Irgm (immunity-related GTPase M) - Rat Genome Database

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Gene: Irgm (immunity-related GTPase M) Rattus norvegicus
Analyze
Symbol: Irgm
Name: immunity-related GTPase M
RGD ID: 1305163
Description: Predicted to enable several functions, including G protein activity; anion binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of organelle organization; positive regulation of protein phosphorylation; and regulation of defense response. Predicted to act upstream of or within cellular response to type II interferon and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; autolysosome; and cytoplasmic vesicle. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and mitochondrial membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ifggd3; Ifi1; immunity-related GTPase family M protein; immunity-related GTPase family, M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; LOC303090
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,734,640 - 33,742,720 (-)NCBIGRCr8
mRatBN7.21033,233,513 - 33,241,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,233,455 - 33,241,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1037,913,410 - 37,921,342 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,451,824 - 6,459,756 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,907,048 - 32,914,980 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,213,885 - 34,221,968 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,213,936 - 34,221,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01033,997,565 - 34,005,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41034,132,512 - 34,140,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11034,133,560 - 34,141,499 (-)NCBI
Celera1032,619,552 - 32,627,490 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alpha-phellandrene  (ISO)
Aroclor 1254  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
ciguatoxin CTX1B  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
endosulfan  (EXP)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hexaconazole  (ISO)
indole-3-methanol  (EXP)
lipopolysaccharide  (ISO)
metam  (ISO)
nefazodone  (EXP)
nevirapine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (ISO)
autophagosome maturation  (ISO,ISS)
CAMKK-AMPK signaling cascade  (ISO)
cellular response to interferon-beta  (IBA,IEA)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (ISO)
defense response  (IBA,ISO)
defense response to bacterium  (ISO,ISS)
defense response to Gram-negative bacterium  (ISO)
defense response to other organism  (IEA)
innate immune response  (ISO,ISS)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cGAS/STING signaling pathway  (ISO)
negative regulation of defense response to virus  (ISO,ISS)
negative regulation of hematopoietic stem cell proliferation  (ISO,ISS)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of NLRP3 inflammasome complex assembly  (ISO,ISS)
negative regulation of type I interferon production  (ISO,ISS)
negative regulation of type II interferon production  (ISO,ISS)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of autophagosome maturation  (ISO)
positive regulation of autophagy  (ISO,ISS)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO,ISS)
positive regulation of lysosome organization  (ISO)
positive regulation of macrophage activation  (ISO,ISS)
positive regulation of mitochondrial fission  (ISO)
positive regulation of mitophagy  (ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of type II interferon-mediated signaling pathway  (ISO)
positive regulation of xenophagy  (ISO)
protein destabilization  (ISO)
protein stabilization  (ISO)
protein targeting to vacuole involved in autophagy  (ISO)
protein-containing complex assembly  (ISO)
regulation of mitochondrial fission  (ISO,ISS)
regulation of protein complex stability  (ISO)
regulation of protein-containing complex assembly  (ISO)
response to bacterium  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11457893   PMID:12477932   PMID:16888103   PMID:19144319   PMID:20072621   PMID:22892676   PMID:23012479   PMID:25891078   PMID:28389568  


Genomics

Comparative Map Data
Irgm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,734,640 - 33,742,720 (-)NCBIGRCr8
mRatBN7.21033,233,513 - 33,241,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,233,455 - 33,241,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1037,913,410 - 37,921,342 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,451,824 - 6,459,756 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,907,048 - 32,914,980 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,213,885 - 34,221,968 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,213,936 - 34,221,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01033,997,565 - 34,005,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41034,132,512 - 34,140,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11034,133,560 - 34,141,499 (-)NCBI
Celera1032,619,552 - 32,627,490 (-)NCBICelera
Cytogenetic Map10q21NCBI
IRGM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,846,521 - 150,902,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,846,521 - 150,900,736 (+)EnsemblGRCh38hg38GRCh38
GRCh375150,226,083 - 150,281,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,207,879 - 150,208,424 (+)NCBINCBI36Build 36hg18NCBI36
Celera5146,307,411 - 146,309,557 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,371,946 - 145,374,092 (+)NCBIHuRef
CHM1_15149,658,892 - 149,661,038 (+)NCBICHM1_1
T2T-CHM13v2.05151,383,019 - 151,438,900 (+)NCBIT2T-CHM13v2.0
Irgm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391148,756,072 - 48,762,247 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1148,752,795 - 48,762,510 (-)EnsemblGRCm39 Ensembl
GRCm381148,865,245 - 48,871,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1148,861,968 - 48,871,683 (-)EnsemblGRCm38mm10GRCm38
MGSCv371148,678,751 - 48,684,848 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361148,708,672 - 48,714,769 (-)NCBIMGSCv36mm8
Celera1153,447,611 - 53,453,702 (-)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1128.84NCBI
Irgm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554082,338,510 - 2,344,566 (+)NCBIChiLan1.0ChiLan1.0
IRGM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,078,470 - 146,134,350 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,218,016 - 144,273,896 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,274,097 - 146,329,979 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,276,981 - 152,332,575 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,278,581 - 152,308,182 (+)Ensemblpanpan1.1panPan2
LOC606863
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111506,981 - 523,338 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11509,636 - 510,829 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11568,312 - 569,505 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.011470,804 - 485,519 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.111443,994 - 445,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.011531,575 - 532,768 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.011692,999 - 694,192 (-)NCBIUU_Cfam_GSD_1.0
LOC101972667
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,480,944 - 142,493,084 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365044,055,091 - 4,056,089 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRGM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,449,576 - 53,451,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,239,475 - 24,271,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irgm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473341,241,488 - 41,248,162 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irgm
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:162
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000045545
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat

Markers in Region
RH131017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21033,233,683 - 33,233,865 (+)MAPPERmRatBN7.2
Rnor_6.01034,214,060 - 34,214,241NCBIRnor6.0
Rnor_5.01033,997,736 - 33,997,917UniSTSRnor5.0
RGSC_v3.41034,132,683 - 34,132,864UniSTSRGSC3.4
Celera1032,619,723 - 32,619,904UniSTS
RH 3.4 Map10347.1UniSTS
Cytogenetic Map10q21UniSTS
RH133553  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10345.1UniSTS
Cytogenetic Map10q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 35 21 19 21 3 9 11
Low 1 28 22 20 20 8 8 66 33 26 8
Below cutoff 12 8 2 6

Sequence


RefSeq Acc Id: ENSRNOT00000045545   ⟹   ENSRNOP00000047579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,233,514 - 33,241,451 (-)Ensembl
Rnor_6.0 Ensembl1034,213,936 - 34,221,928 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106065   ⟹   ENSRNOP00000094495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,233,455 - 33,241,578 (-)Ensembl
RefSeq Acc Id: NM_001012007   ⟹   NP_001012007
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,734,640 - 33,742,578 (-)NCBI
mRatBN7.21033,233,513 - 33,241,451 (-)NCBI
Rnor_6.01034,213,889 - 34,221,827 (-)NCBI
Rnor_5.01033,997,565 - 34,005,641 (-)NCBI
RGSC_v3.41034,132,512 - 34,140,450 (-)RGD
Celera1032,619,552 - 32,627,490 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246178   ⟹   XP_006246240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,734,640 - 33,742,720 (-)NCBI
mRatBN7.21033,233,513 - 33,241,594 (-)NCBI
Rnor_6.01034,213,885 - 34,221,968 (-)NCBI
Rnor_5.01033,997,565 - 34,005,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246179   ⟹   XP_006246241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,734,640 - 33,742,710 (-)NCBI
mRatBN7.21033,233,513 - 33,241,594 (-)NCBI
Rnor_6.01034,213,885 - 34,221,968 (-)NCBI
Rnor_5.01033,997,565 - 34,005,641 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001012007   ⟸   NM_001012007
- UniProtKB: Q6AYC2 (UniProtKB/Swiss-Prot),   A6HDU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246241   ⟸   XM_006246179
- Peptide Label: isoform X2
- UniProtKB: J7NUQ1 (UniProtKB/TrEMBL),   A0A8I6AM97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246240   ⟸   XM_006246178
- Peptide Label: isoform X1
- UniProtKB: Q6AYC2 (UniProtKB/Swiss-Prot),   A6HDU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047579   ⟸   ENSRNOT00000045545
RefSeq Acc Id: ENSRNOP00000094495   ⟸   ENSRNOT00000106065
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYC2-F1-model_v2 AlphaFold Q6AYC2 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697135
Promoter ID:EPDNEW_R7660
Type:initiation region
Name:Irgm_2
Description:immunity-related GTPase M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7661  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,221,810 - 34,221,870EPDNEW
RGD ID:13697136
Promoter ID:EPDNEW_R7661
Type:single initiation site
Name:Irgm_1
Description:immunity-related GTPase M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7660  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,221,971 - 34,222,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305163 AgrOrtholog
BioCyc Gene G2FUF-25326 BioCyc
Ensembl Genes ENSRNOG00000031138 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018146 UniProtKB/Swiss-Prot
  ENSRNOG00060017821 UniProtKB/Swiss-Prot
  ENSRNOG00065005918 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045545 ENTREZGENE
  ENSRNOT00000045545.4 UniProtKB/Swiss-Prot
  ENSRNOT00000106065.1 UniProtKB/TrEMBL
  ENSRNOT00055030723 UniProtKB/Swiss-Prot
  ENSRNOT00060030495 UniProtKB/Swiss-Prot
  ENSRNOT00065008897 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125255 IMAGE-MGC_LOAD
InterPro G_IRG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunity-related_GTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94096 IMAGE-MGC_LOAD
NCBI Gene 303090 ENTREZGENE
PANTHER IMMUNITY-RELATED GTPASE FAMILY M PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IIGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irgm PhenoGen
PROSITE G_IRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031138 RatGTEx
  ENSRNOG00055018146 RatGTEx
  ENSRNOG00060017821 RatGTEx
  ENSRNOG00065005918 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AM97 ENTREZGENE, UniProtKB/TrEMBL
  A6HDU6 ENTREZGENE, UniProtKB/TrEMBL
  IRGM_RAT UniProtKB/Swiss-Prot
  J7NUQ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYC2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Irgm  immunity-related GTPase M  Irgm  immunity-related GTPase family, M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Irgm  immunity-related GTPase family, M  Ifi1  interferon inducible protein 1  Symbol and Name updated 1299863 APPROVED
2005-12-06 Ifi1  interferon inducible protein 1  Ifi1_predicted  interferon inducible protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ifi1_predicted  interferon inducible protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED