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Gene: Itk (IL2-inducible T-cell kinase) Rattus norvegicus
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Symbol: Itk
Name: IL2-inducible T-cell kinase
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including T cell activation; antigen receptor-mediated signaling pathway; and cytokine production. Predicted to localize to cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; chemokine mediated signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC363577; tyrosine-protein kinase ITK/TSK
Orthologs:
Homo sapiens (human) : ITK (IL2 inducible T cell kinase)  HGNC  Alliance
Mus musculus (house mouse) : Itk (IL2 inducible T cell kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itk (IL2 inducible T cell kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITK (IL2 inducible T cell kinase)
Canis lupus familiaris (dog) : ITK (IL2 inducible T cell kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itk (IL2 inducible T cell kinase)
Sus scrofa (pig) : ITK (IL2 inducible T cell kinase)
Chlorocebus sabaeus (African green monkey) : ITK (IL2 inducible T cell kinase)
Heterocephalus glaber (naked mole-rat) : Itk (IL2 inducible T cell kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01031,431,820 - 31,493,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,431,809 - 31,493,419 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,248,181 - 31,308,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,455,982 - 31,518,075 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11031,457,025 - 31,519,124 (-)NCBI
Celera1030,205,244 - 30,266,599 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Itk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311618
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.