RGD Reference Report - Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production. - Rat Genome Database

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Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production.

Authors: Zwingenberger, K  Harms, G  Pedrosa, C  Omena, S  Sandkamp, B  Neifer, S 
Citation: Zwingenberger K, etal., Clin Immunol Immunopathol. 1990 Nov;57(2):242-9.
RGD ID: 7829781
Pubmed: PMID:2145107   (View Abstract at PubMed)

Accumulating evidence points toward an antagonism between TH1 and TH2 focused immune responses decisive for the outcome of parasitic infections with leishmaniae. Interferon-gamma (IFN-gamma) and interleukin 4 (IL4), the principal cytokines involved in these pathways, as well as IgE and the IgG subclasses differentially modulated by these cytokines, were therefore assessed in 18 Brazilian patients with visceral leishmaniasis. The results are compared to those of a local control group. IL4 was detected in all patient sera but in only one control. Low concentrations of IFN-gamma where detectable in 50% of the Brazilian controls but in only two patients. While group medians of mitogen-induced in vitro synthesis of IL4 and IFN-gamma were similar, release of these lymphokines correlated inversely in patients (Spearman's rho = -0.84). Elevations of serum IgE complement the lymphokine data to indicate prominent TH2 type responses in clinical infections with Leishmania donovani.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IFNGHumanleishmaniasis  IEP  RGD 
IL4Humanleishmaniasis  IEP protein:increased expression:serumRGD 
IfngRatleishmaniasis  ISOIFNG (Homo sapiens) RGD 
IfngMouseleishmaniasis  ISOIFNG (Homo sapiens) RGD 
Il4Ratleishmaniasis  ISOIL4 (Homo sapiens)protein:increased expression:serumRGD 
Il4Mouseleishmaniasis  ISOIL4 (Homo sapiens)protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)
Il4  (interleukin 4)

Genes (Mus musculus)
Ifng  (interferon gamma)
Il4  (interleukin 4)

Genes (Homo sapiens)
IFNG  (interferon gamma)
IL4  (interleukin 4)


Additional Information