IL4 (interleukin 4) - Rat Genome Database
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Gene: IL4 (interleukin 4) Sus scrofa
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Symbol: IL4
Name: interleukin 4
RGD ID: 14099299
Description: ENCODES a protein that exhibits growth factor activity (inferred); interleukin-4 receptor binding (inferred); INVOLVED IN negative regulation of complement-dependent cytotoxicity; negative regulation of endothelial cell apoptotic process; positive regulation of establishment of endothelial barrier; PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); Acute Lung Injury (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH deoxynivalenol; melittin; notoginsenoside R1
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: B-cell stimulatory factor 1; BSF-1; IL-4; interleukin-4; lymphocyte stimulatory factor 1
Orthologs:
Homo sapiens (human) : IL4 (interleukin 4)  HGNC  Alliance
Mus musculus (house mouse) : Il4 (interleukin 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il4 (interleukin 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il4 (interleukin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IL4 (interleukin 4)
Canis lupus familiaris (dog) : IL4 (interleukin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il4 (interleukin 4)
Chlorocebus sabaeus (African green monkey) : IL4 (interleukin 4)
Heterocephalus glaber (naked mole-rat) : Il4 (interleukin 4)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
adult T-cell leukemia  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
Granuloma  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (ISO)
malignant glioma  (ISO)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (ISO)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IBA)
B cell activation  (IEA)
B cell costimulation  (IBA)
cellular response to mercury ion  (ISO)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA)
female pregnancy  (ISO)
innate immune response in mucosa  (IBA)
macrophage activation  (ISO)
microglial cell activation  (IBA)
myeloid dendritic cell differentiation  (IBA)
negative regulation of acute inflammatory response  (IBA)
negative regulation of cellular response to transforming growth factor beta stimulus  (IEA)
negative regulation of chronic inflammatory response  (IBA)
negative regulation of complement-dependent cytotoxicity  (IBA,IMP)
negative regulation of endothelial cell apoptotic process  (IBA,IMP)
negative regulation of epithelial cell migration  (IBA)
negative regulation of extrinsic apoptotic signaling pathway  (IBA)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (IBA)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (IBA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tumor necrosis factor production  (IBA)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (IBA)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (IBA)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of defense response to virus by host  (IBA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of eosinophil chemotaxis  (IBA)
positive regulation of establishment of endothelial barrier  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (IBA)
positive regulation of interleukin-13 production  (IBA)
positive regulation of isotype switching to IgE isotypes  (IBA)
positive regulation of isotype switching to IgG isotypes  (IBA)
positive regulation of macroautophagy  (IBA,ISS)
positive regulation of mast cell degranulation  (IBA)
positive regulation of MHC class II biosynthetic process  (IBA)
positive regulation of mononuclear cell migration  (IBA)
positive regulation of myoblast fusion  (IBA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IMP)
positive regulation of receptor-mediated endocytosis  (IBA)
positive regulation of T cell differentiation  (IBA)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (IBA)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA)
regulation of immune response  (ISO)
regulation of inflammatory response  (ISO)
regulation of protein export from nucleus  (IMP)
regulation of proton transport  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
retina development in camera-type eye  (ISO)
T cell activation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (IBA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7930948   PMID:8424960   PMID:8661698   PMID:16034134   PMID:17082655   PMID:18761033   PMID:19766617   PMID:20017192   PMID:21572032   PMID:24280217  


Genomics

Comparative Map Data
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,009,678 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBI
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBImm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0panPan3
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366472,510,457 - 2,518,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)Ensembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBI
Il4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system reproductive system
High
Medium
Low 2 3 6
Below cutoff 3 1 1 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015605   ⟹   ENSSSCP00000015193
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)Ensembl
RefSeq Acc Id: NM_214123   ⟹   NP_999288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999288   ⟸   NM_214123
- Peptide Label: precursor
- UniProtKB: Q04745 (UniProtKB/Swiss-Prot),   F1CFE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015193   ⟸   ENSSSCT00000015605
Protein Domains
Fibronectin type-III


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014282 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00025056992 UniProtKB/Swiss-Prot
  ENSSSCG00035022691 UniProtKB/Swiss-Prot
  ENSSSCG00045014434 UniProtKB/Swiss-Prot
  ENSSSCG00065022324 UniProtKB/Swiss-Prot
  ENSSSCG00070020063 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000015193 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00025033801 UniProtKB/Swiss-Prot
  ENSSSCP00035011462 UniProtKB/Swiss-Prot
  ENSSSCP00045017009 UniProtKB/Swiss-Prot
  ENSSSCP00065012139 UniProtKB/Swiss-Prot
  ENSSSCP00070033314 UniProtKB/Swiss-Prot
  ENSSSCP00070033317 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015605 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00025077978 UniProtKB/Swiss-Prot
  ENSSSCT00035029644 UniProtKB/Swiss-Prot
  ENSSSCT00045024617 UniProtKB/Swiss-Prot
  ENSSSCT00065029701 UniProtKB/Swiss-Prot
  ENSSSCT00070039772 UniProtKB/Swiss-Prot
  ENSSSCT00070039777 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  IL-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4/IL-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4/IL-13_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4_rcpt-alpha_N UniProtKB/TrEMBL
KEGG Report ssc:397225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene IL4 ENTREZGENE
PANTHER PTHR47401 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL4Ra_N UniProtKB/TrEMBL
PIRSF Interleukin_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
  INTERLEUKIN_4_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL4_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniGene Ssc.15837 ENTREZGENE
UniProt A0A4X1UX20_PIG UniProtKB/TrEMBL
  F1CFE1 ENTREZGENE, UniProtKB/TrEMBL
  IL4_PIG UniProtKB/Swiss-Prot
  M3V818_PIG UniProtKB/TrEMBL
  Q04745 ENTREZGENE
UniProt Secondary Q29054 UniProtKB/Swiss-Prot
  Q8MKE6 UniProtKB/Swiss-Prot
VGNC ID VGNC:89108 ENTREZGENE