signaling pathway acts_upstream_ofISOIl4 (Mus musculus)1624291 PMID:10429671RGDPMID:10429671
Il4Ratextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISOIl4 (Mus musculus)1624291 PMID:12115603RGDPMID:12115603
Il4Ratfemale pregnancy  IEP 2317272 RGD 
Il4Ratimmune response involved_inIEAInterPro:IPR001325 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Il4Ratinnate immune response in mucosa involved_inISOIl4 (Mus musculus)1624291 PMID:9973465RGDPMID:9973465
Il4Ratinterleukin-4-mediated signaling pathway involved_inISOIL4 (Homo sapiens)1624291 PMID:10219247 and PMID:12574355RGDPMID:10219247 and PMID:12574355
Il4Ratinterleukin-4-mediated signaling pathway involved_inIBAPANTHER:PTN002934025 and UniProtKB:P051121600115GO_REF:0000033GO_CentralGO_REF:0000033
Il4Ratisotype switching to IgE isotypes acts_upstream_ofISOIl4 (Mus musculus)1624291 PMID:14988498RGDPMID:14988498
Il4Ratisotype switching to IgG isotypes acts_upstream_ofISOIl4 (Mus musculus)1624291 PMID:14988498RGDPMID:14988498
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Cellular Component

  
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Original Reference(s)
Il4Ratexternal side of plasma membrane located_inISOIl4 (Mus musculus)1624291 PMID:19666510 more ...RGDPMID:19666510 more ...
Il4Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Il4Ratextracellular region located_inIEAInterPro:IPR001325 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Il4Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Il4Ratextracellular space located_inISOIl4 (Mus musculus)1624291 PMID:11057672 more ...RGDPMID:11057672 more ...
Il4Ratextracellular space  IDA 2317286 RGD 
Il4Ratextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il4Ratextracellular space is_active_inISOIL4 (Homo sapiens)1624291 PMID:3279117RGDPMID:3279117

Molecular Function
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Imported Annotations - SMPDB

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Original Reference(s)
Il4RatFc epsilon receptor mediated signaling pathway  ISOIL4 (Homo sapiens)10402751 SMPDBSMP:00358

Imported Annotations - KEGG (archival)

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Original Reference(s)
Il4Ratallograft rejection pathway  IEA 6907045 KEGGrno:05330
Il4Ratasthma pathway  IEA 6907045 KEGGrno:05310
Il4Ratautoimmune thyroiditis pathway  IEA 6907045 KEGGrno:05320
Il4Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Il4RatFc epsilon receptor mediated signaling pathway  IEA 6907045 KEGGrno:04664
Il4RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Il4RatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
Il4Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Il4RatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660
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Imported Annotations - PID (archival)

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Original Reference(s)
Il4Ratinterleukin-12 signaling pathway  ISOIL4 (Homo sapiens)6484113 PIDPID:200045
Il4Ratinterleukin-4 signaling pathway  ISOIL4 (Homo sapiens)6484113 PIDPID:200022
Il4RatNotch signaling pathway   ISOIL4 (Homo sapiens)6484113 PIDPID:200015

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#
Reference Title
Reference Citation
1. Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission. Aguilar D, etal., Tuberculosis (Edinb). 2010 Sep;90(5):319-25. Epub 2010 Sep 15.
2. Increased IL-4 mRNA expression and poly-aromatic hydrocarbon concentrations from children with asthma. Al-Daghri NM, etal., BMC Pediatr. 2014 Jan 23;14:17. doi: 10.1186/1471-2431-14-17.
3. The biological response modifier AM3 attenuates the inflammatory cell response and hepatic fibrosis in rats with biliary cirrhosis. Albillos A, etal., Gut. 2010 Jul;59(7):943-52. doi: 10.1136/gut.2008.168831. Epub 2010 May 4.
4. Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis. Amoli MM, etal., J Rheumatol. 2004 Dec;31(12):2413-7.
5. Determination of intracellular Th1/Th2 type cytokines in lymphocytes of chronic hepatitis B patients treated with interferon-alpha. Atan Ö, etal., Turk J Gastroenterol. 2010 Dec;21(4):401-10. doi: 10.4318/tjg.2010.0127.
6. Serum Interleukin-4 and Total Immunoglobulin E in Nonatopic Alopecia Areata Patients and HLA-DRB1 Typing. Attia EA, etal., Dermatol Res Pract. 2010;2010:503587. doi: 10.1155/2010/503587. Epub 2010 Jun 30.
7. Effect of tea tree oil (Melaleuca alternifolia) on the longevity and immune response of rats infected by Trypanosoma evansi. Baldissera MD, etal., Res Vet Sci. 2014 Jun;96(3):501-6. doi: 10.1016/j.rvsc.2014.03.013. Epub 2014 Mar 31.
8. Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma. Bao ZS, etal., Int Immunopharmacol. 2011 Feb 26.
9. [IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES]. Beloborodova EV, etal., Eksp Klin Gastroenterol. 2015;(3):45-9.
10. Eradication of rat malignant gliomas by retroviral-mediated, in vivo delivery of the interleukin 4 gene. Benedetti S, etal., Cancer Res. 1999 Feb 1;59(3):645-52.
11. Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population. Bijanzadeh M, etal., Lung. 2010 Oct;188(5):415-22. Epub 2010 Jun 4.
12. Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression. Brock P, etal., J Cell Mol Med. 2006 Oct-Dec;10(4):884-95.
13. B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Brown MA, etal., Cell 1987 Aug 28;50(5):809-18.
14. IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Butti E, etal., Gene Ther. 2008 Apr;15(7):504-15. doi: 10.1038/gt.2008.10. Epub 2008 Jan 31.
15. Hydrogen sulfide protects against bleomycin-induced pulmonary fibrosis in rats by inhibiting NF-kappaB expression and regulating Th1/Th2 balance. Cao H, etal., Toxicol Lett. 2014 Jan 30;224(3):387-94. doi: 10.1016/j.toxlet.2013.11.008. Epub 2013 Nov 20.
16. Induction of interleukin-1beta by interleukin-4 in lipopolysaccharide-treated mixed glial cultures: microglial-dependent effects. Cao L, etal., J Neurochem. 2007 Jul;102(2):408-19. Epub 2007 Apr 17.
17. Comparison of the expression of interferon gamma, IL2, IL4, and lymphotoxin mRNA in experimental autoimmune uveoretinitis. Charteris DG and Lightman SL, Br J Ophthalmol. 1994 Oct;78(10):786-90.
18. [The relationship between CD4(-) CD8(-) T cells in the peripheral blood of patients with pancreatic carcinoma and IL-4, IFN-gamma levels] Chen J, etal., Zhonghua Wai Ke Za Zhi. 2009 Jul 1;47(13):995-8.
19. [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. Cheng L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2.
20. Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon gamma levels in a mouse model of Kawasaki disease. Chu MP, etal., Mol Med Rep. 2012 May;5(5):1237-40. doi: 10.3892/mmr.2012.799. Epub 2012 Feb 20.
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PMID:1588041   PMID:1903705   PMID:1983334   PMID:7749983   PMID:7927664   PMID:8022486   PMID:8200916   PMID:8566034   PMID:9013979   PMID:9110977   PMID:9798653   PMID:9841920  
PMID:9973465   PMID:10429671   PMID:10485657   PMID:10549626   PMID:10979977   PMID:11027433   PMID:11057672   PMID:11698262   PMID:11894098   PMID:11971948   PMID:12004164   PMID:12115603  
PMID:12574355   PMID:12757709   PMID:12882831   PMID:12941478   PMID:14607964   PMID:14988498   PMID:15087456   PMID:15187136   PMID:15238617   PMID:15251393   PMID:15826818   PMID:15944273  
PMID:16002150   PMID:16034134   PMID:16116184   PMID:16129705   PMID:16169702   PMID:16229173   PMID:16275384   PMID:16493007   PMID:16503976   PMID:16522370   PMID:16606666   PMID:16769892  
PMID:16972262   PMID:17018025   PMID:17082577   PMID:17277142   PMID:17442941   PMID:17981803   PMID:18042342   PMID:18337562   PMID:18424750   PMID:18464888   PMID:18510219   PMID:18579517  
PMID:18762567   PMID:18792410   PMID:18827184   PMID:18997793   PMID:19139201   PMID:19235892   PMID:19346497   PMID:19420081   PMID:19666510   PMID:20120734   PMID:20399120   PMID:20500673  
PMID:20554961   PMID:20696860   PMID:20706986   PMID:20956546   PMID:20969918   PMID:21149635   PMID:21168220   PMID:21217760   PMID:21460847   PMID:21613615   PMID:21668966   PMID:22201020  
PMID:23904363   PMID:24139939   PMID:24280217   PMID:24319732   PMID:24347527   PMID:24801739   PMID:25256599   PMID:26003274   PMID:26416964   PMID:26927369   PMID:26951461   PMID:28092075  
PMID:28414034   PMID:29061364   PMID:29469038   PMID:30017262   PMID:30634164   PMID:30890073   PMID:31341902   PMID:31432141   PMID:32258110   PMID:32704142   PMID:35240467   PMID:36723732  
PMID:37982769   PMID:38315435  
1 to 10 of 10 rows



Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,272,003 - 38,277,549 (-)NCBIGRCr8
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
T2T-CHM13v2.05133,193,788 - 133,202,478 (+)NCBIT2T-CHM13v2.0
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)EnsemblGRCm39 Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBIMGSCv36mm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,986,571 - 127,995,112 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,126,136 - 126,134,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBIUU_Cfam_GSD_1.0
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,443,750 - 42,449,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Il4
25 total Variants

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:5
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000010029
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 56 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat

1 to 10 of 56 rows
D10Mgh9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81038,276,689 - 38,276,819 (+)Marker Load Pipeline
mRatBN7.21037,775,890 - 37,776,020 (+)MAPPERmRatBN7.2
Rnor_6.01038,968,672 - 38,968,801NCBIRnor6.0
Rnor_5.01038,750,399 - 38,750,528UniSTSRnor5.0
RGSC_v3.41039,079,275 - 39,079,404UniSTSRGSC3.4
RGSC_v3.41039,079,274 - 39,079,404RGDRGSC3.4
RGSC_v3.11039,087,845 - 39,087,975RGD
Celera1037,120,106 - 37,120,235UniSTS
RH 3.4 Map10404.0RGD
RH 3.4 Map10404.0UniSTS
RH 2.0 Map10433.4RGD
SHRSP x BN Map1036.2799RGD
Cytogenetic Map10q22UniSTS
D10Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81038,276,636 - 38,276,824 (+)Marker Load Pipeline
mRatBN7.21037,775,837 - 37,776,025 (+)MAPPERmRatBN7.2
Rnor_6.01038,968,619 - 38,968,806NCBIRnor6.0
Rnor_5.01038,750,346 - 38,750,533UniSTSRnor5.0
RGSC_v3.41039,079,222 - 39,079,409UniSTSRGSC3.4
RGSC_v3.41039,079,221 - 39,079,409RGDRGSC3.4
RGSC_v3.11039,087,792 - 39,087,980RGD
Celera1037,120,053 - 37,120,240UniSTS
RH 3.4 Map10406.6RGD
RH 3.4 Map10406.6UniSTS
RH 2.0 Map10446.0RGD
Cytogenetic Map10q22UniSTS
UniSTS:143568  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,776,887 - 37,777,027 (+)MAPPERmRatBN7.2
Rnor_6.01038,969,669 - 38,969,808NCBIRnor6.0
Rnor_5.01038,751,396 - 38,751,535UniSTSRnor5.0
RGSC_v3.41039,080,272 - 39,080,411UniSTSRGSC3.4
Celera1037,121,103 - 37,121,241UniSTS
Cytogenetic Map10q22UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 7 14 23 33 14 14 14 46 22 13 2 21 19



Ensembl Acc Id: ENSRNOT00000010029   ⟹   ENSRNOP00000010029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)Ensembl
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081309   ⟹   ENSRNOP00000069664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,964,004 - 38,969,501 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090691   ⟹   ENSRNOP00000069983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,964,004 - 38,969,501 (-)Ensembl
RefSeq Acc Id: NM_201270   ⟹   NP_958427
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,272,003 - 38,277,549 (-)NCBI
mRatBN7.21037,771,203 - 37,776,750 (-)NCBI
Rnor_6.01038,963,979 - 38,969,531 (-)NCBI
Rnor_5.01038,745,706 - 38,751,258 (-)NCBI
RGSC_v3.41039,074,582 - 39,080,134 (-)RGD
Celera1037,115,496 - 37,120,965 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_958427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR87867 (Get FASTA)   NCBI Sequence Viewer  
  CAA37256 (Get FASTA)   NCBI Sequence Viewer  
  CAC16091 (Get FASTA)   NCBI Sequence Viewer  
  EDM04390 (Get FASTA)   NCBI Sequence Viewer  
  EDM04391 (Get FASTA)   NCBI Sequence Viewer  
  EDM04392 (Get FASTA)   NCBI Sequence Viewer  
  EDM04393 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010029
  ENSRNOP00000010029.1
GenBank Protein P20096 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_958427   ⟸   NM_201270
- Peptide Label: precursor
- UniProtKB: P20096 (UniProtKB/Swiss-Prot),   A6HED6 (UniProtKB/TrEMBL),   Q6RIC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010029   ⟸   ENSRNOT00000010029
Ensembl Acc Id: ENSRNOP00000069983   ⟸   ENSRNOT00000090691
Ensembl Acc Id: ENSRNOP00000069664   ⟸   ENSRNOT00000081309

Name Modeler Protein Id AA Range Protein Structure
AF-P20096-F1-model_v2 AlphaFold P20096 1-147 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25136 BioCyc
Ensembl Genes ENSRNOG00000007624 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010029 ENTREZGENE
  ENSRNOT00000010029.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-4 UniProtKB/Swiss-Prot
  IL-4/IL-13 UniProtKB/Swiss-Prot
  IL-4/IL-13_CS UniProtKB/Swiss-Prot
KEGG Report rno:287287 UniProtKB/Swiss-Prot
NCBI Gene Il4 ENTREZGENE
PANTHER INTERLEUKIN-4 UniProtKB/Swiss-Prot
  PTHR47401 UniProtKB/Swiss-Prot
Pfam IL4 UniProtKB/Swiss-Prot
PhenoGen Il4 PhenoGen
PIRSF Interleukin_4 UniProtKB/Swiss-Prot
PRINTS INTERLEUKIN4 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007624 RatGTEx
SMART IL4_13 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6HED5_RAT UniProtKB/TrEMBL
  A6HED6 ENTREZGENE, UniProtKB/TrEMBL
  A6HED7_RAT UniProtKB/TrEMBL
  A6HED8_RAT UniProtKB/TrEMBL
  IL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6RIC4 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il4  Interleukin 4      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_regulation inflammatory response causes increase of mRNA in eosinophils 625643