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Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock.

Authors: Ye, Jianrong  Zhang, Qin  Xuan, Yan  Chen, Siyu  Ma, Long  Zhang, Yongqiang  Zheng, Hong 
Citation: Ye J, etal., Korean J Parasitol. 2016 Dec;54(6):769-775. doi: 10.3347/kjp.2016.54.6.769. Epub 2016 Dec 31.
Pubmed: (View Article at PubMed) PMID:28095662
DOI: Full-text: DOI:10.3347/kjp.2016.54.6.769

This retrospective case-control study explored the factors associated with anaphylactic shock during surgery for cystic echinococcosis (CE) at the First Affiliated Hospital of Xinjiang Medical University between October 2008 and September 2013. Patients who suffered from anaphylactic shock (n=16) were age-matched 3:1 to patients who did not (n=43). Multivariate analysis suggested that IL-4 levels (odds ratio=1.096; 95% confidence interval=1.015-1.185; P=0.02) and cyst size (odds ratio=3.028, 95% confidence interval=1.259-7.283, P=0.013) were independently associated with CE-induced perioperative anaphylactic shock. Using the receiver operating characteristic (ROC) curves and a cut-off value of 415.7 ng/ml, IL-4 showed an area under the ROC (AUC) of 0.926, sensitivity of 75.0%, and specificity of 97.7%. Using a cut-off value of 7.8 cm, cyst size showed an AUC of 0.828, sensitivity of 81.3%, and specificity of 76.7%. In conclusion, results suggest that levels of IL-4 and cyst size were independently associated with echinococcosis-induced perioperative anaphylactic shock. These results could help identifying patients with echinococcosis at risk of anaphylactic shock in whom appropriate prophylaxis could be undertaken.

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RGD ID: 14696684
Created: 2019-07-12
Species: All species
Last Modified: 2019-07-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.