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Gene: Il4 (interleukin 4) Mus musculus
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Symbol: Il4
Name: interleukin 4
Description: Exhibits cytokine activity. Involved in several processes, including T-helper cell differentiation; positive regulation of cellular metabolic process; and regulation of leukocyte activation. Localizes to external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); hepatitis B; hepatitis C; pancreatic cancer (multiple); and vasculitis (multiple). Orthologous to human IL4 (interleukin 4); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (20S)-ginsenoside Rh1; (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1,2-dibutyrin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Il-4; interleukin-4; lymphocyte stimulatory factor 1
Orthologs:
Homo sapiens (human) : IL4 (interleukin 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il4 (interleukin 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il4 (interleukin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IL4 (interleukin 4)
Canis lupus familiaris (dog) : IL4 (interleukin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il4 (interleukin 4)
Sus scrofa (pig) : IL4 (interleukin 4)
Chlorocebus sabaeus (African green monkey) : IL4 (interleukin 4)
Heterocephalus glaber (naked mole-rat) : Il4 (interleukin 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBImm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)