Itk (IL2-inducible T-cell kinase) - Rat Genome Database

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Gene: Itk (IL2-inducible T-cell kinase) Rattus norvegicus
Analyze
Symbol: Itk
Name: IL2-inducible T-cell kinase
RGD ID: 1311618
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including T cell activation; antigen receptor-mediated signaling pathway; and protein phosphorylation. Predicted to be located in cell-cell junction; cytosol; and nucleus. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; chemokine mediated signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363577; tyrosine-protein kinase ITK/TSK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,254,667 - 31,316,004 (-)NCBIGRCr8
GRCr8 Ensembl1031,254,667 - 31,316,004 (-)EnsemblGRCr8 Ensembl
mRatBN7.21030,753,344 - 30,814,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,753,344 - 30,814,685 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,480,495 - 35,541,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,018,954 - 4,080,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,455,134 - 30,516,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,431,820 - 31,493,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,431,809 - 31,493,419 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,248,181 - 31,308,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,455,982 - 31,518,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1030,205,244 - 30,266,599 (-)NCBICelera
RGSC_v3.11031,457,025 - 31,519,124 (-)NCBI
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10213685   PMID:12186560   PMID:15662016   PMID:18292523   PMID:23562159   PMID:23793062  


Genomics

Comparative Map Data
Itk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,254,667 - 31,316,004 (-)NCBIGRCr8
GRCr8 Ensembl1031,254,667 - 31,316,004 (-)EnsemblGRCr8 Ensembl
mRatBN7.21030,753,344 - 30,814,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,753,344 - 30,814,685 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,480,495 - 35,541,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,018,954 - 4,080,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,455,134 - 30,516,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,431,820 - 31,493,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,431,809 - 31,493,419 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,248,181 - 31,308,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,455,982 - 31,518,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1030,205,244 - 30,266,599 (-)NCBICelera
RGSC_v3.11031,457,025 - 31,519,124 (-)NCBI
Cytogenetic Map10q21NCBI
ITK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,180,840 - 157,255,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,142,933 - 157,255,185 (+)EnsemblGRCh38hg38GRCh38
GRCh375156,607,851 - 156,682,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,540,485 - 156,614,687 (+)NCBINCBI36Build 36hg18NCBI36
Build 345156,540,484 - 156,614,687NCBI
Celera5152,634,440 - 152,708,658 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,695,940 - 151,769,767 (+)NCBIHuRef
CHM1_15156,040,619 - 156,114,765 (+)NCBICHM1_1
T2T-CHM13v2.05157,699,782 - 157,774,113 (+)NCBIT2T-CHM13v2.0
Itk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,215,975 - 46,280,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,215,977 - 46,280,342 (-)EnsemblGRCm39 Ensembl
GRCm381146,325,148 - 46,389,515 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,325,150 - 46,389,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv371146,138,652 - 46,203,017 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,168,576 - 46,232,923 (-)NCBIMGSCv36mm8
Celera1150,911,124 - 50,975,428 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.75NCBI
Itk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,387,589 - 11,448,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,387,595 - 11,447,896 (+)NCBIChiLan1.0ChiLan1.0
ITK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,364,876 - 152,450,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,504,423 - 150,590,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,582,125 - 152,656,211 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15159,204,016 - 159,277,689 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,204,016 - 159,277,689 (+)Ensemblpanpan1.1panPan2
ITK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1452,902,886 - 52,966,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl452,902,871 - 52,966,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,795,128 - 52,858,373 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,339,439 - 53,402,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl453,340,020 - 53,402,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1453,165,818 - 53,229,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,272,737 - 53,336,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,789,682 - 53,852,963 (-)NCBIUU_Cfam_GSD_1.0
Itk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,441,822 - 107,503,029 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365155,891,828 - 5,952,458 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365155,891,873 - 5,952,400 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1666,010,772 - 66,082,185 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11666,010,766 - 66,082,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,884,821 - 71,940,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,575,113 - 59,650,166 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,575,179 - 59,650,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603417,980,495 - 18,055,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473332,127,388 - 32,198,869 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473332,125,005 - 32,198,901 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itk
532 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:668
Count of miRNA genes:298
Interacting mature miRNAs:371
Transcripts:ENSRNOT00000009211
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AU047252  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81031,262,708 - 31,262,834 (+)Marker Load Pipeline
mRatBN7.21030,761,387 - 30,761,513 (+)MAPPERmRatBN7.2
Rnor_6.01031,439,869 - 31,439,994NCBIRnor6.0
Rnor_5.01031,256,228 - 31,256,353UniSTSRnor5.0
RGSC_v3.41031,464,024 - 31,464,149UniSTSRGSC3.4
Celera1030,213,284 - 30,213,409UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 8 29 89 83 82 51 25 51 6 187 74 11 69 45 58 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000009211   ⟹   ENSRNOP00000009211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1031,254,667 - 31,316,004 (-)Ensembl
mRatBN7.2 Ensembl1030,753,344 - 30,814,685 (-)Ensembl
Rnor_6.0 Ensembl1031,431,809 - 31,493,419 (-)Ensembl
RefSeq Acc Id: NM_001108825   ⟹   NP_001102295
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81031,254,667 - 31,316,004 (-)NCBI
mRatBN7.21030,753,344 - 30,814,685 (-)NCBI
Rnor_6.01031,431,827 - 31,493,357 (-)NCBI
Rnor_5.01031,248,181 - 31,308,814 (-)NCBI
RGSC_v3.41031,455,982 - 31,518,075 (-)RGD
Celera1030,205,244 - 30,266,599 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102295 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04168 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009211
  ENSRNOP00000009211.7
RefSeq Acc Id: NP_001102295   ⟸   NM_001108825
- UniProtKB: A6HDR3 (UniProtKB/TrEMBL),   D4A7W7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009211   ⟸   ENSRNOT00000009211
Protein Domains
PH   Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7W7-F1-model_v2 AlphaFold D4A7W7 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311618 AgrOrtholog
BioCyc Gene G2FUF-25369 BioCyc
Ensembl Genes ENSRNOG00000006860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009211 ENTREZGENE
  ENSRNOT00000009211.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ITK_PTKc UniProtKB/TrEMBL
  ITK_SH3 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/TrEMBL
KEGG Report rno:363577 UniProtKB/TrEMBL
NCBI Gene 363577 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam BTK UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Itk PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_BTK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006860 RatGTEx
SMART BTK UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A6HDR3 ENTREZGENE, UniProtKB/TrEMBL
  D4A7W7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Itk  IL2-inducible T-cell kinase   Itk_predicted  IL2-inducible T-cell kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Itk_predicted  IL2-inducible T-cell kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED