Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Heterocephalus glaber
Analyze
Symbol: Il4
Name: interleukin 4
RGD ID: 18908031
Description: ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN activated T cell proliferation (ortholog); B cell activation (ortholog); B cell costimulation (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Hepatitis (ortholog); Acute Lung Injury (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Interleukin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
Granuloma  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Infections  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (ISO)
type 1 diabetes mellitus  (ISO)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
B cell activation  (ISO)
B cell costimulation  (ISO)
B cell proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to mercury ion  (ISO)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (ISO)
innate immune response in mucosa  (ISO)
interleukin-4-mediated signaling pathway  (ISO)
isotype switching to IgE isotypes  (ISO)
isotype switching to IgG isotypes  (ISO)
macrophage activation  (ISO)
MHC class II biosynthetic process  (ISO)
microglial cell activation  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of acute inflammatory response  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of epithelial cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell chemotaxis  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of eosinophil chemotaxis  (ISO)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of isotype switching to IgE isotypes  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of myoblast fusion  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of immune response  (ISO)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to nematode  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to selenium ion  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
T cell activation  (ISO)
T cell proliferation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
tyrosine phosphorylation of STAT protein  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Il4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
T2T-CHM13v2.05133,193,788 - 133,202,478 (+)NCBIT2T-CHM13v2.0
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)EnsemblGRCm39 Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBIMGSCv36mm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,272,003 - 38,277,549 (-)NCBIGRCr8
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,986,571 - 127,995,112 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,126,136 - 126,134,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBIUU_Cfam_GSD_1.0
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,443,750 - 42,449,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_021237989   ⟹   XP_021093648
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021093648 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00061 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021093648   ⟸   XM_021237989


Additional Information

Database Acc Id Source(s)
NCBI Gene Il4 ENTREZGENE