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Gene: Irgm (immunity-related GTPase M) Rattus norvegicus

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Symbol:

Irgm

Name:

immunity-related GTPase M

RGD ID:

1305163

Description:

Predicted to enable several functions, including G protein activity; anion binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of organelle organization; positive regulation of protein phosphorylation; and regulation of defense response. Predicted to act upstream of or within cellular response to type II interferon and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and vacuole. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and mitochondrial membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ifggd3; Ifi1; immunity-related GTPase family M protein; immunity-related GTPase family, M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; LOC303090

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	33,734,640 - 33,742,720 (-)	NCBI		GRCr8
mRatBN7.2	10	33,233,513 - 33,241,594 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	33,233,455 - 33,241,578 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	37,913,410 - 37,921,342 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	6,451,824 - 6,459,756 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	32,907,048 - 32,914,980 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	34,213,885 - 34,221,968 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,213,936 - 34,221,928 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	33,997,565 - 34,005,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	34,132,512 - 34,140,450 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	34,133,560 - 34,141,499 (-)	NCBI
Celera	10	32,619,552 - 32,627,490 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Crohn's disease (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

inflammatory bowel disease (ISO)

inflammatory bowel disease 19 (ISO)

tuberculosis (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

1,2-dimethylhydrazine (ISO)

15-acetyldeoxynivalenol (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (EXP)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

aldehydo-D-glucose (ISO)

alpha-phellandrene (ISO)

Aroclor 1254 (ISO)

Bavachinin (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (EXP)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chloroprene (EXP)

ciguatoxin CTX1B (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

dieldrin (EXP)

diethyl maleate (EXP)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dimethyl sulfoxide (ISO)

dioxygen (EXP)

endosulfan (EXP)

fluoranthene (ISO)

flusilazole (ISO)

flutamide (EXP)

folic acid (ISO)

fructose (ISO)

gentamycin (EXP)

ginsenoside Re (ISO)

glucose (ISO)

glyphosate (ISO)

hexaconazole (ISO)

indole-3-methanol (EXP)

lipopolysaccharide (ISO)

metam (ISO)

nefazodone (EXP)

nevirapine (EXP)

oxaliplatin (EXP)

ozone (EXP,ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

propiconazole (ISO)

resveratrol (ISO)

SB 203580 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

tetrachloromethane (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

triadimefon (ISO)

trichostatin A (ISO)

trimellitic anhydride (EXP)

Triptolide (EXP)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (IBA,IEA,ISO)

autophagosome maturation (IEA,ISO,ISS)

autophagy (IEA)

CAMKK-AMPK signaling cascade (ISO)

cellular response to interferon-beta (IBA)

cellular response to lipopolysaccharide (ISO)

cellular response to type II interferon (IEA,ISO)

defense response (IEA,ISO)

defense response to bacterium (IEA,ISO,ISS)

defense response to Gram-negative bacterium (ISO)

immune system process (IEA)

innate immune response (IBA,IEA,ISO,ISS)

negative regulation of canonical NF-kappaB signal transduction (ISO)

negative regulation of cGAS/STING signaling pathway (ISO)

negative regulation of defense response to virus (IEA,ISO,ISS)

negative regulation of hematopoietic stem cell proliferation (IEA,ISO,ISS)

negative regulation of inflammatory response (IEA,ISO,ISS)

negative regulation of NLRP3 inflammasome complex assembly (IEA,ISO,ISS)

negative regulation of type I interferon production (IEA,ISO,ISS)

negative regulation of type II interferon production (IEA,ISO,ISS)

nucleotide-binding oligomerization domain containing 2 signaling pathway (ISO)

positive regulation of autophagosome maturation (IEA,ISO)

positive regulation of autophagy (IEA,ISO,ISS)

positive regulation of CD4-positive, alpha-beta T cell proliferation (IEA,ISO,ISS)

positive regulation of lysosome organization (ISO)

positive regulation of macrophage activation (IEA,ISO,ISS)

positive regulation of mitochondrial fission (ISO)

positive regulation of mitophagy (IEA,ISO,ISS)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of peptidyl-threonine phosphorylation (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of protein serine/threonine kinase activity (ISO)

positive regulation of type II interferon-mediated signaling pathway (IEA,ISO)

positive regulation of xenophagy (ISO)

protein destabilization (ISO)

protein lipidation involved in autophagosome assembly (ISO)

protein stabilization (ISO)

protein targeting to vacuole involved in autophagy (ISO)

protein-containing complex assembly (ISO)

regulation of mitochondrial fission (IEA,ISO,ISS)

regulation of protein complex stability (ISO)

regulation of protein-containing complex assembly (ISO)

response to bacterium (IEA,ISO)

Cellular Component

autolysosome (IEA,ISO)

autophagosome (IEA,ISO)

autophagosome membrane (IEA,ISO)

cell projection (IEA)

cytoplasmic vesicle (IEA)

cytosol (ISO)

endoplasmic reticulum membrane (IBA)

endosome (IEA)

Golgi apparatus (IEA,ISO)

Golgi membrane (IEA,ISO,ISS)

late endosome (IEA,ISO)

late endosome membrane (IEA)

lysosomal membrane (IEA,ISO,ISS)

lysosome (IEA,ISO)

membrane (IEA)

mitochondrial membrane (IEA,ISO,ISS)

mitochondrion (IEA,ISO)

phagocytic cup (IEA)

phagocytic vesicle (IEA,ISO)

phagocytic vesicle membrane (IEA)

plasma membrane (IEA)

Molecular Function

BH3 domain binding (ISO)

CARD domain binding (ISO)

cardiolipin binding (IEA,ISO)

G protein activity (ISO)

GTP binding (IEA)

GTPase activity (IBA,IEA,ISO,ISS)

hydrolase activity (IEA)

lipid binding (IEA)

nucleotide binding (IEA)

phosphatidylinositol-3,4,5-trisphosphate binding (IEA,ISO)

phosphatidylinositol-3,4-bisphosphate binding (IEA,ISO)

protein binding (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activator activity (ISO)

protein-macromolecule adaptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11457893	PMID:12477932	PMID:16888103	PMID:19144319	PMID:20072621	PMID:22892676	PMID:23012479	PMID:25891078	PMID:28389568

Genomics

Comparative Map Data

Irgm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	33,734,640 - 33,742,720 (-)	NCBI		GRCr8
mRatBN7.2	10	33,233,513 - 33,241,594 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	33,233,455 - 33,241,578 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	37,913,410 - 37,921,342 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	6,451,824 - 6,459,756 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	32,907,048 - 32,914,980 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	34,213,885 - 34,221,968 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	34,213,936 - 34,221,928 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	33,997,565 - 34,005,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	34,132,512 - 34,140,450 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	34,133,560 - 34,141,499 (-)	NCBI
Celera	10	32,619,552 - 32,627,490 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

IRGM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	150,846,521 - 150,902,402 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	150,846,521 - 150,900,736 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	150,226,083 - 150,281,964 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	150,207,879 - 150,208,424 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	146,307,411 - 146,309,557 (+)	NCBI		Celera
Cytogenetic Map	5	q33.1	NCBI
HuRef	5	145,371,946 - 145,374,092 (+)	NCBI		HuRef
CHM1_1	5	149,658,892 - 149,661,038 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	151,383,019 - 151,438,900 (+)	NCBI		T2T-CHM13v2.0

Irgm1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	48,756,072 - 48,762,247 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	48,752,795 - 48,762,510 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	48,865,245 - 48,871,420 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	48,861,968 - 48,871,683 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	48,678,751 - 48,684,848 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	48,708,672 - 48,714,769 (-)	NCBI		MGSCv36	mm8
Celera	11	53,447,611 - 53,453,702 (-)	NCBI		Celera
Cytogenetic Map	11	B1.2	NCBI
cM Map	11	28.84	NCBI

Irgm
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955408	2,338,510 - 2,344,566 (+)	NCBI	ChiLan1.0	ChiLan1.0

IRGM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	146,078,470 - 146,134,350 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	144,218,016 - 144,273,896 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	146,274,097 - 146,329,979 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	152,276,981 - 152,332,575 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	152,278,581 - 152,308,182 (+)	Ensembl	panpan1.1		panPan2

LOC606863
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	506,981 - 523,338 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	509,636 - 510,829 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	568,312 - 569,505 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	470,804 - 485,519 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	11	443,994 - 445,187 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	531,575 - 532,768 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	692,999 - 694,192 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101972667
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	142,480,944 - 142,493,084 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936504	4,055,091 - 4,056,089 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IRGM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	53,449,576 - 53,451,373 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666034	24,239,475 - 24,271,349 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Irgm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624733	41,241,488 - 41,248,162 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Irgm
32 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	225
Count of miRNA genes:	162
Interacting mature miRNAs:	173
Transcripts:	ENSRNOT00000045545
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	27957626	34490668	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	22918268	36400810	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat

Markers in Region

RH131017

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	33,233,683 - 33,233,865 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	34,214,060 - 34,214,241	NCBI	Rnor6.0
Rnor_5.0	10	33,997,736 - 33,997,917	UniSTS	Rnor5.0
RGSC_v3.4	10	34,132,683 - 34,132,864	UniSTS	RGSC3.4
Celera	10	32,619,723 - 32,619,904	UniSTS
RH 3.4 Map	10	347.1	UniSTS
Cytogenetic Map	10	q21	UniSTS

RH133553

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	10	345.1	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FR734044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000045545 ⟹ ENSRNOP00000047579

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	33,233,514 - 33,241,451 (-)	Ensembl
Rnor_6.0 Ensembl	10	34,213,936 - 34,221,928 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106065 ⟹ ENSRNOP00000094495

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	33,233,455 - 33,241,578 (-)	Ensembl

RefSeq Acc Id:

NM_001012007 ⟹ NP_001012007

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	33,734,640 - 33,742,578 (-)	NCBI
mRatBN7.2	10	33,233,513 - 33,241,451 (-)	NCBI
Rnor_6.0	10	34,213,889 - 34,221,827 (-)	NCBI
Rnor_5.0	10	33,997,565 - 34,005,641 (-)	NCBI
RGSC_v3.4	10	34,132,512 - 34,140,450 (-)	RGD
Celera	10	32,619,552 - 32,627,490 (-)	RGD

Sequence:

show sequence

CCCGGCTGGGCCCTGGCAAACAGATCTCAGATCTAGAAACTGCAGGACAAACTGCTTAGAGACC
AGAGGCAGAAAGGAAATCCACCCGATCAGACCTCGTCTTGGTTCACTCCTCTCAGAACTCCAGA
CCTCTGCATCTCATCTCTAAACATCCGGGTCTAGATTCCAGTTCTGGGTCTCTCTGTAGAGAAC
TTTTGCCGGAGGACCGCAACGTTTATTTCTAAGAAAGAAGGAGGGGGTGACGTTACAGGAAGCC
CACTAACATTGAATCACACATAACTCTTCTGGATCAGGGTTTGAGGAGTATTAAGTGAGATAAG
GCATTCGAAGGAACCAACTCAGATTCAAGACACAGGACCTTCTTGCTGTGTGCTTAGAGTCTAA
GAGTGGAGGAAGAACCTGAGGAACGGCTTCCTCAGAGACCCTAATAAAACCAGAGAGCCTCACC
AGGGAGCTGAGAGGTGCCCAGAAAGCATCACACGGATCTTGTCATGAAACCATCACACAAGTCC
TGCGAGGCTGCTCCACTACTCCCCAAGATGCCAGAGACCAGTACCCATAATGCTCCACTGAACT
TGTCCTTCCCCTCCGTCCCTTCATACCAAATAGGCTGTAGCAGTTTGCCTGAGATCAGTAGGAG
CACTGAAAGAGCTTTAAAAGAAGGAAAACTACCGGAACTGGTCTATGGAGTCAAGGAGACTGTG
GCAACATTGTCCCAAATCCCAGTGAGCATCTTCGTGACTGGGGACTCGGGCAATGGCATGTCAT
CTTTCATCAATGCACTTCGAATCATTGGCCATGAGGAAGATGCCTCGGCTCCCACTGGGGTAGT
AAGGACCACCCAGACACGGGCTGAGTACTCCTCATCCCACTTTCCCAATGTGGTACTGTGGGAC
CTACCTGGATTGGGGGCCACAGCCCAAACCGTAGAGAACTATATAGAAGAGATGAAATTCAGTA
CGTGTGACTTATTCATCATCGTCGCCTCGGAGCAGTTCAGCTCAAATCACGTGAAGCTGGCCAA
AATCATCCAGAGCATGGGAAAGAGGTTCTATGTCATCTGGACCAAGCTGGACCGGGACCTCAGC
ACGAGCGTCCTATCAGAGGTCCGGCTCATACAGAATATCCAGGAGAATATACGGGAGAATCTCC
AGAAGGAGGGAGTGAAGGAAGTTCCCATATTCCTAGTATCCAATCTAGACCCTCTCCTGCATGA
CTTCCCGGAACTTAGGAACACACTTCAGACAGACCTGTCCAACATCAGGTGCTGTGAACCCTTA
AAGACCCTTTATGTCATTTATGAGAAGATCATCGGTGACAAAGTAGCCAACTGGAACCAGATAA
TAGCCAACGGGCGCTTGAAGAGTTCTCTCGGGGTCAGAGATGATGATGACATGGGGGAGTGTCT
GAAAAGGTACCGATTGATATTTGGTATCGATGATGAATCACTTCAGCAGATAGCTCACGGTATG
GGGACAGTAGTCATGGAGTACAAGGCCAACATAAAGTCCCAAGACTTCCACACTCTCCGCAGAG
CGGACTGGAAACTGCGGCTGATGACCTGTACAACTGTGAATGCACTCTTCTGTTTGTTTAAATT
TCTCCCGTGCTTATGCCACTGTTTCAAACGCATGAGACATAAACGCATGCTCCTCTTAGTTGCC
AAGGACACCAAGAACATCCTGAAGAAAATCCTGATGGACGCTGTCTCTCCACCGCAAATCTAGT
GTAAGGGTGGCCTGGTACCCTTCTTTTCATATAGAGCCAATTACCTCTTCCTTAGATCCCTATT
TCTCCACTAGAAATCAAGAGATAAATTCTTTGATAGGAGTTAGTCATGATGGACTCATCCCCCC
CCCACCCAGACTCTAATGTATTGTTCTACTGAGGAACAGGGACAAGTAATGATTAAAAATCAAT
GACTGGGGGCTGACAAGATGGCTCACTGGCTGCTCTTCCACAGGTCCTGAGTTCAGTTCCCAGC
AACCACATGGTGACTCACAACCATCTTTAGGAAAATCTGATGCCTTCTTCAGGCAGGCGGATGT
ATATGCAGCAGAGCACTCATATATTAAATAAATAAACTTTAAAAAAATCAATGACCATGATTCT
TAGATGGAATATAGACATTTTGTTTTCAGCTATTAAGTGTGATTTATGTCTAAATCAATTTTCC
TCTGAAACAATAAAGTCGGTTGGTTCCTCTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006246178 ⟹ XP_006246240

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	33,734,640 - 33,742,720 (-)	NCBI
mRatBN7.2	10	33,233,513 - 33,241,594 (-)	NCBI
Rnor_6.0	10	34,213,885 - 34,221,968 (-)	NCBI
Rnor_5.0	10	33,997,565 - 34,005,641 (-)	NCBI

Sequence:

show sequence

TCAGCCCTGTTGAACTTGGGTCAGCACAGCAGGGCTCTGCTCCTATTTGAAGAATACTAGGCAG
CCGGCCCAGCCCAATTCTGAAAACCAGTTCGTTTCAAGGAATAGAAACTGAAACCGACTCTCTA
TTGGGAGTCCCCTCCCGGCTGGGCCCTGGCAAACAGATCTCAGATCTAGAAACTGCAGGACAAA
CTGCTTAGAGACCAGAGGCAGAAAGGAAATCCACCCGATCAGACCTCGTCTTGGTTCACTCCTC
TCAGAACTCCAGACCTCTGCATCTCATCTCTAAACATCCGGGTCTAGATTCCAGTTCTGGGTCT
CTCTGTAGAGAACTTTTGCCGGAGGACCGCAACGTTTATTTCTAAGAAAGAAGGAGGGGGTGAC
GTTACAGGAAGCCCACTAACATTGAATCACACATAACTCTTCTGGATCAGAGTCTAAGAGTGGA
GGAAGAACCTGAGGAACGGCTTCCTCAGAGACCCTAATAAAACCAGAGAGCCTCACCAGGGAGC
TGAGAGGTGCCCAGAAAGCATCACACGGATCTTGTCATGAAACCATCACACAAGTCCTGCGAGG
CTGCTCCACTACTCCCCAAGATGCCAGAGACCAGTACCCATAATGCTCCACTGAACTTGTCCTT
CCCCTCCGTCCCTTCATACCAAATAGGCTGTAGCAGTTTGCCTGAGATCAGTAGGAGCACTGAA
AGAGCTTTAAAAGAAGGAAAACTACCGGAACTGGTCTATGGAGTCAAGGAGACTGTGGCAACAT
TGTCCCAAATCCCAGTGAGCATCTTCGTGACTGGGGACTCGGGCAATGGCATGTCATCTTTCAT
CAATGCACTTCGAATCATTGGCCATGAGGAAGATGCCTCGGCTCCCACTGGGGTAGTAAGGACC
ACCCAGACACGGGCTGAGTACTCCTCATCCCACTTTCCCAATGTGGTACTGTGGGACCTACCTG
GATTGGGGGCCACAGCCCAAACCGTAGAGAACTATATAGAAGAGATGAAATTCAGTACGTGTGA
CTTATTCATCATCGTCGCCTCGGAGCAGTTCAGCTCAAATCACGTGAAGCTGGCCAAAATCATC
CAGAGCATGGGAAAGAGGTTCTATGTCATCTGGACCAAGCTGGACCGGGACCTCAGCACGAGCG
TCCTATCAGAGGTCCGGCTCATACAGAATATCCAGGAGAATATACGGGAGAATCTCCAGAAGGA
GGGAGTGAAGGAAGTTCCCATATTCCTAGTATCCAATCTAGACCCTCTCCTGCATGACTTCCCG
GAACTTAGGAACACACTTCAGACAGACCTGTCCAACATCAGGTGCTGTGAACCCTTAAAGACCC
TTTATGTCATTTATGAGAAGATCATCGGTGACAAAGTAGCCAACTGGAACCAGATAATAGCCAA
CGGGCGCTTGAAGAGTTCTCTCGGGGTCAGAGATGATGATGACATGGGGGAGTGTCTGAAAAGG
TACCGATTGATATTTGGTATCGATGATGAATCACTTCAGCAGATAGCTCACGGTATGGGGACAG
TAGTCATGGAGTACAAGGCCAACATAAAGTCCCAAGACTTCCACACTCTCCGCAGAGCGGACTG
GAAACTGCGGCTGATGACCTGTACAACTGTGAATGCACTCTTCTGTTTGTTTAAATTTCTCCCG
TGCTTATGCCACTGTTTCAAACGCATGAGACATAAACGCATGCTCCTCTTAGTTGCCAAGGACA
CCAAGAACATCCTGAAGAAAATCCTGATGGACGCTGTCTCTCCACCGCAAATCTAGTGTAAGGG
TGGCCTGGTACCCTTCTTTTCATATAGAGCCAATTACCTCTTCCTTAGATCCCTATTTCTCCAC
TAGAAATCAAGAGATAAATTCTTTGATAGGAGTTAGTCATGATGGACTCATCCCCCCCCCACCC
AGACTCTAATGTATTGTTCTACTGAGGAACAGGGACAAGTAATGATTAAAAATCAATGACTGGG
GGCTGACAAGATGGCTCACTGGCTGCTCTTCCACAGGTCCTGAGTTCAGTTCCCAGCAACCACA
TGGTGACTCACAACCATCTTTAGGAAAATCTGATGCCTTCTTCAGGCAGGCGGATGTATATGCA
GCAGAGCACTCATATATTAAATAAATAAACTTTAAAAAAATCAATGACCATGATTCTTAGATGG
AATATAGACATTTTGTTTTCAGCTATTAAGTGTGATTTATGTCTAAATCAATTTTCCTCTGAAA
CAATAAAGTCGGTTGGTTCCTCTTCATTGA

hide sequence

RefSeq Acc Id:

XM_006246179 ⟹ XP_006246241

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	33,734,640 - 33,742,710 (-)	NCBI
mRatBN7.2	10	33,233,513 - 33,241,594 (-)	NCBI
Rnor_6.0	10	34,213,885 - 34,221,968 (-)	NCBI
Rnor_5.0	10	33,997,565 - 34,005,641 (-)	NCBI

Sequence:

show sequence

TCAGCCCTGTTGAACTTGGGTCAGCACAGCAGGGCTCTGCTCCTATTTGAAGAATACTAGGCAG
CCGGCCCAGCCCAATTCTGAAAACCAGTTCGTTTCAAGGAATAGAAACTGAAACCGACTCTCTA
TTGGGAGTCCCCTCCCGGCTGGGCCCTGGCAAACAGATCTCAGATCTAGAAACTGCAGGACAAA
CTGCTTAGAGACCAGAGGCAGAAAGGAAATCCACCCGATCAGACCTCGTCTTGGTTCACTCCTC
TCAGAACTCCAGACCTCTGCATCTCATCTCTAAACATCCGGGTCTAGATTCCAGTTCTGGGTCT
CTCTGTAGAGAACTTTTGCCGGAGGACCGCAACGTTTATTTCTAAGAAAGAAGGAGGGGGTGAC
GTTACAGGAAGCCCACTAACATTGAATCACACATAACTCTTCTGGATCAGGCTGCTCCACTACT
CCCCAAGATGCCAGAGACCAGTACCCATAATGCTCCACTGAACTTGTCCTTCCCCTCCGTCCCT
TCATACCAAATAGGCTGTAGCAGTTTGCCTGAGATCAGTAGGAGCACTGAAAGAGCTTTAAAAG
AAGGAAAACTACCGGAACTGGTCTATGGAGTCAAGGAGACTGTGGCAACATTGTCCCAAATCCC
AGTGAGCATCTTCGTGACTGGGGACTCGGGCAATGGCATGTCATCTTTCATCAATGCACTTCGA
ATCATTGGCCATGAGGAAGATGCCTCGGCTCCCACTGGGGTAGTAAGGACCACCCAGACACGGG
CTGAGTACTCCTCATCCCACTTTCCCAATGTGGTACTGTGGGACCTACCTGGATTGGGGGCCAC
AGCCCAAACCGTAGAGAACTATATAGAAGAGATGAAATTCAGTACGTGTGACTTATTCATCATC
GTCGCCTCGGAGCAGTTCAGCTCAAATCACGTGAAGCTGGCCAAAATCATCCAGAGCATGGGAA
AGAGGTTCTATGTCATCTGGACCAAGCTGGACCGGGACCTCAGCACGAGCGTCCTATCAGAGGT
CCGGCTCATACAGAATATCCAGGAGAATATACGGGAGAATCTCCAGAAGGAGGGAGTGAAGGAA
GTTCCCATATTCCTAGTATCCAATCTAGACCCTCTCCTGCATGACTTCCCGGAACTTAGGAACA
CACTTCAGACAGACCTGTCCAACATCAGGTGCTGTGAACCCTTAAAGACCCTTTATGTCATTTA
TGAGAAGATCATCGGTGACAAAGTAGCCAACTGGAACCAGATAATAGCCAACGGGCGCTTGAAG
AGTTCTCTCGGGGTCAGAGATGATGATGACATGGGGGAGTGTCTGAAAAGGTACCGATTGATAT
TTGGTATCGATGATGAATCACTTCAGCAGATAGCTCACGGTATGGGGACAGTAGTCATGGAGTA
CAAGGCCAACATAAAGTCCCAAGACTTCCACACTCTCCGCAGAGCGGACTGGAAACTGCGGCTG
ATGACCTGTACAACTGTGAATGCACTCTTCTGTTTGTTTAAATTTCTCCCGTGCTTATGCCACT
GTTTCAAACGCATGAGACATAAACGCATGCTCCTCTTAGTTGCCAAGGACACCAAGAACATCCT
GAAGAAAATCCTGATGGACGCTGTCTCTCCACCGCAAATCTAGTGTAAGGGTGGCCTGGTACCC
TTCTTTTCATATAGAGCCAATTACCTCTTCCTTAGATCCCTATTTCTCCACTAGAAATCAAGAG
ATAAATTCTTTGATAGGAGTTAGTCATGATGGACTCATCCCCCCCCCACCCAGACTCTAATGTA
TTGTTCTACTGAGGAACAGGGACAAGTAATGATTAAAAATCAATGACTGGGGGCTGACAAGATG
GCTCACTGGCTGCTCTTCCACAGGTCCTGAGTTCAGTTCCCAGCAACCACATGGTGACTCACAA
CCATCTTTAGGAAAATCTGATGCCTTCTTCAGGCAGGCGGATGTATATGCAGCAGAGCACTCAT
ATATTAAATAAATAAACTTTAAAAAAATCAATGACCATGATTCTTAGATGGAATATAGACATTT
TGTTTTCAGCTATTAAGTGTGATTTATGTCTAAATCAATTTTCCTCTGAAACAATAAAGTCGGT
TGGTTCCTCTTCATTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012007	(Get FASTA)	NCBI Sequence Viewer
	XP_006246240	(Get FASTA)	NCBI Sequence Viewer
	XP_006246241	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79106	(Get FASTA)	NCBI Sequence Viewer
	CBY66007	(Get FASTA)	NCBI Sequence Viewer
	EDM04201	(Get FASTA)	NCBI Sequence Viewer
	EDM04202	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000047579
	ENSRNOP00000047579.2
	ENSRNOP00000094495.1
	ENSRNOP00000099006
GenBank Protein	Q6AYC2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012007 ⟸ NM_001012007

- UniProtKB:

Q6AYC2 (UniProtKB/Swiss-Prot), A6HDU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKPSHKSCEAAPLLPKMPETSTHNAPLNLSFPSVPSYQIGCSSLPEISRSTERALKEGKLPELV
YGVKETVATLSQIPVSIFVTGDSGNGMSSFINALRIIGHEEDASAPTGVVRTTQTRAEYSSSHF
PNVVLWDLPGLGATAQTVENYIEEMKFSTCDLFIIVASEQFSSNHVKLAKIIQSMGKRFYVIWT
KLDRDLSTSVLSEVRLIQNIQENIRENLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSN
IRCCEPLKTLYVIYEKIIGDKVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESL
QQIAHGMGTVVMEYKANIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHK
RMLLLVAKDTKNILKKILMDAVSPPQI

hide sequence

RefSeq Acc Id:	XP_006246241 ⟸ XM_006246179
- Peptide Label:	isoform X2
- UniProtKB:	J7NUQ1 (UniProtKB/TrEMBL), A0A8I6AM97 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPETSTHNAPLNLSFPSVPSYQIGCSSLPEISRSTERALKEGKLPELVYGVKETVATLSQIPVS IFVTGDSGNGMSSFINALRIIGHEEDASAPTGVVRTTQTRAEYSSSHFPNVVLWDLPGLGATAQ TVENYIEEMKFSTCDLFIIVASEQFSSNHVKLAKIIQSMGKRFYVIWTKLDRDLSTSVLSEVRL IQNIQENIRENLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSNIRCCEPLKTLYVIYEK IIGDKVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESLQQIAHGMGTVVMEYKA NIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHKRMLLLVAKDTKNILKK ILMDAVSPPQI hide sequence

RefSeq Acc Id:	XP_006246240 ⟸ XM_006246178
- Peptide Label:	isoform X1
- UniProtKB:	Q6AYC2 (UniProtKB/Swiss-Prot), A6HDU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPSHKSCEAAPLLPKMPETSTHNAPLNLSFPSVPSYQIGCSSLPEISRSTERALKEGKLPELV YGVKETVATLSQIPVSIFVTGDSGNGMSSFINALRIIGHEEDASAPTGVVRTTQTRAEYSSSHF PNVVLWDLPGLGATAQTVENYIEEMKFSTCDLFIIVASEQFSSNHVKLAKIIQSMGKRFYVIWT KLDRDLSTSVLSEVRLIQNIQENIRENLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSN IRCCEPLKTLYVIYEKIIGDKVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESL QQIAHGMGTVVMEYKANIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHK RMLLLVAKDTKNILKKILMDAVSPPQI hide sequence

Ensembl Acc Id:

ENSRNOP00000047579 ⟸ ENSRNOT00000045545

Ensembl Acc Id:

ENSRNOP00000094495 ⟸ ENSRNOT00000106065

Protein Domains

IRG-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYC2-F1-model_v2	AlphaFold	Q6AYC2	1-411	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697135

Promoter ID:

EPDNEW_R7660

Type:

initiation region

Name:

Irgm_2

Description:

immunity-related GTPase M

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R7661

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	34,221,810 - 34,221,870	EPDNEW

RGD ID:

13697136

Promoter ID:

EPDNEW_R7661

Type:

single initiation site

Name:

Irgm_1

Description:

immunity-related GTPase M

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R7660

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	34,221,971 - 34,222,031	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305163	AgrOrtholog
BioCyc Gene	G2FUF-25326	BioCyc
Ensembl Genes	ENSRNOG00000031138	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045545	ENTREZGENE
	ENSRNOT00000045545.4	UniProtKB/Swiss-Prot
	ENSRNOT00000106065.1	UniProtKB/TrEMBL
	ENSRNOT00000127882	ENTREZGENE
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7125255	IMAGE-MGC_LOAD
InterPro	G_IRG_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Immunity-related_GTPase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IRG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:303090	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:94096	IMAGE-MGC_LOAD
NCBI Gene	303090	ENTREZGENE
PANTHER	IMMUNITY-RELATED GTPASE FAMILY M PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INTERFERON-INDUCIBLE GTPASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	IIGP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Irgm	PhenoGen
PROSITE	G_IRG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000031138	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AM97	ENTREZGENE, UniProtKB/TrEMBL
	A6HDU6	ENTREZGENE, UniProtKB/TrEMBL
	IRGM_RAT	UniProtKB/Swiss-Prot
	J7NUQ1	ENTREZGENE, UniProtKB/TrEMBL
	Q6AYC2	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-11	Irgm	immunity-related GTPase M	Irgm	immunity-related GTPase family, M	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Irgm	immunity-related GTPase family, M	Ifi1	interferon inducible protein 1	Symbol and Name updated	1299863	APPROVED
2005-12-06	Ifi1	interferon inducible protein 1	Ifi1_predicted	interferon inducible protein 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ifi1_predicted	interferon inducible protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM