RGD Reference Report - [Effect of Smilax china bioactive fraction on tumor necrosis factor-alpha and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease].

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[Effect of Smilax china bioactive fraction on tumor necrosis factor-alpha and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease].
Authors:	Luo, Y Ma, Y Song, L Luo, H Hou, L
Citation:	Luo Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):236-40.
RGD ID:	10402794
Pubmed:	PMID:24589604 (View Abstract at PubMed)
OBJECTIVE: To study the mechanism that mediates the therapeutic effect of the bioactive fraction of Baqia (Smilax china) on chronic pelvic inflammatory disease (CPID). METHODS: Seventy rats were randomized into CPID model group, sham-operated group, normal control group, Jingangteng capsule group, and high-, medium-, and low-dose Baqia groups. Rat models of CPID were established by inducing chemical burns of the uterus and corresponding treatments were administered. After 14 days of treatment, the rat uterus was observed for swelling and inhibition rate, and the expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 (IL-4) in the uterine tissues were determined using enzyme-linked immunosorbent assay. RESULTS: The bioactive fraction of Baqia at the 3 doses obviously reduced the inflammatory cells in the endometrium, promoted epithelial cell proliferation, and ameliorated congestion and edema of the serosa. High and medium doses of Baqia bioactive fraction significantly decreased uterus swelling rate of the rats (P<0.01). All the 3 doses of the Baqia bioactive fraction obviously decreased uterine TNF-alpha content (P<0.01) and significantly increased uterine IL-4 expression level (P<0.05), and IL-4 up-regulation was especially obvious in high and medium dose groups (P<0.01). CONCLUSION: Baqia bioactive fraction can ameliorate uterine swelling, lower uterine TNF-alpha and increase IL-4 expressions in rats with CPID, which may be a pharmacological mechanism underlying its therapeutic effect on CPID and cervical adhesion.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
IL4	Human	pelvic inflammatory disease	treatment	ISO	Il4 (Rattus norvegicus)		RGD
Il4	Rat	pelvic inflammatory disease	treatment	IDA			RGD
Il4	Mouse	pelvic inflammatory disease	treatment	ISO	Il4 (Rattus norvegicus)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Il4 (interleukin 4)

Genes (Mus musculus)

Il4 (interleukin 4)

Genes (Homo sapiens)

IL4 (interleukin 4)

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[Effect of Smilax china bioactive fraction on tumor necrosis factor-alpha and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease].