RGD Reference Report - [Effects of BCG-PSN on serum levels of IL-4 and IL-12 in patients with condyloma acuminatum]. - Rat Genome Database

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[Effects of BCG-PSN on serum levels of IL-4 and IL-12 in patients with condyloma acuminatum].

Authors: Zuo, CX  Huang, JH  Liao, ZH  Lu, JY  Chen, J 
Citation: Zuo CX, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):690-2.
RGD ID: 7829774
Pubmed: (View Article at PubMed) PMID:16114559

OBJECTIVE: To determine the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG-PSN) on serum levels of interleukin-4 (IL-4) and interleukin-12 (IL-12) in patients with condyloma acuminatum (CA) and to investigate the mechamism of immunoregulation of BCG-PSN on CA. METHODS: Sixty CA cases were randomly divided into 2 groups. The serum levels of IL-4 and IL-12 were respectively measured by Double-antibody sandwich ELISA method before and after the treatment. The serum levels of IL-12 and IL-4 of health control were also measured. The recurrent rate of each group was used as an index to assess the effect of BCG-PSN in CA patients. RESULTS: Compared with healthy controls, the serum levels of IL-12 in patients with CA were decreased significantly (P < 0.05), while the serum levels of IL-4 were increased significantly (P < 0.05) before the treatment. The serum levels of IL-12 were negatively correlated with the serum levels of IL-4 (r = -0.287, P < 0.05). After the treatment, the serum levels of IL-12 were increased significantly( P < 0.05), and the serum levels of IL4 were decreased significantly (P < 0.05) in the treatment group. But in the control group, the serum levels of IL-12 and IL-4 were similar before and after the treatment (P > 0.05). The recurrent rate of treatment group was significantly lower than that of the control group (chi2 = 4.356, P < 0.05). CONCLUSIONS: There is an imbalance of Th1/Th2 cytokines production in patients with condyloma acuminatum. BCG-PSN could increase the serum level of IL-12 and decrease the serum level of IL-4 in CA patients. BCG-PSN could decrease the recurrent rate of CA. The effect may be related to the regulation and modulation of BCG-PSN to Thl/Th2 cytokines imbalance,which then enhances the cellular immunity in CA patients.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il12b  (interleukin 12B)
Il4  (interleukin 4)

Genes (Mus musculus)
Il12b  (interleukin 12b)
Il4  (interleukin 4)

Genes (Homo sapiens)
IL12B  (interleukin 12B)
IL4  (interleukin 4)


Additional Information