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Gene: Itk (IL2-inducible T-cell kinase) Rattus norvegicus

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Symbol:

Itk

Name:

IL2-inducible T-cell kinase

RGD ID:

1311618

Description:

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including T cell activation; antigen receptor-mediated signaling pathway; and protein phosphorylation. Predicted to be located in cell-cell junction; cytosol; and nucleus. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; chemokine mediated signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC363577; tyrosine-protein kinase ITK/TSK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ITK (IL2 inducible T cell kinase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Itk (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Itk (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ITK (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ITK (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Itk (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ITK (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ITK (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Itk (IL2 inducible T cell kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ITK (IL2 inducible T cell kinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Itk (IL2 inducible T cell kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	itk (IL2 inducible T cell kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Btk29A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Btk29A	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	itk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	31,254,667 - 31,316,004 (-)	NCBI		GRCr8
GRCr8 Ensembl	10	31,254,667 - 31,316,004 (-)	Ensembl		GRCr8 Ensembl
mRatBN7.2	10	30,753,344 - 30,814,685 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,753,344 - 30,814,685 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	35,480,495 - 35,541,820 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	4,018,954 - 4,080,268 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	30,455,134 - 30,516,447 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	31,431,820 - 31,493,413 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,431,809 - 31,493,419 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	31,248,181 - 31,308,814 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	31,455,982 - 31,518,075 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	30,205,244 - 30,266,599 (-)	NCBI		Celera
RGSC_v3.1	10	31,457,025 - 31,519,124 (-)	NCBI
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome (ISO)

Chediak-Higashi syndrome (ISO)

genetic disease (ISO)

lymphoproliferative syndrome (ISO)

lymphoproliferative syndrome 1 (ISO)

vitiligo (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP,ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetohydrazide (ISO)

alpha-Zearalanol (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

cyclophosphamide (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

diethylstilbestrol (ISO)

disodium selenite (ISO)

diuron (ISO)

furan (EXP)

hydrazine (ISO)

hydroxychloroquine (ISO)

isoprenaline (ISO)

methapyrilene (EXP)

methotrexate (ISO)

N,N-diethyl-m-toluamide (EXP)

nickel atom (ISO)

ochratoxin A (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

silicon dioxide (ISO)

sulfasalazine (ISO)

temozolomide (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IBA,IEA,ISO)

B cell receptor signaling pathway (IBA)

gamma-delta T cell activation (IEA,ISO)

immune system process (IEA)

intracellular signal transduction (IEA)

NK T cell differentiation (IBA,IEA,ISO)

positive regulation of cytokine production (IEA,ISO)

protein phosphorylation (ISO)

signal transduction (IEA)

T cell activation (IEA)

T cell receptor signaling pathway (IBA,IEA,ISO)

Cellular Component

cell-cell junction (IEA,ISO)

cytoplasm (IEA)

cytosol (IEA,ISO)

nucleus (IEA,ISO)

plasma membrane (IBA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

metal ion binding (IEA)

non-membrane spanning protein tyrosine kinase activity (IBA,IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA)

transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

T cell receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10213685	PMID:12186560	PMID:15662016	PMID:18292523	PMID:23562159	PMID:23793062

Genomics

Comparative Map Data

Itk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	31,254,667 - 31,316,004 (-)	NCBI		GRCr8
GRCr8 Ensembl	10	31,254,667 - 31,316,004 (-)	Ensembl		GRCr8 Ensembl
mRatBN7.2	10	30,753,344 - 30,814,685 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,753,344 - 30,814,685 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	35,480,495 - 35,541,820 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	4,018,954 - 4,080,268 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	30,455,134 - 30,516,447 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	31,431,820 - 31,493,413 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,431,809 - 31,493,419 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	31,248,181 - 31,308,814 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	31,455,982 - 31,518,075 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	30,205,244 - 30,266,599 (-)	NCBI		Celera
RGSC_v3.1	10	31,457,025 - 31,519,124 (-)	NCBI
Cytogenetic Map	10	q21	NCBI

ITK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	157,180,840 - 157,255,185 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	157,142,933 - 157,255,185 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	156,607,851 - 156,682,195 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	156,540,485 - 156,614,687 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	156,540,484 - 156,614,687	NCBI
Celera	5	152,634,440 - 152,708,658 (+)	NCBI		Celera
Cytogenetic Map	5	q33.3	NCBI
HuRef	5	151,695,940 - 151,769,767 (+)	NCBI		HuRef
CHM1_1	5	156,040,619 - 156,114,765 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	157,699,782 - 157,774,113 (+)	NCBI		T2T-CHM13v2.0

Itk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	46,215,975 - 46,280,342 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	46,215,977 - 46,280,342 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	46,325,148 - 46,389,515 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	46,325,150 - 46,389,515 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	46,138,652 - 46,203,017 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	46,168,576 - 46,232,923 (-)	NCBI		MGSCv36	mm8
Celera	11	50,911,124 - 50,975,428 (-)	NCBI		Celera
Cytogenetic Map	11	B1.1	NCBI
cM Map	11	27.75	NCBI

Itk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	11,387,589 - 11,448,199 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	11,387,595 - 11,447,896 (+)	NCBI	ChiLan1.0	ChiLan1.0

ITK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	152,364,876 - 152,450,621 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	150,504,423 - 150,590,168 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	152,582,125 - 152,656,211 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	159,204,016 - 159,277,689 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	159,204,016 - 159,277,689 (+)	Ensembl	panpan1.1		panPan2

ITK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	52,902,886 - 52,966,465 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	52,902,871 - 52,966,542 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	52,795,128 - 52,858,373 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	53,339,439 - 53,402,778 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	53,340,020 - 53,402,842 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	53,165,818 - 53,229,419 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	53,272,737 - 53,336,070 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	53,789,682 - 53,852,963 (-)	NCBI		UU_Cfam_GSD_1.0

Itk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	107,441,822 - 107,503,029 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936515	5,891,828 - 5,952,458 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936515	5,891,873 - 5,952,400 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	66,010,772 - 66,082,185 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	66,010,766 - 66,082,263 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	71,884,821 - 71,940,522 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ITK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	59,575,113 - 59,650,166 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	59,575,179 - 59,650,559 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	17,980,495 - 18,055,594 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Itk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	32,127,388 - 32,198,869 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	32,125,005 - 32,198,901 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Itk
532 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	668
Count of miRNA genes:	298
Interacting mature miRNAs:	371
Transcripts:	ENSRNOT00000009211
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	23422121	32490778	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	29377046	52699134	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31129113	76129113	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

AU047252

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	10	31,262,708 - 31,262,834 (+)	Marker Load Pipeline
mRatBN7.2	10	30,761,387 - 30,761,513 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,439,869 - 31,439,994	NCBI	Rnor6.0
Rnor_5.0	10	31,256,228 - 31,256,353	UniSTS	Rnor5.0
RGSC_v3.4	10	31,464,024 - 31,464,149	UniSTS	RGSC3.4
Celera	10	30,213,284 - 30,213,409	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	8	29	89	83	82	51	25	51	6	187	74	11	69	45	58	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009211 ⟹ ENSRNOP00000009211

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	31,254,667 - 31,316,004 (-)	Ensembl
mRatBN7.2 Ensembl	10	30,753,344 - 30,814,685 (-)	Ensembl
Rnor_6.0 Ensembl	10	31,431,809 - 31,493,419 (-)	Ensembl

RefSeq Acc Id:

NM_001108825 ⟹ NP_001102295

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	31,254,667 - 31,316,004 (-)	NCBI
mRatBN7.2	10	30,753,344 - 30,814,685 (-)	NCBI
Rnor_6.0	10	31,431,827 - 31,493,357 (-)	NCBI
Rnor_5.0	10	31,248,181 - 31,308,814 (-)	NCBI
RGSC_v3.4	10	31,455,982 - 31,518,075 (-)	RGD
Celera	10	30,205,244 - 30,266,599 (-)	RGD

Sequence:

show sequence

AACTGCATCCTGTCGCGTTCCCAGCCGTTCCTCTCCTTCAGTCGAACTCAGGGGTGATGCCCGA
GGCGCCTCACCTTTCAGAACTGGACCATGAACAACTTCATCCTCCTGGAAGAACAGCTGATCAA
GAAGTCCCAACAGAAGAGAAGGACTTCTCCCTCGAATTTTAAAGTCCGTTTCTTCGTCTTAACG
AAAGCCAGCCTGGCATACTTCGAGGACCGCCACGGGAAGAAGCGCACGTTGAAGGGCTCCATCG
AACTCTCCAGAATCAAGTGCGTGGAGATTGTCAAGAGTGACATTAGCATCCCGTGCCACTATAA
ATACCCTTTTCAGACTCTTACGTCCTTCCAGGTCATGCACGACAACTACCTCCTGTACGTGTTT
GCTCCAGACTGCGAGAGCCGTCAGCGCTGGGTGCTCACCCTTAAAGAAGAAACGAGGAATAACA
ACAGCCTAGTATCCAAGTATCACCCTAATTTCTGGATGGATGGGCGGTGGAGGTGCTGTTCCCA
GCTAGAGAAGCTTGCCGTAGGCTGTGCTCCCTACGACCCAACGAAGAATGCTTCAAAGAAGCCT
CTTCCTCCTACTCCTGAAGACAACAGGCGGTCATTTCAGGAACCTGAAGAAACCCTGGTCATTG
CCTTGTACGACTACCAAACCAACGATCCTCAGGAGCTCGCGCTGCGGCGTGATGAAGAGTACTA
CCTGCTGGACAGCTCCGAGATCCACTGGTGGCGGGTTCAAGACAAGAATGGGCATGAAGGATAT
GCACCCAGCAGTTACCTGGTGGAAAAGTCTCCAAATAGCCTTGAAACCTACGAGTGGTACAATA
AAAGCATCAGCCGAGACAAAGCTGAAAAACTTCTTTTGGACACAGGTAAAGAAGGAGCATTCAT
GGTCCGAGATTCCAGGACACCCGGGACATACACAGTCTCTGTCTTCACCAAGGCCATCATAAGT
GAGAACAACCCCTGTATAAAACATTATCACATCAAAGAAACAAATGACAGCCCCAAGCGGTACT
ATGTGGCTGAGAAGTATGTGTTTGACTCCATCCCTCTCCTCATCCAGTATCACCAATACAATGG
AGGAGGTTTGGTCACTCGACTCCGGTATCCAGTTTGCTCCTGGAGGCAGAAAGCCCCTGTCACA
GCAGGGCTAAGATATGGGAAGTGGGTGATCCAGCCCTCGGAGCTAACTTTCGTGCAGGAGATTG
GCAGCGGGCAGTTTGGACTGGTGCATCTCGGCTACTGGCTCAACAAGGACAAGGTGGCCATCAA
GACCATTCAGGAAGGGGCGATGTCAGAAGAAGACTTTATCGAGGAGGCAGAAGTCATGATGAAA
CTCTCTCACCCCAAGCTGGTGCAGCTCTATGGGGTGTGCTTGGAGCAAGCCCCCATCTGCCTGG
TGTTTGAGTTCATGGAGCACGGCTGCCTATCGGATTACCTTCGAAGTCAGCGGGGTCTCTTTGC
TGCAGAGACCCTGCTGGGCATGTGCCTGGACGTGTGTGAGGGCATGGCCTACCTAGAAAAAGCG
TGTGTCATCCACAGAGACCTGGCCGCCAGGAACTGTTTGGTGGGAGAAAACCAGGTCATCAAGG
TGTCCGACTTCGGCATGACAAGGTTTGTCCTTGATGATCAATATACCAGCTCCACGGGCACCAA
ATTCCCAGTGAAGTGGGCATCCCCAGAAGTGTTCTCCTTCAGCCGCTACAGCAGCAAGTCAGAT
GTGTGGTCATTTGGTGTACTGATGTGGGAAGTCTTCAGCGAAGGCAAAATCCCATATGAAAACC
GAAGCAATTCAGAGGTCGTGGAAGACATCAGCACTGGCTTTCGGTTATACAAGCCCCGCCTGGC
CTCCCCTCATGTCTACCAGGTCATGAATCACTGCTGGAAAGAGAAACCGGAAGACCGGCCACCC
TTCTCCCGGCTGTTAAGCCAACTGGCTGAAATCGCAGAATGTGGACTTTAGCCGGGACTCATTG
ACCAGCCACCGCCATGAATCCTGAGCGAAGGAACAATGTCCCTTTTCCAAAGCATTAAAAGCTG
CCACCAGCCCAGGACCCCCACAGGTGCCTGGACCATGGCGGCAGCACCTGTGCAGCCACAACTG
CAGCATCCTAGAAGACGCTGGAGGGCCAGCCGCCGAGCCAACAGCTGGGCCGCAGCTGGAGCAG
TGTCTCTGTGTCTGCCCCATCCCAGCCTCTTGTCATATGCTGTACTCGAGGCTCCATTGCCCGC
TCTCAGGAACAGCCCTTCCCCTTCTCAGCAATCAGGAGAGGCAGATGTAGGCCACGCTCTTCTT
TTTATTATTATTTTAAGAATAGTTCAAGTAATCTTTAATTTGACCCAACGAGACTATATGCCTA
TTTTATGGATGGGAGAGTAGGAAAGCACCGTTCTTTTTCTAAGAAACCCACGGGGTGGTTAAAG
CAGGGTGTTCTACTGCTGCAAGGCTGGCAGCCATAGCTTCCTGCCACACACGAGGCAGAGTGGA
TGCTTGTGCCAGAGGCCGGATGTCATACAACTTCAGAGCACACTGCCACCTCTCTTTGATGGGG
CACAGCGAGCTCCACTGGGTGGATAGAGTGGGGTGACACATTCAGAGCCCATGGCTGGACCACA
GGGTGTCTGAGTCTAGTCAGGAATGAGAGGGCCTCCGATGGTGGGAATAAACGGGTGCAGAAGA
AGTCTTTGGGTTGTTACTGATCCTATGACCCTGTGTAATGGCGAGCCACGTGCGTGACTGGATC
TCCTGTTCTGCGTAGAATGCTGTGGCGATGACTACAGAATGTTCGCCACTCCAGCCTCTCAGGA
GCGGCGTCCACACGGCACTGCCCACATGAACCGAGATAGGGCAGCACTGTGATGATCATGTTAC
TTTGAGACATTGGGTTCTCTCAGGCCCTAGGGGTTTGTTTAGCAGTCTGAAGGTTGAGTCAAGC
ACTGGGCGGTGCTTCCAAAATGCACAGAATGTTGATTGGCACTTGCACAGGTGACAGGCATATA
GCCCGCATGCTGGTTATTCCTGAGGAACCGCAGTTCATCCCAAGCCAGACAACTGTCCTGGTGA
CAGAACTGGGAAGGACAGAGATTGAGACGCCACCCAAATATAATCCAGGGCAGCCTCTTAGCTC
TTCTCAACACTGCCTCCTGCTGAGACCGGACTGCTAAGGACGGTAACATAGGAAAGTCAGACCT
TAATCAGCCACACCCCCACCCAACCATGTTGTTCCTACATAGAGCACTGGGGGGCACAGTGGGA
CCCTCCAATTTGAAACGGACTGTTCTCTTTCTTCATCTTCATCCTCACCTTCATCTGAGTTCAC
AACCCTCGAGCCACTCAAAATTAACCCTTTCATTCTCCCAGCCTACCAGAGTCACATCGCCTGA
GGCCATTTATACAAGAGCTTCAAAGGTGCTCTCAACTAGCCTCCTGCAGACTGTTTGCTGTAAT
TATCCCTTCAACCTAGAGCTGGATCTCTTGTGAGGAGGAGGATTCCCTGATGCCAGGCACACTT
GATTTCCCTGCAGTGTTCAAACAAAGCTCCTAGAAAAATGATCAGAGTCACAGATTTCCTCTTC
CTAAGTCACACAGCATTTTGTCTGGCTTGCACTTCAGATGCATCACTTCCGGCTGTAATCACCA
TGTCCAGCTAAAACTCTGTCACTCAGAAAACAATCTTCCTCAACTGGCCCACACTCGTCTCTGT
TTATGTCTCAGCCTACTGTACATTCTCTTTTGGGAACCCTTAATTAAGAGACGGTTTCTGGGAC
ATCCAACCTAGACGCTAAACACTGGAACTGAGAGATGTCTGTGGTGTGGTCTAGGAGACTGCCC
TCCCCCACCATACCGTGGTCTTGGCCCTCTAACCTCAAATGTGTGGAGGCTTTGATGGGCGTGT
GTGCACCGCTTACTCCAGTGTCCCGCTTAGGAAGATGGGATTCTCTTCTGCTGGTTTCTGTCTT
ACATTTTTGTAAATGGTGCCCAGTGTTCACAGAAAGGTTTTGGTTCGAAATGTATTTTGTAGGT
TTTGCAATTCGTAATGTTTGGGACTACGTATTTATGCCTGGATCGGGAGAGTATTTATTGCTTG
TGTTCCAGATAAAAGTACTTCAGATATGTCTTACCCTCTGTAGGAGGCACAAGTCAACAGTTGC
TTATGGAAAAAAAAATAATAATAAAGTTACATGTTTTAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102295	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM04168	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009211
	ENSRNOP00000009211.7

RefSeq Acc Id:

NP_001102295 ⟸ NM_001108825

- UniProtKB:

A6HDR3 (UniProtKB/TrEMBL), D4A7W7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE
IVKSDISIPCHYKYPFQTLTSFQVMHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHP
NFWMDGRWRCCSQLEKLAVGCAPYDPTKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTND
PQELALRRDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNSLETYEWYNKSISRDKAE
KLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENNPCIKHYHIKETNDSPKRYYVAEKYVFD
SIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVH
LGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGC
LSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRF
VLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVED
ISTGFRLYKPRLASPHVYQVMNHCWKEKPEDRPPFSRLLSQLAEIAECGL

hide sequence

Ensembl Acc Id:

ENSRNOP00000009211 ⟸ ENSRNOT00000009211

Protein Domains

PH Protein kinase SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7W7-F1-model_v2	AlphaFold	D4A7W7	1-620	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311618	AgrOrtholog
BioCyc Gene	G2FUF-25369	BioCyc
Ensembl Genes	ENSRNOG00000006860	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009211	ENTREZGENE
	ENSRNOT00000009211.8	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	ITK_PTKc	UniProtKB/TrEMBL
	ITK_SH3	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/TrEMBL
KEGG Report	rno:363577	UniProtKB/TrEMBL
NCBI Gene	363577	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Itk	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	TECBTKDOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006860	RatGTEx
SMART	BTK	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A6HDR3	ENTREZGENE, UniProtKB/TrEMBL
	D4A7W7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Itk	IL2-inducible T-cell kinase	Itk_predicted	IL2-inducible T-cell kinase (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Itk_predicted	IL2-inducible T-cell kinase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)