IL4 (interleukin 4) - Rat Genome Database

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Gene: IL4 (interleukin 4) Canis lupus familiaris
Analyze
Symbol: IL4
Name: interleukin 4
RGD ID: 12235618
Description: ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); growth factor activity (inferred); INVOLVED IN activated T cell proliferation (ortholog); B cell activation (ortholog); B cell costimulation (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Hepatitis (ortholog); Acute Lung Injury (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH cannabidiol; luteolin
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell stimulatory factor 1; BSF-1; IL-4; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBI
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBI
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)Ensembl
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBI
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBI
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
Granuloma  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (ISO)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cannabidiol  (EXP)
luteolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
activation of Janus kinase activity  (IBA)
B cell activation  (IEA,ISO)
B cell costimulation  (IBA,ISO)
B cell proliferation  (ISO)
cellular response to mercury ion  (ISO)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
female pregnancy  (ISO)
immune response  (IEA)
innate immune response in mucosa  (IBA)
isotype switching to IgE isotypes  (ISO)
isotype switching to IgG isotypes  (ISO)
macrophage activation  (ISO)
MHC class II biosynthetic process  (ISO)
microglial cell activation  (IBA,ISO)
myeloid dendritic cell differentiation  (IBA)
negative regulation of acute inflammatory response  (IBA,ISO)
negative regulation of apoptotic process  (ISS)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (IBA,ISO)
negative regulation of complement-dependent cytotoxicity  (IBA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell apoptotic process  (IBA)
negative regulation of epithelial cell migration  (IBA)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (IBA,ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of osteoclast differentiation  (ISO,ISS)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (IBA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (IBA)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO,ISS)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of defense response to virus by host  (IBA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IBA,ISO)
positive regulation of eosinophil chemotaxis  (IBA,ISO)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (IBA,ISO)
positive regulation of interleukin-13 production  (IBA)
positive regulation of isotype switching to IgE isotypes  (IBA,ISO,ISS)
positive regulation of isotype switching to IgG isotypes  (IBA,ISO,ISS)
positive regulation of macroautophagy  (IBA,ISS)
positive regulation of mast cell degranulation  (IBA,ISO)
positive regulation of MHC class II biosynthetic process  (IBA,ISO,ISS)
positive regulation of mononuclear cell migration  (IBA,ISO)
positive regulation of myoblast fusion  (IBA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (IBA)
positive regulation of T cell differentiation  (IBA)
positive regulation of T cell proliferation  (ISO,ISS)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA,ISO)
regulation of immune response  (ISO,ISS)
regulation of inflammatory response  (ISO)
regulation of phosphorylation  (ISS)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
T cell activation  (ISO)
T cell proliferation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (IBA,ISO)
transcription by RNA polymerase II  (ISO)
tyrosine phosphorylation of STAT protein  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9887351   PMID:10487243   PMID:11730929   PMID:11741347   PMID:18789870   PMID:20187917   PMID:20188584   PMID:21511273   PMID:21991344   PMID:23605681   PMID:33582406  


Genomics

Comparative Map Data
IL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,972,693 - 20,981,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBI
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBI
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)Ensembl
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBI
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBI
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBI
IL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,673,986 - 132,682,678 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,009,681 - 132,018,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,037,272 - 132,046,267 (+)NCBINCBI36hg18NCBI36
Build 345132,037,271 - 132,046,267NCBI
Celera5128,139,502 - 128,148,524 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,201,979 - 127,210,672 (+)NCBIHuRef
CHM1_15131,442,973 - 131,451,670 (+)NCBICHM1_1
T2T-CHM13v2.05133,193,788 - 133,202,478 (+)NCBI
Il4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBImm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
Il4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)Ensembl
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,058,052 - 4,065,999 (+)NCBIChiLan1.0ChiLan1.0
IL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,253,039 - 134,261,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,253,039 - 134,261,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,091,342 - 128,099,886 (+)NCBIMhudiblu_PPA_v0panPan3
IL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,986,817 - 134,994,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,986,817 - 134,994,365 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,455,331 - 140,462,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,492,158 - 35,501,349 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,492,939 - 35,501,258 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603442,443,750 - 42,449,550 (-)NCBIVero_WHO_p1.0
Il4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,412,800 - 39,420,079 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 1 6 1
Below cutoff 2 4 13 3 6 3 4 2 9 1 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001367   ⟹   ENSCAFP00000001253
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1120,972,690 - 20,981,534 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019424   ⟹   ENSCAFP00845015186
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1121,758,630 - 21,767,482 (+)Ensembl
RefSeq Acc Id: NM_001003159   ⟹   NP_001003159
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11120,972,693 - 20,981,539 (+)NCBI
Dog10K_Boxer_Tasha1119,774,149 - 19,783,205 (+)NCBI
ROS_Cfam_1.01121,758,633 - 21,767,487 (+)NCBI
UMICH_Zoey_3.11120,477,129 - 20,485,985 (+)NCBI
UNSW_CanFamBas_1.01120,324,686 - 20,333,537 (+)NCBI
UU_Cfam_GSD_1.01120,967,178 - 20,976,037 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001003159   ⟸   NM_001003159
- Peptide Label: precursor
- UniProtKB: A1E293 (UniProtKB/Swiss-Prot),   O77762 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001253   ⟸   ENSCAFT00000001367
RefSeq Acc Id: ENSCAFP00845015186   ⟸   ENSCAFT00845019424


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000880 Ensembl
  ENSCAFG00030011649 UniProtKB/Swiss-Prot
  ENSCAFG00040006346 UniProtKB/Swiss-Prot
  ENSCAFG00845010991 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00030018780 UniProtKB/Swiss-Prot
  ENSCAFP00040010259 UniProtKB/Swiss-Prot
  ENSCAFP00845015186 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00030021538 UniProtKB/Swiss-Prot
  ENSCAFT00040011833 UniProtKB/Swiss-Prot
  ENSCAFT00845019424 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-4 UniProtKB/Swiss-Prot
  IL-4/IL-13 UniProtKB/Swiss-Prot
  IL-4/IL-13_CS UniProtKB/Swiss-Prot
KEGG Report cfa:403785 UniProtKB/Swiss-Prot
NCBI Gene IL4 ENTREZGENE
PANTHER PTHR47401 UniProtKB/Swiss-Prot
Pfam IL4 UniProtKB/Swiss-Prot
PIRSF Interleukin_4 UniProtKB/Swiss-Prot
PRINTS INTERLEUKIN4 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot
SMART IL4_13 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A1E293 ENTREZGENE
  IL4_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1E293 UniProtKB/Swiss-Prot
VGNC ID VGNC:41987 ENTREZGENE