Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Rattus norvegicus
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Symbol: Il4
Name: interleukin 4
RGD ID: 2898
Description: Predicted to have cytokine activity. Involved in several processes, including positive regulation of leukocyte migration; regulation of defense response; and regulation of reactive oxygen species biosynthetic process. Localizes to extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dichloroethane; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: B-cell growth factor 1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BSF-1; IL-4; Il4e12; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,771,203 - 37,776,750 (-)NCBI
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Hepatitis  (IDA)
Acute Lung Injury  (IEP)
adult T-cell leukemia  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (IEP,ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IDA,IMP)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (IMP)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (IEP)
bronchiolitis obliterans  (IEP)
cardiomyopathy  (ISO)
carotid stenosis  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (IEP)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic echinococcosis  (ISO)
cystitis  (IEP)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Pancreatitis, Acute  (IEP)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
Granuloma  (IDA)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (IEP)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (IEP)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (IDA,ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (IDA)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
middle cerebral artery infarction  (IEP)
multiple sclerosis  (ISO)
Nematode Infections  (IEP)
nephritis  (IEP)
nephrotic syndrome  (IEP)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Otitis Media with Effusion  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (IDA)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (IEP)
psoriasis  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISS)
Spinal Cord Injuries  (IMP)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (IEP)
type 1 diabetes mellitus  (ISS)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-trans-(S)-allethrin  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-lipoic acid  (EXP)
1,2-dibutyrin  (ISO)
1,2-dichloroethane  (EXP)
1,3,5-trinitrobenzene  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
13,14-dihydro-15-ketoprostaglandin D2  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-ethylphenol  (ISO)
4-nonylphenol  (ISO)
4-tolyl isocyanate  (ISO)
5-azacytidine  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetone  (ISO)
acetylsalicylic acid  (ISO)
acrylic acid  (EXP)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allicin  (EXP)
alpha-galactosylceramide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antigen  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
azathioprine  (ISO)
BAPTA  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
bexarotene  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
Brevetoxin B  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
buprenorphine  (ISO)
butenafine  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcipotriol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbachol  (ISO)
carbamazepine  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
caryophyllene oxide  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
cetirizine  (ISO)
chlorambucil  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorphenamine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysin  (ISO)
cilostazol  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clarithromycin  (ISO)
clopidogrel  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cupressuflavone  (ISO)
curcumin  (EXP,ISO)
cyclopentanes  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
D-penicillamine  (EXP)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
Deguelin  (EXP,ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzothiazol-2-yl disulfide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
dicyclohexylmethane-4,4'-diisocyanate  (ISO)
diethyl maleate  (ISO)
diethylamine  (ISO)
diflorasone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
donepezil hydrochloride  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
emodin  (ISO)
epinastine  (EXP,ISO)
equol  (ISO)
Erionite  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
famotidine  (ISO)
fentanyl  (ISO)
ferric oxide  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
fomepizole  (EXP)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
formoterol fumarate  (EXP,ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furfuryl alcohol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
Gastrodin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
ginsenoside C-K  (ISO)
glutathione  (ISO)
graphite  (ISO)
helenalin  (ISO)
heroin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxyzine  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
immunological adjuvant  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
levamisole  (EXP,ISO)
lidocaine  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (EXP)
lipoxin A4  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loperamide  (ISO)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
methadone  (ISO)
methanol  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methyl salicylate  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mitogen  (ISO)
MK 571  (ISO)
Monobutylphthalate  (ISO)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morphine  (ISO)
moxifloxacin  (ISO)
mycophenolic acid  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
neocuproine  (ISO)
Nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrendipine  (ISO)
nitric oxide  (ISO)
nitrites  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
Olopatadine hydrochloride  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
patulin  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
polyphosphates  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
progesterone  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pyrene  (ISO)
Pyridostigmine bromide  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
ribavirin  (ISO)
ricinoleic acid  (ISO)
Ro 41-5253  (ISO)
rolipram  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 203580  (EXP,ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hexachloroplatinate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
spathulenol  (ISO)
SR 144528  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
styrene  (ISO)
Sucralfate  (EXP)
sulfasalazine  (EXP)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
Sunset Yellow FCF  (ISO)
synephrine  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thromboxane B2  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolnaftate  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-piceid  (EXP)
tremolite asbestos  (ISO)
triamcinolone acetonide  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
tributyrin  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
verrucarin A  (ISO)
vitamin E  (EXP,ISO)
WIN 55212-2  (EXP)
wortmannin  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IBA,ISO)
B cell activation  (IEA)
B cell costimulation  (IBA,ISO)
cellular response to mercury ion  (IEP)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
female pregnancy  (IEP)
immune response  (IEA)
innate immune response in mucosa  (IBA,ISO)
macrophage activation  (ISO)
microglial cell activation  (IBA,IDA)
myeloid dendritic cell differentiation  (IBA,ISO)
negative regulation of acute inflammatory response  (IBA,IDA)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (IBA,IDA)
negative regulation of complement-dependent cytotoxicity  (IBA,ISO)
negative regulation of endothelial cell apoptotic process  (IBA,ISO)
negative regulation of epithelial cell migration  (IBA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (IBA,IMP)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (IBA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (IDA)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (IBA,IDA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,IDA,ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of defense response to virus by host  (IBA,IDA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of eosinophil chemotaxis  (IBA,IDA)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (IBA,IDA,ISO)
positive regulation of interleukin-13 production  (IBA,ISO)
positive regulation of isotype switching to IgE isotypes  (IBA,ISO)
positive regulation of isotype switching to IgG isotypes  (IBA,ISO)
positive regulation of macroautophagy  (IBA,ISO,ISS)
positive regulation of mast cell degranulation  (IBA,ISO)
positive regulation of MHC class II biosynthetic process  (IBA,ISO)
positive regulation of mononuclear cell migration  (IBA,IDA)
positive regulation of myoblast fusion  (IBA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (IBA,IDA,ISO)
positive regulation of T cell differentiation  (IBA,ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (IBA,IDA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA,ISO)
regulation of immune response  (ISO)
regulation of inflammatory response  (IDA)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (IDA)
response to cytokine  (IEP)
response to drug  (IEP)
response to ethanol  (IEP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
retina development in camera-type eye  (IEP)
signal transduction  (IEA)
T cell activation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (IBA,ISO)

Cellular Component

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1588041   PMID:1903705   PMID:1983334   PMID:7749983   PMID:7927664   PMID:8022486   PMID:8200916   PMID:8566034   PMID:9013979   PMID:9110977   PMID:9798653   PMID:9841920  
PMID:9973465   PMID:10429671   PMID:10485657   PMID:10549626   PMID:10979977   PMID:11027433   PMID:11057672   PMID:11698262   PMID:11894098   PMID:11971948   PMID:12004164   PMID:12115603  
PMID:12574355   PMID:12757709   PMID:12882831   PMID:12941478   PMID:14607964   PMID:14988498   PMID:15087456   PMID:15187136   PMID:15238617   PMID:15251393   PMID:15826818   PMID:15944273  
PMID:16002150   PMID:16034134   PMID:16116184   PMID:16129705   PMID:16169702   PMID:16229173   PMID:16275384   PMID:16493007   PMID:16503976   PMID:16522370   PMID:16606666   PMID:16769892  
PMID:16972262   PMID:17018025   PMID:17082577   PMID:17277142   PMID:17442941   PMID:17981803   PMID:18042342   PMID:18337562   PMID:18424750   PMID:18464888   PMID:18510219   PMID:18579517  
PMID:18762567   PMID:18792410   PMID:18827184   PMID:18997793   PMID:19139201   PMID:19235892   PMID:19346497   PMID:19420081   PMID:19666510   PMID:20120734   PMID:20399120   PMID:20500673  
PMID:20554961   PMID:20696860   PMID:20706986   PMID:20956546   PMID:20969918   PMID:21149635   PMID:21168220   PMID:21217760   PMID:21460847   PMID:21613615   PMID:21668966   PMID:22201020  
PMID:23904363   PMID:24139939   PMID:24280217   PMID:24319732   PMID:24347527   PMID:24801739   PMID:25256599   PMID:26003274   PMID:26416964   PMID:26927369   PMID:26951461   PMID:28092075  
PMID:28414034   PMID:29061364   PMID:29469038   PMID:30017262   PMID:30634164   PMID:30890073   PMID:31341902   PMID:31432141   PMID:32258110   PMID:32704142  


Genomics

Candidate Gene Status
Il4 is a candidate Gene for QTL Eau7
Comparative Map Data
Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,771,203 - 37,776,750 (-)NCBI
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBImm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0panPan3
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBI
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBI
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBI
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBI
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBI
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBI
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)Ensembl
Vero_WHO_p1.0NW_02366603442,443,750 - 42,449,550 (-)NCBI
Il4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBI

Position Markers
D10Mgh9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,775,890 - 37,776,020 (+)MAPPER
Rnor_6.01038,968,672 - 38,968,801NCBIRnor6.0
Rnor_5.01038,750,399 - 38,750,528UniSTSRnor5.0
RGSC_v3.41039,079,274 - 39,079,404RGDRGSC3.4
RGSC_v3.41039,079,275 - 39,079,404UniSTSRGSC3.4
RGSC_v3.11039,087,845 - 39,087,975RGD
Celera1037,120,106 - 37,120,235UniSTS
RH 3.4 Map10404.0RGD
RH 3.4 Map10404.0UniSTS
RH 2.0 Map10433.4RGD
SHRSP x BN Map1036.2799RGD
Cytogenetic Map10q22UniSTS
D10Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,775,837 - 37,776,025 (+)MAPPER
Rnor_6.01038,968,619 - 38,968,806NCBIRnor6.0
Rnor_5.01038,750,346 - 38,750,533UniSTSRnor5.0
RGSC_v3.41039,079,221 - 39,079,409RGDRGSC3.4
RGSC_v3.41039,079,222 - 39,079,409UniSTSRGSC3.4
RGSC_v3.11039,087,792 - 39,087,980RGD
Celera1037,120,053 - 37,120,240UniSTS
RH 3.4 Map10406.6UniSTS
RH 3.4 Map10406.6RGD
RH 2.0 Map10446.0RGD
Cytogenetic Map10q22UniSTS
UniSTS:143568  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,776,887 - 37,777,027 (+)MAPPER
Rnor_6.01038,969,669 - 38,969,808NCBIRnor6.0
Rnor_5.01038,751,396 - 38,751,535UniSTSRnor5.0
RGSC_v3.41039,080,272 - 39,080,411UniSTSRGSC3.4
Celera1037,121,103 - 37,121,241UniSTS
Cytogenetic Map10q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101646873661468736Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101824639453637634Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101940281464402814Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)1020170031102897474Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102152390683549467Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)12152390690312401Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102152390690312401Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102170776664648311Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102290149793886300Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102386101566539843Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1023861015112626471Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102488408447487910Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102723753064648311Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)1027237530101482600Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1027237530102427718Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102878928073789280Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)103002135454057745Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103009990975099909Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103009990975099909Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103098380575983805Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103191939778343192Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103317903078179030Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103334319278343192Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103513942480139424Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103566946546851407Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103618592982675365Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103618592995845311Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103658437353645194Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103658437366539843Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103658456066015527Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7
Count of miRNA genes:5
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000010029
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 1 1 1 1 2 1 1
Below cutoff 4 8 4 7 4 5 1 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010029   ⟹   ENSRNOP00000010029
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081309   ⟹   ENSRNOP00000069664
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,964,004 - 38,969,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090691   ⟹   ENSRNOP00000069983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1038,964,004 - 38,969,501 (-)Ensembl
RefSeq Acc Id: NM_201270   ⟹   NP_958427
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21037,771,203 - 37,776,750 (-)NCBI
Rnor_6.01038,963,979 - 38,969,531 (-)NCBI
Rnor_5.01038,745,706 - 38,751,258 (-)NCBI
RGSC_v3.41039,074,582 - 39,080,134 (-)RGD
Celera1037,115,496 - 37,120,965 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_958427   ⟸   NM_201270
- Peptide Label: precursor
- UniProtKB: P20096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010029   ⟸   ENSRNOT00000010029
RefSeq Acc Id: ENSRNOP00000069983   ⟸   ENSRNOT00000090691
RefSeq Acc Id: ENSRNOP00000069664   ⟸   ENSRNOT00000081309

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin