Il4 (interleukin 4) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Il4 (interleukin 4) Rattus norvegicus
Symbol: Il4
Name: interleukin 4
RGD ID: 2898
Description: Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; rhinitis (multiple); and trypanosomiasis. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dichloroethane; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
Previously known as: B-cell growth factor 1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BSF-1; IL-4; Il4e12; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKY
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP)
Acute Hepatitis  (IDA)
Acute Lung Injury  (IEP)
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (IEP,ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IDA,IMP)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (IMP)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (IEP)
bronchiolitis obliterans  (IEP)
cardiomyopathy  (ISO)
carotid stenosis  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (IEP)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystitis  (IEP)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
Granuloma  (IDA)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (IEP)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (IEP)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (IDA,ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (IDA)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
middle cerebral artery infarction  (IEP)
multiple sclerosis  (ISO)
Nematode Infections  (IEP)
nephritis  (IEP)
nephrotic syndrome  (IEP)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Otitis Media with Effusion  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (IDA)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (IEP)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISS)
Spinal Cord Injuries  (IMP)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (IEP)
type 1 diabetes mellitus  (ISS)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-trans-(S)-allethrin  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-lipoic acid  (EXP)
1,2-dibutyrin  (ISO)
1,2-dichloroethane  (EXP)
1,3,5-trinitrobenzene  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
13,14-dihydro-15-ketoprostaglandin D2  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-ethylphenol  (ISO)
4-nonylphenol  (ISO)
4-tolyl isocyanate  (ISO)
5-azacytidine  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetone  (ISO)
acetylsalicylic acid  (ISO)
acrylic acid  (EXP)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allicin  (EXP)
alpha-galactosylceramide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
azathioprine  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
bexarotene  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
Brevetoxin B  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
buprenorphine  (ISO)
butane-2,3-dione  (ISO)
butenafine  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calciol  (EXP)
calcipotriol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbachol  (ISO)
carbamazepine  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
caryophyllene oxide  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
cetirizine  (ISO)
chlorambucil  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorphenamine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysin  (ISO)
cilostazol  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clarithromycin  (ISO)
clopidogrel  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cupressuflavone  (ISO)
curcumin  (EXP,ISO)
cyclopentanes  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
D-penicillamine  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (EXP,ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzothiazol-2-yl disulfide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
dicyclohexylmethane-4,4'-diisocyanate  (ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (ISO)
diethylamine  (ISO)
diflorasone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
donepezil hydrochloride  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
emodin  (ISO)
epinastine  (EXP,ISO)
equol  (ISO)
Erionite  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
famotidine  (ISO)
fentanyl  (ISO)
ferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
fomepizole  (EXP)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
formoterol fumarate  (EXP,ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furfuryl alcohol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
Gastrodin  (ISO)
genistein  (ISO)
ginsenoside C-K  (ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
graphite  (ISO)
helenalin  (ISO)
heroin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxyzine  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
levamisole  (EXP,ISO)
lidocaine  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (EXP)
lipoxin A4  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loperamide  (ISO)
losartan  (EXP)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
methadone  (ISO)
methanol  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methyl salicylate  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitogen  (ISO)
MK 571  (ISO)
Monobutylphthalate  (ISO)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morphine  (ISO)
Morroniside  (ISO)
moxifloxacin  (ISO)
mycophenolic acid  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
neocuproine  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrendipine  (ISO)
nitric oxide  (ISO)
nitrites  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
Olopatadine hydrochloride  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
patulin  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
polyphosphates  (ISO)
prednisolone  (EXP,ISO)
prednisone  (ISO)
progesterone  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pyrene  (ISO)
Pyridostigmine bromide  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
ribavirin  (ISO)
ricinoleic acid  (ISO)
Ro 41-5253  (ISO)
rolipram  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 203580  (EXP,ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hexachloroplatinate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
spathulenol  (ISO)
SR 144528  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
styrene  (ISO)
Sucralfate  (EXP)
sulfasalazine  (EXP)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
Sunset Yellow FCF  (ISO)
synephrine  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
thalidomide  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thromboxane B2  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolnaftate  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-piceid  (EXP)
tremolite asbestos  (ISO)
triamcinolone acetonide  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
tributyrin  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
verrucarin A  (ISO)
vitamin D  (EXP)
vitamin E  (EXP,ISO)
WIN 55212-2  (EXP)
wortmannin  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
activation of Janus kinase activity  (IBA,ISO)
B cell activation  (ISO)
B cell costimulation  (IBA,ISO)
B cell proliferation  (ISO)
cellular response to mercury ion  (IEP)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
female pregnancy  (IEP)
innate immune response in mucosa  (IBA,ISO)
isotype switching to IgE isotypes  (ISO)
isotype switching to IgG isotypes  (ISO)
macrophage activation  (ISO)
MHC class II biosynthetic process  (ISO)
microglial cell activation  (IBA,IDA)
myeloid dendritic cell differentiation  (IBA,ISO)
negative regulation of acute inflammatory response  (IBA,IDA)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (IBA,IDA)
negative regulation of complement-dependent cytotoxicity  (IBA,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell apoptotic process  (IBA,ISO)
negative regulation of epithelial cell migration  (IBA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (IBA,IMP)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (IBA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (IDA)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (IBA,IDA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,IDA,ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of defense response to virus by host  (IBA,IDA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IBA,IDA,ISO)
positive regulation of eosinophil chemotaxis  (IBA,IDA)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (IBA,IDA,ISO)
positive regulation of interleukin-13 production  (IBA,ISO)
positive regulation of isotype switching to IgE isotypes  (IBA,ISO)
positive regulation of isotype switching to IgG isotypes  (IBA,ISO)
positive regulation of macroautophagy  (IBA,ISO,ISS)
positive regulation of mast cell degranulation  (IBA,ISO)
positive regulation of MHC class II biosynthetic process  (IBA,ISO)
positive regulation of mononuclear cell migration  (IBA,IDA)
positive regulation of myoblast fusion  (IBA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (IBA,IDA,ISO)
positive regulation of T cell differentiation  (IBA,ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA,ISO)
regulation of immune response  (ISO)
regulation of inflammatory response  (IDA)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (IDA)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (IEP)
signal transduction  (ISO)
T cell activation  (ISO)
T cell proliferation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (IBA,ISO)
transcription by RNA polymerase II  (ISO)
tyrosine phosphorylation of STAT protein  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission. Aguilar D, etal., Tuberculosis (Edinb). 2010 Sep;90(5):319-25. Epub 2010 Sep 15.
2. Increased IL-4 mRNA expression and poly-aromatic hydrocarbon concentrations from children with asthma. Al-Daghri NM, etal., BMC Pediatr. 2014 Jan 23;14:17. doi: 10.1186/1471-2431-14-17.
3. The biological response modifier AM3 attenuates the inflammatory cell response and hepatic fibrosis in rats with biliary cirrhosis. Albillos A, etal., Gut. 2010 Jul;59(7):943-52. doi: 10.1136/gut.2008.168831. Epub 2010 May 4.
4. Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis. Amoli MM, etal., J Rheumatol. 2004 Dec;31(12):2413-7.
5. Determination of intracellular Th1/Th2 type cytokines in lymphocytes of chronic hepatitis B patients treated with interferon-alpha. Atan Ö, etal., Turk J Gastroenterol. 2010 Dec;21(4):401-10. doi: 10.4318/tjg.2010.0127.
6. Serum Interleukin-4 and Total Immunoglobulin E in Nonatopic Alopecia Areata Patients and HLA-DRB1 Typing. Attia EA, etal., Dermatol Res Pract. 2010;2010:503587. doi: 10.1155/2010/503587. Epub 2010 Jun 30.
7. Effect of tea tree oil (Melaleuca alternifolia) on the longevity and immune response of rats infected by Trypanosoma evansi. Baldissera MD, etal., Res Vet Sci. 2014 Jun;96(3):501-6. doi: 10.1016/j.rvsc.2014.03.013. Epub 2014 Mar 31.
8. Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma. Bao ZS, etal., Int Immunopharmacol. 2011 Feb 26.
9. [IMMUNOGENETICS AND PROGRESSION OF CHRONIC VIRAL HEPATITES]. Beloborodova EV, etal., Eksp Klin Gastroenterol. 2015;(3):45-9.
10. Eradication of rat malignant gliomas by retroviral-mediated, in vivo delivery of the interleukin 4 gene. Benedetti S, etal., Cancer Res. 1999 Feb 1;59(3):645-52.
11. Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population. Bijanzadeh M, etal., Lung. 2010 Oct;188(5):415-22. Epub 2010 Jun 4.
12. Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression. Brock P, etal., J Cell Mol Med. 2006 Oct-Dec;10(4):884-95.
13. B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Brown MA, etal., Cell 1987 Aug 28;50(5):809-18.
14. IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Butti E, etal., Gene Ther. 2008 Apr;15(7):504-15. doi: 10.1038/gt.2008.10. Epub 2008 Jan 31.
15. Hydrogen sulfide protects against bleomycin-induced pulmonary fibrosis in rats by inhibiting NF-kappaB expression and regulating Th1/Th2 balance. Cao H, etal., Toxicol Lett. 2014 Jan 30;224(3):387-94. doi: 10.1016/j.toxlet.2013.11.008. Epub 2013 Nov 20.
16. Induction of interleukin-1beta by interleukin-4 in lipopolysaccharide-treated mixed glial cultures: microglial-dependent effects. Cao L, etal., J Neurochem. 2007 Jul;102(2):408-19. Epub 2007 Apr 17.
17. Comparison of the expression of interferon gamma, IL2, IL4, and lymphotoxin mRNA in experimental autoimmune uveoretinitis. Charteris DG and Lightman SL, Br J Ophthalmol. 1994 Oct;78(10):786-90.
18. [The relationship between CD4(-) CD8(-) T cells in the peripheral blood of patients with pancreatic carcinoma and IL-4, IFN-gamma levels] Chen J, etal., Zhonghua Wai Ke Za Zhi. 2009 Jul 1;47(13):995-8.
19. [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. Cheng L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2.
20. Pachyman treatment improves CD4+CD25+ Treg counts and serum interleukin 4 and interferon gamma levels in a mouse model of Kawasaki disease. Chu MP, etal., Mol Med Rep. 2012 May;5(5):1237-40. doi: 10.3892/mmr.2012.799. Epub 2012 Feb 20.
21. Nasal cytokine modulation by montelukast in allergic children: a pilot study. Ciprandi G, etal., Eur Ann Allergy Clin Immunol. 2003 Oct;35(8):295-9.
22. Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. Ciprandi G, etal., Eur Ann Allergy Clin Immunol. 2004 Jun;36(6):237-40.
23. Differential regulation of the production of reactive oxygen species in Th1 cytokine-treated thyroid cells. Colin IM, etal., Thyroid. 2014 Mar;24(3):441-52. doi: 10.1089/thy.2013.0142. Epub 2013 Dec 13.
24. Adenovirus-mediated gene transfer in rat liver of interleukin 4 but not interleukin 10 produces severe acute hepatitis. David A, etal., Cytokine. 1997 Nov;9(11):818-29.
25. Anti-adenovirus immune responses in rats are enhanced by interleukin 4 but not interleukin 10 produced by recombinant adenovirus. David A, etal., Hum Gene Ther. 1998 Aug 10;9(12):1755-68.
26. Treatment in vitro of retinal cells with IL-4 increases the survival of retinal ganglion cells: the involvement of BDNF. de Araujo-Martins L, etal., Neurochem Res. 2013 Jan;38(1):162-73. doi: 10.1007/s11064-012-0904-0. Epub 2012 Oct 16.
27. Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils. Emonts M, etal., J Infect Dis. 2008 May 1;197(9):1244-53. doi: 10.1086/533501.
28. Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1, and DEFA4 in meningococcal disease in three populations. Emonts M, etal., Shock. 2010 Jul;34(1):17-22. doi: 10.1097/SHK.0b013e3181ce2c7d.
29. Characterization of a 2,4-dinitrochlorobenzene-induced chronic dermatitis model in rats. Fujii Y, etal., Skin Pharmacol Physiol. 2009;22(5):240-7. Epub 2009 Aug 18.
30. Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. Gao J, etal., J Autoimmun. 2006 Mar;26(2):90-103. Epub 2006 Jan 18.
31. alpha1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death. Gao W, etal., J Heart Lung Transplant. 2014 Mar;33(3):309-15. doi: 10.1016/j.healun.2013.10.031. Epub 2013 Oct 25.
32. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26.
33. Splanchnic Th(2) and Th(1) Cytokine Redistribution in Microsurgical Cholestatic Rats. Garcia-Dominguez J, etal., J Surg Res. 2009 Nov 11.
34. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
35. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
36. Role of oxidative stress on diesel-enhanced influenza infection in mice. Gowdy KM, etal., Part Fibre Toxicol. 2010 Nov 22;7:34.
37. Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis. Guo H, etal., Evid Based Complement Alternat Med. 2014;2014:943596. doi: 10.1155/2014/943596. Epub 2014 Apr 27.
38. Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis. Haas CS, etal., Arthritis Rheum. 2006 Aug;54(8):2402-14.
39. Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification. Haddad el-B, etal., J Immunol 2002 Mar 15;168(6):3004-16.
40. Immunotherapy for the prevention of myointimal hyperplasia after experimental balloon injury of the rat carotid artery. Hansrani M, etal., Angiology. 2010 Jul;61(5):437-42. doi: 10.1177/0003319710366128. Epub 2010 May 24.
41. Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. Hasegawa M, etal., J Rheumatol. 1997 Feb;24(2):328-32.
42. Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model. Hassan HM, etal., Inflamm Allergy Drug Targets. 2014 Feb;13(1):74-9.
43. Glatiramer acetate reverses cognitive deficits from cranial-irradiated rat by inducing hippocampal neurogenesis. He F, etal., J Neuroimmunol. 2014 Jun 15;271(1-2):1-7. doi: 10.1016/j.jneuroim.2014.03.015. Epub 2014 Mar 26.
44. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. Heinzel FP, etal., J Exp Med. 1989 Jan 1;169(1):59-72.
45. Association of colonic regulatory T cells with hepatitis C virus pathogenesis and liver pathology. Hetta HF, etal., J Gastroenterol Hepatol. 2015 Oct;30(10):1543-51. doi: 10.1111/jgh.12936.
46. Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. Hogaboam CM, etal., J Clin Invest. 1997 Dec 1;100(11):2766-76.
47. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
48. Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Hwang JH, etal., Exp Ther Med. 2018 Jul;16(1):310-320. doi: 10.3892/etm.2018.6190. Epub 2018 May 18.
49. Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Ishige K, etal., Int J Cancer. 2008 Dec 15;123(12):2915-22.
50. Study on changes in the level of serum IL-4 and soluble CD 23(s-CD23) with immunotherapy in nasal allergy patients. Ito H, etal., Acta Otolaryngol Suppl. 1996;525:98-104.
51. Effects of azelastine on the level of serum interleukin-4 and soluble CD23 antigen in the treatment of nasal allergy. Ito H, etal., Arzneimittelforschung. 1998 Dec;48(12):1143-7.
52. Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia. Jeong GR, etal., J Neuroimmunol. 2016 Jun 15;295-296:21-9. doi: 10.1016/j.jneuroim.2016.04.009. Epub 2016 Apr 13.
53. The assay of interleukin 4 in the serum of normal subjects and atopic patients using a novel immunoassay. Jones KP, etal., Cytokine. 1997 Jul;9(7):529-34.
54. A new technique of bronchial microsampling and proteomic analysis of epithelial lining fluid in a rat model of acute lung injury. Kamiyama I, etal., Mol Immunol. 2014 Jun;59(2):217-25. doi: 10.1016/j.molimm.2014.02.013. Epub 2014 Mar 25.
55. Nasal messenger RNA expression of interleukins 2, 4, and 5 in patients with allergic rhinitis. Karlsson MG, etal., Diagn Mol Pathol. 1995 Jun;4(2):85-92.
56. [A method for the quantification of interleukin-4 in serum (sandwich ELISA) and IL-4 levels in patients with atopic dermatitis]. Kasamatsu M, etal., Arerugi. 1993 Jul;42(7):878-82.
57. Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis. Katoh T, etal., Kidney Int. 1994 Aug;46(2):341-9.
58. Targeting interleukin-4 receptors for effective pancreatic cancer therapy. Kawakami K, etal., Cancer Res. 2002 Jul 1;62(13):3575-80.
59. Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families. Kawashima T, etal., J Med Genet. 1998 Jun;35(6):502-4.
60. Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis. Khadem F, etal., J Antimicrob Chemother. 2017 Feb;72(2):467-477. doi: 10.1093/jac/dkw448. Epub 2016 Dec 20.
61. Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt. Khalil H, etal., J Infect Dev Ctries. 2017 Mar 31;11(3):261-268. doi: 10.3855/jidc.8127.
62. Circulatory levels of T-cell cytokines (interleukin -2, IL-4, IL-17, and transforming growth factor-beta) in patients with vitiligo. Khan R, etal., J Am Acad Dermatol. 2012 Mar;66(3):510-1. doi: 10.1016/j.jaad.2011.07.018.
63. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. Khoury SJ, etal., J Exp Med. 1992 Nov 1;176(5):1355-64.
64. Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity. Kim BS, etal., Pharmacogenet Genomics. 2010 Dec;20(12):748-58. doi: 10.1097/FPC.0b013e3283402155.
65. Changes of cytokine mRNA expression and IgG responses in rats infected with Capillaria hepatica. Kim DK, etal., Korean J Parasitol. 2007 Jun;45(2):95-102.
66. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Kim GT, etal., Clin Rheumatol. 2010 Mar;29(3):273-9. doi: 10.1007/s10067-009-1316-7. Epub 2009 Dec 2.
67. Acquired immunity in nude mice induced by expression of the IL-2 or IL-4 gene in human pancreatic carcinoma cells and anti-tumor effect generated by in vivo gene transfer using retrovirus. Kimura M, etal., Int J Cancer. 1999 Aug 12;82(4):549-55.
68. Antiinflammatory properties of a peptide derived from interleukin-4. Klementiev B, etal., Cytokine. 2013 Oct;64(1):112-21. doi: 10.1016/j.cyto.2013.07.016. Epub 2013 Aug 20.
69. Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. Kraus J, etal., J Biol Chem 2001 Nov 23;276(47):43901-8.
70. Phaseolin: a 47.5kDa protein of red kidney bean (Phaseolus vulgaris L.) plays a pivotal role in hypersensitivity induction. Kumar S, etal., Int Immunopharmacol. 2014 Mar;19(1):178-90. doi: 10.1016/j.intimp.2014.01.014. Epub 2014 Jan 24.
71. VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration. Larbi KY, etal., Blood. 2000 Nov 15;96(10):3601-9.
72. Lentiviral mediated IL-4 and IL-13 RNAi decrease airway inflammation and hyperresponsiveness. Lee CC, etal., Hum Gene Ther. 2011 Mar 7.
73. Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury. Lee SI, etal., J Neurosci Res. 2010 Aug 15;88(11):2409-19.
74. Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. Li B, etal., Am J Transplant. 2008 Aug;8(8):1614-21. Epub 2008 Jun 28.
75. [Effect of Radix Astragali on signal transducer and activator of transcription activator-4 and its mRNA expression in a rat model of asthma] Li CC, etal., Zhonghua Er Ke Za Zhi. 2007 Oct;45(10):727-31.
76. Alterations of T helper lymphocyte subpopulations in sepsis, severe sepsis, and septic shock: a prospective observational study. Li J, etal., Inflammation. 2015;38(3):995-1002. doi: 10.1007/s10753-014-0063-3.
77. [Effects of electroacupuncture and manual acupuncture interventions on contents of serum inflammatory cytokines in rats with chronic adjuvant arthritis]. Li WX, etal., Zhen Ci Yan Jiu. 2012 Aug;37(4):271-6.
78. [Effects of natural moxibustion on cytokines and specific transcription factors in asthma rats]. Li YM and Ling CM, Zhongguo Zhen Jiu. 2014 Apr;34(4):379-83.
79. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Li YX, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Jun;43(6):447-50.
80. Protection Effect of Zhen-Wu-Tang on Adriamycin-Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage. Liang CL, etal., Evid Based Complement Alternat Med. 2014;2014:131604. doi: 10.1155/2014/131604. Epub 2014 Apr 9.
81. Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis. Liang M, etal., Mediators Inflamm. 2018 Jun 24;2018:7964654. doi: 10.1155/2018/7964654. eCollection 2018.
82. Post-shock mesenteric lymph drainage ameliorates cellular immune function in rats following hemorrhagic shock. Liu H, etal., Inflammation. 2015 Apr;38(2):584-94. doi: 10.1007/s10753-014-9965-3.
83. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
84. The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion. Lively S and Schlichter LC, J Neuroinflammation. 2013 Jun 21;10:75. doi: 10.1186/1742-2094-10-75.
85. [Effect of Smilax china bioactive fraction on tumor necrosis factor-alpha and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease]. Luo Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):236-40.
86. IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro. Lyons A, etal., J Neurochem. 2007 May;101(3):771-81. Epub 2007 Jan 23.
87. Expression of IL4 (VNTR intron 3) and IL10 (-627) genes polymorphisms in childhood immune thrombocytopenic purpura. Makhlouf MM and Abd Elhamid SM, Lab Med. 2014 Summer;45(3):211-9. doi: 10.1309/LMB0QC5T1RXTTRZQ.
88. Production of interleukins 4 and 10 in children with hepatic involvement in the course of Toxocara spp. infection. Mazur-Melewska K, etal., Parasite Immunol. 2016 Feb;38(2):101-7. doi: 10.1111/pim.12303.
89. TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs. Meng L, etal., PLoS One. 2011 Feb 25;6(2):e17252.
90. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
91. Unifying candidate gene and GWAS Approaches in Asthma. Michel S, etal., PLoS One. 2010 Nov 12;5(11):e13894.
92. Th2-biased immune responses are important in a murine model of chronic hypersensitivity pneumonitis. Mitaka K, etal., Int Arch Allergy Immunol. 2011;154(3):264-74. Epub 2010 Sep 21.
93. Anti-tumor necrosis factor-alpha treatment reduces allergic responses in an allergic rhinitis mouse model. Mo JH, etal., Allergy. 2011 Feb;66(2):279-86. doi: 10.1111/j.1398-9995.2010.02476.x. Epub 2010 Sep 7.
94. Neuroprotective effect of resveratrol in diabetic cerebral ischemic-reperfused rats through regulation of inflammatory and apoptotic events. Mohamed HE, etal., Diabetol Metab Syndr. 2014 Aug 17;6(1):88. doi: 10.1186/1758-5996-6-88. eCollection 2014.
95. Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages. Nagarkar DR, etal., J Immunol. 2010 Aug 15;185(4):2525-35. Epub 2010 Jul 19.
96. Detection of serum cytokines before and after pharmacological and surgical treatment in patients with cystic echinococcosis. Naik MI, etal., J Helminthol. 2016 Jan;90(1):91-5. doi: 10.1017/S0022149X15000085. Epub 2015 Mar 2.
97. Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen. Nakada T, etal., Int Immunopharmacol. 2002 Jun;2(7):901-11.
98. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Ong CJ, etal., Cell Immunol. 1999 Aug 25;196(1):60-8.
99. Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with hepatitis C virus. Pimentel JP, etal., J Med Virol. 2013 Jun;85(6):1009-18. doi: 10.1002/jmv.23554.
100. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
101. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
102. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
103. Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4. Prigent P, etal., J Clin Invest. 1995 Sep;96(3):1484-9.
104. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Qiu Y, etal., Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.
105. Recombinant murine interleukin 4 protein therapy for psoriasis in a transgenic VEGF mouse model. Ren X, etal., Dermatology. 2009;219(3):232-8. doi: 10.1159/000235974. Epub 2009 Aug 29.
106. GOA pipeline RGD automated data pipeline
107. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
108. Comprehensive gene review and curation RGD comprehensive gene curation
109. Cytokine polymorphisms and Alzheimer disease: possible associations. Ribizzi G, etal., Neurol Sci. 2010 Jun;31(3):321-5. doi: 10.1007/s10072-010-0221-9. Epub 2010 Mar 6.
110.  Effects of interleukin-4 and interleukin-12B gene polymorphisms on hepatitis B virus vaccination. Roh EY, etal., Ann Hepatol. 2017 Jan-Feb 2017;16(1):63-70. doi: 10.5604/16652681.1226816.
111. The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Ronis MJ, etal., Alcohol. 2010 Mar;44(2):157-69. Epub 2010 Jan 29.
112. Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. Ruscher K, etal., PLoS One. 2012;7(9):e45118. doi: 10.1371/journal.pone.0045118. Epub 2012 Sep 18.
113. Increased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis. Sakkas LI, etal., Clin Diagn Lab Immunol. 1999 Sep;6(5):660-4.
114. Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes. Seddon B and Mason D, J Exp Med. 1999 Jan 18;189(2):279-88.
115. N-acetylcysteine and selenium modulate oxidative stress, antioxidant vitamin and cytokine values in traumatic brain injury-induced rats. Senol N, etal., Neurochem Res. 2014 Apr;39(4):685-92. doi: 10.1007/s11064-014-1255-9. Epub 2014 Feb 12.
116. Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease. Shahram F, etal., Clin Exp Rheumatol. 2011 May 31.
117. Interleukin-4 polymorphisms and response to combination therapy in Egyptian chronic hepatitis C patients. Shalaby SM, etal., Cell Immunol. 2012 Mar-Apr;276(1-2):110-3. doi: 10.1016/j.cellimm.2012.04.009. Epub 2012 Apr 21.
118. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
119. Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma. Shimamura T, etal., Cancer Res. 2007 Oct 15;67(20):9903-12.
120. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Shimizu E, etal., J Immunol. 2008 Nov 1;181(9):6503-13.
121. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
122. Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens. Swain SD, etal., Infect Immun. 2011 Feb 22.
123. Interleukin-4 ameliorates experimental glomerulonephritis and up-regulates glomerular gene expression of IL-1 decoy receptor. Tam FW, etal., Kidney Int. 1997 Nov;52(5):1224-31.
124. Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. Tinsley JH, etal., Am J Hypertens. 2009 Oct;22(10):1107-14. Epub 2009 Jul 16.
125. Medical treatment reverses cytokine pattern in allergic and nonallergic chronic rhinosinusitis in asthmatic children. Tosca MA, etal., Pediatr Allergy Immunol. 2003 Jun;14(3):238-41.
126. IL-6 receptor-mediated lung Th2 cytokine networking in silica-induced pulmonary fibrosis. Tripathi SS, etal., Arch Toxicol. 2010 Dec;84(12):947-55. Epub 2010 May 20.
127. Interleukin-4 and -13 promote basolateral secretion of H(+) and cathepsin L by glomerular epithelial cells. Van Den Berg JG, etal., Am J Physiol Renal Physiol. 2002 Jan;282(1):F26-33.
128. Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis. Vandenbroeck K, etal., J Neuroimmunol 1997 Jun;76(1-2):189-92.
129. Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. Vargiolu M, etal., Osteoarthritis Cartilage. 2010 Jun;18(6):810-6. doi: 10.1016/j.joca.2010.02.005. Epub 2010 Feb 26.
130. Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphoma. Vowels BR, etal., J Invest Dermatol. 1994 Nov;103(5):669-73.
131. Genistein modulate immune responses in collagen-induced rheumatoid arthritis model. Wang J, etal., Maturitas. 2008 Apr 20;59(4):405-12. Epub 2008 May 21.
132. Characterization of cis-regulatory elements conferring mercury-induced interleukin-4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites. Wu Z, etal., Immunology. 2009 Aug;127(4):530-8.
133. [The effect of specific immunotherapy on the regulation of Th1/Th2 cell ratio of the patients with allergic rhinitis in serum]. Xiao C, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Oct;24(20):924-7.
134. Global gene expression profile progression in Gaucher disease mouse models. Xu YH, etal., BMC Genomics. 2011 Jan 11;12:20.
135. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. Yamaji-Kegan K, etal., J Immunol. 2010 Nov 1;185(9):5539-48. Epub 2010 Oct 1.
136. Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock. Ye J, etal., Korean J Parasitol. 2016 Dec;54(6):769-775. doi: 10.3347/kjp.2016.54.6.769. Epub 2016 Dec 31.
137. Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. Yigit S, etal., Gene. 2014 Mar 1;537(1):6-9. doi: 10.1016/j.gene.2013.12.060. Epub 2014 Jan 7.
138. Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints. Yorimitsu M, etal., Osteoarthritis Cartilage. 2008 Jul;16(7):764-71. Epub 2008 Jan 7.
139. IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis. Yousefi A, etal., Expert Rev Gastroenterol Hepatol. 2016;10(5):659-63. doi: 10.1586/17474124.2016.1139449. Epub 2016 Feb 11.
140. Interleukin 4 plasma levels in psoriasis vulgaris patients. Zalewska A, etal., Med Sci Monit. 2004 Apr;10(4):CR156-62.
141. [Time trends of Th1 and th2 cytokines in induced sputum of asthmatic subjects during acute upper respiratory viral infections]. Zhang D, etal., Arch Bronconeumol. 2010 Sep;46(9):459-65. doi: 10.1016/j.arbres.2010.04.010. Epub 2010 Jun 22.
142. Study on the T-helper cell 1/2 cytokine profile in blister fluid of patients with herpes zoster and its clinical significance. Zhang M, etal., J Dermatol. 2011 Dec;38(12):1158-62. doi: 10.1111/j.1346-8138.2011.01289.x. Epub 2011 Sep 29.
143. Valproic acid attenuates inflammation in experimental autoimmune neuritis. Zhang Z, etal., Cell Mol Life Sci. 2008 Dec;65(24):4055-65.
144. Effect of TGF-beta1 on the expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats. Zhao J, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Dec;27(6):643-5.
145. [The expression and significance of NF-kappaB in the rat model of otitis media with effusion experimentally induced by ovalbumin] Zhao S, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Aug;22(16):751-5.
146. Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Zhong W, etal., Oncotarget. 2017 Jun 20;8(25):40486-40500. doi: 10.18632/oncotarget.17119.
147. [Effects of BCG-PSN on serum levels of IL-4 and IL-12 in patients with condyloma acuminatum]. Zuo CX, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):690-2.
148. Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production. Zwingenberger K, etal., Clin Immunol Immunopathol. 1990 Nov;57(2):242-9.
Additional References at PubMed
PMID:1588041   PMID:1903705   PMID:1983334   PMID:7749983   PMID:7927664   PMID:8022486   PMID:8200916   PMID:8566034   PMID:9013979   PMID:9110977   PMID:9798653   PMID:9841920  
PMID:9973465   PMID:10429671   PMID:10485657   PMID:10549626   PMID:10979977   PMID:11027433   PMID:11057672   PMID:11698262   PMID:11894098   PMID:11971948   PMID:12004164   PMID:12115603  
PMID:12574355   PMID:12757709   PMID:12882831   PMID:12941478   PMID:14607964   PMID:14988498   PMID:15087456   PMID:15187136   PMID:15238617   PMID:15251393   PMID:15826818   PMID:15944273  
PMID:16002150   PMID:16034134   PMID:16116184   PMID:16129705   PMID:16169702   PMID:16229173   PMID:16275384   PMID:16493007   PMID:16503976   PMID:16522370   PMID:16606666   PMID:16769892  
PMID:16972262   PMID:17018025   PMID:17082577   PMID:17277142   PMID:17442941   PMID:17981803   PMID:18042342   PMID:18337562   PMID:18424750   PMID:18464888   PMID:18510219   PMID:18579517  
PMID:18762567   PMID:18792410   PMID:18827184   PMID:18997793   PMID:19139201   PMID:19235892   PMID:19346497   PMID:19420081   PMID:19666510   PMID:20120734   PMID:20399120   PMID:20500673  
PMID:20554961   PMID:20696860   PMID:20706986   PMID:20956546   PMID:20969918   PMID:21149635   PMID:21168220   PMID:21217760   PMID:21460847   PMID:21613615   PMID:21668966   PMID:22201020  
PMID:23904363   PMID:24139939   PMID:24280217   PMID:24319732   PMID:24347527   PMID:24801739   PMID:25256599   PMID:26003274   PMID:26416964   PMID:26927369   PMID:26951461   PMID:28092075  
PMID:28414034   PMID:29061364   PMID:29469038   PMID:30017262   PMID:30634164   PMID:30890073   PMID:31341902   PMID:31432141   PMID:32258110   PMID:32704142   PMID:35240467  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKY
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
T2T-CHM13v2.05133,193,788 - 133,202,478 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)EnsemblGRCm39 Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBIMGSCv36mm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12335,492,158 - 35,501,349 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,443,750 - 42,449,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il4
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:5
Interacting mature miRNAs:6
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,775,890 - 37,776,020 (+)MAPPERmRatBN7.2
Rnor_6.01038,968,672 - 38,968,801NCBIRnor6.0
Rnor_5.01038,750,399 - 38,750,528UniSTSRnor5.0
RGSC_v3.41039,079,274 - 39,079,404RGDRGSC3.4
RGSC_v3.41039,079,275 - 39,079,404UniSTSRGSC3.4
RGSC_v3.11039,087,845 - 39,087,975RGD
Celera1037,120,106 - 37,120,235UniSTS
RH 3.4 Map10404.0RGD
RH 3.4 Map10404.0UniSTS
RH 2.0 Map10433.4RGD
SHRSP x BN Map1036.2799RGD
Cytogenetic Map10q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,775,837 - 37,776,025 (+)MAPPERmRatBN7.2
Rnor_6.01038,968,619 - 38,968,806NCBIRnor6.0
Rnor_5.01038,750,346 - 38,750,533UniSTSRnor5.0
RGSC_v3.41039,079,221 - 39,079,409RGDRGSC3.4
RGSC_v3.41039,079,222 - 39,079,409UniSTSRGSC3.4
RGSC_v3.11039,087,792 - 39,087,980RGD
Celera1037,120,053 - 37,120,240UniSTS
RH 3.4 Map10406.6UniSTS
RH 3.4 Map10406.6RGD
RH 2.0 Map10446.0RGD
Cytogenetic Map10q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,776,887 - 37,777,027 (+)MAPPERmRatBN7.2
Rnor_6.01038,969,669 - 38,969,808NCBIRnor6.0
Rnor_5.01038,751,396 - 38,751,535UniSTSRnor5.0
RGSC_v3.41039,080,272 - 39,080,411UniSTSRGSC3.4
Celera1037,121,103 - 37,121,241UniSTS
Cytogenetic Map10q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
Low 2 1 1 1 1 2 1 1
Below cutoff 4 8 4 7 4 5 1 10 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010029   ⟹   ENSRNOP00000010029
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)Ensembl
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081309   ⟹   ENSRNOP00000069664
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,964,004 - 38,969,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090691   ⟹   ENSRNOP00000069983
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,964,004 - 38,969,501 (-)Ensembl
RefSeq Acc Id: NM_201270   ⟹   NP_958427
Rat AssemblyChrPosition (strand)Source
mRatBN7.21037,771,203 - 37,776,750 (-)NCBI
Rnor_6.01038,963,979 - 38,969,531 (-)NCBI
Rnor_5.01038,745,706 - 38,751,258 (-)NCBI
RGSC_v3.41039,074,582 - 39,080,134 (-)RGD
Celera1037,115,496 - 37,120,965 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_958427   ⟸   NM_201270
- Peptide Label: precursor
- UniProtKB: P20096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010029   ⟸   ENSRNOT00000010029
RefSeq Acc Id: ENSRNOP00000069983   ⟸   ENSRNOT00000090691
RefSeq Acc Id: ENSRNOP00000069664   ⟸   ENSRNOT00000081309

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20096-F1-model_v2 AlphaFold P20096 1-147 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2898 AgrOrtholog
BioCyc Gene G2FUF-25136 BioCyc
Ensembl Genes ENSRNOG00000007624 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010029 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010029 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-4 UniProtKB/Swiss-Prot
  IL-4/IL-13 UniProtKB/Swiss-Prot
  IL-4/IL-13_CS UniProtKB/Swiss-Prot
KEGG Report rno:287287 UniProtKB/Swiss-Prot
PANTHER PTHR47401 UniProtKB/Swiss-Prot
Pfam IL4 UniProtKB/Swiss-Prot
PhenoGen Il4 PhenoGen
PIRSF Interleukin_4 UniProtKB/Swiss-Prot
SMART IL4_13 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt IL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il4  Interleukin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation inflammatory response causes increase of mRNA in eosinophils 625643