Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Mus musculus
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Symbol: Il4
Name: interleukin 4
RGD ID: 10796
MGI Page MGI
Description: Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; positive regulation of cellular metabolic process; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (20S)-ginsenoside Rh1; (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1,2-dibutyrin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Il; Il-4; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBImm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
adult T-cell leukemia  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (IEP,ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (IEA,ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (IEP,ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (IDA,ISO)
common cold  (IEP)
contact dermatitis  (IEP)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP,ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (IMP,ISO)
Gaucher's disease  (IEP)
Granuloma  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (IMP)
Human Influenza  (IEP)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (IEP)
Knee Osteoarthritis  (ISO)
leishmaniasis  (IMP,ISO)
Lung Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (IDA,ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
psoriasis  (IDA,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IMP)
pulmonary tuberculosis  (IEP)
respiratory allergy  (IMP,ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (IEA)
Spinal Cord Injuries  (ISO)
Staphylococcal Infections  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (ISO)
type 1 diabetes mellitus  (IEA)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-trans-(S)-allethrin  (ISO)
(20S)-ginsenoside Rh1  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R)-lipoic acid  (ISO)
1,2-dibutyrin  (EXP)
1,2-dichloroethane  (ISO)
1,3,5-trinitrobenzene  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
13,14-dihydro-15-ketoprostaglandin D2  (EXP)
15-acetyldeoxynivalenol  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-acetyldeoxynivalenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-ethylphenol  (EXP)
4-nonylphenol  (ISO)
4-tolyl isocyanate  (EXP)
5-azacytidine  (ISO)
6-anilino-5,8-quinolinedione  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-cis-retinoic acid  (EXP,ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetone  (ISO)
acetylsalicylic acid  (ISO)
acrylic acid  (ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allicin  (ISO)
alpha-galactosylceramide  (EXP)
alpha-hexylcinnamaldehyde  (EXP,ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (EXP)
aluminium hydroxide  (EXP,ISO)
aluminium(0)  (EXP)
ammonium chloride  (ISO)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (EXP)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP,ISO)
asperentin  (EXP)
azathioprine  (ISO)
BAPTA  (ISO)
beclomethasone  (EXP,ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzofurans  (EXP)
berberine  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
bexarotene  (ISO)
bifenthrin  (EXP)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
boric acid  (EXP,ISO)
boron atom  (ISO)
Brevetoxin B  (ISO)
bucladesine  (ISO)
budesonide  (EXP)
buprenorphine  (ISO)
butenafine  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcipotriol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
carbachol  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
caryophyllene oxide  (EXP)
ceric oxide  (EXP)
cerium trichloride  (EXP)
cetirizine  (EXP)
chlorambucil  (ISO)
chloroform  (EXP)
chloroquine  (EXP)
chlorphenamine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cilostazol  (EXP)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
cladribine  (ISO)
clarithromycin  (ISO)
clopidogrel  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP)
crocidolite asbestos  (EXP)
cupressuflavone  (EXP)
curcumin  (EXP,ISO)
cyclopentanes  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
D-penicillamine  (ISO)
daidzein  (EXP)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
Deguelin  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenzothiazol-2-yl disulfide  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicloxacillin  (EXP)
dicyclohexylmethane-4,4'-diisocyanate  (EXP)
diethyl maleate  (ISO)
diethylamine  (EXP)
diflorasone  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
diphenylmethane-4,4'-diisocyanate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
donepezil hydrochloride  (EXP)
doxorubicin  (ISO)
dydrogesterone  (EXP,ISO)
edaravone  (ISO)
elemental boron  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP)
epinastine  (ISO)
equol  (EXP)
Erionite  (EXP)
estriol  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
famotidine  (EXP)
fentanyl  (ISO)
ferric oxide  (EXP)
fisetin  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (EXP)
flutamide  (EXP)
fluticasone  (ISO)
folic acid  (EXP)
fomepizole  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP)
formoterol fumarate  (ISO)
fragrance  (ISO)
fulvestrant  (EXP)
furfuryl alcohol  (EXP)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
Gastrodin  (EXP)
gemcitabine  (ISO)
genistein  (EXP)
ginsenoside C-K  (EXP)
glutathione  (EXP,ISO)
graphite  (EXP)
helenalin  (ISO)
heroin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexamethylene diisocyanate  (EXP)
histamine  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
hydroxyzine  (EXP)
ibuprofen  (EXP)
IC-87114  (EXP)
idelalisib  (EXP)
immunological adjuvant  (ISO)
indometacin  (ISO)
ionomycin  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isophorone diisocyanate  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (EXP)
lactacystin  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (EXP)
leflunomide  (EXP,ISO)
leukotriene B4  (ISO)
levamisole  (EXP,ISO)
lidocaine  (EXP)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lipoxin A4  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
loperamide  (ISO)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
melatonin  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (ISO)
methadone  (ISO)
methanol  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl isocyanate  (ISO)
methyl salicylate  (EXP)
miconazole  (ISO)
mifepristone  (EXP,ISO)
mitogen  (EXP)
MK 571  (EXP)
Monobutylphthalate  (ISO)
monodansylcadaverine  (EXP)
montelukast  (EXP)
morphine  (EXP,ISO)
moxifloxacin  (ISO)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naproxen  (ISO)
naringin  (EXP)
neocuproine  (EXP)
Nicardipine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrendipine  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP)
nitrogen dioxide  (EXP)
nitroprusside  (EXP,ISO)
Nivalenol  (EXP)
nonanoic acid  (EXP)
Nonylphenol  (EXP)
NS-398  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
Olopatadine hydrochloride  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
patulin  (ISO)
PCB138  (ISO)
pentachlorophenol  (EXP)
pentamidine  (EXP)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phthalaldehyde  (EXP)
phthalic anhydride  (EXP,ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
polyphosphates  (ISO)
prednisolone  (EXP,ISO)
prednisone  (ISO)
progesterone  (EXP,ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
pyrene  (EXP,ISO)
Pyridostigmine bromide  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
ribavirin  (ISO)
ricinoleic acid  (ISO)
Ro 41-5253  (ISO)
rolipram  (EXP)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylic acid  (ISO)
SB 203580  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (EXP)
serotonin  (EXP)
serpentine asbestos  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP)
silver(1+) nitrate  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium hexachloroplatinate  (EXP)
Sodium salicylate  (ISO)
sodium stibogluconate  (EXP,ISO)
spathulenol  (EXP)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
styrene  (EXP)
Sucralfate  (ISO)
sulfasalazine  (ISO)
sulfur dioxide  (EXP)
sumatriptan  (ISO)
Sunset Yellow FCF  (EXP)
synephrine  (EXP,ISO)
syringin  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP,ISO)
thioacetamide  (ISO)
thiram  (EXP)
thromboxane B2  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
tolnaftate  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-piceid  (ISO)
tremolite asbestos  (EXP)
triamcinolone acetonide  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tributyrin  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (EXP,ISO)
Triptolide  (EXP)
uranium atom  (EXP)
urethane  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
verrucarin A  (EXP)
vitamin E  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IBA,ISO)
autophagy  (IEA)
B cell activation  (IEA)
B cell costimulation  (IBA,IDA)
cellular response to mercury ion  (ISO)
cholesterol metabolic process  (IMP)
defense response to protozoan  (IMP)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IDA)
female pregnancy  (ISO)
immune response  (IEA)
innate immune response in mucosa  (IBA,IDA)
macrophage activation  (ISO)
microglial cell activation  (IBA,ISO)
myeloid dendritic cell differentiation  (IBA,ISO)
negative regulation of acute inflammatory response  (IBA,ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (IBA,ISO)
negative regulation of complement-dependent cytotoxicity  (IBA,ISO)
negative regulation of endothelial cell apoptotic process  (IBA,ISO)
negative regulation of epithelial cell migration  (IBA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,IDA)
negative regulation of inflammatory response  (ISO)
negative regulation of macrophage activation  (IBA,ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of osteoclast differentiation  (IDA)
negative regulation of T cell activation  (IDA)
negative regulation of T-helper 17 cell differentiation  (IBA,IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tumor necrosis factor production  (IDA)
negative regulation of white fat cell proliferation  (IDA)
neuroinflammatory response  (ISO)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of amyloid-beta clearance  (IBA,IDA,ISO)
positive regulation of ATP biosynthetic process  (IDA)
positive regulation of B cell activation  (IDA)
positive regulation of B cell proliferation  (IDA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cellular respiration  (IDA)
positive regulation of chemokine production  (IDA)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of defense response to virus by host  (IBA,ISO)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of eosinophil chemotaxis  (IBA,ISO)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of immunoglobulin production  (IGI,IMP)
positive regulation of interleukin-10 production  (IBA,ISO)
positive regulation of interleukin-13 production  (IBA,ISO)
positive regulation of isotype switching to IgE isotypes  (IBA,IDA)
positive regulation of isotype switching to IgG isotypes  (IBA,IDA)
positive regulation of macroautophagy  (IBA,IDA)
positive regulation of mast cell degranulation  (IBA,IGI,IMP)
positive regulation of MHC class II biosynthetic process  (IBA,IDA)
positive regulation of mononuclear cell migration  (IBA,ISO)
positive regulation of myoblast fusion  (IBA,IDA,IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (IBA,IDA,ISO)
positive regulation of T cell differentiation  (IBA,ISO)
positive regulation of T cell proliferation  (IDA)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI)
positive regulation of transcription, DNA-templated  (IBA,IDA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IBA,IDA,ISO)
regulation of immune response  (IDA)
regulation of inflammatory response  (ISO)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
T cell activation  (ISO)
T-helper 1 cell lineage commitment  (IGI)
T-helper 2 cell differentiation  (IBA,IDA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell death  (IAGP)
abnormal circulating complement protein level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interleukin-4 secretion  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal lymph node germinal center morphology  (IAGP)
abnormal lymph node size  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal response to infection  (IAGP)
abnormal salivary gland physiology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal spleen size  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal susceptibility to Riboviria infection  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
alveolar process atrophy  (IAGP)
autoimmune response  (IAGP)
CNS inflammation  (IAGP)
decreased airway responsiveness  (IAGP)
decreased anti-nuclear antigen antibody level  (IAGP)
decreased B cell number  (IAGP)
decreased basophil cell number  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased core body temperature  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased fatty acids level  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-13 secretion  (IAGP)
decreased interleukin-3 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased noradrenaline level  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to autoimmune disorder  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased susceptibility to systemic lupus erythematosus  (IAGP)
emphysema  (IAGP)
enlarged spleen  (IAGP)
esophageal epithelium hyperplasia  (IAGP)
esophageal inflammation  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
ileum inflammation  (IAGP)
impaired eosinophil recruitment  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased B cell proliferation  (IAGP)
increased basophil cell number  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating glucose level  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG2c level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-5 secretion  (IAGP)
increased mast cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to parasitic infection induced morbidity/mortality  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
insulitis  (IAGP)
lacrimal gland inflammation  (IAGP)
liver inflammation  (IAGP)
lung epithelium hyperplasia  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
salivary gland inflammation  (IAGP)
spleen hyperplasia  (IAGP)
stomach inflammation  (IAGP)
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Additional References at PubMed
PMID:1197194   PMID:1349581   PMID:1358285   PMID:1360278   PMID:1401920   PMID:1431102   PMID:1431136   PMID:1530915   PMID:1545131   PMID:1559701   PMID:1588041   PMID:1596564  
PMID:1613462   PMID:1649220   PMID:1937872   PMID:1948049   PMID:1969921   PMID:1993171   PMID:2377456   PMID:2466396   PMID:2563351   PMID:2784591   PMID:2789124   PMID:2902144  
PMID:3005865   PMID:3029676   PMID:3083412   PMID:3498301   PMID:6977612   PMID:7485382   PMID:7507352   PMID:7507968   PMID:7512032   PMID:7515717   PMID:7515912   PMID:7517363  
PMID:7532600   PMID:7591152   PMID:7594565   PMID:7598937   PMID:7609051   PMID:7613115   PMID:7636230   PMID:7691937   PMID:7691943   PMID:7697544   PMID:7705393   PMID:7720090  
PMID:7729546   PMID:7749983   PMID:7750457   PMID:7760829   PMID:7790826   PMID:7807002   PMID:7807021   PMID:7826951   PMID:7873190   PMID:7873877   PMID:7874121   PMID:7889406  
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PMID:8906833   PMID:8911153   PMID:8916957   PMID:8921430   PMID:8934515   PMID:8943375   PMID:8943570   PMID:8977198   PMID:8977282   PMID:8992981   PMID:8992993   PMID:8996242  
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