RGD Reference Report - [The relationship between CD4(-) CD8(-) T cells in the peripheral blood of patients with pancreatic carcinoma and IL-4, IFN-gamma levels] - Rat Genome Database

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[The relationship between CD4(-) CD8(-) T cells in the peripheral blood of patients with pancreatic carcinoma and IL-4, IFN-gamma levels]

Authors: Chen, J  Du, M  Li, WB  Lei, C  Yang, B  Tang, HK  Zhai, ZM  Ma, JL  Li, Q 
Citation: Chen J, etal., Zhonghua Wai Ke Za Zhi. 2009 Jul 1;47(13):995-8.
RGD ID: 2317261
Pubmed: PMID:19957810   (View Abstract at PubMed)

OBJECTIVE: To investigate the relationship between CD4- CD8- T cells ratio and IL-4, IFN-gamma levels in the peripheral blood of patients with pancreatic carcinoma. METHODS: Flowcytometer was used to analyze the CD4- CD8- T cells ratio in the peripheral blood of patients with pancreatic carcinoma and the IL-4, IFN-gamma levels were detected by ELISA. RESULTS: The ratio of CD4- CD8- T cell in CD3+ T cell from 25 pancreatic carcinoma patients was (4.2 +/- 1.7)%, the ratio of CD4- CD8- T cell in CD3+ T cell from 45 healthy person was (6.3 +/- 2.6)%, there was significant deviation between the two groups (P < 0.01). The IL-4 level of 25 pancreatic carcinoma patients was (86.3 +/- 23.3) fg/L, the IL-4 level of 45 healthy person was (56.2 +/- 9.2) fg/L,there was significant deviation between the two groups (P < 0.01). The IFN-gamma level of 25 pancreatic carcinoma patients was (16.4 +/- 4.8) fg/L before operation, the IFN-gamma level of 45 healthy person was (27.4 +/- 3.8) fg/L, there was significant deviation between the two groups (P < 0.01). The ratio of CD4- CD8- T cell in pancreatic carcinoma patient after operation was higher than before operation. It could be found negative correlation between CD4- CD8- T cells ratio and IL-4 level in pancreatic carcinoma patient,it could also be found positive correlation between CD4- CD8- T cells ratio and IFN-gamma level in pancreatic carcinoma patient. In pancreatic carcinoma patient, the CD4- CD8- T cells ratio and IL-4 level was significant associated with clinical stage (P < 0.05), but no relationship with hisological differentiation (P > 0.05), it could be found no relationship between IFN-gamma level and clinical stage, hisological differentiation (P > 0.05). CONCLUSION: The CD4- CD8- T cells ratio in the peripheral blood of patients is decreased,it may be participate in the carcinogenesis and development of pancreatic carcinoma by influence the IFN-gamma levels.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic cancer disease_progressionIEP 2317261protein:increased expression:bloodRGD 
pancreatic cancer disease_progressionISOIL4 (Homo sapiens)2317261; 2317261protein:increased expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il4  (interleukin 4)

Genes (Mus musculus)
Il4  (interleukin 4)

Genes (Homo sapiens)
IL4  (interleukin 4)


Additional Information