Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Mus musculus
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Symbol: Il4
Name: interleukin 4
RGD ID: 10796
MGI Page MGI
Description: Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Il; Il-4; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,503,287 - 53,509,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,493,809 - 53,509,496 (-)EnsemblGRCm39 Ensembl
GRCm381153,612,460 - 53,618,665 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,602,982 - 53,618,669 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,425,962 - 53,432,167 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,455,891 - 53,462,088 (-)NCBIMGSCv36mm8
Celera1158,191,990 - 58,198,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
Acute Lung Injury  (ISO)
acute myocardial infarction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (IEP,ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (IAGP,ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (IEP,ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (ISO)
bronchiolitis obliterans  (ISO)
cardiomyopathy  (ISO)
carotid stenosis  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
colitis  (IDA,ISO)
common cold  (IEP)
contact dermatitis  (IEP)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP,ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (IMP,ISO)
Gaucher's disease  (IEP)
Granuloma  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (IMP)
Human Influenza  (IEP)
hypothyroidism  (ISO)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (ISO)
Kawasaki disease  (IEP)
Knee Osteoarthritis  (ISO)
leishmaniasis  (IMP,ISO)
Lung Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (IDA,ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
psoriasis  (IDA,ISO)