IL4 (interleukin 4) - Rat Genome Database
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Gene: IL4 (interleukin 4) Pan paniscus
Analyze
Symbol: IL4
Name: interleukin 4
RGD ID: 11755364
Description: ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN activation of Janus kinase activity (ortholog); B cell costimulation (ortholog); cellular response to mercury ion (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Acute Hepatitis (ortholog); Acute Lung Injury (ortholog); adult T-cell leukemia (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: interleukin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
adult T-cell leukemia  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
Granuloma  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (ISO)
Meningococcal Infections  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (ISO)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO)
B cell costimulation  (ISO)
cellular response to mercury ion  (ISO)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (ISO)
innate immune response in mucosa  (ISO)
macrophage activation  (ISO)
microglial cell activation  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of epithelial cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of eosinophil chemotaxis  (ISO)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of isotype switching to IgE isotypes  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of myoblast fusion  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of immune response  (ISO)
regulation of inflammatory response  (ISO)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
retina development in camera-type eye  (ISO)
T cell activation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0panPan3
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBImm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,771,203 - 37,776,750 (-)NCBI
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366472,510,457 - 2,518,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBI
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)Ensembl
Il4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000031203   ⟹   ENSPPAP00000008567
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000031207   ⟹   ENSPPAP00000008571
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000031209   ⟹   ENSPPAP00000008573
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5134,253,104 - 134,258,882 (+)Ensembl
RefSeq Acc Id: XM_003829298   ⟹   XP_003829346
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.15134,253,039 - 134,261,581 (+)NCBI
Mhudiblu_PPA_v05128,091,342 - 128,099,883 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003829299   ⟹   XP_003829347
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.15134,253,039 - 134,261,581 (+)NCBI
Mhudiblu_PPA_v05128,091,345 - 128,099,886 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024928848   ⟹   XP_024784616
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.15134,253,104 - 134,258,882 (+)NCBI
Mhudiblu_PPA_v05128,091,407 - 128,097,216 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003829346 (Get FASTA)   NCBI Sequence Viewer  
  XP_003829347 (Get FASTA)   NCBI Sequence Viewer  
  XP_024784616 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003829346   ⟸   XM_003829298
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003829347   ⟸   XM_003829299
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024784616   ⟸   XM_024928848
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSPPAP00000008567   ⟸   ENSPPAT00000031203
RefSeq Acc Id: ENSPPAP00000008571   ⟸   ENSPPAT00000031207
RefSeq Acc Id: ENSPPAP00000008573   ⟸   ENSPPAT00000031209


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000008567 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000008571 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000008573 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000031203 UniProtKB/TrEMBL
  ENSPPAT00000031207 UniProtKB/TrEMBL
  ENSPPAT00000031209 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-4 UniProtKB/TrEMBL
  IL-4/IL-13 UniProtKB/TrEMBL
  IL-4/IL-13_CS UniProtKB/TrEMBL
KEGG Report pps:100988878 UniProtKB/TrEMBL
NCBI Gene IL4 ENTREZGENE
PANTHER PTHR47401 UniProtKB/TrEMBL
Pfam IL4 UniProtKB/TrEMBL
PIRSF Interleukin_4 UniProtKB/TrEMBL
PRINTS INTERLEUKIN4 UniProtKB/TrEMBL
PROSITE INTERLEUKIN_4_13 UniProtKB/TrEMBL
SMART IL4_13 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A2R8ZVJ1_PANPA UniProtKB/TrEMBL
  A0A2R8ZXQ5_PANPA UniProtKB/TrEMBL
  A0A2R9A020_PANPA UniProtKB/TrEMBL