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Glatiramer acetate reverses cognitive deficits from cranial-irradiated rat by inducing hippocampal neurogenesis.

Authors: He, F  Zou, JT  Zhou, QF  Niu, DL  Jia, WH 
Citation: He F, etal., J Neuroimmunol. 2014 Jun 15;271(1-2):1-7. doi: 10.1016/j.jneuroim.2014.03.015. Epub 2014 Mar 26.
Pubmed: (View Article at PubMed) PMID:24713401
DOI: Full-text: DOI:10.1016/j.jneuroim.2014.03.015

Patients received cranial-irradiation can be affected with cognitive deficits and decreasing hippocampal neurogenesis. In this work, we characterized the cognitive ability and immune-induced neurogenesis of the pre- and post-treated cranial-irradiated rats with Glatiramer acetate (GA), known as a weak CNS auto-antigen. The GA-treated rats displayed better cognitive abilities in Morris water maze (MWM). The numbers of Iba-I-positive microglia, BrdU(+)/DCX(+) cells and BrdU(+)/NeuN(+) cells in hippocampus increased, which are accompanied with increased IFN-gamma and decreased IL-6, IL-4. Furthermore, GA reverted the Th1/Th2 balance. GA treatment can reverse the cognitive deficits caused by cranial irradiation through a mechanism that likely involves immunomodulation.


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RGD ID: 10402800
Created: 2015-10-29
Species: All species
Last Modified: 2015-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.