RGD Reference Report - Production of interleukins 4 and 10 in children with hepatic involvement in the course of Toxocara spp. infection. - Rat Genome Database

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Production of interleukins 4 and 10 in children with hepatic involvement in the course of Toxocara spp. infection.

Authors: Mazur-Melewska, K  Figlerowicz, M  Cwalinska, A  Mikos, H  Jonczyk-Potoczna, K  Lewandowska-Stachowiak, M  Sluzewski, W 
Citation: Mazur-Melewska K, etal., Parasite Immunol. 2016 Feb;38(2):101-7. doi: 10.1111/pim.12303.
RGD ID: 11534298
Pubmed: PMID:26732352   (View Abstract at PubMed)
DOI: DOI:10.1111/pim.12303   (Journal Full-text)

Toxocara spp. infestations present with a wide spectrum of symptoms, from general inflammation of internal organs with eosinophilic granuloma formulation through ocular or brain involvement. There is also an asymptomatic form. The known factors that influence the clinical form of the disease are the intensity of the infestation, the localization of the larvae, the age of the patient, the efficiency of the immune system and the history of reinfection. The aim of our study was to evaluate the production of interleukins 4 (IL-4) and 10 (IL-10) in children in the course of Toxocara spp. infections with hepatic involvement. The analysis of peripheral leucocytes, eosinophils, immunoglobulin E, and IL-4 and IL-10 concentrations presented significantly higher values in children with radiologically confirmed liver granuloma than in uncomplicated hepatomegaly. Based on statistical analysis, we confirmed the IL-4/IL-10 ratio variation in the analysed groups: patients with liver lesions showed a ratio of <1, while children without granulomas had a ratio of >2. The relevant analysis confirmed a positive statistical correlation in both seropositive groups for IgE and IL-4, and only in the granuloma group for IgE and IL-10.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL4Humantoxocariasis treatmentIEP  RGD 
Il4Rattoxocariasis treatmentISOIL4 (Homo sapiens) RGD 
Il4Mousetoxocariasis treatmentISOIL4 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il4  (interleukin 4)

Genes (Mus musculus)
Il4  (interleukin 4)

Genes (Homo sapiens)
IL4  (interleukin 4)


Additional Information